theodore j. huppert, phdhuppertlab.net/wp-content/uploads/2017/11/huppert_cv_2016.pdf · theodore...

Theodore J. Huppert, PhD 200 Lothrop St. PUH-B822.1! Pittsburgh PA, 15213

Phone: 412-647-8459 ! Fax: 412-647-9700 ! E-Mail: [email protected]

Education

Ph.D. 2007.HarvardUniversity,CambridgeMA(Biophysics).Advisor: David, A. Boas, Ph.D (Associate Professor of Radiology; Harvard MedicalSchool) “Hemodynamic-Based Inference of Cerebral Oxygen Metabolism” (ThesisTitle) Summary: The purpose of this work was to develop advanced methods forimproving theestimateofCMRO2 fromhemodynamic-based imagingmethodssuchas functional MRI and non-invasive optical (NIRS) imaging using vascular model-baseddatafusionmethods.

B.S. 2002.UniversityofWisconsin,MadisonWI(Genetics-Honors)

B.S. 2002.UniversityofWisconsin,MadisonWI(Biochemistry-Honorsinresearch)

ResearchOverview

Mylabworksondiffuseopticalspectroscopymethods.Specifically,biologicaltissuehaslowopticalabsorptiontoredtonear-infraredlight,whichallowslightatthesewavelengthstobedirectednon-invasively into tissue where it can travel (diffusely) up to several centimeters. This techniqueallowsimagingofspecificchromophoreconcentrationssuchashemoglobinandlipidfromsensorsplacedonthesurfaceoftheskin. Mylabdevelopsinstrumentationanddataanalysismethodsforcollectingnear-infraredsignalsforbothmusclephysiologyandbrainimagingapplications. Inthebrain,near-infraredlightcanbeusedtonon-invasivelymeasureabout5-8mmintothecortexofthebrainandisusedinbothclinicalmonitoring/assessmentandfunctionalneuroscienceapplications.This is aportableand low-cost alternative tomethods like fMRIandhasbeenwidelyadopted inspecificapplicationssuchasneuroimagingofmovementdisorders,childpsychology,andbedsidemonitoringwhere fMRImethods are less applicable. My lab primarily focuses on novelmethoddevelopment (particularly digital signal processing, image reconstruction, and analysismethods)and we collaborate with numerous groups worldwide to apply this technology. In particular, Iwrote the open source analysis package used widely by this community (with currently 1,600registeredusers)andamafoundingboardmemberforthesocietyforfunctionalNIRS.

Labwebsite:www.pitt.edu/~huppert1

Softwaretoolswebsite:www.bitbucket.org/huppertt/nirs-toolbox

Skills

Computer programing (Matlab, R, Labview, C++, objective-C, HTML, VS98-2014). Neuroscienceapplications (SPM, AFNI, FSL [fMRI], DTIstudio [DSI-MRI], Freesurfer [sMRI], MNE [MEG],NetStation [EEG]). DSP techniques (e.g. linearandnon-linearnon-stationary systems, system ID,kalmanestimation,ARIMA,real-timeDSP,generalnon-linear/linearmodels,regression, filtering),Machine Learning (SVM/R, artificial neural networks, linear discriminate analysis, graph orderestimation), Inverse model estimation (Bayesian models, restricted maximum likelihoodestimation,expectation-maximization, regularization),dataacquisition/hardware interfacing,MRIacquisition (Siemens TIM and Philips platforms), MEG acquisition (Neuromag platform), EEGacquisition (NetStationEGIandBrainVisionplatforms),NIRSacquisition. I alsodeveloped total-internalreflectancemicroscopesforsingle-moleculefluorescencestudies

IRB(since2009)andFDA-INDregulations(5yearexperience;drugtrial).Labmanagement(3PhD,1MSc,8postdocs,3NIHk01-awards,15undergraduatesmentored’07-‘16).

Theodore J. Huppert, PhD

Experience

• AssociateProfessor(Tenured)ofRadiology;UniversityofPittsburgh

August2014-Current

• AssociateProfessor(Tenured)ofBioengineering;UniversityofPittsburgh

August2014-Current

• AssistantProfessorofRadiology;UniversityofPittsburgh January2008-2014• AssistantProfessorofBioengineering;UniversityofPittsburgh January2008-2014• PostdocResearchAssociate,DartmouthCollege;ThayerSchoolofEngineering(underSolomonDiamond,Ph.D.AssistantProfessorofEngineering)Topic:Multimodalimagingofhumanbrainfunction.Iworkedonthedevelopmentofnovelhigh-speed(10Hz)EPIBOLDmethodsformeasuringcerebralvascularcomplianceoflargebloodvesselsusingthein-flow(T1)effect.Ialsoworkedonthesiteprepfortheinstallationofa4DMEGsystemattheThayerSchool.

June2007-January2008

• HowardHughesMedicalInstitute(HHMI)predoctorialfellow• Fieldresearchassistant.MountainResearchLaboratory/Ethiopia,Africa(underRogerHainsworth,M.D.UniversityofLeeds,UK)Topic:Iperformednear-infraredopticalmeasurementsduringstressteststoevaluatecerebralvascularreserveathigh-altitude(3620m).

2002-2007March2005

• GraduateStudentResearcher,Harvard/MassachusettsGeneralHospital;A.A.MartinosCenterforBiomedicalImaging(underDavid,A.Boas,Ph.D.AssociateProfessorofRadiology;HarvardMedicalSchool)(seePhDthesisdescription)

2003-2007

• GraduateStudentResearcher,HarvardUniversityMedicalSchool;Dept.ofNeurobiology(underDavidClapham,Ph.D./M.D.HowardHughesMedicalInstitute)Topic:IstudiedtheendocytosisofTRPchannelsusingmicroscopytechniquesandthebiosynthesisofnovelflorescentfusionproteins.

2003

• GraduateStudentResearcher,HarvardUniversity;DeptofMolecularandCellularBiology(underNancyKleckner,Ph.D.HerchelSmithProfessorofMolecularBiology)Topic:IpreformedchromosomeconformationcapturetechniquesonS.cerevisiaetodeterminethetemperaturedependenceoftheconformationalstructureofchromosomes.

2002

• Researchassistant,UniversityofWisconsin-Madison;Dept.ofChemistry(underJamesC.Weisshaar,Ph.D.ProfessorofChemistry)Topic:Istudiedthemechanismofthemolecularmechanismsofvesiclefusionviathesynaptotagimin/SNAREcomplexinsupportedlipidmembranestructures.

2000-2002

• Researchassistant,UniversityofWisconsin-Madison;Dept.ofChemistry(underSilviaCavagnero,Ph.D.;AssistantProfessorofChemistry)Topic:IstudiedthestructureapomyoglobinusingproteinNMR.

2000-2002


Publications/Presentations

InvitedPresentations

1. HuppertTJ.RecentAdvancementsoffNIRSDataAnalysis.InvitedkeynoteatfNIRS2014conference

2. Huppert,TJ.Functionalbrainimagingofchronicirritabilityinschoolagechildren.UniversityofIowa;DeltaCenterforChildDevelopment.

October2014

March2013

3. HuppertTJ.Multimodalimagingofneuralvascularcoupling.MediterraneanNeuroscienceSociety.IstanbulTurkey.

4. HuppertTJ.IntroductiontofunctionalNIRbrainimaging.UniversityofMichigan

September2012

August2012

5. HuppertTJ.Multimodalfunctionalimagingofneuro-vascularcoupling.UniversityofMontreal

July2012

6. HuppertTJ.AdvanceddataanalysismethodsinfunctionalNIRS.UniversityofIowa;DeltaCenterforChildDevelopment

February2012

7. HuppertTJ.IntroductiontofunctionalNIRSbrainimaging.UniversityofIowa;DeltaCenterforChildDevelopment.

February2011

8. Huppert,TJ.Multimodalmodelingofneurovascularcoupling.UniversityofPennsylvania,PhiladelphiaPA,

April2010

9. Huppert,TJ.Illuminatingthebrain:Introductiontonear-infraredspectroscopyofhumanbrainfunction.UniversityofMichigan,AnnArborMI

March2010

10. Huppert,TJ.Illuminatingthebrain:Introductiontonear-infraredspectroscopyofhumanbrainfunction.UniversityofCincinnati,CincinnatiOH,

November2009

11. Huppert,TJ.MultimodalimagingofCerebralOxygenMetabolism.UniversityofMontreal

August2009

12. Huppert,TJ.Introductiontoopticalimagingofbrainfunction.BaylorSchoolofMedicine,HoustonTX

September2009

13. Huppert,TJ,DiamondS.G,andBoasD.A.“QuantitativeestimationofcerebralhemodynamicchangesthroughthemultimodalityfusionofBOLDandDiffuseOpticalTomography”.12thannualmeetingoftheFinnishInverseSociety.Tampere,Finland

December2006

14. HuppertTJ,HogeRD,FranceschiniMA,BoasDA.“ASpatial-TemporalComparisonoffMRIandNIRSHemodynamicResponsestoMotorStimuliinAdultHumans”.EuropeanConferenceofBiomedicalOptics.Munich,Germany

2005


Peer-ReviewedPublications

H-index(asofJuly5th2016):h=16.

Sumoftimescited:1389

Averagecitationsperitem:31.57

1. Chow,C.C.,Chow,C.,Raghunathan,V.,Huppert,T.J.,Kimball,E.B.,&Cavagnero,S.(2003).Chainlengthdependenceofapomyoglobinfolding:structuralevolutionfrommisfoldedsheetstonativehelices.Biochemistry,42(23),7090-7099.doi:10.1021/bi0273056

2. Diamond,S.G.,Huppert,T. J.,Kolehmainen,V.,Franceschini,M.A.,Kaipio, J.P.,Arridge, S.R.,&Boas, D. A. (2005). Physiological system identificationwith the Kalman filter in diffuse opticaltomography.MedImageComputComputAssistInterv,8(Pt2),649-656.

3. Hoge,R.D.,Franceschini,M.A.,Covolan,R.J.,Huppert,T.,Mandeville, J.B.,&Boas,D.A.(2005).Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow usingdiffuse optical imaging and arterial spin-labeling MRI. Neuroimage, 25(3), 701-707. doi:10.1016/j.neuroimage.2004.12.032

4. Diamond,S.G.,Huppert,T. J.,Kolehmainen,V.,Franceschini,M.A.,Kaipio, J.P.,Arridge, S.R.,&Boas, D. A. (2006). Dynamic physiological modeling for functional diffuse optical tomography.Neuroimage,30(1),88-101.doi:10.1016/j.neuroimage.2005.09.016

5. Franceschini,M.A.,Joseph,D.K.,Huppert,T.J.,Diamond,S.G.,&Boas,D.A.(2006).Diffuseopticalimagingofthewholehead.JBiomedOpt,11(5),054007.doi:10.1117/1.2363365

6. Huppert,T.J.,Hoge,R.D.,Dale,A.M.,Franceschini,M.A.,&Boas,D.A.(2006).Quantitativespatialcomparison of diffuse optical imaging with blood oxygen level-dependent and arterial spinlabeling-based functional magnetic resonance imaging. J Biomed Opt, 11(6), 064018. doi:10.1117/1.2400910

7. Huppert, T. J.,Hoge,R.D.,Diamond, S.G., Franceschini,M.A.,&Boas,D.A. (2006).A temporalcomparisonofBOLD,ASL,andNIRShemodynamicresponsestomotorstimuli inadulthumans.Neuroimage,29(2),368-382.doi:10.1016/j.neuroimage.2005.08.065

8. Joseph,D.K.,Huppert,T.J.,Franceschini,M.A.,&Boas,D.A.(2006).Diffuseopticaltomographysystemtoimagebrainactivationwithimprovedspatialresolutionandvalidationwithfunctionalmagneticresonanceimaging.ApplOpt,45(31),8142-8151.

9. Huppert, T. J., Allen, M. S., Benav, H., Jones, P. B., & Boas, D. A. (2007). A multicompartmentvascularmodelforinferringbaselineandfunctionalchangesincerebraloxygenmetabolismandarterialdilation.JCerebBloodFlowMetab,27(6),1262-1279.doi:10.1038/sj.jcbfm.9600435

10. Themelis,G.,D'Arceuil,H.,Diamond,S.G.,Thaker,S.,Huppert,T.J.,Boas,D.A.,&Franceschini,M.A.(2007).Near-infraredspectroscopymeasurementofthepulsatilecomponentofcerebralbloodflowandvolumefromarterialoscillations.JBiomedOpt,12(1),014033.doi:10.1117/1.2710250

11. Becerra, L.,Harris,W., Joseph,D.,Huppert,T.,Boas,D.A.,&Borsook,D. (2008).Diffuseopticaltomographyofpainandtactilestimulation:activationincorticalsensoryandemotionalsystems.Neuroimage,41(2),252-259.doi:10.1016/j.neuroimage.2008.01.047

12. Boas, D. A., Jones, S. R., Devor, A., Huppert, T. J., & Dale, A. M. (2008). A vascular anatomicalnetwork model of the spatio-temporal response to brain activation.Neuroimage, 40(3), 1116-1129.doi:10.1016/j.neuroimage.2007.12.061


13. Grignon, S., Forget, K., Durand, M., & Huppert, T. (2008). Increased left prefrontal activationduring staring/mutism episodes in a patient with resistant catatonic schizophrenia: a nearinfrared spectroscopy study. Cogn Behav Neurol, 21(1), 41-45. doi:10.1097/WNN.0b013e3181684d87

14. Huppert, T. J., Diamond, S. G., & Boas, D. A. (2008). Direct estimation of evoked hemoglobinchangesbymultimodalityfusionimaging.JBiomedOpt,13(5),054031.doi:10.1117/1.2976432

15. Abdelnour, A. F., & Huppert, T. (2009). Real-time imaging of human brain function by near-infraredspectroscopyusinganadaptivegeneral linearmodel.Neuroimage,46(1),133-143.doi:10.1016/j.neuroimage.2009.01.033

16. Abdelnour,F.,Schmidt,B.,&Huppert,T.J.(2009).Topographiclocalizationofbrainactivationindiffuse optical imaging using spherical wavelets. Phys Med Biol, 54(20), 6383-6413. doi:10.1088/0031-9155/54/20/023

17. Huppert, T. J., Allen, M. S., Diamond, S. G., & Boas, D. A. (2009). Estimating cerebral oxygenmetabolism from fMRIwithadynamicmulticompartmentWindkesselmodel.HumBrainMapp,30(5),1548-1567.doi:10.1002/hbm.20628

18. Huppert,T.J.,Diamond,S.G.,Franceschini,M.A.,&Boas,D.A.(2009).HomER:areviewoftime-seriesanalysismethodsfornear-infraredspectroscopyofthebrain.ApplOpt,48(10),D280-298.

19. Huppert, T. J., Jones, P. B., Devor, A., Dunn, A. K., Teng, I. C., Dale, A. M., & Boas, D. A. (2009).Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow duringhypercapnia.JBiomedOpt,14(4),044038.doi:10.1117/1.3210779

20. Mesquita,R.C.,Huppert,T.J.,&Boas,D.A.(2009).Exploringneuro-vascularandneuro-metaboliccoupling in rat somatosensory cortex. Phys Med Biol, 54(2), 175-185. doi: 10.1088/0031-9155/54/2/001

21. Abdelnour, F., Genovese, C., & Huppert, T. (2010). Hierarchical Bayesian regularization ofreconstructions for diffuse optical tomography usingmultiple priors.BiomedOptExpress,1(4),1084-1103.doi:10.1364/BOE.1.001084

22. Abdelnour, F.,&Huppert,T. (2010).A random-effectsmodel for group-level analysis ofdiffuseopticalbrainimaging.BiomedOptExpress,2(1),1-25.doi:10.1364/BOE.2.000001

23. Sevy, A. B., Bortfeld, H., Huppert, T. J., Beauchamp, M. S., Tonini, R. E., & Oghalai, J. S. (2010).Neuroimaging with near-infrared spectroscopy demonstrates speech-evoked activity in theauditorycortexofdeafchildren followingcochlear implantation.HearRes,270(1-2),39-47.doi:10.1016/j.heares.2010.09.010

24. Gagnon, L., Yucel, M. A., Dehaes, M., Cooper, R. J., Perdue, K. L., Selb, J., Boas, D. A. (2012).Quantification of the cortical contribution to the NIRS signal over the motor cortex usingconcurrent NIRS-fMRI measurements. Neuroimage, 59(4), 3933-3940. doi:10.1016/j.neuroimage.2011.10.054

25. Karim, H., Schmidt, B., Dart, D., Beluk, N., & Huppert, T. (2012). Functional near-infraredspectroscopy (fNIRS)ofbrain functionduringactivebalancingusingavideogamesystem.GaitPosture,35(3),367-372.doi:10.1016/j.gaitpost.2011.10.007

26. Yucel,M.A.,Huppert,T.J.,Boas,D.A.,&Gagnon,L.(2012).CalibratingtheBOLDsignalduringamotortaskusinganextendedfusionmodelincorporatingDOT,BOLDandASLdata.Neuroimage,61(4),1268-1276.doi:10.1016/j.neuroimage.2012.04.036

27. Barker, J. W., Aarabi, A., & Huppert, T. J. (2013). Autoregressive model based algorithm for


correctingmotionandserially correlatederrors in fNIRS.BiomedOptExpress,4(8),1366-1379.doi:10.1364/BOE.4.001366

28. Huppert, T., Schmidt, B., Beluk, N., Furman, J., & Sparto, P. (2013). Measurement of brainactivationduringanuprightsteppingreactiontaskusingfunctionalnear-infraredspectroscopy.HumBrainMapp,34(11),2817-2828.doi:10.1002/hbm.22106

29. Karim,H.,Fuhrman,S.I.,Sparto,P.,Furman,J.,&Huppert,T.(2013).Functionalbrainimagingofmulti-sensory vestibular processing during computerized dynamic posturography using near-infraredspectroscopy.Neuroimage,74,318-325.doi:10.1016/j.neuroimage.2013.02.010

30. Karim,H.T.,Fuhrman,S.I.,Furman,J.M.,&Huppert,T.J.(2013).Neuroimagingtodetectcorticalprojectionofvestibularresponsetocaloricstimulationinyoungandolderadultsusingfunctionalnear-infrared spectroscopy (fNIRS). Neuroimage, 76, 1-10. doi:10.1016/j.neuroimage.2013.02.061

31. Karim,H.T.,Sparto,P.J.,Aizenstein,H.J.,Furman,J.M.,Huppert,T.J.,Erickson,K.I.,&Loughlin,P.J. (2014). Functional MR imaging of a simulated balance task. Brain Res, 1555, 20-27. doi:10.1016/j.brainres.2014.01.033

32. Kontos,A.P.,Huppert,T.J.,Beluk,N.H.,Elbin,R.J.,Henry,L.C.,French,J.,...Collins,M.W.(2014).Brain activation during neurocognitive testing using functional near-infrared spectroscopy inpatients following concussion compared to healthy controls. Brain Imaging Behav. doi:10.1007/s11682-014-9289-9

33. Muhei-aldin,O.,VanSwearingen,J.,Karim,H.,Huppert,T.,Sparto,P.J.,Erickson,K.I.,&Sejdic,E.(2014). An investigation of fMRI time series stationarity during motor sequence learning foottappingtasks.JNeurosciMethods,227,75-82.doi:10.1016/j.jneumeth.2014.02.003

34. Perlman,S.B.,Luna,B.,Hein,T.C.,&Huppert,T.J.(2014).fNIRSevidenceofprefrontalregulationof frustration in early childhood. Neuroimage, 85 Pt 1, 326-334. doi:10.1016/j.neuroimage.2013.04.057

35. Schmidt,B.T.,Ghuman,A.S.,&Huppert,T. J. (2014).Wholebrain functionalconnectivityusingphase locking measures of resting state magnetoencephalography. Front Neurosci, 8, 141. doi:10.3389/fnins.2014.00141

36. Yucel,M.A.,Evans,K.C.,Selb,J.,Huppert,T.J.,Boas,D.A.,&Gagnon,L.(2014).Validationofthehypercapnic calibrated fMRImethod using DOT-fMRI fusion imaging.Neuroimage, 102P2, 729-735.doi:10.1016/j.neuroimage.2014.08.0521.

37. Barker JW, Panigrahy A, Huppert TJ. Accuracy of oxygen saturation and total hemoglobinestimates in the neonatal brain using the semi-infinite slab model for FD-NIRS data analysis.Biomed Opt Express. 2014;5(12):4300-12. doi: 10.1364/BOE.5.004300. PubMed PMID:25574439;PMCID:PMC4285606.

38. KarimHT,SpartoPJ,AizensteinHJ,FurmanJM,HuppertTJ,EricksonKI,LoughlinPJ.FunctionalMR imaging of a simulated balance task. Brain Res. 2014;1555:20-7. doi:10.1016/j.brainres.2014.01.033.PubMedPMID:24480476;PMCID:PMC4001860.

39. Kontos AP, Huppert TJ, Beluk NH, Elbin RJ, Henry LC, French J, Dakan SM, Collins MW. Brainactivationduringneurocognitive testingusing functionalnear-infraredspectroscopy inpatientsfollowingconcussioncomparedtohealthycontrols.BrainImagingBehav.2014;8(4):621-34.doi:10.1007/s11682-014-9289-9.PubMedPMID:24477579.

40. Muhei-aldin O, VanSwearingen J, Karim H, Huppert T, Sparto PJ, Erickson KI, Sejdic E. AninvestigationoffMRItimeseriesstationarityduringmotorsequencelearningfoottappingtasks.J


Neurosci Methods. 2014;227:75-82. doi: 10.1016/j.jneumeth.2014.02.003. PubMed PMID:24530436;PMCID:PMC3987746.

41. PerlmanSB,LunaB,HeinTC,HuppertTJ.fNIRSevidenceofprefrontalregulationoffrustrationinearly childhood. Neuroimage. 2014;85 Pt 1:326-34. doi: 10.1016/j.neuroimage.2013.04.057.PubMedPMID:23624495;PMCID:PMC3796135.

42. Schmidt BT, Ghuman AS, Huppert TJ.Whole brain functional connectivity using phase lockingmeasures of resting state magnetoencephalography. Front Neurosci. 2014;8:141. doi:10.3389/fnins.2014.00141.PubMedPMID:25018690;PMCID:PMC4071638.

43. Yucel MA, Evans KC, Selb J, Huppert TJ, Boas DA, Gagnon L. Validation of the hypercapniccalibratedfMRImethodusingDOT-fMRIfusionimaging.Neuroimage.2014;102Pt2:729-35.doi:10.1016/j.neuroimage.2014.08.052.PubMedPMID:25196509;PMCID:PMC4252607.

44. Perlman SB, Huppert TJ, Luna B. Functional Near-Infrared Spectroscopy Evidence forDevelopmentofPrefrontalEngagementinWorkingMemoryinEarlyThroughMiddleChildhood.CerebCortex.2015.doi:10.1093/cercor/bhv139.PubMedPMID:26115660.

45. AarabiA,HuppertTJ.Characterizationof therelativecontributions fromsystemicphysiologicalnoise to whole-brain resting-state functional near-infrared spectroscopy data using single-channel independent component analysis. Neurophotonics. 2016;3(2):025004. doi:10.1117/1.NPh.3.2.025004.PubMedPMID:27335886.

46. BarkerJW,RossoAL,SpartoPJ,HuppertTJ.Correctionofmotionartifactsandserialcorrelationsfor real-time functional near-infrared spectroscopy. Neurophotonics. 2016;3(3):031410. doi:10.1117/1.NPh.3.3.031410.PubMedPMID:27226974;PMCID:PMC4876834.

47. HarrivelAR,WeissmanDH,NollDC,HuppertT,PeltierSJ.Dynamicfilteringimprovesattentionalstate prediction with fNIRS. Biomed Opt Express. 2016;7(3):979-1002. doi:10.1364/BOE.7.000979.PubMedPMID:27231602;PMCID:PMC4866469.

48. Huppert TJ. Commentary on the statistical properties of noise and its implication on generallinearmodels in functionalnear-infraredspectroscopy.Neurophotonics.2016;3(1):010401.doi:10.1117/1.NPh.3.1.010401.PubMedPMID:26989756;PMCID:PMC4773699.

49. Perlman SB, Huppert TJ, Luna B. Functional Near-Infrared Spectroscopy Evidence forDevelopmentofPrefrontalEngagementinWorkingMemoryinEarlyThroughMiddleChildhood.Cereb Cortex. 2016;26(6):2790-9. doi: 10.1093/cercor/bhv139. PubMed PMID: 26115660;PMCID:PMC4869813.

UnderReview

1. HuppertTJ,RedfernM, JenningsR,LoughlinP. Neuroimagingofdual-taskeffectsonvestibularfunctionusingnear-infraredspectroscopy.GaitandPosture

2. HuppertTJ,BarkerJW,SchmidtBT,WallsS,GhumanAS.ComparisonneuralandvascularresponsestoparametricmediannervestimulationfromconcurrentNIRS-MEGandNIRS-MRI.Neuroimage

3. Perlman S, Huppert TJ. TwoHeads are Better than One: Neural Synchrony in HumanSocialInteraction

4. Huppert TJ Karim KT, Sparto PS, Furman J. Functional near-infrared imaging of thetemporal-parietaljunctionduringrotationalvestibulartesting.

BookChapters.


1. HuppertTJ,FranceschiniMA,BoasDA“NoninvasiveImagingofCerebralActivationwithDiffuseOpticalTomography."(BookChapter)InVivoOpticalImagingofBrainFunction.Ed.R.D.Frostig.BocaRaton:CRCPress.(2009)

2. Huppert TJ. “History of Diffuse Optics Spectroscopy” (Book Chapter) in Optical Methods andInstrumentationinBrainImagingandTherapyeditedbySteenMadsen

Dissertations1. Barker JW. (HuppertAdvisor). Estimationofcerebralphysiologyandhemodynamicsvianear-

infrared spectroscopy. Pittsburgh PA, Graduate Department in Bioengineering (PhD Thesis).2014.

2. Schmidt BT (Huppert Advisor). Application of big data computing to whole brain functionalconnectivity.PittsburghPA,GraduateDepartmentinBioengineering(PhDThesis).2013.

3. Huppert TJ. The Hemodynamic Inference of Cerebral OxygenMetabolism. Boston, MA: GraduateProgramsinBiophysics,HarvardUniversity(PhDThesis);2007.

4. HuppertTJ.HighfieldMRmicrsocopyimagingoflimbregenrationintheurotodemodel.Boston,MA:GraduateProgramsinBiophysics,HarvardUniversity(M.ScThesis);2004.

SelectedConferenceProceedings1. Chow, C.K., Chow, C., Rhagunathan, V., Huppert TJ., Kimball, E., Jungbauer, L.M., Cavagnero, S.

Towards Probing More Biologically Relevant Protein Energy Landscapes: the Chain LengthDependence of Sperm Whale Apomyoglobin Folding. 6th Annual Johns Hopkins Protein FoldingMeeting.BerkeleySprings,WestVirginia,September2001(Poster)

2. Jungbauer, L.M., Bakke, C., Huppert TJ., Kimball, E., Cavagnero, S. The Cotranslational FoldingPathways of an All-alpha-helical Globular Protein' 15th Symposium of the ProteinSociety.Philadelphia,Pennsylvania,July2001(Poster)

3. Huppert TJ, Hoge RD, Franceschini MA, Boas DA. Calculation of task-evoked changes in thecerebralmetabolic rate of oxygen consumption fromsimultaneousASL-BOLD fMRI andDiffuseOptical Imaging. Biomedical Optics Topical Meeting for the Optical Society of America,Miami,FloridaApril2004.(Poster)

4. FranceschiniMA,AndreCJ,HuppertTJ,JosephD,StottJ,andBoasDA.Diffuseopticalimagingofthe whole head. Annual Meeting of the Organization for Human Brain Mapping, BudapestHungary,June2004(Poster)

5. Huppert TJ, Hoge, RD, Francescini, MA, Boas DA. A Temporal Comparison of SimultaneouslyAcquired BOLD fMRI and Near-Infrared Spectroscopy (NIRS) Hemodynamic ResponseFunctions.AnnualMeetingoftheOrganizationforHumanBrainMapping,BudapestHungary,June2004(Poster)

6. Huppert TJ, Hoge RD, Franceschini MA, Boas DA. A Spatial Comparison of fMRI and NIRSHemodynamicResponses.AnnualMeetingofSPIE-PhotonicsWest, SanJose,California, January2005.(OralPresentation)

7. HuppertTJ,BoasDA.HOMER:AgraphicalinterfaceforNIRSdataanalysis.AnnualMeetingoftheOrganizationforHumanBrainMapping,Toronto,Canada.June2005.(Poster)

8. Huppert TJ, Hoge RD, Franceschini MA, Boas DA. A Spatial-Temporal Comparison of fMRI andNIRS Hemodynamic Responses to Motor Stimuli in Adult Humans.Annual Meeting of theOrganizationforHumanBrainMapping,Toronto,Canada.June2005.(Poster)


9. Huppert TJ, Hoge RD, Franceschini MA, Boas DA. A Temporal Comparison of fMRI and NIRSHemodynamic Responses to Motor Stimuli. International Society for Magnetic Resonance inMedicine,MiamiFL,May2005(Poster)

10. Huppert TJ, HogeRD, FranceschiniMA, andBoasDA. A Spatial Comparison of fMRI andNIRSHemodynamicResponses toMotorStimuli inAdultHumans.EuropeanConferenceofBiomedicalOptics,Munich,Germany.June2005.(ConferenceTalk)

11. Allen, M.A, Huppert TJ, and Boas, DA. Estimating CMRO2 with multimodality imaging using amulti-compartmentvascularmodel.AnnualMeetingofSPIE-PhotonicsWest, SanJose,California,January2006..(ConferenceTalk)

12. Johny,M.B.,Diamond,S.G.,Huppert,T.J.,Laxminarayan,S.&Boas,D.A.(2006).Aphysiologically-basedmodel for fusionofelectroencephalography(EEG)anddiffuseoptical tomography(DOT).Biomed.Eng.Soc.AnnualMeeting(BMES),Chicago,IL,Oct.11–14.(Poster)

13. Diamond, S.G., Huppert, T.J., Purdon, P.L., Stufflebeam, S.M. Bonmassar, G., Hämäläinen, M.S.,Brown,E.N.&Boas,D.A.(2006).Dynamicmultimodalintegration(DMI):astate-spaceframeworkforfunctionalneuroimaging.12thAnnualMeetingoftheOrganizationforHumanBrainMapping(OHBM),Florence,Italy,June11–15.(Poster)

14. HuppertTJ,DiamondSG,BoasDA. MultimodalFusion Imagingof fMRIand fNIRS.12thAnnualMeeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, June 11–15.(ConferenceTalk)

15. HuppertTJ,DiamondS.D,andBoas,DA.State-spacemodelingformulti-modalityfusionofBOLDand Diffuse Optical Tomography. AnnualMeeting of SPIE- PhotonicsWest, San Jose, California,January2006.(Poster)

16. Nissilä I, Stufflebeam, S., Diamond, S., Huppert, TJ, Hämäläinen M, and Franceschini M.A.Responses toMedian Nerve Stimulation as Recorded by Simultaneous Diffuse Optical Imagingand Magnetoencephalography Biomedical Optics Topical Meeting for the Optical Society ofAmerica,Ft.Lauderdale,Florida,April2006.(OralPresentation)

17. Huppert TJ, Diamond, S.G. and Boas, DA. Quantitative estimation of cerebral hemodynamicchanges through themultimodality fusionofBOLDandDiffuseOpticalTomography.BiomedicalOpticsTopicalMeetingfortheOpticalSocietyofAmerica,Ft.Lauderdale,Florida,April2006.(OralPresentation)

18. Huppert TJ, Allen, M.A, and Boas, DA. Estimating CMRO2 with multimodality imaging using amulti-compartment vascularmodel. BiomedicalOpticsTopicalMeeting for theOpticalSocietyofAmerica,Ft.Lauderdale,Florida,April2006.

19. Themelis, G., D’Arceuil,H.,Diamond, S.G.,Thacker, S., Huppert, TJ., BoasD.A., and Franceschini,M.A.NIRSmeasurementofthepulsatilecomponentofcerebralbloodflowandvolumefromthearterial oscillations. Biomedical Optics Topical Meeting for the Optical Society of America,Ft.Lauderdale,Florida,April2006.

20. Huppert TJ, Diamond, S.G. and Boas, DA. Quantitative estimation of cerebral hemodynamicchanges through the multimodality fusion of BOLD and Diffuse Optical Tomography.AnnualMeetingoftheOrganizationforHumanBrainMapping,Florence,Italy,June2006.

21. Huppert TJ, Allen, M.A, and Boas, DA. Estimating CMRO2 with multimodality imaging using amulti-compartment vascular model.Annual Meeting of the Organization for Human BrainMapping,Florence,Italy,June2006.

22. Huppert TJ, AllenMS, and Boas DA. Inferring baseline and functional blood flow, volume, and


cerebralmetabolismfrommeasurementsofbloodoxygenationAnnualMeetingofSPIE-PhotonicsWest,SanJose,California,January2007.

23. Abdelnour AF, Huppert TJ. Reconstruction of brain activity from diffuse optical topography ofusing surface-based wavelets. Annual Meeting of SPIE- Photonics West, San Jose, California,January2008.

24. AbdelnourAF,Schmidt,BS.HuppertTJ.Anadaptivegenerallinearmodelforreal-timeestimationofbrainactivitybyCWNIRS.AnnualMeetingofSPIE-PhotonicsWest,SanJose,California,January2008.

25. Huppert TJ, Diamond, S.G. andBoas, DA.Optically-Calibrated FunctionalMRI.BiomedicalOpticsTopicalMeetingfortheOpticalSocietyofAmerica,St.Petersburg,Florida,March2008.

26. Huppert TJ, Diamond, S.G. and Boas, DA. Optically-Calibrated Functional MRI. InternationalSocietyofMagneticResonanceinMedicine.TorontoCanada,May3-92008

27. Huppert TJ, AllenMS, and Boas DA. Inferring baseline and functional blood flow, volume, andcerebralmetabolismfrommeasurementsofbloodoxygenation.InternationalSocietyofMagneticResonanceinMedicine.TorontoCanada,May3-92008.

28. HuppertTJ,BurkeB,andDiamondSG.High-speedMRImagingofIntervascularPhysiolgy.InternationalSocietyofMagneticResonanceinMedicine.TorontoCanada,May3-92008.

29. Abdelnour AF, Huppert TJ. Reconstruction of brain activity from diffuse optical topography ofusing surface-based wavelets. Annual Meeting of SPIE- Photonics West, San Jose, California,January2008.

30. AbdelnourAF,Schmidt,BS.HuppertTJAnadaptivegenerallinearmodelforreal-timeestimationofbrainactivitybyCWNIRS.AnnualMeetingofSPIE-PhotonicsWest,SanJose,California,January2008.

31. Abdelnour AF, Huppert TJ. Reconstruction of brain activity from diffuse optical topography ofusing surface-basedwaveletsOrganization forHumanBrainMapping. SanDiego, CA June18th2009(Poster)

32. Abdelnour,F,Schmidt,B,HuppertTJ.Anadaptivegenerallinearmodelforreal-timeanalysisandbiofeedbackofbrainactivationusingnear-infraredspectroscopy.OrganizationforHumanBrainMapping.SanDiego,CAJune18th2009(Poster)

33. Schmidt, BS., Abdelnour AF,Huppert TJ Real-time Functional Brain Imaging of AttentionUsingNear-Infrared. Organization for Human Brain Mapping. San Diego, CA June 18th 2009(ConferenceTalk)

34. Schunn,C.D.,Moss,J.,Huppert,T.,&Schneider,W.(2009,October).Real-timeNIRSfeedbackmayhelp improve self-explanation learning strategy use. Society for Neuroscience, Chicago, IL.(ConferenceTalk)

35. TamburoRJ,KimSG,HuppertTJ,DouaihyAB,MartineckDM,AizensteinHJ,Becker JT.CerebralVascular Response to Hypercapnia for Middle-Aged Males with HIV. Organization for HumanBrainMapping.SanDiego,CAJune18th2009(Poster)

36. Schmidt, BS, Abdelnour AF,Huppert TJ. Real-time Functional Brain Imaging of AttentionUsingNear-Infrared Spectroscopy. Biomedical Engineering Society Annual Meeting May 8th 2009.PittsburghPA(ConferenceTalk)

37. Huppert TJ, AllenMS, and Boas DA. Inferring baseline and functional blood flow, volume, andcerebral metabolism from measurements of blood oxygenation. SAND fourth international


workshoponStatisticalAnalysisofNeuralData(SAND4).PittsburghPA.(Poster)

38. Huppert TJ, SchmidtB, BelukN, Sparto P. Portable brain imaging of step-initiation using near-infrared spectroscopy. 3rd International Congress onGait&Mental Function.WashingtonD.C.,USA,February26-28,2010(Poster)

39. HuppertTJ,SchmidtB,BelukN,SpartoP.HuppertTJ,SchmidtB,BelukN,SpartoP.Portablebrainimagingofstep-initiationusingnear-infraredspectroscopy.OpticalSocietyofAmericaApril12th2010.MiamiFL(ConferenceTalk)

40. HuppertTJ.NIRS-SpecificAdaptationoftheGeneralLinearModelforStatisticalMappingofBrainActivityOpticalSocietyofAmericaApril12th2010.MiamiFL(Poster)

41. HuppertTJ,AbdelnourAF,Schmidt,BSGroupAnalysisforFunctionalOpticalBrainImagingusingaRandomEffectsModel.OpticalSocietyofAmericaApril12th2010.MiamiFL(Poster)

42. HuppertTJ,AbdelnourAF.EmpiricalBayesianRegularizationoftheInverseProblemforDiffuseOpticalTomographywithMultiplePriors.Optical SocietyofAmericaApril12th2010.MiamiFL(ConferenceTalk)

43. Schmidt, BS, Abdelnour AF,Huppert TJ. Real-time Functional Brain Imaging of AttentionUsingNear-Infrared Spectroscopy. Optical Society ofAmericaApril 12th 2010.MiamiFL (ConferenceTalk)

44. Huppert, TJ, Panagrahy A. (2012). A Study of Preschool Irritability: NIRS Brain Imaging ofcorrelates of clinical irritability. Talk presented at Functional Near Infrared SpectroscopyConference,London,England.(Poster)

45. Perlman, SB, Huppert, TJ. (2012). A Study of Preschool Irritability: NIRS Brain Imaging ofcorrelates of clinical irritability. Functional Near Infrared Spectroscopy Conference, London,England.(ConferenceTalk)

46. Huppert TJ Ghuman A (2012) Multimodal investigation of neural-vascular coupling duringsomatosensory stimulation and resting state using concurrent MEG-NIRS and MRI-NIRS"FunctionalNearInfraredSpectroscopyConference,London,England.(Poster)

47. AarabiAandHuppertTJ(2012).GrouplevelanalysismethodsinNIRS"FunctionalNearInfraredSpectroscopyConference,London,England.(Poster)

48. Karim H, Furman J, Huppert TJ. (2012) Functional brain imaging of vestibular function.FunctionalNearInfraredSpectroscopyConference,London,England.(Poster)

49. HuppertTJ. (2012)MultimodalimagingofneurovascularcouplingMediterraneanNeuroscienceSocietyAnnualMeeting.IstanbulTurkey(Invitedtalk)

50. Karim H, Furman J, Huppert TJ. (2012) Functional brain imaging of vestibular function.MediterraneanNeuroscienceSocietyAnnualMeeting.IstanbulTurkey(Poster)

51. Barker, J, Aarabi, A, PanigrahyA,Huppert TJ (2013)Validation of fNIRS in the visual cortex ofneonates via simultaneous fNIRS/fMRI imaging. SPIE Photonics West Feb 2013 (ConferenceTalk)

52. Aarabi A, Ghuman A, Huppert TJ. Multimodal characterization of neural-vascularcoupling:Concurrent NIRS-MEG & NIRS-fMRI brain imaging. SPIE Photonics West Feb 2013(ConferenceTalk)

53. KarimH,SpartoPJ,FurmanJ,HuppertTJ.ImagingofMulti-sensoryIntegrationusingFunctionalNear-InfraredSpectroscopy(fNIRS).SPIEPhotonicsWestFeb2013(ConferenceTalk)


54. Aarabi A, Barker J, Huppert TJ. Identification of physiological sources of noise in optical brainimaging.SPIEPhotonicsWestFeb2013(ConferenceTalk)

55. Aarabi A, Barker J, Schmidt BS, BelukN, Huppert TJ Functional NIRSData Analysis Tools SPIEPhotonicsWestFeb2013(Poster)

56. KarimH,FurhmanSI,SpartoPJ,FurmanJ,HuppertTJ(2013)FunctionalBrainImagingofMulti-SensoryVestibularProcessingduringComputerizedDynamicPosturographyusingNear-InfraredSpectroscopy. Association for Research in Otolaryngology Annual Meeting. Feb 16-23 2013.(Poster)

57. Huppert T, Karim H, Fuhrman SI, Furman JM: Functional near-infrared spectroscopy (fNIRS)during vestibulo-ocular and postural challenges (Poster presentation). 27th Barany SocietyMeeting,UppsalaSweden,June10-13,2012.

58. Kontos AP, Huppert T, Beluk N, Elbin RJ, Henry L, French J, Collins MW (2013, February).Emerging approaches for assessing sport-related concussion: Functional near infraredspectroscopy-Assessingbrainactivityfollowingconcussion.InvitedplenarylecturepresentedatBigSkySportsMedicineConference,BigSky,MT.

59. XiangHe, SerterGumus, Jung-HwanKim,AyazAghayev,BretGoodpaster,TedHuppert,DmitriyYablonskiy and Kyongtae Ty Bae, Assessment of Skeletal Muscle Oxygen Kinetics UsingQuantitativeBOLD(qBOLD),ProcISMRM2013,SaltLakeCity,Utah,p.3524.

60. Clarkson B, Huppert T, Beluk N, Schaefer W, Resnick N, Tadic S. ICS Conference 2012 BeijingPoster Presentation Do Near Infrared Spectroscopy (NIRS) and functional MRI agree wheninvestigatingbraincontrolofthelowerurinarytract?

61. ClarksonB,SchaeferW,TadicS,BelukN,HuppertT,GriffithsD,ResnickNICSConference2011Glasgow Podium Presentation PRIZE AWARD: Best Basic Science Presentation Exploring thepotentialofneuroimagingusingnearinfraredspectroscopyduringcomplexclinicalurodynamics

62. BClarkson,WSchaefer,NResnick,DGriffiths,THuppert, STadicAging Institute researchday2011 Functional near infrared spectroscopy during comprehensive urodynamic testing AgingInstituteresearchday2012UseoffunctionalMRItovalidateNIRSinvestigationofbraincontrolduringurgencyandurgeurinaryincontinence

ResearchExperience

Fundinginformation

Current(totalcurrent$4,268,344)

09/15-08/18.NationalInstitutesofHealth(NIHK01OH010759)PIChambers Title.In-vivochangesinlowerextremityjointsandmusclesduringprolongedstanding.Objective:

To apply muscle NIRS and dynamic CT to look at the relationships of hemodynamics and jointcompressiononfatigueinprolongedstanding.Directamount:$107,960

1/11/16 1/10/17 National Institutes of Health (Intergovernmental Personnel Act) PI Huppert)

Objective: This agreementwill be to assist the RehabilitationMedicine Department, NIH ClinicalCenter in efforts towards development of a robust processing stream formulti-modal data sets,includingthecapabilitytoperformindividualandgroupanalysisinhealthypopulationsandthosewithbraininjury.Directamount:$49,951


04/2016-04/2021NationalInstitutesofHealth(NIHU01-AG051197)PIBecker

Title: Connectomics of Brain Aging and Dementia. Objective. Collect MRI, MEG, and PET-PiBimaging on Alzheimer’s patients as part of the NIHHuman connectome project. Direct amount:$662,581

05/2015-06/2020NationalInstitutesofHealth(NIH2P30AG24827)PIGreenspan Title:PittsburghOlderAmericans IndependenceCenter. Objective: Developmentandsupportof

fNIRSbrainimagingduringbalanceandmobility.Directamount:$1,017,19401/2016-01/2018BrainandBehaviorResearchFoundationPIPerlman Title: Interpersonal Neural Coordination during Social Interaction in Children with Autism

Spectrum Disorders. Objective: Investigate inter-personal connectivity (hyperscanning) usingfNIRSinautisticchildrenandtheirparents.Directamount:$6,647

04/2016-04/2019NationalInstitutesofHealth(NIHK99MH101235)PIYoung

Title: Effects of Amygdala Neurofeedback on Depressive Symptoms and Processing Biases.Objective:Todevelopreal-timefMRIbiofeedback.Directamount:$82,382

09/2014-09/2016NationalInstitutesofHealth(NIHKL2TR000146)PIRosso

Title:NeuralMechanismsofCommunityMobilityinOlderAdults.Objective:TodevelopandapplyportablefNIRSimagingduringdualtaskgaitandcognitivefunction.Directamount:$1,821,761

04/2016-04/2021NationalInstitutesofHealth(NIH5R01MH094328)PISalisbury

Title:Mismatchnegativityandcomplexsecond-ordersensorymemoryinschizophrenia.Objective:AdvancedfMRIandEEGimagingofsensoryresponsesinschizophrenia.Directamount:$250,000

3/2015-3/2017NationalInstitutesofHealth(NIHK01MH104348)PIManelis

Title:Taskpreparationabnormalityinindividualswithunipolarandbipolardepression.Objective:Development of portable fNIRS brain imaging for patients with depression. Direct amount:$144,853

09/15-08/20NationalInstitutesofHealth(R01MH107540)PI:Perlman. Title: From Irritability to Impairment:Howneurodevelopment of executive function and parent-

childneuralsynchronyinfluencethetransitionfromnormaltoabnormalfunctioning.Objective:ToapplyfunctionalNIRSduringtaskandhyperscanning(interpersonalinteractions)inalongitudinalcohortofschoolagedchildren(4-6yo).Directamount:$279,896

05/16-07/18.NationalInstitutesofHealth(NIH1R03EB020078)PIHuppert

Title:DevelopmentofaHyperspectralFD-NIRSDeviceforMusclePhysiology.Objective:Buildanovelfrequency-domainNIRSsystemtomeasurecytochromec-oxidaseinmuscle.Directamount:$50,000

05/16-07/18.NationalInstitutesofHealth(R21MH103592).Co-PI:Huppert,TJ/GhumanA.

Title: Neurovascular Basis of the Somatosensory and Frontal-parietal Spontaneous Networks.Objective: Investigation of neural-vascular coupling during resting state fluctuations usingconcurrent fNIRS-MEG (magnetoencephalography) and concurrent fNIRS-fMRI. Direct Amount:$275,000


01/13-07/16.NIHSBIR(Phase II)(R44MH100707) (Subcontract toElectrogeodesics Inc);PIPoulsenEGITitle: IntegratedEEG/NIRSensorSystemfor Infants. Objective: Todevelopan integrated fNIRS-EEG system and show efficacy of the instrument in the monitoring of neonatal seizures. DirectAmount:$588,012

Completed(totalcompleted$3,152,385)09/13-08/15.NationalInstitutesofHealth(R21-PA-11-261):PI:PerlmanS

Title: A study of preschool irritability: Brain imaging in the clinical setting. Objective: ToinvestigatebraincorrelatesofclinicalirritabilityinpreschoolchildrenusingfNIRSimaging.DirectAmount$275,000

07/13-06/15.UPMCMEGPilotprogram;PIHuppert;

Title: Neurovascular coupling of spontaneous functional connectivity. Objective: Investigation ofneural-vascular coupling during resting state fluctuations using concurrent fNIRS-MEG(magnetoencephalography)andconcurrentfNIRS-fMRI.DirectAmount:$20,000

09/13-09/14.Lion’sFoundationofWesternPA.(Co-I).PI:SpartoPJ. Title: FunctionalBrain Imaging inPatientsRecovering fromUnilateralVestibularLossObjective:

Toinvestigatebrainactivationdifferencesinconcussedchildren(14-18y/o)withbalancedisordersand to follow progression (compensation) during the course of physical therapy rehabilitation.DirectAmount$20,000

10/13-10/14.PepperPilotSub-award.(subprojecttoNIHP30AG024827;PIStudenski,S).

Title: Relationships between frailty, falls and measures of mobility, cognition, and functionalneuroimaginginresidentsoflongtermcare(LTC).Objective:Usingaportablefield-researchfNIRSbrain imaging system, we will investigate elderly individuals in long-term care facilities duringcognitive(trailsmakinganddigitsymbolsubstitution)testingandbalancetesting.DirectAmount$25,000

10/13-10/14.PittsburghInstituteonAging.(Co-I).PI:SpartoPJ.

Title: Relationships between frailty, falls and measures of mobility, cognition, and functionalneuroimaginginresidentsoflongtermcare(LTC)Objective:Usingaportablefield-researchfNIRSbrain imaging system, we will investigate elderly individuals in long-term care facilities duringcognitive(trailsmakinganddigitsymbolsubstitution)testingandbalancetesting.DirectAmount:$20,000

01/13-01/14.DARPA;DepartmentofDefense.(Co-I).PI:Romalis,M.

Title:CombinedSERFroom-temperaturemagnetometryandNIRSimagingtechnology. Objective:To demonstrate source-localization of brain activity using a novel room-temperaturemagnetometrytechnologybasedonSERFsensors.DirectAmount:$168,000

06/12-06/13.PittsburghCTSI;PISusanPerlman(HuppertCo-I).

Title:AnfNIRSPilotStudyofPervasiveIrritabilityinPreschoolChildren.Objective:Toinvestigatebrain correlates of clinical irritability in preschool children using fNIRS imaging. Direct Amount:$25,000

07/12-06/14.AmericanDiabetesAssociation;PIHe(HuppertCo-I).


Title:EvaluationofSkeletalMuscleOxidativeMetabolisminTypeIIDiabetesbyQuantitativeBOLD.Objective: To develop quantitative BOLD (QBOLD) MRI imaging of muscle oxygenation and tovalidatethisnovelmethodagainstNIRSandbloodgasmeasurements.DirectAmount:$43,182

08/11-07/13.NationalInstitutesofHealth(NIH-R03-AG038583)PI:SchaeferW.

Title: NIRS Brain Imaging of Urodynamic Function Control. Objective:We are using NIRS brainimagingto investigatethecognitiveaspectsofurodynamic incontinency inelderlywomen.DirectAmount:$6,518

09/11-09/12.InstituteonAging(PittsburghInstituteonAgingPilot)PI:TadicS.

Title:MultimodalfMRI-NIRSBrainImagingofBladderSensation. Objective:WeareusingfMRItovalidateNIRSbrainimagingofurodynamicincontinencyinelderlywomen.DirectAmount:$20,000

03/12-09/12. Pepper Pilot Sub-award. (subproject toNIHP30AG024827-0609;). PI: Van Swearginen.

Title:MotorLearningInducedChangesinFunctionalBrainNetworks.DirectAmount:$20,00003/11-06/12.PepperPilotSub-award.(subprojecttoNIHP30AG024827-0609;).PI:FurmanJ.

Title: NIRS Brain Imaging During Vestibular Testing. Objective: In this project, we are recordingbrainsignalsduringcaloricandrotationalvestibulartestinginyoungandelderlyindividuals.DirectAmount:$20,000

02/11-01/13.Industrialsub-contact.PI:RedfernM..

Title:NIRSMeasurementsofMusclePhysiology.Objective:Inthisproject,weareusingfrequency-domainNIRStomeasurebloodflowandoxygenationinmusclesofthelegduringprolonged(>6hr)standing.

04/11-03/14NationalInstitutesofHealth(NIH-RO1:RO1EB013210-01)PI:HuppertTJ.

Title: Characterization of Brain Noise Using Multimodal Mutual Information. Objective: Theobjective of this project is toutilize concurrentmultimodal recordingsusing functionalmagneticresonance imaging (fMRI), near-infrared optical (NIRS) and measures of systemic physiology inordertoseparatethecontributionsofeachofthesetypesofnoise.DirectAmount:$720,000

06/10-06/12NationalInstitutesofHealth.(NIHP30AG024827-0609;SubprojectPI).PI:Studenski,SA.

Title:PittsburghOlderAmericansIndependenceCenter.Objective:Inthisproject,wewilldevelopnewmethodsfornear-infraredbrainimagingandapplythesetostudybrainactivationduringstep-initiationinelderlysubjects.DirectAmount:$923,838

06/09-05/11.NationalInstitutesofHealth.(NIHR21;R21NS064457-01A109).PI:Huppert,TJ.

Title: A Cerebral Functional Unit Model for Multimodal Imaging of Neurovascular Coupling.Objective.Near-infraredbrainimagingwillbeusedconcurrentlywithmagnetoencephalogy(MEG)tostudytheinteractionsbetweenneuralandhemodynamicresponsesinthebrain.DirectAmount:$411,765


09/09-08/11. National Institutes of Health. (NIH R01; R01AG029546-03S110 Co-I). PI: Loughlin PS.Title:ModelingSensory IntegrationandAttention inPosturalControlofOlderAdults. Objective:The aim of this competing revision to R01 AG 029546, submitted under ARRA, is to extend ourresearch into balance and attention by hiring a post-doctoral researcher to acquire and analyzecortical brain activity using NIRS imaging of subjects while they perform our current dual taskexperimentaltrials.DirectAmount:$93,173

02/09-02/11.DARPA;DepartmentofDefense.(Co-I).PI:SchneiderW.

Title:BiologicallyAcceleratedLearningTechnology.Objective:Todevelopaportablebrainimagingtechnology to assess the quality of the acquisition of learning skills and to develop adaptivestrategiestoenhancelearningusingreal-timebio-feedback.DirectAmount:$336,080

03/11-02/12.PepperPilotSub-award.(subprojecttoNIHP30AG024827).PI:FurmanJ.

Title: NIRS Brain Imaging During Vestibular Testing. Objective: In this project, we are recordingbrainsignalsduringcaloricandrotationalvestibulartestinginyoungandelderlyindividuals.DirectAmount:$4,829

TeachingExperience

FacultyMentoring2014-current Secondary K-award mentor for Andrea Rossi, PhD (U of Pitt; Dept of

Epidemology). The use of functional NIRS during gait and dual-taskcognitivefunctionintheelderly.

2014-current. (PendingNIHfiscalcouncilreview;scoredat14thpercentile)SecondaryK-

awardmentor forAprilChambers,PhD(UofPitt;DeptofBioengineering).Measurement of muscle energetics and application to ergonomics usingnear-infraredspectroscopy.

DegreeStudents2011-2014 PhDAdvisor. Jeff Barker. Dept ofBioengineering,University of Pittsburgh

(HuppertAdvisor). “Estimationof cerebralphysiologyandhemodynamicsvianear-infraredspectroscopy”.ExpectedcompletionNov25th2014.

2009-2013 PhD Advisor. Benjamin Schmidt. Dept of Bioengineering, University ofPittsburgh.(HuppertAdvisor).“Applicationofbigdatacomputingtowholebrainfunctionalconnectivity”.Spring2013

AdvisoryCommittees/DoctorialCommittees2012. University of Michigan. Functional NIRS steering committee (part of NIH

S10-sharedinstrumentaward)2012 CarnegieMellonUniv.Advisor/Consultant$130k(directfundingfromDean)

givenbydeantoestablishNIRSimaginglabatCMU(PI:Holt/Tarr)2011-2014. fNIRSSociety;Foundingmember/steeringcommittee2011-current.UniversityofIowa;DeltaCenterforChildDevelopment;Externaladvisory

board(NSFprogramprojectaward)2010-present Doctorial Defense Committee. Angela Harivile (D. Noll advisor). Dept of

Bioengineering.UniversityofMichigan.2010 SummerAdvisor.DwightDart(PhDcandidate),Deptof Bioengineering,JamesMadisonUniversity(June-July2010)

In


2009 Doctorial Defense Committee. Minje Wu (H. Aizenstein advisor), Dept ofBioengineering,UniversityofPittsburgh

ConferenceChair/Organizer2009 Co-organizer. MathematicalProblemsinImagingScience:FromtheNeural

totheQuantumWorld.August17-222009.MontrealCanada.2010 Co-organizer. 1st Annual meeting Functional Near-infrared Spectroscopy,

October2010.CambridgeMA.2012 Co-organizer. 2ndmeeting FunctionalNear-infrared Spectroscopy,October

2012.London,UK.2014 Co-organizer. 4rdmeeting Functional Near-infrared Spectroscopy, October

2014.MontrealCA.2014 Founding boardmember of the Society of fNIRS. Society became officially

recognizedasanon-profitinAugust2014.Electedasboardmember2014-2020.

Otherteaching2010-2014 Instructor (2 lectures onNIRS). Univ of PittsburghBioE2505.Multimodal

Imaging.KangKiminstructor2012 Instructor, University College London, NIRS-DOT Visiting Fellowship

Program(Designandanalysisofnon-invasiveopticalmeasurementsofbrainfunction),LondonUK

2010-2014 Instructor SummerMultimodal Neuroscience Training Program UniversityofPittsburgh/CarnegieMellonUniversity.(June-July2010)

2010 Instructor. Incorporating multimodal nueroimaging techniques into yourclinical and translational research. Pittsburgh Clinical and TranslationalScienceInstitute.April6th2010.

2003-2011, 2013 Instructor,MassachusettsGeneralHospital,NIRS-DOTVisiting FellowshipProgram(Designandanalysisofnon-invasiveopticalmeasurementsofbrainfunction),BostonMA

2004-2006 Undergraduate Research Supervisor, HST/MGH/A.A. Martinos Center forBiomedicalImaging

2004-2007 TrainingInstructor,TechEnInc,MilfordMA2004,2005 Guest Lecturer, Harvard University; Dept. of Psychology (Experimental

designandmethodsinfMRI)2004 Teaching Assistant, Harvard University; Dept. of Molecular and Cellular

Biology(Introductiontobiochemistry)2000-2002 TeachingAssistant,UniversityofWisconsin-Madison;Dept.ofChemistry

ProfessionalDevelopment

2014-2020MemberoftheExecutiveboardfortheSocietyforfNIRS2008-2012 PepperCenterJuniorScholarsFellowship2002-2007 HowardHughesMedicalInstitutePre-DoctorialFellowship2000-2002 HilldaleUndergraduateResearchGrant(UniversityofWisconsin-Madison)

AdhocScientificPublicationReviewer:


PNAS,J.BiomedicalOptics,SPIETransactionsonMedicalImaging,HumanBrainMapping,ExperimentalBrainResearch,Neuroimage,PhysicsinMedicineandBiol,SpectroscopyLetters,OpticsExpress,J.BiomedicalOpticsExpress,OpticsLettersA,FrontiersinPsychiatry,J.NeuralEngineering,NeuralNetworks,GaitandPosture,J.NeuroscienceMethods,BiomechanicsinModelingandMechanobiology,NeuroscienceLetters,TransactionsinBiomedicalEngineering,ExpBrainResearch,OpenNeuroimagingJ

AdhocScientificGrantReviewer:National Institutes of Health (mail in reviewer), Polish National Science Foundation (invitedreviewer),SwissNationalScienceFoundation(mailinreviewer)

AWARDSANDHONORS:

2006 StudentPaperAward,OpticalSocietyofAmerica,Ft.Lauderdale,FL2006 StudentTravelAward,HumanBrainMapping,FlorenceItaly2005 Best“PhotonMigration”abstract,EuropeanConferenceofBiomedicalOptics2002-07 HowardHughesMedicalInstitutePre-DoctorialFellowship2001 BestPosterAward,6thJohnsHopkinsUniversityProteinFoldingMeeting2000-2002 HilldaleUndergraduateResearchAward,Univ.ofWisconsin-Madison

ServiceCommittees:2011-2014.MemberofUniversityofPittsburghInstitutionalReviewBoard(committeeC[2011-

2013],D[2013-2014]&G[2013-2014])2012-2013.UniversityofPittsburghMRResearchPilotGrantAwardCommittee2012-current.UniversityofPittsburghMEGPilotGrantAwardCommittee

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