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2012 Center Annual Report.doc

The Hypertension and Vascular Research Center

2011 – 2012 Annual Report Summary

Director: Debra I. Diz, PhD, FAHA

Assistant Director: E. Ann Tallant, PhD, FAHA

Center Vision The HVRC promotes excellence in basic science and clinical research through a team approach

targeting translation of cutting edge scientific advances to the patient and community at large.

Center Mission The mission of the center is to effectively facilitate research, education and clinical management

of hypertension and vascular disease.

Center Values The underpinning of our success is a commitment to leadership in all areas of our mission to have the following EFFECTS:

E xcellence in all facets of our mission

F acilitation of novel concepts for translating to the clinical setting

F ostering training of the next generation of individuals in research

E ducation of medical professionals for implementation of patient care

C ommunity outreach for ensuring that outcomes are broadly available

T eamwork for leveraging individual strengths

S upport of institutional goals

Hypertension & Vascular Research Center (Org 223000) Edward Abraham, Dean Medical School

Jan Wagner, VP, Senior Associate Dean Research

Laurie Molloy, Director of Centers

TSI

Debra Diz, Director

Ann Tallant, Assistant Director

Clinical Research

TBN Director, Clinical Research

David Cline, MD

John Fortunato, MD

Leanne Groban, MD

Amret Hawfield, MD

Kathi Kemper, MD

Dany Kim-Shapiro, PhD

Pavel Levy, MD

Gary Miller, PhD

Hossam Shaltout, PhD

Charles Tegeler, MD

Patricia DePaulis, Secretary

TBN Clinical Studies Coordinator

COSEHC

President, Michael Moore, MD

Executive Director, Debra Simmons

JaNae Joyner, PhD

Jeff Atwell

Janie Marshall

Susan Pollock

Basic Science

Basic Science Labs:

Director, Debra Diz, PhD

Bridget Brosnihan, PhD

Mark C. Chappell, PhD

Debra Diz, PhD

Patricia Gallagher, PhD

Leanne Groban, MD

TanYa Gwathmey, PhD

Hossam Shaltout, PhD

Ann Tallant, PhD

Jasmina Varagic, MD, PhD

Liliya Yamaleyeva, MD, MSc

TBN, Strawn Replacement

Core Laboratories

Hypertension Assay Core

Director, Bridget Brosnihan, PhD

TanYa Gwathmey-Williams, PhD Pam Dean

Katie Busalacchi

Transgenic Animals and Instrumentation Core

Director, Jasmina Varagic, MD, PhD

TBN and Ellen Tommasi

Molecular & Cellular Biology Core

Directors, Patricia Gallagher, PhD, and Ann Tallant, PhD

Rob Lanning and Tennille Howard

HPLC & Peptide Metabolism Core

Director, Mark Chappell, PhD

Nancy Pirro

Clinical Non-Invasive Hemodynamic Lab

Directors, Debra Diz, PhD and Hossam Shaltout, PhD

TBN, Clinical Faculty John Fortunato, MD

Pavel Levy, MD Anya Brown, Project Coordinator

Training Programs

EICS Directors, Ann Tallant, PhD and

Debra Diz, PhD

Nobi Sarver, Program Coordinator

TSI Summer Scholars

Director, Debra Diz, PhD


PREP Scholars Director, Debra Diz, PhD

Executive Committee: Lorna Moore, PhD, Azeez Aileru, PhD


US-Brazil Exchange Program

Directors, Mark Chappell, PhD and Azeez Aileru, PhD


Sarah Smith, CPS

Jenny Morris, Admin Secretary Brooks Jones, Proj Coord

Nobi Sarver Patricia DePaulis

Core Faculty and Fellows Center Faculty

Various Departments

Figure 1

HVRC Core Faculty

Debra I Diz, PhD

Center Director, 0.15 FTE

E. Ann Tallant, PhD

Assistant Director, 0.05 FTE

Azeez, Aileru, PhD (added FY12) K. Bridget Brosnihan, PhD

Mark C. Chappell, PhD John Fortunato, MD (added FY12)

Patricia Gallagher, PhD Leanne Groban, MD, MSc

TanYa Gwathmey (adding FY13) Amret Hawfield, MD (added FY12) Sarah H. Lindsey, PhD (left FY12)

Snezana Petrovic, MD, PhD (added FY12) Hossam Shaltout, PhD (added FY12)

Jasmina Varagic, MD, PhD Liliya Yamaleyeva, MD, MS

Center roles Include service as Core Resource Directors or Key Personnel, Training

Program Directors, Website Management; they represent 8 different departments and 9 Institutes/Centers; total of

0.4 FTE funded through Center in FY12, no funded

FTE for FY13 Figure 2

Hypertension & Vasc Res Ctr FY2010 FY2011$16,005,802 $12,357,599

$17,531,470 $13,828,403119 87

$52,609 $39,751$1,034 $2,347

$30,000 $43,427

20102011 NA2012

*Data shown from WFSM investigators only (not inv outside inst)Values do not reflect co-investigator data with non-center faculty

1 0

21 18161 1450 5

1

Abstracts

203

1150

378

290

473Miscellaneous

Total Publications 371

22

PUBLICATIONS

BooksJournal Articles

Chapters

FY2012FY2010

1240

Core Faculty Clinical Research Activity and ACUC Protocols

Hypertension & Vasc Res Ctr Institutional Training Grants

FY2011

FY ACUC

NANA23

Hypertension & Vascular Res Ctr

$35,000NANA

Funded Clinical ProjectsIRB Clinical Projects

Award $NA

$243,905

FY2010

FY2011

58 Staff/Admin.

55 Staff/Admin.

62 Staff/Admin.

91 Members

103 Members

111 Members

Updated 9/20/2012

EXTRAMURAL AWARD INFORMATION

2012 CENTERMETRICS

FY2012NIH Funding Amount $12,023,500

Ind/Assoc/Fdn $1,525,668 $1,470,804 $2,747,320Total Extramural Funding Amount $14,770,820

Funding Amount

NIH $551,924 $333,989 $316,408DIRECTOR: Debra I. Diz, PhD Average $ / Faculty Ind/Assoc/Fdn $72,298

Hypertension & Vascular Research Center # of Awards 83

Institutional $1,82633 Faculty

Institutional $34,688

$222,657

Average Award Size Ind/Assoc/Fdn $37,211 $54,474 $94,735

NIH $205,203 $205,960

FY2010 FY2011 FY2012

48 Faculty

Hypertension & Vascular Res Ctr

49 Faculty

EXTRAMURAL PROPOSAL INFORMATIONNIH 2.69 1.62 1.42

NIH Proposals (All Yrs) $71,526,794 $84,600,491 $69,462,917 Average # / Faculty Ind/Assoc/Fdn 1.41 0.73 0.76Ind/Assoc/Fdn Proposals (All Yrs) $2,932,538 $10,996,612 $9,158,149

Institutional 0.03 0.05 0.05Total Extramural Proposal $ (All Yrs) $74,459,332 $95,597,103 $78,621,066*Data shown from WFSM investigators only; Values do not reflect co-investigator with non-center faculty# of Proposals 117 120 148

Total Extramural Proposal $ (First Yr) $17,431,471 $33,571,963 $30,364,775

(All Yrs)

Average Proposal NIH (All Yrs) $2,466,441 $2,286,500 $1,827,972$ / Faculty Ind/Assoc/Fdn (All Yrs) $101,122 $297,206 $241,004

Institutional (All Yrs) $7,931 $2,347 $1,826

NIH (All Yrs) 2.69 2.43 2.53

ACADEMIC EFFORT

Average # / Faculty In/Assoc/Fdn (All Yrs) 1.45 0.81 1.3713 6Institutional (All Yrs) 0.10 0.05 0.05

Total Institutional

21

FY2010 NA NA NA22

FY2012

FY2012 9FY2011 9 18

17

FY Ctr Faculty as Director

Ctr Fac as Participating

Mentors

HVRC Summary Report -2011-2012


2. Current Membership List, Membership Criteria, Invitation Letter and

Application

Faculty membership represents 23 different departments within WFSM and at least 10 other Centers/Institutes. There are also members from 8 outside institutions, including two minority serving institutions (WSSU, NCCU), and WFU. Highlights of some of the areas of research expertise represented by the faculty are shown in Figure 3.

Hypertension, Vascular Disease Atherosclerosis Cellular & Molecular Biology Kidney Fluid & Electrolyte

Balance/Salt & Hypertension Endocrinology & Gender

Differences/Hypertension in Pregnancy

Cardiac Physiology and Pathophysiology

Primate and transgenic rat models of CVD

Inflamation and Oxidative Stress

Cardiovascular Disease Areas

of Research Interest/Expertise Aging Fetal Programming Metabolic Syndrome Renin-Angiotensin

System Neural Control of the

Circulation/Autonomic Function

Cell Growth & Signaling (vascular and cancer)

Receptor Pharmacology Peptide Biochemistry

Figure 3.

Criterion for membership, an example invitation letter and the application are provided on the following pages. Paperwork on a group of ~12 new candidates for membership is in process.

Current Center Memberships (Self-Reported and Per FEC Minutes) -- Run Date 2/3/2011DeptID of

Primary

Acad Appt

Dept Name - Primary

Academic Appointment

Primary

Academic

Rank Code

Primary Academic Rank

Description

Faculty

Type Emplid Last Name Name CenterID Center Name

Eff Start

Date

Continuation of Center

Memberhip for FY2013?

Yes / No

Phys/Pharm-WSSU 0019096 Aileru Azeez A. Aileru, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

Community hys 0067522 Aragon Stephen J. Aragon, Ph.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

150019 Surgery Hypertension 0128 Adjunct Associate Professor V 0004622 Averill David B. Averill, Ph.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

Phys/Pharm-NCCU 0116612 Awumey Emmanuel M. Awumey, M.Sc., Ph.D.223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

108020 PHS-Epidemiology 0020 Professor F 0004892 Bell Ronny A. Bell, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

150019 Surgery Hypertension 0020 Professor F 0004640 Brosnihan Simmons Kathleen B. Brosnihan Simmons, Ph.D.223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

156000 Neurology 0022 Associate Professor F 0077260 Bushnell Cheryl D. Bushnell, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

150019 Surgery Hypertension 0020 Professor F 0004630 Chappell Mark C. Chappell, Ph.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

150100 Emergency Medicine 0020 Professor F 0031519 Cline David M. Cline, M.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

104010 Comparative Medicine 0020 Professor F 0004659 Cline J. Mark Cline, D.V.M., Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

Surgery-Hypertension-VT 0096204 Davy Kevin P. Davy, Ph.D. 223000 Hypertension & Vascular Res Ct 5/1/2008 yes ***

155020 Int Med-Gerontology 0020 Professor F 0004844 Delbono Osvaldo Delbono, M.D., Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

150019 Surgery Hypertension 0020 Professor F 0004631 Diz Debra I. Diz, Ph.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

150019 Surgery Hypertension 0020 Professor F 0004631 Diz Debra I. Diz, Ph.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

159000 Pediatrics 0024 Assistant Professor F 0066792 Fortunato Jr John E. Fortunato Jr, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

155050 Int Med-Nephrology 0020 Professor F 0004511 Freedman Barry I. Freedman, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

150019 Surgery Hypertension 0022 Associate Professor F 0005031 Gallagher Patricia E. Gallagher, Ph.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

108020 PHS-Epidemiology 0020 Professor F 0005590 Goff Jr David C. Goff Jr, M.D., Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 no ***

152030 Cardiac Anesthesia 0022 Associate Professor F 0006526 Groban Leanne Groban, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

155050 Int Med-Nephrology 0024 Assistant Professor F 0000695 Hawfield Amret Thompson Hawfield, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

155030 Int Med-Cardiology 0020 Professor F 0004223 Herrington David M. Herrington, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

105000 Physiology_Pharmacology 0020 Professor F 0019202 Howlett Allyn Howlett, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

Surgery-Hypertenion-COSEHC 0029088 Joyner JaNae Joyner 223000 Hypertension & Vascular Res Ct 6/1/2009 yes ***

104010 Comparative Medicine 0020 Professor F 0003029 Kaplan Jay R. Kaplan, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

224000 Translational Institute 0020 Professor F 0003029 Kaplan Jay R. Kaplan, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

159000 Pediatrics 0020 Professor L 0030056 Kemper Kathi J. Kemper, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

Physics-WFU 0020860 Kim-Shapiro Daniel Kim-Shapiro 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

155040 Int Md-Hematology and Oncology 0020 Professor F 0005265 Lesser Glenn J. Lesser, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

150016 Surgery Vascular 0022 Associate Professor F 0006096 Levy Pavel J. Levy, M.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

150019 Surgery Hypertension 0026 Instructor F 0078399 Lindsey Sarah Hoffmann Lindsey, Ph.D. 223000 Hypertension & Vascular Res Ct 7/1/2010 yes ***

102000 Cancer Biology 0020 Professor F 0005436 Miller Mark S. Miller, M.Phil, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

150100 Emergency Medicine 0022 Associate Professor F 0044808 Miller Chadwick David Miller, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

WFU-Graduate School 0086043 Moore Lorna Moore, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 no ***

Danville-COSEHC 0002991 Moore Michael A. Moore 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

155010 Int Med-General 0024 Assistant Professor F 0064886 Mount David L. Mount, Psy.D. 223000 Hypertension & Vascular Res Ct10/1/2007 yes ***

159000 Pediatrics 0020 Professor F 0003876 O'Shea T. Michael D O'Shea, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

Phys/Pharm-NCCU 0116672 Pointer Mildred A. Pointer, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2010 yes ***

162020 Radiation Biology 0020 Professor F 0028468 Robbins Michael E.C. Robbins, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

150040 Surgery Orthopedics 0020 Professor F 0003221 Smith Thomas L. Smith, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

Surgery-Hypertension-Retired 0006514 Smith Ronald D. Smith, M.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

104020 Pathology - Lipid Sciences 0020 Professor F 0003689 Sorci-Thomas Mary G. Sorci-Thomas, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

150019 Surgery Hypertension 0020 Professor F 0004602 Tallant Elisabeth A. Tallant, Ph.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

156000 Neurology 0020 Professor F 0004139 Tegeler IV Charles H. Tegeler IV, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

155030 Int Med-Cardiology 0022 Associate Professor F 0067984 Thohan Vinay Thohan, M.D. 223000 Hypertension & Vascular Res Ct 3/1/2008 yes ***

150019 Surgery Hypertension 0024 Assistant Professor F 0070815 Varagic Jasmina Varagic, M.D., Ph.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***

159000 Pediatrics 0022 Associate Professor F 0029897 Washburn Lisa K. Washburn, M.D. 223000 Hypertension & Vascular Res Ct 8/1/2009 yes ***

150019 Surgery Hypertension 0026 Instructor F 0049248 Yamaleyeva Liliya Marsovna Yamaleyeva 223000 Hypertension & Vascular Res Ct12/13/2010 yes ***

150019 Surgery Hypertension 0129 Adjunct Assistant Professor V 0005358 Yunis Carla Yunis, M.D. 223000 Hypertension & Vascular Res Ct 1/1/2007 yes ***OB/GYN 0024 Assistant Professor F Shaltout Hossam Shaltout, Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2011 yes ***

105000 Physiology_Pharmacology 0024 Assistant Professor F Petrovic Snezana Petrovic, M.D., Ph.D. 223000 Hypertension & Vascular Res Ct 8/1/2011 yes ***



3. Narrative of Center’s Facilitation of Research, Education and Training

2011 – 2012 HVRC Annual Report Summary of Accomplishments:

Efforts continue toward our mission to foster collaborations in both clinical and basic science research in hypertension and vascular disease. However, service to the institution and professional societies is encouraged. In particular, senior faculty link other colleagues and junior investigators with professional society leadership opportunities. In accomplishing our goals, ~60% of Center faculty provide service as president, chair or committee member to major societies [APS, FASEB, ASPET, AHA, Consortium for Southeastern Hypertension Control (COSEHC)], in peer review for national agencies (NIH, CDC, CSR) and associations (NKF, AFAR, COSEHC, AHA), and volunteer service at the VA. Notable highlights include service on boards/external advisory committees (AHA Mid-Atlantic Affiliate, Leadership Committee for Council for High Blood Pressure Research, Winston-Salem Heart Ball, North Carolina American Indian Health Board, HBCU-UP NSF at Johnson C. Smith University, Minority Access for Research Careers (MARC) and RISE programs at Winston-Salem State University, COSEHC, Kern Aspen Lipid Conference, International PedCAM Network, International Freshwinds Institute of Integrated Medicine of Mitra Programme, UK, International Board of Advisors of NIKIM of the Dutch Society of Integrative Medicine, Planning Committee of the Forsyth County Health Disparities Town Hall Meeting, Forsyth Davie Stokes Medical Society). These activities are listed in the Faculty Achievement Table following the narrative. Center members continue to be well represented throughout WFSM on committees, task forces and working groups for administration, teaching and research, including as member of ATI teams.

Highlights of Research Recognition and Leadership Activities Reported by Center Faculty:

Aileru, Research & Development Excellence Award, The North Carolina BioTech in the Triad Best Doctors in America: Herrington, Kemper, O’Shea, Lesser, Tegeler, Thohan Bell, WFHS Division of Public Health Sciences Professional and Community Service Award,

WFHS

Diz, elected for Executive Leadership in Academic Medicine (ELAM) program Kemper, Winner, Body/Mind/Spirit Category Indie Book Awards for Mental Health, Naturally! O’Shea, Faculty Mentoring Award, WFSM Shaltout, Arthur Guyton New Investigator Award, Consortium for Southeastern Hypertension

Control (COSEHC)

Tallant, completed Career Development for Women Leaders (CDWL), WFSM, WHCOE Tallant and Gallagher, Received Patent no. 8,034,781 entitled "Angiotensin-(1-7) and

Angiotensin-(1-7) Agonists for Inhibition of Cancer Cell Growth" Tegeler, President, North Carolina Neurological Society

Varagic, selected for Career Development for Women Leaders (CDWL), WFSM, WHCOE Yamaleyeva, Kidney Council New Investigator Award, American Heart Association

Collaborative Research Activities Fostered by the Center

Center Core Faculty increased to fourteen for 2011-12 (Diz, Aileru, Brosnihan, Chappell, Fortunato, Gallagher, Groban, Hawfield, Lindsey, Petrovic, Shaltout, Tallant, Varagic, Yamaleyeva). Core faculty are defined as those who direct Center resources (see Organizational Charts for details) or provide key expertise for collaborative activities and represent 17 different departments and Institutes/Centers. This overlap affords good



communication between programmatic elements within the institution. Core faculty hold biweekly “Data Chats” to encourage shared ideas, feedback for plans for grants, strategic thinking for programmatic funding. Four Core Faculty are junior investigators whose submitted proposals in 2011-12 will be starting in FY13. Figures 4-6 illustrate the funding history of the Core Faculty, the collaborative nature of their funding, and the increase in clinical research grant activity by these investigators.

HVRC Core Faculty

5-Year Extramural Funding History

0

1

2

3

4

5

6

2007 2008 2009 2010 2011 2012

4.44.6 4.7 4.7

5.7 5.6

Direct

Indirect

Total

Fu

nd

ing

(in

mil

lio

ns

)

An

nu

al

Co

sts

# of Faculty 10 9 8 7 9 14

HVRC Core Faculty Collaborative

Funding FY2011-FY2012

0

20

40

60

80

100

2011 2012

PercentPercent of Applications with at

least 1 other Center Faculty

Figure 4 Figure 5

HVRC Core Faculty (14 Faculty)

Applications FY2011-FY2012

0

5

10

15

20

25

30

35

40

45

2011 2012

Total

Clinical

Basic

Training

Equipment

Nu

mb

er

of

Ap

pli

ca

tio

ns

Figure 6

Major support for collaborative research activity includes Core faculty as integral to two program project grants, one continuing program ‘Vasodepressor Mechanisms in Hypertension (HL-51952)’ and one renewed this year entitled ‘Prenatal Events - Postnatal Consequences (HD-047584)’. Center members are involved in other programmatic funding in the Pepper Center (AG021332), Lipid Sciences “Lipoprotein Metabolism in Atherosclerosis (HL-49373), Comprehensive Cancer Center and in clinical trials (SPRINT, ACCORD, TRIP, CARDIA, CLIP,SEA, ACTION, HELP-PD).

Collaborative efforts led to new funding from intramural sources (TSI, Pepper Center, Center for Biomolecular Imaging, IRSC, Center for Integrative Medicine, WFSM Venture Fund and Lois Groskert Heart Fund) and extramural NIH and industry funding for competitive research grants using magnetic resonance spectroscopy for correlating brain transmitters with autonomic function and adiposity, applying vascular anti-growth agents for cancer therapy in children,



characterization of cellular growth properties of muscadine extracts that have been extended from vascular actions to anti-cancer effects, and application of vascular measures in non-human primates.

Center support for core facilities generated pilot data for research leading to extramural support, including data obtained with equipment purchased with capital funds for human subject studies leading to 4 new grants and additional planned clinical research grant submissions; two Center cores made substantial contributions to the data generated by TSI mini-grant funding and core faculty have obtained internal funds from other Centers for pilot studies. Examples of ongoing clinical/translational research topics facilitated or funded by HVRC core resources (Figures 7 – 9 illustrate core facilities and technologies): human urine proximal tubule cells used for expression of components of the renin-angiotensin system; urinary vitamin D and racial differences in adolescents born prematurely (Pediatrics, Ob/Gyn, Perinatal, Nephrology); non-invasive autonomic or vascular dysfunction assessment for dietary nitrite intervention, characterization of children with chronic nausea, as objective measures of behavioral interventions for stress and weight reduction, and coupled with magnetic resonance spectroscopy for brain transmitters in the elderly and as correlates with adiposity (Pediatrics, Complementary and Integrative Medicine, Reynolda faculty, Neurology, Anesthesiology, Pepper Center, CBI, Maya Angelou Center); cancer treatment Phase I/II trials (Pediatrics, Cancer Center); treatment modalities to reduce cognitive function decline following radiation treatment, to reduce fibrosis after radiation treatment, and to prevent cardiac pathology associated with cytotoxic therapies or drug abuse (Brain Tumor Center of Excellence, Radiation Biology, Orthopedic Surgery, Cancer Biology, Physiology & Pharmacology, Neuroscience); and sex differences in sub-clinical vascular disease in patients at risk for stroke (Neurology). Translational studies focus on non-invasive blood pressure and vascular measures to complement neurohumoral profiles in Vervet monkeys (Primate Center), angiogenesis and cell growth (Cancer Center), gender differences and salt sensitivity related to aging, heart function and renal injury in rats, pre-eclampsia in humans and rats, and fetal programming of cardiometabolic disease in humans and sheep (Anesthesiology, Perinatal, Pediatrics, Nephrology).

The Consortium for Southeastern Hypertension Control - Community Outreach (COSEHC – Debra Simmons, Michael Moore)

Hypertension Registry (CDC – David Cline) Hypertension Non-Invasive Hemodynamic

Diagnostic Lab (Shaltout, Diz, Levy,Fortunato) Ambulatory BP/Continuous BP Nevrokard - Autonomic Function Assessments BioZ – impedance cardiography SphygmoCor, HDI CR-2000 – pulse wave velocity Colin VP-2000 – ABI

HVRC

Research Core Resources

Hypertension Core Assay Lab (Brosnihan) CLIA certified clinical lab Multiplex assays (Luminex, Searchlight)

Cellular & Molecular Biology Lab (Tallant & Gallagher)

Transgenic Animal Core (Varagic) Peptide Biochemistry & Metabolism (Chappell)

Consultation/Collaboration, Fee for service routine assays, Assay or probe development/implementation, Training, Pilot project support

HVRC

Research Core Resources (cont.)

Figure 7 Figure 8



Proteomics – Luminex and Searchlight Technology Multiple analytes in one sample (Multiplex Assays)

Robotics Extraction System

Tools for Measurement of RAAS Components

Peptides/hormones [Ang II, Ang-(1-7), Ang I] Precursor proteins (Angiotensinogen) Enzymes (Renin, ACE, ACE2, NEP)

MR Spectroscopy for Brain Transmitters w/ Autonomic Function

Assessment

Hypertension Non-Invasive Human Hemodynamic & Autonomic

Function Laboratory

New FY13: Non-invasive VeVo Unltrasound LAZR imaging fo

rodents

Funded by P01, R21, Equipment Grants, Institution, Industry

HVRC

New Technological Developments

Figure 9

Collaborative efforts led to acquisition of the Vevo LAZR small animal imaging equipment (~$1 million), funded in July FY13 by a large equipment grant to Hypertension Center faculty (Figure 9) in collaboration with the Center for Biomolecular Imaging. This equipment will provide state-of-the-art small animal imaging to investigators in the Hypertension Center as well as throughout the medical campus, to provide non-invasive imaging of cardiovascular function, blood flow and angiogenesis, to generate pilot data for research leading to extramural support. Initial costs for pilot projects will be offset by HVRC faculty effort and technical and computer support from CBI.

Center membership increased from 48 to 49 with ~12 new members in process. Collaborations are the basis for both grants and publications with Anesthesiology, Biochemistry, Cancer Biology, Cardiology, Comparative Medicine, Emergency Medicine, Gerontology & Geriatrics, Health & Exercise Science, Hematology/Oncology, Internal Medicine, Molecular Genetics & Genomics, Molecular Medicine, Nephrology, Neurobiology & Anatomy, Neurology, Obstetrics & Gynecology, Orthopedic Surgery, Pathology-Lipids, Pediatrics, Physics, Physiology & Pharmacology, Public Health Sciences, Radiation Oncology, Center for Biomolecular Imaging, Complementary & Integrative Medicine, MACHE, Sticht and Pepper Centers, Primate Center, Translational Science Center, Translational Sciences Institute, Women’s Health Center, and WSSU, NCCU, VaTech, and Livingstone.

Center faculty maintained outstanding productivity with over 203 journal articles, 23 books or book chapters as shown in Figure 10. Figure 11 shows that the 14 core faculty members in FY11 had 31 full length publications, 72% of which are with another Center Faculty member, and have ~100 different internal and external co-authors as a measure of their collaborative approach to research.



HVRC

3 Year Publication History

0

50

100

150

200

250

300

2010 2011 2012

Journal Articles

Books and Chapters

Publications

# of Center

Faculty

2010 - 36

2011 - 48

2012 - 49

HVRC Core Faculty (9 Faculty

FY11; 14 Faculty FY12)

2 Year Publication History

0

10

20

30

40

50

60

2010 2011 2012

Journal Articles

Book Chapters

Publications

72% include

other

Center

faculty

members as

co-authors;

100 different

co-authors

Figure 10 Figure 11

Figures 12 and 13 highlight historical funding for Center Faculty and the funding sources for FY12. There are ~83 projects for $14.8 million in total funding reported by the 38 Center faculty members whose data are reported through WFSM (does not include the faculty from other institutions). The 14 core faculty held ~$4.2 million in annual direct costs funding in FY2011, with over 86% of their grants held with 1 or more co-investigators within the Center. Another $1.5 million in annual direct costs in new funding starts in July 2012 for Core Faculty. All core faculty have clinical research collaborations with active or pending grants.

HVRC Extramural and Institutional

Funding FY2009-FY2012

0

2

4

6

8

10

12

14

16

18

2009 2010 2011 2012

Direct

Institution

Funding (in millions)

# of Center

Faculty

2009 - 16

2010 - 36

2011 - 48

2012 - 49

HVRC

FY2012 Funding Sources

NIH/Federal

AHA/Fdn/Ind

Inst Awards

Inst Basic Dollar

Cores/Service

Figure 12 Figure 13

Community Engagement and Research

The Consortium for Southeastern Hypertension Control (COSEHC), headquartered within the Center, maintains community outreach activities including screening and educational sessions that involve Center faculty, students and fellows.

Collaborative research efforts by center faculty with local pharmaceutical/nutraceutical companies focused on a novel drug for the treatment of hypertension (Targacept) and mucadine grape extracts to reduce angiogenesis/tumor growth (Nature’s Pearl).

Long-standing pipeline programs continue including the 20th year of the Excellence in Cardiovascular Sciences Summer Program, the 5th year of the Translational Sciences Institute Scholars summer programs, and the 10th year of the Post-baccalaureate Research Education Program (PREP) to increase diversity in PhD graduate programs. Competing continuation applications were submitted and are pending for both the summer program and the PREP.



The Hypertension Core Laboratory maintained CLIA certification and provided service to basic science and clinical research projects and clinical practice conducting over 7907 assays for 19 different internal investigators in 2011-12 for North Carolina Baptist Hospital Pathology, Pediatrics, Radiation Biology, Cardiology, Anesthesiology, Nephrology, Cancer Biology, Health & Exercise Sciences, General Surgery, Sticht Center, and Neurology. In addition, extramural use includes 13 investigators from 9 different institutions (Vanderbilt, Iowa, Alberta, Wright State, Mississippi, Florida, Northwestern, Toronto, Delaware). Billings were ~$300,000.

Other cores provide support to basic science and clinical research projects including the Cellular & Molecular Biology Lab, Transgenic Animal Core and Peptide Biochemistry & Metabolism.

Clinical support includes: CDC-sponsored hypertensive registry for the emergency room; non-invasive hemodynamics lab for arterial stiffness, vascular resistance and central pressures; and ambulatory blood pressure. We implemented autonomic function assessments for research and as billable clinical procedures to be used independently or in combination with tilt table testing in 2011.

Research Education, Training, and Career Development

Faculty contributed to medical student, resident and fellow, and graduate and undergraduate teaching and research training. Center core faculty are involved as training faculty in 17 of the 21 funded T32 or R25 training programs at the institution and are program directors or on Internal Advisory Committees of 9 (Figure 14). Center faculty were leaders of 3 graduate programs and participate in all Biomedical Sciences Tracks.

HVRC

Contributions to Training Grants

0

5

10

15

20

25

Total #Directed by Center Faculty

# with Center Faculty Mentors

2011

2012

Institutional Training Grants

Figure 14

A US-Brazil Consortium, funded by DOE in collaboration with Wright State University, WSSU, NCCU and 4 institutions in Brazil, hosted 12 Brazilian undergraduate students for 6 months.

The Excellence in Cardiovascular Sciences and TSI Summer Programs, along with partnerships with JC Smith University and WSSU, hosted 21 undergraduate students for research experiences.

The NIGMS Post-baccalaureate Research Education Program (PREP) to increase diversity in graduate programs sent 4 students into PhD programs, 1 into an MD program, with 2 continuing for a second year, and 7 new students entered the program in August 2012.

Faculty participated on the Advisory Committee, Minority Access for Research Careers (MARC), at Winston-Salem State University, and served as mentors.

Junior faculty in Surgical Sciences (Orthopedic and Plastic Surgery), Pediatrics, Obstetrics & Gynecology, Internal Medicine, Nephrology and Geriatrics internally, and from external



institutions such as North Carolina Central, WSSU and University of Florida have been assisted in terms of research and career mentoring, provision of pilot data and active collaborations for grant submissions. Five junior faculty were funded in FY12 or will have grants starting in FY13.

Summary:

These efforts fulfill the Center’s mission to expand collaborative efforts in hypertension and vascular disease research in both clinical and basic science arenas throughout the institution, to develop stronger collaborative approaches for non-invasive detection of autonomic dysfunction and vascular disease and apply these to treatments for cardiometabolic disorders and in cancer control, and to expand activities of faculty in research training and education in conjunction with the activities of the Translational Science Institute.

2011-2012 FACULTY INFORMATION TABLE

DEPARTMENT OR DIVISION NAME: HYPERTENSION & VASCULAR RESEARCH CENTER

FACULTY RECEIVING AWARDS / HONORS

Faculty Member Name

(Ex: John Q. Smith,

Ph.D.)

Exact Name of Award Received Granting Organization

(No abbreviations)

Date of

Presentation

Azeez Aileru, PhD Research & Development Excellence Award The North Carolina BioTech in the Triad 04/2012

Stephen J. Aragon, PhD “The Provider Patient-Centeredness and Disparities Outcome

Measurement Initiative” (NIH/NCMHD #P20MD002303)

NIH/NCMHD 2007, 2008, 2009,

2010, 2011, 2012

Emmanuel M. Awumey,

PhD

2P20 MD00175 NCCU Center for Translational Health Equality

Research

Co-Investigator, Project 2: Role of Extracellular Calcium in

Obesity, Hypertension and Diabetes.

National Institute on Minority Health and Health

Disparities, NIH

6/13/2012 –

5/31/2017

Ronny A. Bell, PhD WFHS Division of Public Health Sciences Professional and

Community Service Award

Division of Public Health Sciences, Wake Forest

Health Sciences

10/11/ 2012

Mark Chappell, PhD

Review paper selected as AJP Editor’s Choice

Immunofluorescent images of the novel estrogen

receptor GPR30 and protein transporter megalin

within the kidney were featured on the cover of

the October issue of the journal Hypertension

(Lindsey SH, Yamaleyeva LM, Brosnihan KB,

Gallagher PE, Chappell MC. Estrogen Receptor

GPR30 Reduces Oxidative Stress and Proteinuria

in the Salt-Sensitive Female mRen2 Rat.

American Physiological Society

(Hypertension is the premier journal on

hypertension and cardiovascular

disease published by the American

Heart Association.)

Hypertension 2011;

58:665-671. PMID:

21844484).

Debra I Diz, PhD Accepted into ELAM (Executive Leadership in Academic

Medicine) class of 2012-13 Executive Leadership in Academic Medicine 05/2012

Arnold AC et al. paper on autonomic function and hydronephrosis

selected for a Podcast

American Journal of Physiology: Heart &

Circulation 07/2011

John E. Fortunato, MD National Center Clinical Research Program American Heart Association 01/01/2012

David M. Herrington, MD,

MHS

Top Docs 2012 US News & World Report 2012

JaNae Joyner, PhD Johns Hopkins School of Public Health Summer Institute in

Biostatistics and Epidemiology Selected Institute Participant

Johns Hopkins School of Medicine 06/18-29/ 2012

Lorelle F. Martin Lectureship Award Mount Olive College 02/15/ 2012

Kathi J. Kemper, MD,

MPH Best Doctors in America 1996- present

Silver Award for Mental Health, Naturally! Nautilus Books 2011

Gold Award for Mental Health, Naturally! Foreword Reviews 2011

Winner, Body/Mind/Spirit Category Indie Book Awards for

Mental Health, Naturally! 2012

Glenn J. Lesser, MD Recognized in Best Doctors in America Database 2011

Selected as Top Oncologist International Association of Oncologists 2011

Recognized in America's Top Doctors for Cancer America's Top Doctors, 11th Edition 2011

Selected for Patients' Choice Award America Registry 2011

Top Doctor, Top 1% in Nation in Specialty US News and World Report 2012

David Mount, PsyD, MA,

HSP-P

Association of Black Psychologists 2000-present

Diversity Leadership Committee Missouri Health Sciences Psychology Consortium 2002-present

Hossam Shaltout, PhD Arthur Guyton New Investigator Award presented at the 18th

annual scientific sessions

Consortium for Southeastern Hypertension Control 11/04/2011

Michael O’Shea, MD Faculty Mentoring Award Wake Forest School of Medicine 05/15/2012

Mildred A. Pointer, PhD NCCU EXPORT P20 MD00175 NCCU Health Equality Research

Center

NIH National Institute on Minority Health Disparity 6/13/2012

Ann Tallant, PhD, Completed Career Development for Women Leaders (CDWL) WFSM, WHCOE 05/2012

Ann Tallant, PhD Patricia

Gallagher, PhD

Received Patent no. 8,034,781 entitled "Angiotensin-(1-7) and

Angiotensin-(1-7) Agonists for Inhibition of Cancer Cell Growth" US Patent Office 10/11/2011

Vinay Thohan, PhD Recognized in Best Doctors in America Database 2011

Michael E. Robbins, PhD Modulation of Radiation-induced Brain Injury in the Nonhuman

Primate

National Cancer Institute 05/01/2012

Jasmina Varagic, MD, PhD Accepted into 2012-13 CDWL class WFSM, WHCOE 06/2012

Liliya M. Yamaleyeva,

MD, MS Kidney Council New Investigator Award American Heart Association 09/2011

FACULTY SERVING AS JOURNAL EDITORS / EDITORIAL BOARD MEMBERS

Faculty Member Name

(Ex: John Q. Smith,

Ph.D.)

Type of Service

(Do not include article reviewer or book editor.)

Full Name of Journal

(No abbreviations)

Inclusive Dates of

Service

K. Bridget Brosnihan

Simmons, PhD Editorial Board Member Hypertension 2002-present

American Journal of Physiology/Heart & Circ. 2005-present

Current Hypertension Reviews 2004-present

Journal of Clinical Pharmacology 2009-present

Mark C. Chappell, PhD Editorial Board Member Hypertension 2004-present

American Journal of Hypertension 2011-present

ISRN Biochemistry 2011-present

Physiology Journal 2012

Associate Editor Gender Medicine 2011-present

Debra I. Diz, PhD Editorial Board Member Current Hypertension Reviews 2004-present

Current Hypertension Reports 2010-present

Associate Editor Frontiers in Integrative Physiology 2010-present

Barry I. Freedman MD,

FACP

Editorial Board Member Clinical Journal of the American Society of

Nephrology

2005-2015

American Journal of Nephrology 2005-2015

Diabetes 2009-2012

Leanne Groban, MD Editorial Board Member Anesthesia Analgesia 2003-present

Anesthesiology 2004-present

Journal of Clinical Anesthesia 2005-present

Hypertension 2005-present

Journal of Anesthesia and Pain Management 2006-present

Cardiovascular Diabetology 2007-present

Echocardiography 2008-present


MPH

Editorial Board Member Alternative Medicine Alert Newsletter 2003-present

Explore: Journal of Science and Healing 2004-present

International Journal of Holistic Health and

Medicine 2005-present

Complementary Health Practice Review 2005-present

The Scientific World Holistic Health and Medicine 2006-present

International Journal of Child Health and Human

Development 2007-present

Journal of Alternative Medicine Research 2008-present

Natural Triad Magazine 2009-present

Journal of Evidence-Based Complementary &

Alternative Medicine (JEBCAM)

2010-present

European Journal of Integrative Medicine: Evidence

for Integrative Medicine (North American Edition);

special issue editor 2012 (Integrity in Integrative

Medicine)

2011-present

FACULTY SERVING AS PRESIDENT OR CHAIR OF MAJOR PROFESSIONAL / SCIENTIFIC ORGANIZATIONS

Faculty Member Name

(Ex: John Q. Smith,

Ph.D.)

Office Held

(President/Chair level only)

Full Name of Organization

(No abbreviations)

Inclusive Dates of

Service


Simmons, PhD Executive Committee Inter-American Society of Hypertension 2003-present

Cheryl Bushnell, MD,

MHS

Writing Group Guidelines for Cardiovascular Disease Prevention

in Women

Fellow of the American Heart Association 2011

Writing Group for Stroke Risk Adjustment consensus Fellow of the American Heart Association 2012

Writing Group Stroke Primary Prevention Guidelines Statement,

(vice-chair). Fellow of the American Heart Association 2012

Chair, Writing Group for Prevention of Stroke in Women American Heart Association 2012-2013

Chair, Quality Outcomes Committee of the Stroke Council American Heart Association 2012-2013

Chair, Women and Special Populations Committee, Clinical

Cardiology American Heart Association 2011-2012

Mark C. Chappell, PhD Elected Member at Large, Leadership Committee American Heart Association, Council for High

Blood Pressure Research 2008-present

Elected Member, Committee on Committee American Physiological Society 2008-present

Faculty of 1000, Renal Section F1000 Post Publication Peer Review 2008-present

David M. Cline, MD,

FACEP Board Member Consortium for Southeastern Hypertension Control 01/2011-2013

Debra I. Diz, PhD Nominations and Awards Committee Member The Consortium for Southeastern Hypertension

Control (COSEHC) 2008-Present

Member, Council of Division Chairs The American Society for Pharmacology and

Experimental Therapeutics 2009-2012

Executive Committee, Cardiovascular Division The American Society for Pharmacology and

Experimental Therapeutics. 2010-present

Appointed, HBPR Excellence Award Selection Committee American Heart Association, Council for High


Barry I. Freedman MD,

FACP

Chair, Board of Directors

Southeastern Kidney Council, ESRD Network 6

Leanne Groban, MD Board of Directors

The Consortium for Southeastern Hypertension

Control (COSEHC)

2010-2013


MHS

Board of Directors North American Artery Board 2012

Allyn C. Howlett, PhD Co-Chair International Union of Pharmacologists

Nomenclature Committee, Subcommittee on the

Cannabinoid Receptors

1996-present


MPH

Immediate Past Chair Section on Complementary and Integrative

Medicine, AAP

2011-present


HSP-P

Director of Partnership MACHE 2011-2012

Director of Community Core NIH P60 2011-2012

Board of Directors Children’s Home of Winston Salem 2011-2012

Community Care Center 2011-2012

E. Ann Tallant, PhD Vice-Chairperson, Membership and communications Committee American Heart Association, Council for High

Blood Pressure Research 2010-2012

Michael E. Robbins, PhD Vice-Chair and reviewer Radiation Oncology Research Study Sections 03/2012

FACULTY SERVING AS CONSULTANTS TO NIH / OTHER FEDERAL AGENCIES

Faculty Member Name

(Ex: John Q. Smith,

Ph.D.)

Type of Service

(Consultant, Grant Reviewer, Panel Member, etc.)

Full Name of Institute or Agency

(No abbreviations except NIH) Date(s) of Service

Azeez Aileru, PhD Publication Review Panel Hypertension Journal, American Heart Association 11/2011

Frontiers in Physiology 01/2012

NIHMD-NIH Loan Repayment Grant Application Review National Institute of Minority Health and Health

Disparities, NIH

02/2012

Stephen J. Aragon, PhD Technical Reviewer Patient-Centered Outcomes Research Institute 2012

Emmanuel M. Awumey,

PhD

Hypertension & Microcirculation Study Section. Center for Scientific Review, NIH 10/16/2011-

10/17/2011;

6/14/2012 -

6/15/2012

Ronny A. Bell, PhD Invited Reviewer, HDM ZRG1 90-T, Health Care Deliveries and

Methodologies

NIH 2/2/2012.

Invited Reviewer National Institute of Mental Health SRSP (Mental

Health Services in Specialty Mental Health Settings)

2/10/2012

Invited Reviewer, HDM ZRG1 90-T, Health Care Deliveries and

Methodologies

National Institutes of Health 6/28/2012

SPIRP Special Emphasis Panel ZNS1 SRB N (02) (Chair),

National Institute of Neurological Disorders and

Stroke (NINDS)

7/26-27/2012


Simmons, PhD Abstract Reviewer

American Heart Association, Council for High


Program Project Review NIH, National Heart Lung Blood Institute 2011

AHA Innovative Grant Review American Heart Association 2011-present

T32 Grant Review NIH, National Heart Lung Blood Institute 2011-2012

Mark C. Chappell, PhD Abstract Reviewer American Heart Association, Council for High


Program Project Reviews National Heart Lung Blood Institute 2011

J. Mark Cline, DVM, PhD,

DACVP Programmatic Reviewer, Integration Panel Breast Cancer Research Program 2008-present

Study Section Member NCRR Division of Comparative Medicine 2010-2012

Leanne Groban, MD Grant Reviewer American Federation on Aging Research 2009-present Osvaldo Delbono, MD,

PhD Study Section member

NIH College of Center for Scientific Review

Reviewers 02/2010-01/2012

Grant Reviewer Comitato di Indirizzo per la Valutazione della

Ricerca (Research Evaluation Committee Italy) 2006-present

Alberta Heritage Foundation for Medical Research 2007-present

Debra I. Diz, PhD NIH Reviewers Reserve NIH 1995-present

Abstract Reviewer American Heart Association, Council for High

Blood Pressure Research 1993- present

American Heart Association, National Sessions 2010-present

Minority Biomedical Research Support Grant Reviews National Center on Minority Health and Health

Disparities 08/2009

Special Emphasis Panel for R25 Minority and Training Programs National Heart Lung Blood Institute 01/2010-present

Committee for review of NHLBI R25 Cardiovascular Program North Carolina Central University 01/2001-present

NHLBI T35 Grant Reviews National Heart Lung Blood Institute 08/2011

Program Project Reviews National Heart Lung Blood Institute 2011-2012

Chair, Special Review Committee, Teleconferences NIH 1996-present

Executive Leadership Team for Winston-Salem’s American Heart American Heart Association, Winston-Salem 2011-2012

Ball

Medical Chair, Executive Leadership Team for Winston-Salem’s

American Heart Ball

American Heart Association, Winston-Salem 2012-2013

Small conference grant reviews National Heart Lung Blood Institute 04/2012

Loan repayment applications NIH 08/2011

Patricia E. Gallagher, PhD Molecular Signaling 2.Unified Peer Review Study Group American Heart Association 2002-present

Special Emphasis Panel, “NIH Support for Conferences and

Scientific Meetings” National Heart Lung Blood Institute 2012


MHS

Peer Reviewer, Population Sciences & Epidemiology Integrated

Review Group

NIH 06/2012

Special Emphasis Panel Reviewer, Sequencing Centers NIH/NHGRI 07/2011

Allyn C. Howlett, PhD Editorial Board: Journal of Biological Chemistry American Society for Biochemistry and Molecular

Biology

2010-2015

Jay R. Kaplan, PhD Panel Member – Committee on the Use of Chimpanzees in

Biomedical and Behavioral Research

Institute of Medicine, National Academies 05/2011-12/2011

Chair, R25 Special Emphasis Panel, NIH, NCRR 10/25/2011

Member, P01 Special Emphasis Panel, NHLBI, NIH 10/21/ 2011

Member, R13 Special Emphasis Panel, Conferences and Scientific

Meetings, NIH

03/06/2012

Member, National Scientific Advisory Board, California National

Primate Research Center, NIH, NCRR

01/01/2012-present

Michael O’Shea, MD NIH Heath Services Organization and Delivery Study Section NIH 2/29-3/1/2012

Data Safety Monitoring Committee – NICHD Neonatal Research

Network

National Institute of Child Health & Human

Development

07/01/ 2011-

06/30/2012

Snezana Petrovic, MD,

PhD, FASN

Manuscript reviews American Journal Physiology, Comparative

Physiology and Biochemistry, BioMedCentral

2005 – present

Co-Chair, Renal Section

Focused Topic: Regulation of Transport Proteins in

Kidney Intercalated Cells, Experimental Biology

2012

Review Editorial Board

Frontiers in Renal and Epithelial Physiology 2012-present

Mildred A. Pointer, PhD Reviewer NIH National Institute of Neurological Disorders and

Stroke

07/26-27/2012

Daniel Kim-Shapiro, PhD Grant Reviewer NIH 10/2011

04/2012

Mary Sorci-Thomas, PhD Charter Member AICS, NIH Study Section NIH 2008-2012

Charles Tegeler, MD President North Carolina Stroke Association 2010 - Present

Michael E. Robbins, PhD Reviewer Radiation Oncology Research Study Sections 03/2012

University of Rochester CMCR Pilot Grants 05/2012

E. Ann Tallant, PhD Abstract Grader American Heart Association, Council for High


Special Emphasis Panel, “NIH Support for Conferences and

Scientific Meetings National Heart Lung Blood Institute 2011

SEP: EXPORT (P20, P60), RIMI (P20) and Loan Repayment

Reviewer (L60)

National Institute on Minority Health and Health

Disparities

Ongoing

Review Panel - K01 and R25 RFAs to Promote Faculty and

Trainee Diversity National Heart Lung Blood Institute

2012

Jasmina Varagic, MD, PhD Grant Reviewer, Cardio Renal Section American Heart Association 2011

FACULTY SERVING ON BOARDS

Faculty Full Name &

Degree(s) Type of Service

Full Name of Institute or Agency

(no abbreviations except NIH) Date(s)

Debra I. Diz, PhD Member of Executive Board Consortium for Southeastern Hypertension Control 1997-present

Member, Executive Committee, Minority Access for Research

Careers (MARC) and RISE programs Winston-Salem State University 2009-present

Member, External Advisory Board, Science, Technology &

Engineering Programs, National Science Foundation

Historically Black Colleges & Universities (HBCU-UP)

Johnson C. Smith University 02/2010 – 01/2013


MPH Advisory Board

International PedCAM Network 2009-present

International Freshwinds Institute of Integrated

Medicine of Mitra Programme, UK

2009-present

ZAT1 HS-04 Study Section for NIH NCCAM 2011

International Board of Advisors of NIKIM Dutch Society of Integrative Medicine 2011


HSP-P

Planning Committee Forsyth County Health Disparities Town Hall Meeting 2012

E. Ann Tallant, PhD Webmaster, Leadership Committee American Heart Association, Council for High Blood

Pressure Research 2008-2012

Research Committee American Heart Association 2011-2013

Mentor, Training Committee American Heart Association, Council for High Blood

Pressure Research 2008-2012

Member, Awards Committee American Physiological Society, Cardiovascular

Section 2010-2012

Vinay Thohan, PhD Treasurer

Forsyth Davie Stokes Medical Society 2011

Executive planning committee

AHA Heart Ball 2011

Liliya M. Yamaleyeva,

MD, MS Member, Early Career Committee

American Heart Association, Kidney in

Cardiovascular Disease (KCVD) Council

2012-present

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