the role of insulin- like growth factor-1 in schizophrenia by karen kiernan
DESCRIPTION
Aim of Article Role of IGF-1 deficiency - Insulin Resistance - Pathogenesis of SchizophreniaTRANSCRIPT
The Role of Insulin-Like Growth Factor-1 in
Schizophrenia
By Karen Kiernan
Aim of Article
Schizophrenia - Impaired Glucose Tolerance - Insulin Resistance - Type 2 Diabetes Mellitus
Antipsychotics?
Aim of Article
Role of IGF-1 deficiency
- Insulin Resistance
- Pathogenesis of Schizophrenia
IGF-1
Protein Hormone
Similar structure to Insulin
Stimulates cell growth
Inhibits apoptosis
Experiment
Patients with Schizophrenia - no previous treatment with
psychotropic medication
Healthy Comparison Subjects
Low risk of Diabetes
Simplified Indian Diabetes Risk Score
Age [years]< 35 035 - 49 20≥ 50 30 Abdominal obesityWaist <80 cm [female] , <90 [male] 0Waist ≥ 80 – 89 cm [female], ≥ 90 – 99 cm [male] 10Waist ≥90 cm [female], ≥ 100 cm [male] 20 Physical activityExercise [regular] + strenuous work 0Exercise [regular] or strenuous work 20No exercise and sedentary work 30 Family historyNo family history 0Either parent 10Both parents 20 Minimum score 0 Maximum score 100
Method
12 hour overnight fast - Glucose - Insulin - IGF-1
Results
Schizophrenia Patients
- Glucose – Similar to healthy subjects- High Insulin- Low IGF-1- High Insulin Resistance
- Negative correlation between Insulin and IGF-1
Connection with Schizophrenia? Deficiency of IGF-1
- Increased incidence of DM among patients with Schizophrenia
- Pathogenesis of Schizophrenia itself?
IGF-1 deficiency
Low Birth Weight Leanness Decrease in stature
All indicate increase risk of Schizophrenia
Also - Negative Cancer correlation
Genetics
Chromosome 12p13-q13
- Linked with Schizophrenia
- Close to gene coding for IGF-1
Pathogenesis
IGF-1 Neuro-protective Anti-apoptotic effect
Crucial for optimal neurodevelopment
Specific Hypothesis
High concentrations of IGF-1 receptors in Hippocampus
Hippocampus dysfunction in Schizophrenia
- Auditory HallucinationsHigher deficiency of IGF-1 - More severe
Auditory Hallucinations
Conclusion
Strong evidence of link
More studies needed!
Thank you for your attention
Source
Insulin and Insulin like growth factor1 anormalities in antipsychotic naive schizophrenia
American Journal on Psychiatry, October 2007