the path to wellness through big data
TRANSCRIPT
MARYCAIREMD
THE PATH TO WELLNESS
THROUGH BIG DATA
23andMeGenetic GenieTree of LifePast medical historyFamily historySymptom documentationBiomarkersInflammatory markersHormonal levels
Cortisol levelsMicrobiome testingNutritional analysisMetabolic markersToxicity testingLipid testingVitamin/mineral reportingVital signsWearables
25%
/MaryCaireMD
@MaryCaireMD
/in/MaryCaireMD
The Path to Wellness Through Big Data
Big Data. Shared. Simply. Securely.
Roy WildsDirector of Product ManagementPHEMI [email protected]
PHEMI COPYRIGHT 2016
Physiological DiagnosisTrial and Error Therapy
Systemic DeliveryLate Stage Care
Ineffective TherapyUnsustainable Healthcare CostsPatient Lacks Knowledge And
Power
Present PracticeMolecular Diagnosis
Therapy Based on Molecular Diagnosis
Targeted DeliveryPreventive Care
Patient Specific, Effective Treatment
Reduced WastePatient Empowerment
Personalized Medicine
Personalized Medicine: A Massive Change In Medical Practice Driven By New Technologies That Characterize Individuals at the Molecular Level
TECHNOLOGY
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PHEMI COPYRIGHT 2016
Vancouver-based not-for-profit organizationVision: Introduce an individualized approach to
preventive and curative healthcare based on the molecular makeup of the individual and their disease
More effective and safer therapeutics
Better matching of treatment to disease
More effective preventive medicine; patient empowerment
More efficient healthcare Identification of new drug targets
and therapeutics
BenefitsMolecular “Omic”
Analyses
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PHEMI COPYRIGHT 2016
MYCO provides: a comprehensive, molecular-level health monitoring program for preventive
medicine to detect early disease and monitor response to therapy. a molecular analysis program to stratify disease to better match treatment
to the individual patient
THE MOLECULAR YOU PROGRAM• Whole exome sequencing up front• Every four months:
• Proteomic analysis of blood (>200 proteins)• Metabolomic analysis of blood (>200 metabolites)• Microbiomic analysis of colon (>1,000 bacteria)• Download continuous monitoring of vital signs (heart rate etc.)• Bioinformatic analysis of data (early signs of disease, response to therapy etc.)• Consultation with healthcare professional to interpret data
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Molecular You Corporation: Precision Health
PHEMI COPYRIGHT 2016
Molecular You Co. uses PHEMI to advance preventive and curative healthcare
• Early warning system• Prevent, delay, mitigate• Quarterly molecular screening• Grow to 25,000 patients• 15+ varied data sources• Integrate “omics” with • clinical data• Longitudinal study • Rich research
Precision Medicine
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Life Sciences Institute
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The Data Dilemma in Precision Medicine
Share and Protect?
Data available analysis, insights, and new services
Analytics Applications
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How do I share data
for secondary use
without compromising privacy,
security, and governance?
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PHEMI Central Big Data Warehouse
OmicsSpreadsheetsTextSystemsDatabase SensorsImages
Custom Applications
Advanced Analytics
Data Science• Flexible, agile data repository for
multi-structured data
• Support advanced analytics, data science and new services
• Govern, manage and control access to protect privacy and manage data sharing
• Publish data marts
• Scale as your data and users grow
• Deploy on premise or in the cloud
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Addressing Precision Medicine Challenges
Collect
Index and catalog for findability
Protect and Share
Privacy, Security & Governance
Curate and Transform
Analytics-ready
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Metadata Billions of Assets
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User AttributesAccess Control Based on User Attributes
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ProtectZero Trust to Read Data
PHEMI Central’s Policy Enforcement Engine reduces the risk of data breach by enforcing rules universally and consistently for each user and data element.
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Each user (or application) sees only data they are authorized to see
Example Applications
Privacy Controlled Data Warehouse
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Architecture ComponentsPrivacy, Security, and Governance “out of the box”
• Distributed, scalable base
• PHEMI Central
• Coordinates and manages all processes
• Abstracts and simplifies distributed concepts
• Audits and manages data and interactions HDP
Am
bari
Spark Map-Reduce
Kaf
ka
PHEMI Central
Accumulo
YARN
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Questions?
Roy Wilds, PhDDirector of Product Management, PHEMI Systems