The Biotech IndustryBy Prof. Nitpal Singh

INDIAN SECTOR PROFILE

• At the beginning of the decade, this industry began to take shape with the sprouting of dozens of start-up companies as well as the diversification of established Pharma players by setting up biotech divisions.

• A lot of significant developments have taken place in the sector since.

• For instance, Shantha Biotech gave the sector a new lease with the first indigenous Hepatitis B vaccine.

• This sector has witnessed three emerging trends. Biopharma, which constitutes nearly two-thirds of the Indian biotech sector, invests in innovative product development

• The second trend relates to the high profile BioAgri segment. This segment emerged when the first transgenic product (Bt cotton) was approved in early 2002

• Biofuels is the third vital component of the Indian biotech story based on the experience of the US and Brazil. So far, the national policy has discouraged the diversion of crop lands and with more than 30 million hectares of degraded and waste lands available

Current Status of Biotech Sector

•ABLE Biotech Industry Survey 2011 has revealed that during the fiscal year 2010-11 the Indian biotech sector grew at 21.5% after two slack years to reach Rs 17,400 crores in revenues.

•The overall figure easily crosses $ 4 million (Rs 18,400 crores) for the first time.

•According to a report by Frost and Sullivan, the global industry size is set to reach $433 billion by 2015.

• Indian Biotech Industry has to achieve the $10 billion mark in the next three years, the Industry has to grow over 40% year-on-year.

• India has missed the $5 billion mark it was estimated to achieve by 2010, according to global research and consulting firm Frost and Sullivan (F&S).

•Approx. 40% of Indian biotech revenue comes from Bangalore which has been ranked among the top 12 biotech destinations globally.

•Biopharmaceuticals contribute 62% of the Indian biotech industry.

•The Global biopharmaceutical market, worth about US$137 billion today, according to industry estimate is expected to touch US$319 billion by 2020 of which Indian biopharmaceuticals market share is a miniscule 1.4 per cent of it (at around US$2 billion) even though it is logging over 30 per cent growth rate.

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Biotech Industry Segment Share

Biotech Industry Segment Share

Biotech Industry Segment Share

Biopharma -61.77%Bioagri -14.38%

Bioservices -18.82%

Bioindustry -3.63%Bioinformatics - 1.47%

•The biopharma segment continues to maintain dominance, followed by the bioindustrial segment.

•The bioagri segment has registered the fastest growth rate, surging from<5% market share five years ago to over 14% in the most recent survey.

•This is mainly due to Bt cotton, the area under which increased to 9.4 million ha with production estimated to be 29.5 million bales.

• The southern region ie(Karnataka, Andhra Pradesh and Tamil Nadu) contributed to 44.22% share of the industry, slightly higher than the western region’s (Gujarat and Maharashtra) share of 43.60%.

•The northern region (Delhi, Haryana) chipped in with 12.18%.

International Front

TCGRE International Biotech Park – Pune

•Biotech Park of 81 acres•Joint venture between TCGRE (The

Chatterjee Group Real Estate) and MIDC (Maharashtra Industrial Development Corporation)

•Biotechnology regulatory standards modeled on international best practices

•Master Planning & Infrastructure Engineering designed by renowned Pell Frishman, London

•32 acres of Biotech Special Economic Zone

•Proposed Multi Faceted development which includes Retail / Commercial, Residential, Business Hotel, Food Court & an Entertainment Zone

•More than 40% of the project is developed and occupied by Leading Biotech Companies

DIVISION…• The Biotech Industry in India can be categorized into

five different segments.

BioPharma: Biopharmaceuticals are generally proteins, drugs and antibodies that are used for diagnostics and therapeutics.

• BioIndustrial : Bioindustrial's usually consists of enzymes, yeast and yeast-based products and organic amino acids.

• BioServices: Bioservices refers to research based contract, manufacturing contracts and clinical research contracts.

• BioAgri: The BioAgri sector consists of biofertilisers, biopesticides and genetically modified seeds.

• Bio-IT: This sectors consists of the different products and services that represent bioinformatics.

Top 10 Biotech Companies in India (2011)• Biocon Ltd• Serum Institute of India Ltd.• Panacea Biotec• Nicholas Piramal• Novo Nordisk• GlaxoSmithKline• Bharat Biotech• Krebs Biochemicals and Industries Limited• Zydus Cadila• Indian Immunologicals

Global Biotechnology Market

• The global biotech industry, led by the United States, was $84.6 billion in 2010 and is expected to grow at a 7% CAGR to $103 billion by 2013 as a result of the following primary drivers:

Active participation by private players

Rising information technology innovation

Improving healthcare infrastructure worldwide

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• Despite the recent economic downturn, there was only a 10% decrease in the number of biotechnology companies worldwide through September 2010 from the year prior

• The United States remains the bedrock of the biotech industry, though Europe and Asia are fast growing international markets

• Several European biotechnology companies have announced plans to outsource their manufacturing through collaborations with international partners, increasing production efficiencies and adding to corporate earnings growth

Some Major Players…

•Pifzer•Johnson & Johnson•Merck•Bristol-Mayers Squibb•Abbot Laboratories

Career Overview

Bio-Tech careers are primarily focused on Research & Development, but may incorporate other business facets such as:

•Marketing•Engineering•Computer Programming•Health Care Professionals

Job Requirements in Biotech and Pharmaceuticals

Educational requirements rangewith position from the entry levelrequirements of a lab tech to thoserequiring a BS, MBA or other MS,PhD, post doctoral or MD.

J ob titles include:• Lab tech• Research Associate• Research Scientist• Sales Rep• Marketing Analyst/ Associate Product Manager• Product Manager• Programmer/Analyst• Regulatory Affairs Specialist• Patent Attorney• Clinical Research Physician

Advice for getting hired:• Do your homework and knowwho you are talking to• Be flexible• Be ready to demonstrate that youcan apply what you have learned inschool!

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Career Tracks-Details

Marketing Analyst/Associate Product Manager Responsible for coordinating and implementing campaigns for specific drugs and/or audiences

Sales Representative

Focus on working with physicians, hospitals, HMOs, and countless other medical institutions to keep health-care professionals abreast of—and, if possible, partial toward—your company's line of products.

Product Manager

Requires managing a team of people and working to determine price, distribution, brand image, forecasting, and overall strategy for one or more drugs

Programmer/Analyst

Programmers create and maintain complex databases, particularly for clinical trials, which can involve thousands of patients

•Regulatory Affairs Specialist Communicate with government agencies,

complete forms, and fulfill requests to ensure a

company’s compliance with governmental regulations

Patent Agent Help obtain patents for newly developed

products or work with regulatory affairs development and manufacturing processes specialists to ensure that a company is in accordance with the extraordinarily detailed regulations imposed by the FDA/ Authorities