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ScopeTheVol. 13 No 1

MUSC DEPARTMENT OF OTOLARYNGOLOGY HEAD & NECK SURGERY

Paul R. Lambert, M.D.

INSIDEUpward Trajectory

Faculty Spotlight

Publications

Clinical Update

Research Realm

Residents & Fellows

Faculty

CME Events

Chairman’s Corner

ENT.musc.edu

Fall 2012

Continuing anUpwardTrajectoryWorking harder and growing bigger

are not necessarily laudable goals; however, working smarter to achieve

strategic growth is worthwhile. Our department has had strong success with strategic growth in both the clinical and research arenas, and we are beginning to put mechanisms in place which will hopefully allow us to work with greater efficacy and efficiency.

On the growth side, I am pleased to introduce two new faculty members in this newsletter: Barry Malin, MD, MPP, an Assistant Professor in the Head and Neck Division, and Ashli O’Rourke, MD, an Assistant Professor in the Laryngology Division. Combining their superb clinical skills with our departmental/institutional infrastructure will allow them to succeed as clinician-scientists. Our full-time clinical faculty now numbers 17, with four part-time faculty at our VA Hospital and outreach sites. This past year we saw more than 35,000 outpatients and performed more than 4,000 surgical procedures.

On the research front, this newsletter highlights important insights into the association of age-related hearing loss and loss of myelin in the spiral ganglion and cochlear afferent nerve fibers. Interestingly, changes in myelinated nerve fibers have been seen in a number of neurodegenerative disorders, including Alzheimer’s disease. Our growth in basic science research has been

strategic, allowing us to maintain our top 10 status in NIH funding for Otolaryngology – Head and Neck Surgery departments for over a decade. The productivity of our clinical and basic research enterprises is captured in the 68 manuscripts published in 2011.

How does one work smarter? Each of our faculty is provided a monthly dashboard displaying a plethora of information (charges, collections, work RVUs, payor mix, most frequently billed codes, etc.). Synthesizing that data for the group and developing practice strategies will be the responsibility of a new departmental committee directed by M. Boyd Gillespie, M.D. in his role as Vice Chair for Clinical Outreach. It is our anticipation that these strategies will improve both patient outcomes and physician satisfaction. We look forward to sharing within these pages best practices that prove themselves over time.

Paul R. Lambert, M.D. Professor and Chair,Otolaryngology - Head & Neck Surgery

• FullTimeClinicalFaculty=17• FullTimeResearchFaculty=12• Audiologists=8• OutpatientVisits>35,000/year• SurgicalProcedures>4000/year• Top10NIHFunding• PublishedManuscripts2011=68

Ashli O’Rourke, M.D., M.S. joined the MUSC Evelyn Trammell Institute for Voice and Swallowing in September 2012. Dr. O’Rourke began her professional career as a Speech-Language Pathologist (SLP), earning her Masters degree in Speech-Language Pathology and Audiology from Florida State University. After seven years of clinical speech therapy practice at Emory University Hospital, she attended medical school at the Medical College of Georgia. She completed her residency in Otolaryngology – Head and Neck Surgery at University of Virginia in Charlottesville, Virginia and fellowship in Laryngology – Voice and Swallowing Disorders at the Medical College of Georgia.

Dr. O’Rourke treats adult patients with problems located in the larynx and the esophagus. This includes hoarseness or voice disturbances, dysphagia, or breathing difficulties due to airway stenosis or scar. She is particularly interested in the diagnosis and treatment of swallowing disorders as well as laryngopharyngeal reflux disease. Her research interests include exploring less invasive techniques for the diagnosis of laryngopharyngeal reflux. Dr. O’Rourke sees patients in Mount Pleasant and downtown Charleston. She is board certified through the American Board of Otolaryngology.

Barry T. Malin, M.D., M.P.P., joined the MUSC Head and Neck Surgery Division in July 2012. Originally from Buffalo, NY, Dr. Malin graduated from medical school at the University of California at San Francisco (UCSF) followed by residency training in Otolaryngology - Head & Neck Surgery at the State University of New York at Buffalo. He then completed fellowship training in Surgical Oncology and Microvascular Reconstruction of the Head and Neck at MUSC. Additionally, he completed a Master’s Program in Health Policy at Harvard University.

Dr. Malin’s practice is dedicated to the treatment of head and neck cancer. In addition to the full range of head and neck ablative surgery, Dr. Malin also performs microvascular free flap reconstruction. His clinical interests include the treatment of advanced non-melanoma skin cancers and microvascular reconstruction of the head and neck. Dr. Malin sees patients at the Hollings Cancer Center and the Ralph H. Johnson VA Medical Center.

Dr. Malin has authored five chapters in major Head and Neck surgery textbooks and several manuscripts in Otolaryngology - Head & Neck Surgery. His current primary research interests include topics related to quality of care, access to care and treatment disparities among patients with head and neck cancer. Dr. Malin is board-certified by the American Board of Otolaryngology.

Cannon TY, Strub GM, Yawn RJ, Day TA (2011). Oromandibular Reconstruction. Clinical Anatomy, 25(1); 108-119.

Nguyen SA, Walker D, Gillespie MB, Gutkind JS, Day TA (2011). MTOR inhibitors and its role in the treatment of head and neck squamous cell carcinoma. Current Treatment options in Oncology. Springer.

Davis, BK (2012). Cleft Lip and Palate: Prosthetic Rehabilitation in the Growing Cleft Patient. Current Therapy in Oral and Maxillofacial Surgery, Mosby/Elsevier.

Carie CM, White DR, Discolo CM (2011). Postoperative massive tongue edema in craniosynostotic children. Int J Pediatr Otorhinolaryngol; 75(9):1173-1175.

Day KE, Discolo CM, Meier JD, Wolf BJ, Halstead LA, White DR (2012). Risk factors for supraglottoplasty failure. OHNS; 146(2):298-301.

Wang LF, White DR, Andreoli SM, Mulligan RM, Discolo CM, Schlosser RJ (2012). Cigarette smoke inhibits dynamic ciliary beat frequency in pediatric adenoid explants. OHNS;(4):659-663.

Horwitz AR, Ahlstrom JB, Dubno JR (2011). Level-dependent changes in detection of temporal gaps in noise markers by adults with normal and impaired hearing. J Acoust Soc Am 130, 2928-2938.

Poling GL, Horwitz AR, Dubno JR (2012). Individual differences in behavioral estimates of cochlear nonlinearities. J Assoc Res Otolaryngol 13, 91-108.

Vaden KI, Kunchinsky SE, Keren N, Harris KC, Ahlstrom JB, Dubno JR, Eckert MA (2011). Inferior frontal sensitivity to common speech sounds is amplified by increasing word intelligibility. Neuropsychologia 49, 3563-3572.

Kuchinsky SE, Vaden KI, Keren N, Harris KC, Ahlstrom JB, Dubno JR, Eckert MA (2011). Word intelligibility and age predict visual cortex activity during word listening. Cereb Cortex, [Epub] doi:10.1093/cercor/bhr211.

Horwitz AR, Ahlstrom JB, Dubno JR (2012). Individual and level-dependent differences in masking for adults with normal and impaired hearing. J Acoust Soc Am 131, EL323-328.

Xing Y, Samuvel DJ, Stevens SM, Dubno JR, Schulte BA, Lang H (2012). Age-related changes in myelin basic protein in mouse and human auditory nerve. PLoS One 7, e34500.

Harris KC, Wilson S, Eckert MA, Dubno JR (2012). Human evoked cortical activity to silent gaps in noise: Effects of age, attention, and cognitive processing speed. Ear Hear 33, [Epub].

Vaden KI, Gebregziabher M, Kuchinsky SE, Eckert MA (2012). Multiple imputation of missing fMRI data in whole brain analysis. Neuroimage; 60(3): 1843-1855.

Gillespie MB, Intaphan J, Nguyen SA (2012). Endoscopic-assisted management of chronic sialadenititis. Head Neck; 33: 1346-51.

Wolf GT, Fee WE Jr, Dolan RW, Moyer JS, Kaplan MJ, Spring PM, Suen J, Kenady DE, Newman JG, Carroll WR, Gillespie MB, et al (2011). Novel neoadjuvant immunotherapy regimen safety and survival in head and neck squamous cell cancer. Head Neck; 33: 1666-74.

Gillespie MB, Wylie P, Lee-Chiong T, Rapoport DM (2012). Effect of palatal implants on CPAP pressure and compliance. OHNS; 144: 230-236.

Gillespie MB, Ayers CM, Nguyen SA, Abidin MR (2011). Outcomes of hyoid myotomy and suspension using a mandibular screw suspension system. OHNS; 144:225-229.

Reeves TD, Hill EG, Armeson KE, Gillespie MB (2011). Cetuximab therapy for squamous cell carcinoma of the head and neck: a systematic review of the data. OHNS; 144: 676-684.

Davis KS, Welsh CT, Hawes RH, Gillespie MB (2011). Pathology quiz case 3:Heterotopic gastric mucosa. Arch OHNS; 137:831.

Gillespie MB, Koch M, Iro H, Zenk J (2011). Endoscopic-assisted gland-preserving therapy for chronic sialadenitis: a German and U.S. Comparison. Arch OHNS; 137: 903-908.

Saddoughi SA, Garrett-Mayer E, Chaudhary U, O’Brien PE, Afrin LB, Day TA, Gillespie MB, et al (2011). Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C18-ceramide as a novel biomarker for monitoring response. Clin Can Res. [Epub]

Sharma S, Gillespie MB, Palanisamy V, Gimzewshi JK (2011). Quantitative nano-struture and single molecule force spectroscopy biomolecular analysis of human-saliva-derived exosomes. Langmuir; 6:14394-400.

Banks CA, Ayers CM, Gillespie MB (2012). Thyroid disease and compressive symptoms. Laryngoscope; 122: 13-16.

Talwar S, Carroll B, Liu A, Gillespie MB, Palanisamy V (2011). Hypoxi-induced cleavage of HuR regulates c-Myc expression in head and neck oral squamous cell carcinoma. J Biol Chem; 286: 32333-43.

Reddy R, White DR, Nguyen SA, Gillespie MB (2011). Obstructive parotitis secondary to an acute masseteric bend. ORL J Otorhinolaryngol Relat Spec; 74:12-15.

2 http://ENT.musc.edu musc • discovery, understanding, healing since 1824

Barry T. Malin, M.D., MPP

Publications

– continued on page 8

Ashli K. O’Rourke, M.D., M.S.

SpotlightFaculty

The Charleston Course: 2nd Annual Otolaryngology Literature UpdateThe department hosted its 2nd Annual Literature Update Course on July 27 - 29, 2012 at the beautiful Kiawah Island Golf Resort. Over 30 Otolaryngologists representing 14 states enjoyed the two-and-a-half days of our faculty critically analyzing the year’s most relevant, evidence-based medical literature. Afternoons were free to enjoy the beaches, golf, tennis, restaurants and many other activities on the island, or to take a short drive into historic

downtown Charleston. We hope you can join us for the 2013 Annual Otolaryngology Literature Update to be held on July 26 - 28, again at Kiawah. Bring the family and experience all the area has to offer.

1st Annual Charleston Sleep Surgery SymposiumOur inaugural Sleep Surgery Symposium was held at the Charleston Renaissance Hotel

February 24 - 25, 2012 under the direction of M. Boyd Gillespie, MD, MSc. Over 40 otolaryngologists from 22 states attended the lectures, roundtable discussions, live

patient demonstration, and hands-on labs focused on procedures for snoring and sleep disordered breathing. Guest professors included Lon R. Doles, DDS (South Carolina);

Stacey L. Ishman, MD (Johns Hopkins); J. Scott Magnuson, MD (UAB); and Kathleen Yaremchuk, MD (Henry Ford)

musc • discovery, understanding, healing since 1824 http://ENT.musc.edu 3

12th Annual Charleston Magnolia ConferenceOur distinguished guest speakers for the 2012 Magnolia Conference held June 1-2, 2012 were John W. House, MD (California), Heinrich Iro, MD (Germany), John S. Rhee, MD (Wisconsin), and James D. Sidman, MD (Minnesota). More than 50 attendees from around the country came for the presentations and round table lunch discussions covering the breadth of our specialty, directed by Department Chair, Paul R. Lambert, MD. The weather was ideal, providing the perfect setting to enjoy historic Charleston, the beaches, golf, and the Spoleto Festival USA.

Please join us for the 13th Annual Magnolia Conference, May 31 - June 1, 2013 for another several days of exceptional education and recreation.

Temporal Bone Dissection CoursesIntensive two-day otology courses for the practicing otolaryngologist focused on procedures for chronic ear disease. This biannual course includes hands-on training in our state-of-the-art temporal bone lab.

Course Director: Ted A. Meyer, M.D., Ph.D.

Fall Course - December 2-3, 2011 Guest Speaker: Larry R. Lustig, M.D. (UCSF)Spring Course - May 11-12, 2012 Guest Speaker: John L. Dornhoffer, M.D. (University of Arkansas)

3rd Annual Pediatric Audiology Conference: Auditory Neuropathy Spectrum DisorderThe 2012 Pediatric Audiology Conference was held on March 16, directed by Meredith Holcomb, AuD. Guest lecturers were Patricia Roush, AuD (North Carolina) and Yvonne Siniger, PhD (California). More than 60 attendees from North and South Carolina, and Georgia participated in the educational event complete with a sun-washed Charleston waterfront luncheon.

The Carolinas Pediatric Airway CourseThis resident training course held on October 13 - 14, 2011 was co-hosted by MUSC and the University of North Carolina. The two days of lectures and hands-on labs focused on pediatric endoscopic and open airway surgical techniques. Drs. David R. White (MUSC) and Carlton J. Zdanski (UNC) co-

directed the course with faculty instructors and residents from MUSC, UNC, Duke, Emory, Georgia Health Sciences and Wake Forest.

The fourth annual course will be held in Chapel Hill,December 13 - 14, 2012.

EducationContinuing


UpdateClinicalRisk Factors for Survival in Thyroid Cancer:

Insight from the SEER Database

Eric J. Lentsch, M.D. and Valerie Smith, M.D.

The treatment of thyroid cancer is relatively well-standardized; however, there remain several areas of controversy and debate. Two of these areas are the

importance of age and cervical lymph node involvement as prognostic factors for survival in patients with well-differentiated thyroid carcinoma (DTC). Our group recently published studies on each of these topics which may help elucidate them (1,2).

Patient age has long been known to be a prognostic factor in patients with DTC. In fact, the current staging system underscores the importance of age by creating two dichotomous patient groups based on a somewhat arbitrary age cutoff of

45 years. However, since it is somewhat unclear how and why the age of 45 was chosen for the staging guidelines, we chose to study this question using the Surveillance, Epidemiology, and End Results (SEER) database. A total of 42,209 patients with DTC were studied with disease specific survival (DSS) as the main study endpoint. Two important findings came out of our study. First, we identified that the DSS for patients actually worsens earlier than the staging system says. We found that patients over the age of 35 were 14 times more likely to die of their disease than patient’s younger than 35 years. This is 10 years less than the staging system describes, and at least 5 years younger than any previous study has described. Secondly,

we showed a continued decline in disease-specific survival with each advancing decade over age 35 years (Figure 1). Thus rather than a dichotomous division into 2 age groups, survival in DTC represents a continuum with advancing age conferring an independent risk factor for mortality. The clinical implication of this finding is realized when counseling patients of various ages. For example, patients in the 65- to 74-year age range have a 3- to 5-fold increase in disease-specific mortality compared with patients aged 45 to 54 years. And the mortality rate for the 65- to 74-year-old patients approaches 10% and 20% - far from the excellent prognosis generally associated with a diagnosis of DTC.

The second area of controversy we chose to address concerns the issue of whether or not cervical lymph node metastasis increases the risk of death in patients with DTC. Multiple studies have indicated that the presence of cervical metastasis does not worsen survival but instead increases their chance of recurrence. We again chose the SEER database to study this counter-intuitive notion. We looked at over 11,000 patients with DTC, 40% of whom had lymph node metastasis at the time of diagnosis. We found that for those patients less than 45 years old, lymph node metastasis did not significantly affect DSS – supporting the current literature. However, what was unexpected was that DSS was indeed worse for patient’s greater than 45 years old

Figure 1.

References1. Reevaluating the Prognostic Significance of Age in Differentiated Thyroid Cancer. Oyer SL, Smith VA, Lentsch EJ. Otolaryngol Head Neck Surg. 2012 Mar 30.

2. Cervical lymph node metastasis and papillary thyroid carcinoma: Does the compartment involved affect survival? Experience from the SEER database. Smith VA, Sessions RB, Lentsch EJ. J Surg Oncol. 2012 Mar 5.

who had lateral compartment or mediastinal involvement of the lymph nodes. (Figure 2). Clinically this may be important in our counseling of patients with lateral or mediastinal nodal disease who are over 45 years old, since they appear to have a significantly worse survival.

These studies and others we are doing on topics such as melanoma and sarcoma utilize the SEER database. This is a large population-based registry that allows for the identification of exceptionally large cohorts for study. SEER lacks the referral and reporting biases that may be inherent in institutional studies and reflects the care of patients across a spectrum of community hospitals, county hospitals, academic medical centers, and health maintenance organizations. It is therefore a valuable tool that we hope to use in the future to provide a better idea as to what the prognostic factors are for many other disease entities.

Figure 2.

HonorsAwards

Judy R. Dubno, PhD was one of two recipients of the inaugural Peggy Schachte Research Mentor

Award. Drs. Dubno and Jeanette Andrews were selected among other faculty nominees for their excellence in mentoring and guiding junior faculty in obtaining research support. Dr. Dubno, an audiology researcher, has mentored about 50 students and junior faculty including 27 individuals since 2009.

Kelly C. Harris, PhD, received the 2012-2013 John R. Raymond Fellows Award, a fellowship that provides

support for female faculty members to initiate a relationship with a mentor affiliated with an outside

institution. Dr. Harris is a Research Assistant Professor of Otolaryngology - Head & Neck Surgery focused on

cognitive neuroscience, audiology, and speech.

A. Lawrence Lemel, MD: Four Decades of Service and Still Going Strong

Few people in the MUSC Department of Otolaryngology-Head and Neck Surgery have touched the lives of so many residents as Dr. A. Lawrence Lemel. Dr. Lemel rightly deserves his esteemed reputation as a teacher, mentor, and friend of young ENT doctors in training. He has faithfully fulfilled his duty as clinical associate faculty every Thursday in the ENT clinic at the Ralph H. Johnson VA Medical Center since 1965, and

is the only faculty to have served under all chairmen of the department including Drs. Hanckel, Adkins, and Lambert. He performed this service not for money, benefits, or prestige. He has done it because serving as a teacher and mentor is part of the fabric of his being.

Dr. Lemel was raised in Ohio where he attended Case Western Medical School, followed by residency training in otolaryngology at the University of Illinois-Chicago. He received an additional 2 years of advanced training in otologic surgery followed by two years in the U.S. Air Force before moving to Charleston in 1965 where he opened a solo otolaryngology practice. Although he retired from private practice in 2004, Dr. Lemel still enjoys his Thursdays at the VA, referring to it as “my day of youth.” Dr. Lemel meets the ENT residents at 7AM sharp every Thursday morning for breakfast and an otology quiz at the Roper Hospital doctor dining and records room, which was started by Dr. Lemel as a way to entice doctors to come in and sign their charts. They then proceed across the street to the Ralph H. Johnson VA ENT clinic where they treat between 40 and 50 patients in a given day. Believing that young doctors function best when well-fed, the team usually makes time to eat and discuss the morning patients during lunch at Roper.

Dr. Lemel is proud of the residents, and states that they seem to be getting better and better every year. As a model airplane aficionado, Dr. Lemel recently challenged residents to build model airplanes as a way of developing spatial and fine motor skills. There are currently 5 airplanes in production vying for the $500 grand prize. His relationship with the residents and their families goes beyond the usual aspects of training and continues long after the residents have left MUSC. He continues to be a source of comfort and advice when his former protégées face health, family, or financial challenges. His message to the graduating residents is “teaching what you know in life is the best method to strengthen your own knowledge.”

Peggy Schachte, center, congratulates Drs. Judy Dubno, left, and Jeanette Andrews.



RealmResearchHainan Lang, M.D., Ph.D. and Judy R. Dubno, Ph.D

Age-Related Spiral Ganglion Neuron Loss in Human Temporal Bones

Figure 1. Immunolocalizations of myelin basic protein (MBP) in the human inner ear. Left panel: Low-power view of apical and middle turns of the cochlea from a 46-year-old temporal bone donor shows auditory nerve fibers labeled with MBP antibody (green). Nuclei were stained with propidium iodide (PI, red). Right panel: Enlarged images corresponding to the boxed areas labeled A to F in the left panel. A: MBP+ fibers located within Rosenthal’s canal (RC) in the apical turn. B: MBP+ fibers in the central projection (CP) of the auditory nerve within the modiolus. C: MBP+ fibers in the peripheral process (PP) of the auditory nerve within the osseous spiral lamina (OSL). D: MBP+ intraganglionic spiral bundle (ISB) fibers. E: MBP+ fibers located within Rosenthal’s canal of the middle turn. F: Transverse section of MBP+ fibers in the CP within the mo-diolus. Abbreviations: OCT, organ of Corti; SL, spiral ligament; SM, scala media; ST, scala tympani; SV, scala vestibuli. Scale bar, 7 mm in F applies to A-F.

About half of all people over age 75 have some degree of age-related hearing loss (presbyacusis).

One of the most common pathological changes seen in presbyacusis is the loss and malfunction of cells in the inner ear, including spiral ganglion neurons of the auditory nerve and their projections. Characterizing the molecular basis of spiral ganglion neuron degeneration in the human inner ear will lead to a better understanding of the pathophysiology of presbyacusis. Such information is critical to advance diagnosis and prevention, and to design effective therapies for this common neurodegenerative disorder. Studies of histopathologic and molecular changes of the human inner ear are challenging for several reasons: (1) very limited numbers of temporal bones are available from older donors to address research questions related to presbyacusis; (2) the auditory nerve is inaccessible to surgical biopsy; (3) the time to fixation of human tissue is often delayed, which can result in deterioration of important proteins; (4) medical and hearing health histories and functional data are lacking from most donors; and (5) few well-established methods are available for studying age-related cellular and molecular changes in human inner ear tissue. These factors have significantly hindered progress in defining the cellular and molecular bases of age-related degeneration in the human inner ear.

In the past two decades, our Hearing Research Program has collected temporal bones at autopsy from donors at MUSC, especially from individuals over 60 years of age. With a collaborative team of scientists, clinicians, and staff from the Departments of Otolaryngology-Head and Neck Surgery and Pathology and Laboratory Medicine, we have acquired multiple inner ear specimens collected and fixed within six hours of death. Drawing from this valuable archive and a “normal aging” animal model, our recent study revealed that myelin-associated spiral ganglion neuron degeneration may play a critical role in age-related hearing loss

(Xing, Samuvel, Stevens, Dubno, Schulte and Lang, PloS ONE 7: e34500, 2012; Figures 1 and 2).

Myelin is an electrical insulation material that forms a sheath around neuronal cell bodies. It is essential for the normal function of the nervous system because it enhances the speed and fidelity of neural conduction. In the mammalian inner ear, the processes of spiral ganglion neurons are enclosed within several layers of myelin sheaths made by Schwann cell cytoplasm. Myelin basic proteins (MBPs) are the major element of the myelin sheath in the nervous system and comprise 30% of the total protein found in myelinating cells. MBP is part of a family of proteins consisting of multiple polypeptide chains. This protein family is the product of a large gene complex called Golli (Genes of OLigodendrocytes Lineage) having 10 exons in humans. Because MBP is

essential to the formation of nervous system myelin, it is also referred to as the “executive molecule of myelin.”

Age-related degeneration of myelin and the loss of the myelinated nerve fibers have been seen in several age-related neurodegenerative disorders, including Alzheimer’s disease. Studies have shown myelin degeneration in several regions of patients’ brains, including the cerebral cortex, corpus callosum, and optic nerve. Based on these observations, we hypothesized that an age-related loss of MBP occurs in the auditory nerve and that these changes may be associated with age-related hearing loss. To test this hypothesis, we first characterized the expression pattern of MBP in the auditory nerve using an animal model, aged CBA/CaJ mice. CBA/CaJ mice provide a widely used “normal aging” animal model in hearing research. These mice show little

C

A

B

D

E

F


change in auditory nerve function until very late in life; significant auditory brainstem response threshold shifts across a wide range of frequencies are typically not seen until mice are older than 2 years. Electron microscopic observations and MBP immunohistochemical analysis in the aged CBA/CaJ mice revealed that abnormalities of the myelin sheath, such as sheath disruption and reduction of MBP immunostaining, occur prior to a significant loss of spiral ganglion neurons. Changes in MBP immunostaining pattern and the loss of nerve fibers in these mice were associated with ultrastructural changes of the myelin sheath and a significant decline of auditory nerve function.

To determine if these findings are similar in inner ears of older humans, we assessed age-related myelin degeneration and changes of MBP expression in human ear tissues from 13 temporal bones from 10 human donors, which had been acquired previously through our temporal bone donation program. These donors included 4 adults aged 38-46 years (middle-aged group) and 6 adults aged 63-91 years (older group). We determined that MBP was expressed in the auditory nerve of both middle-aged (Figure 1) and older groups. Through comparison of MBP immunostaining patterns and the number of MBP+ nerve fibers in temporal bones from middle-aged and older human donors, we observed an age-related reduction of MBP immunostaining in the spiral ganglion, similar to the results seen in the mouse model. The density of MBP+ fibers in peripheral processes (within the osseous spiral lamina) and central processes (within the modiolus) declined significantly in the older group as compared to the middle-age group (Figure 2). In addition, spiral ganglion neuron loss was revealed in the auditory nerves of the older group by immunostaining with neuronal markers, neurofilament 200 and class III β-tubulin. Taken together, our study provides the first evidence of age-related spiral ganglion neuron degeneration associated with expression abnormalities of a key myelin protein in the human auditory nerve. Further molecular and functional studies of this very abundant protein will continue to determine the causes of myelin degeneration and age-related spiral ganglion neuron loss in the human inner ear.

Figure 2. Age-related reduction of MBP+ fibers and immunostaining for MBP in human inner ears. MBP+ nerve fibers (red) are shown in peripheral central portions of ears from 46-year-old (A) and 91-year-old (B) donors. Losses of MBP+ fibers and the intensity of MBP immunoreactivity were seen in many myelinated fibers of the older donor (white arrowheads). Counts of MBP+ fibers in two different locations of peripheral (C, D) and central (E, F) projections revealed a statistically significant reductions in fiber density in older compared to middle-aged human cochleas using an unpaired t-test (*p<0.05). Scale bar, 12 mm in B applies to A-B.

Judy R. Dubno, PhDPI, Duke Univ., Resources for Mentorship of Clinician Scientists in Hearing & Balance Disorders $23,779, Dec 2011-Nov 2014

Mark A. Eckert, PhDPI, NIH/NICHD, Methods for Retrospective Multi-Site Research $307,732, May 2012-April 2017

Bonnie Martin-Harris, PhDPI, VMAC, Speech Pathologist & Data Management Research, RHJ, VAMC, Charleston, SC $162,400 Feb 2012-Feb 2014

Jennifer K. Mulligan, PhDPI, VAMC Sub, IPA Agreement, Jennifer Mulligan $22,205 Mar 2012-Feb 2014

Shaun A. Nguyen, MD, MAPI, Global Life Technologies, Reduction of Staph Aureus Carriage by Non-Antibiotic Nasal Antiseptic $33,125, Jul 2012-Sept 2012

Alkis Psaltis, MD, PhDPI, JK Mulligan -Mentor, AAO Allergy, Role of VD3 in Atopic CRSwNP $15,000, Nov 2011-Oct 2013

Rodney J. Schlosser, MDPI, SA Nguyen Co-PI, Pharmanet, A 12-month Open-Label multicenter study evaluating the safety of intranasal administration of Fluticasone Propionate twice a day (BID) using a novel bi-directional device in subjects with C $57,497, Jul 2012-Jul 2013

PI, VAMC Sub, IPA Agreement, Tucker Williamson $90,458, Mar 2012-Feb 2014

PI, Charleston Research Institute, Smoke Impaired Epithelial Function in Sinusitis $100,000, Jul 2012-Jun 2015

Gregg Schmedes, MDPI, KG Patel Mentor, AAO, Novel Biofeedback Therapy for Facial Paresis/Paralysis $4,803, Jul 2012 - Feb 2013

Zachary M. Soler, MD, MScPI, Charleston Research Institute, Second Hand Smoke, Sinusitis, and Cognition $100,000, Jul 2012-Jun 2015

PI, Oregon Health Sciences University, Determinants of Medical & Surgical Treatment Outcomes in Chronic Sinusitis $20,944, Oct 2011-Mar 2016

PI, Oregon Health Sciences University, Determinants of Medical & Surgical Treatment Outcomes in Chronic Sinusitis $39,008, Apr 2012-Mar 2016

David R. White, MDPI, SA Nguyen Co-PI, A Prospective, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Phase 1B Study of Oto-201 Given as a Single Intratympanic Injection for Intra-Operative Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement $150,591, Sept 2011-Oct 2013

GrantsGrants

The Dysphagia Research Society celebrated its 20th Anniversary at their Annual meeting in Toronto, CA in March 2012. The Society’s past presidents celebrated 20 years of interdisciplinary research that is disseminated throughout the international community of basic and clinical scientists who study the mechanisms and treatments for swallowing disorders. Our Dr. Bonnie Martin-Harris was the DRS President for 2008.

Bonnie Martin-Harris, Ph.D., Steven Leder, Ph.D., Barbara Sonies, Ph.D., Reza Shaker, M.D. (Founder & 1st President), Bronwyn Jones, M.D., Jeffrey Palmer, M.D., Benson Massey, M.D., Tim McCulloch, M.D., JoAnne Robbins, Ph.D., Rosemary Martino, Ph.D.


Publications continued from page 2

Gillespie MB, Albergotti WG, Eisele DW (2012). Recurrent Salivary Gland Cancer. Curr Treat Options Oncol.

Gillespie MB (2011). Neck spaces and fascial planes. In Leee KJ, Chan Y, Das S, eds. KJ Lee’s Essential OHNS. McGraw-Hill, Columbus, OH.

Brodsky MB, McNeil MR, Martin-Harris B, Palmer CV, Grayhack JP, Verdolini Abbott K(2011). Effects of divided attention on swallowing in healthy participants. Dysphagia. doi:10.1007/s00455-011-9367-8.

Martin-Harris B, Blair J, Focht KL (2011). Meeting the challenges of communication and swallowing disorders after treatment for head and neck cancer. In N.E. Leupold & J.S. Sciubba (Eds.), Meeting the challenges of oral and head and neck cancer: a survivor’s guide (2nd ed). San Diego, CA: Plural Publishing, Inc.

Davis S, Harris KC, Dubno JR (2011). The Bilingual Brain: Benefits and challenges of communicating in multiple languages. Audiology Today; 23(3):62-63.

Terrell Z, Ketcham A, Lentsch E, Nguyen S, Hornig JD (2011). Should Obesity be a Contraindication to Min Invasive Video Assisted Thyroidectomy? AHNS.

Banks CA, Ayers CM, Hornig JD, Lentsch EJ, Day TA, Nguyen SA, Gillespie MB (2012). Thyroid disease and compressive symptoms. Laryngoscope;122(1):13-6

Hornig JD(2012), Malin B. History and Physical Examination of the Head & Neck. Head & Neck Cancer: A MultiDisciplinary Approach 4th Edition.

Byrd JK, Lentsch EJ (2011). Endoscopic minimally invasive thyroidectomy: what’s new? Otorinolaringologia;61(3):95-9

Smith VA, Lentsch EJ (2011-12). Sentinel node biopsy in head and neck desmoplastic melanoma: an analysis of 244 cases. Laryngoscope; 122(1):116-20. [Epub]

Smith VA, Madan OP, Lentsch EJ (2011). Tumor Location Is an Independent Prognostic Factor in Head and Neck Merkel Cell Carcinoma. OHNS. 146 (3): 403-408. [PMID: 22166964]

Smith VA, Cunningham JE, Lentsch EJ (2012). Completion Node Dissection in Patients with Sentinel Node-Positive Melanoma of the Head and Neck. OHNS. [Epub]. [PMID: 22237296]

Chou PC, Shunmugavel A, El Sayed H, Desouki MM, Nguyen SA, Khan M, Singh I, Bilgen M (2011). Preclinical use of longitudinal MRI for screening the efficacy of S-nitrosoglutathione in treating spinal cord injury. J Magn Reson Imaging;33(6):1301-11.

Nguyen SA, Schlosser R (2011). Assessment of Palatability of Two Sublingual Diluents in Allergic Patients: A Prospective Pilot Study. American J of Rhinology & Allergy. [Epub].

Meir JD, Nguyen SA, White DR (2011). Improved Growth Curve Measurements After Supraglottoplasty. Laryngoscope;121(7):1574-7.

Carroll W, Wilhoit CS, Intaphan J, Nguyen SA, Gillespie MB (2012). Snoring Management with Nasal Surgery and Upper Airway Radiofrequency Ablation. OHNS. [Epub].

Nguyen SA, Griffin WT, Deleon CD, Middaugh LD (2012). Effects of Vigabatrin, an Irreversible GABA Transaminase Inhibitor, on Ethanol Reinforcement and Ethanol Discriminative Stimuli in Mice. Behav Pharmacol;23(2):178-90.

Psaltis AJ, Soler ZM, Nguyen SA, Schlosser RJ (2012). Changing trends in sinus and septal surgery, 2007 to 2009. Int Forum Allergy Rhinol. doi: 10.1002/alr.21036. [Epub]

Gady HE, Nathan CA, Day TA, Nguyen SA (2012). Multidisciplinary Approach to Head & Neck Neoplams. Thieme Medical Publishing Head & Neck Surgery. Thieme Medical Publishing

Patel KG, Pitzer GB (2011). Proper Care of Early Wounds to Optimize Care and Prevent Complications. FPS Clinics of N America; 19(3).

Stevens SM, Patel KG (2011). Scar Camouflage: Chapter in Bailey’s HNO. Lippincott Williams and Wilkins. 5th ed.

Patel KG, Senders C (2011). Cleft Lip and Palate: Chapter in Essentials in Otolaryngology (ed. KJ Lee). McGraw Hill Publishing: 10th ed.

Patel KG, Sykes JM (2011). Concepts in local flap design and classification. (GUEST EDITOR for this issue with Dr. Jonathan Sykes) Operative Techniques in Otolaryngology, 22(1):13-23.

Bleier BS, Debnath I, O’Connell BP, Vandergrift WA 3rd, Palmer JN, Schlosser RJ (2011). Preliminary study on the stability of beta-2 transferrin in extracorporeal cerebrospinal fluid. OHNS;144(1):101-3.

Bleier BS, Schlosser RJ. Endoscopic anatomy of the postganglionic pterygopalatine innervations of the posterolateral nasal mucosa. Intl Forum Allergy Rhinol 2011;1(2):113-7.

Mulligan J, Bleier B, O’Connell B, Mulligan R, Wagner C, Schlosser RJ (2011). Vitamin D3 inversely correlates with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Clin Exp Immunol;164(3):312-20.

Bleier BS, Wang EW, Schlosser RJ (2011). The Bipedicled Anterior Septal(BAS) Flap: A Radioanatomic and Cadaveric Study. Laryngoscope;121(7):1367-71.

Wang EW, Vandergrift WA, Schlosser RJ (2011). Spontaneous CSF rhinorhea. Oto Clin N Amer;44(4):845-56.

Smith TL, Kern RC, Palmer JN, Schlosser RJ, Chandra RK, Chiu AG, Conley D, Mace JC, Fu RF, Stankiewicz JA (2011). Medical therapy vs surgery for chronic rhinosinusitis: a prospective multi-institutional study. Inter Forum Allergy Rhinol;1(4):235-41.

Mulligan JK, Mulligan RM, Atkinson C, Schlosser RJ (2011). Human sinonasal epithelial cells direct dendritic cell function and T-cell T helper 1/T helper 2 skewing follosing Aspergillus exposure. Inter Forum Allergy Rhinol;1(4):268-74.

Ayers CM, Schlosser RJ, O’Connell BP, Atkinson C, Mulligan RM, Casey SE, Bleier BS, Wang EW, Sansoni ER, Kuhlen JL, Mulligan JK (2011). Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Inter Forum Allergy Rhinol;1(4):296-302.

Schlosser RJ, Harvey RJ (2011). Pro/con analysis on role of ESS in pediatric chronic rhinosinusitis. Arch OHNS;137(7):702-4.

Bleier BS, Wang EW, Vandergrift WA 3rd, Schlosser RJ (2011). Mucocele rate after endoscopic skull base reconstruction using vascularized pedicled flaps. Am J Rhinol Allergy 201;25(3):186-7.

Woody J, Wise SK, Koepp SK, Schlosser RJ (2011). Clinical improvement after escalation for Sublingual Immunotherapy (SLIT). ENT J;90(9):E16-22.

Soler ZM, Wittenberg E, Schlosser RJ, Mace JC, Smith TL (2011). Health State Utility Values in Patients Undergoing Endoscopic Sinus Surgery. Laryngoscope;121(12):2672-8.

Wang EW, Gullung JL, Schlosser RJ (2011). Modified endoscopic medial maxillectomy for recalcitrant chronic maxillary sinusitis. Inter Forum Allergy Rhinol;1(6):493-7.

Bleier BS, Mulligan RM, Schlosser RJ (2012). Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis. J Pharm Pharmacol;64(3):449-56.

Bleier BS, Debnath I, Harvey RJ, Schlosser RJ (2011). Temporospatial quantification of fluorescein-labeled sinonasal irrigation delivery. Int Forum Allergy Rhinol;1(5):361-5.

Sessions, Roy (2012). The Cancer Experience. Rowman & Littlefield Publishers.

Platt MP, Soler ZM, Metson R, Stankovic K (2011). Pathways analysis of molecular markers in

chronic sinusitis with polyps. OHNS; 144(5):802-8.

Soler ZM, Platt MP, Leung M, Mong S, Metson R (2011). Sinonasal Abnormalities in Patients with Graves’ Orbitopathy. Laryngoscope; 121: 656-60.

Platt, MP, Soler ZM, Metson R, Stankovic K (2011). Topographic gene expression in the sinonasal cavity of patients with nasal polyps. OHNS; 145(1):171-5.

Rudmik L, Soler ZM, Orlandi RR, Stewart MG, Bhattacharrya N, Kennedy DW, Smith TL (2011). Early postoperative care following endoscopic sinus surgery: an evidence-based review with recommendations. Int Forum Allergy Rhinol; 1(6): 417-30.

Soler ZM, Litvak JR, Mace J, Smith TL (2012). Chronic rhinosinusits, race, and ethnicity. Am J Rhinol Allergy; 26: 110-116.

Soler ZM, Smith TL (2012). How I Do It: Endoscopic sinus surgery checklist. Laryngoscope; 122: 137-139.

Soler ZM, Smith TL (2012). Triologic Best Practice: Endoscopic versus open craniofacial resection of esthesioneuroblastoma: what is the evidence? Laryngoscope; 122: 244-245.

Soler ZM, Platt MP. Common errors in sinus surgery. In: Schlosser RJ, Harvey RJ Eds. Endoscopic Sinus Surgery: Optimizing Outcomes and Avoiding Failures. San Diego, CA: Plural Publishing, 187-202.

Rudmik L. Schlosser RJ, Smith TL, Soler ZM (2012). Impact of topical nasal steroid therapy on symptoms of nasal polyposis: a meta-analysis. Laryngoscope. [Epub]

Carrol SR, Zald PB, Soler ZM et al (2012). Innate immunity gene single nucleotide polymorphisms and otitis media. Int J Pediatr Oto. [Epub]

Winkler AA, Soler ZM, Leong P, et al (2012). Complications Associated with Alloplastic Implants in Rhinoplasty. Arch Facial Plast Surg.

Soler ZM, Oyer SL, Kern RC, et al (2012). Antimicrobials and Chronic Rhinosinusitis with or without Polyposis in Adults: an Evidenced-based Review with Recommendations. Int Forum Allergy Rhinol.


to MUSC!Welcome2012-13 FellowsPGY2 Residents

Meet the Residents: Drs. Michael Moore, Chris Ayers, and Alex Sokohl

MUSC offers otolaryngology fellowships in Head & Neck Oncologic and Reconstructive Surgery, Rhinology and Endoscopic Sinus/Skull Base Surgery, Pediatric Otolaryngology, and Otology and Neurotology. In addition to an extensive surgical experience, fellows benefit from a multidisciplinary approach by participating in outpatient clinics, rounds, and didactic conferences.

To learn more about our residency and fellowhip programs please visit our website at ENT.musc.edu

Arnaud Bewley, MDMD: Columbia University Medical SchoolResidency: Hospital of the University of PennsylvaniaInterests: Head & Neck Oncology

Allison Dobbie, MDMD: Wayne State UniversityResidency: University of California, DavisSpecial Interests: Pediatric Otolaryngology

Oswaldo Henriquez, MDMD: Universidad Central de Venezuela, Escuela Luis RazettiResidency: Emory UniversitySpecial Interests: Rhinology and endoscopic skull base surgery

Stephen Kieran, MD, PhDMB BCh BAO: University College Dublin Residency: Royal College of Surgeons in IrelandFellowship: Pediatric Otolaryngology - Harvard Medical SchoolSpecial Interests: Otology, Neurotology, Pediatric Otology

Mayuri Rajapurkar, MDMBBS: M.S. Univ. BarodaResidency: Pramukh Swami Medical CollegeFellow: Tata Memorial Hospital M.Ch. HN Oncology: Amrita Institute of Med Sci and Research CtrSpecial interest: Microvascular HN Oncology

Christopher Ayers, M.D., was born and raised in Columbia, SC. A longtime Clemson fan, he had the pleasure of attending Clemson University for his undergraduate degree where he majored in financial management. From there, he went on to earn his Masters in Public Health from the University of South Carolina. He attended medical school at the Medical University of South Carolina where he was elected into Alpha Omega Alpha and served as president of the organization. He has assisted in multiple research projects in the areas of sinusitis, speech and swallowing, thyroid disease and sleep apnea.

Dr. Ayers and his wife Lauren have been blessed in seven years of marriage and have a precious, spunky two year old at home named Ashley. This fall they will have the blessing of welcoming a new baby girl to their growing family. They love spending time at the beach, pulling for their Clemson Tigers, and enjoying all that the city of Charleston has to offer.

Michael Moore, M.D., was born and raised in Houston, Texas. He grew up playing sports and participating in Boy Scouts, where he earned the rank of Eagle Scout. Wanting a taste of life outside of Texas, Michael attended Boston College where he lettered three years as a varsity swimmer and graduated Summa Cum Laude with a BS in Biology. Michael returned home to attend the University of Texas medical school in Houston, where he was elected AOA, and married his high-school sweetheart Sarah. During his fourth year, he performed research on robotic head and neck surgery at MD Anderson. After

three years of marriage, Michael and Sarah welcomed their daughter Violet to the family. They have enjoyed taking advantage of the beaches, great food, and warm hospitality of Charleston.

Hailing from the Appalachian foothills of Chattanooga, TN, Dr. Alexander Sokohl spent his childhood enjoying the great outdoors and his most revered spot, Lookout Mountain. A loyal Red Bank Lion, he spent his high school years among his best friends as an avid cross country runner, tennis and baseball player before attending Georgetown University on scholarship to study languages and linguistics. During college, he worked with his congressman on Capitol Hill and as a lobbyist in the U.S. Chamber of Commerce. He lived in Ecuador, Spain and Brazil where he pursued his linguistics major. Following college, he accepted a position at the United States Department of Justice working in international criminal extraditions and serving as a Spanish and Portuguese translator. Alex subsequently transitioned from the legal field to pursue his lifelong dream of medicine by fulfilling his pre-medicine requirements at Johns Hopkins, where he also met his beautiful wife, Margaret Gallagher. Prior to medical school, Alex conducted research at Children’s National Medical Center in Washington, D.C., investigating genetic expression of vanishing white matter diseases. He and his wife both attended medical school at Georgetown University. After four years, they eagerly accepted the opportunity to start their new life in Charleston where they look forward to raising their recently born son, Jacob Nathaniel.

OtOlOgy & NeurOtOlOgyPaul R. Lambert, M.D.Professor and ChairmanDirector, Otology-NeurotolgyM.D.: Duke UniversityResidency: UCLA Fellowship: House Ear Institute, Los Angeles

Ted A. Meyer, M.D., Ph.D.Assistant ProfessorDirector, Cochlear Implant ProgramM.D. & Ph.D: University of IllinoisResidency: Indiana UniversityFellowship: University of Iowa


Faculty

MaxillOfacial PrOsthOdONtics

Betsy K. Davis, D.M.D., M.S.Associate ProfessorDirector, Division of Maxillofacial ProsthodonticsD.M.D.: MUSC

Residency: University of IowaFellowship: M.D. Anderson ; UCLA

Terry A. Day, M.D.Professor and DirectorMUSC HN Tumor ProgramWendy and Keith Wellin Chair in Head & Neck SurgeryM.D.: University of OklahomaResidency: LSU-Shreveport Fellowship: UC Davis

M. Boyd Gillespie, M.D., M.Sc.ProfessorDirector, MUSC Snoring ClinicM.D., Residency & Fellowship: Johns Hopkins

Joshua D. Hornig, M.D., FRCS(C)Associate ProfessorDirector, Microvascular Surgery and Functional OutcomesM.D. & Residency: University of AlbertaFellowship: MUSC

Eric J.Lentsch, M.D.Assistant ProfessorM.D. & Residency: University of LouisvilleFellowship: M.D. Anderson

Barry T. Malin, M.D., MPPAssistant ProfessorM.D.: UC San FranciscoResidency: State University of New YorkMPP: Harvard UniversityFellowship: MUSC

Roy B. Sessions, M.D.ProfessorM.D.: Louisiana State University, New OrleansResidency: Washington University School of Medicine, St. Louis

Mary Beth Chalk, MSN, RN, APRN-BCNurse PractitionerMSN: MUSC

Holly L. Drechsler, PA-CPhysician AssistantMSPAS: MUSC

Ashley Laursen, BSN, RNRegistered Nurse, Program CoordinatorBSN: MUSC

Jennifer R. Page, RN, MSN, NP-CNurse PractitionerMSN: MUSC

head & Neck ONcOlOgy

facial Plastic & recONstructive surgery

Krishna G. Patel, M.D., Ph.D.Assistant ProfessorDirector, FPRS M.D./Ph.D. : Medical College of GeorgiaResidency: UNC Chapel HillFellowship: UC Davis

Judith M. Skoner, M.D.Assistant ProfessorM.D.: University of South CarolinaResidency: MUSCFellowship: Oregon Health and Science University

audiOlOgyKimberly A. Orr, Au.D., CCC-ADirector, AudiologyM.A.: Ohio State UniversityAu.D.: A.T. Still University

Elizabeth Camposeo, Au.D., CCC-AInstructorAu.D.: Northwestern University

Laura A. Droege, Au.D., CCC-AInstructorM.A.: Northern Illinois UniversityAu.D.: A.T. Still University

Meredith A. Holcomb, Au.D., CCC-AInstructor,Clinical Coordinator, Cochlear Implant ProgramAu.D.: UNC Chapel Hill

Cortney J. Hudak, Au.D., CCC-AInstructor Au.D.: University of Akron/Kent State University

Elizabeth A. Poth, M.S., CCC-AInstructor M.S.: UNC Chapel Hill

Michelle L. Reiter, Au.D., CCC-AInstructor,Au.D.: UNC Chapel Hill

Christine C. Strange, Au.D., CCC-AInstructorM.A.: SUNY PlattsburghAu.D.: A.T. Still University

Otolaryngology Head & Neck Surgery

Pediatric OtOlaryNgOlOgy David R. White. M.D.Associate ProfessorDirector, Pediatric OtolaryngologyDirector, MUSC Airway and Aspiration Center for ChildrenM.D.: MUSC

Residency: UNC Chapel HillFellowship: Cincinnati Children’s Hospital

Christopher M. Discolo, M.D., M.S.C.R.Assistant ProfessorM.D.: State University of New York, BrooklynResidency: Cleveland ClinicFellowship: University of

Minnesota / Pediatric ENT Associates

Carissa Carie, PNPPediatric Nurse PractitionerMSN.: MUSC

geNeral OtOlaryNgOlOgy& allergy

Mark J. Hoy, M.D.Assistant ProfessorDirector, General Otolaryngology & AllergyM.D.: Temple UniversityResidency: University of Lousiville

Robert C. Waters, M.D.Clinical Assistant ProfessorM.D.: MUSCResidency: Barnes Hospital Washington University School of Medicine

Mary Ann Howerton, PA-CPhysician AssistantMSPAS: MUSC

Claire O’Bryan, ANP-CNurse PractionerMSN: MUSC


ResearchFu-Shing Lee, Ph.D.Assistant ProfessorMUSC Hearing Research ProgramPh.D.: MUSC

Lois J. Matthews, M.S.InstructorMUSC Hearing Research ProgramM.S.: Purdue University

Jennifer K. Mulligan, Ph.D.Assistant ProfessorRhinology & Sinus SurgeryPh.D.: MUSC

Jayne B. Ahlstrom, M.S.InstructorMUSC Hearing Research ProgramM.S.: Vanderbilt University

Mark A. Eckert, Ph.D.Associate ProfessorMUSC Hearing Research ProgramPh.D.: University of Florida

Kelly C. Harris, Ph.D.Assistant ProfessorMUSC Hearing Research ProgramPh.D.: University at Buffalo

Shaun A. Nguyen, M.D., M.A., CPIAssociate ProfessorDirector, Clinical ResearchMD & Residency: University College LondonFellowship: MUSC

M. Rita I. Young, Ph.D.ProfessorHead and Neck ResearchAssociate Director for Research, Ralph H. Johnson VA Medical Center

rhiNOlOgy & siNus surgeryRodney J. Schlosser, M.D.ProfessorDirector, Nasal and Sinus CenterM.D.: Mayo ClinicResidency: University of Virginia

Fellowship: University of Pennsylvania

Zachary M. Soler, M.D., M.Sc.Assistant ProfessorM.D.: Wake Forest UniversityResidency: Oregon Health and Science UniversityFellowship: Harvard Medical School

Brittany Crosby, PA-CPhysician AssistantMSPAS: MUSC

evelyN traMMell iNstitute fOr vOice aNd swallOwiNg

Lucinda A. Halstead, M.D.Associate ProfessorMedical Director, ETIVS M.D.: George Washington UniversityResidency: New England Medical Center, Boston

Bonnie Martin-Harris, Ph.D., CCC-SLP, BRS-SProfessorDirector, ETIVSM.S.: Purdue UniversityPh.D.: Northwestern University

Ashli O’Rourke, M.D.Assistant ProfessorM.D.: Medical College of GeorgiaResidency: University of Virginia

Fellowship: Medical College of Georgia

Judy R. Dubno, Ph.D.Professor, Director, MUSC Hearing Research ProgramPh.D.: City University of New York

The 3rd Annual Emerging Controversies in the Management of Thyroid and Parathyroid DiseaseOctober 12 - 13, 2012, Charleston Harbor Resort & MarinaLectures and a hands-on lab designed to enable physicians who are actively involved in the care of these patients to become comfortable with the emerging technologies and treatments. Guest speakers: Bryan Haugen, MD (Colorado); F. Christopher Holsinger, MD (Texas)

– Thyroid/Parathyroid Disease course to be held in conjunction with The 27th Annual F. Johnson Putney Lectureship in Head & Neck CancerFree half-day conference that will discuss multidisciplinary management of oral cavity tumors in accordance with National Cancer Institute guidelines and evidence-based literature. F. Johnson Putney Lecturer in Head & Neck Cancer: Mark K. Wax, M.D., F.R.C.S. (Oregon)

Charleston Sleep Surgery SymposiumFebruary 22- 23, 2013 Renaissance Hotel, CharlestonLectures, round table discussions, and hands-on labs focused on procedures for snoring and sleep disordered breathing. For practicing otolaryngologists. Guest speakers: Lon R. Doles, DDS (South Carolina); Mustafa Gerek, MD (Turkey); Peter J. Koltai, MD, FACS, FAAP (California); Ryan J. Soose, MD (Pennsylvania); David L. Steward, MD (Ohio)

Sinus MastersMarch 15 - 17, 2013 Kiawah Island Resort and MUSC CampusAn invitational program for Sinus and General Otolaryngology surgeons.

Spring Temporal Bone Dissection CourseApril 19 - 21, 2013 MUSC CampusLectures and hands-on labs focused on procedures for chronic ear disease.

Southern States Rhinology CourseMay 2 - 4, 2013 Kiawah Island Resort and MUSC CampusLectures & hands on labs designed to provide a comprehensive update on the medical and surgical practice of rhinology.

13th Annual Charleston Magnolia ConferenceMay 31 - June 1, 2013 Charleston Marriott, Lockwood Two half-day sessions covering the broad spectrum of Otolaryngology - Head & Neck Surgery. Guest speakers: George T. Hashisaki, MD (Virginia); Robert C. Kern, MD (Illinois), Gregory Postma, MD (Georgia)

The Charleston Course:3rd Annual Otolaryngology Literature UpdateJuly 26 - 28, 2013 Kiawah Island Resort Designed to help the busy clinician stay current with our faculty members’ expert critical assessments of over 100 of the past year’s most relevant, current evidence-based publications.

Head & Neck Oncology Sea to SummitOctober 17-19, 2013 Kiawah Island ResortCo-hosted with the University of Utah

Department of Otolaryngology- Head & Neck Surgery

135 Rutledge Avenue, MSC 550Charleston, SC 29425-5500

Phone 843-792-8299

Website: ENT.musc.edu

CME EventsUpcoming

Paul R. Lambert, M.D.department chair, editor-in-chief

M. Boyd Gillespie, M.D.executive editor

Alison Padlan-Gillettecreative & production manager

©2012 muSc otolaryngology - hnS

SPONSOR

For registration or more information contact:Beth Cummings, (843) 876-0943, [email protected]

Website: ent.musc.edu

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