the brain. extreme abuse / neglect perry, 1997 abuse affects corpus callosum development
TRANSCRIPT
The Brain
Extreme abuse / neglect
Perry, 1997
Abuse affects corpus callosum development
Oxytocin modulates amygdala activity
• 15 male participants• Intranasal puffs of
oxytocin versus placebo
• fMRI• Angry/ fearful faces• Fearful/ threatening
scenes• Oxytocin
significantly reduced amygdala activation
(Kirsch et al., 2005)
Paediatric-onset PTSD secondary to abuse
De Bellis, 2002
The role of stress hormones
Toxic Stress Changes Brain Architecture
Normal
Toxic stress
Prefrontal Cortex andHippocampus
Typical neuron— many connections
Damaged neuron— fewer connections
Sources: Radley et al. (2004)
Bock et al. (2005)
Brake failure: reduced size of frontal cortex in Antisocial Personality Disorder
• A pattern of disregard for, and violation of, the rights of others (DSM-IV-TR, 2008)
• Also referred to as ‘psychopathy’ and ‘sociopathy’
• Left hemisphere of the brain• Comparing violent/ non-violent
individuals• Left image is outter (lateral) left-
hemisphere; right image is inner (medial) left-hemisphere in reverse
• Left-medial-prefrontal cortex is outlined: shows reduced volume in violent individuals
• These are signs that something different is going on in the brains of pathologically aggressive people
(Narayan et al., 2007)
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