the development of biologically active medication to treat tbc patients malkov s. А., shironosov...
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The development of biologically active medication to treat TBC patients
Malkov S. А., Shironosov O.V., Shironosova G.I.
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PROBLEM TOPICALITY
Every year TBC causes the following:
1 billon people
infection; 8-10 billion people
illness; 3-4 billion people death.
WHO declared TBC the global danger in 1993.
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Is expensive (the average cost of one bed day - 1600 rubles);
Causes poisonous effect; Requires long-term (4-6
months) administration; Is aggravated by
multidrug resistance.
Modern TBC patient treatment
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Galleria Mellonella – The Greater Wax Moth
I.I. Mechnikov (1889); S.А. Mukhin (1955); N.А. Spiridonov (1989).
Extract's properties:1. Immune protective;2. Antimicrobial;3. Antioxidant.
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HOW TO GET A BIOACTIVE PRODUCT FROM THE GREATER WAX MOTH LARVAE(21)4938002/14 (22) 2603.91 (46)2706.95 Bulletin №18 (71) Institute of Theoretical and Experimental Biophysics, USSR Academy of Sciences(72) Spiridonov NA; Rachkov AK; Mukhin SA; Kondrashova MN. (73) Spiridonov Nikolay Aleksandrovich(55) USSR certificate of authorship N 1284229, 61 35/04. 1989. А К
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The way of noncontact activation
Solutions with negative redox potential
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THE PROJET’S AIM
is the development of bioactive medication (with long-lasting redox potential) on the basis of water solutions of The Greater Wax Moth larvae to treat TBC patients.
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DYNAMICS OF REDOX POTENTIAL CHANGE
Date 09.07.11 12.08.11 18.08.11 24.08.11 06.09.11
Control (redox potential , mV)
80 84 82 79 83
Experiment (redox potential , mV)
-193 -248 -301 -445 -476
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Clinical research
Republican tuberculosis dispensary:
15 patients; Infiltrative TB. Average age - 40 years; Gender - male; Treatment duration – 3,5
months.
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Research results
twofold reduction of abacillary duration;reduction of intoxication;improvement of blood value (reduction of the number of lymphocytes, improvement of differential blood cell count, ESR reduction, etc.).
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Commercialization perspectives
Bed day shortening by 1,5-2 times.
Treatment course depreciation.
Increase of medication’s biological activity .
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Demand assessment after launching
Demand assessment after launching:
1st year (USD) 3rd year (USD)
Russia 50 000 200 000
CIS countries 70 000 300 000
ЕС countries, USA 100 000 350 000
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