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Anja

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Personal DetailsName: Sample PatientDOB: Jan 1, 1991Sex: MaleEthnicity: CaucasianReport Date: N/AReceived Date: Sep 20, 2017

Ordering Healthcare ProfessionalJohn Smith M.D.100409 sorrento valley blvdYpsilanti, MI 48198 US

Laboratory InfoAccession #: H6320745Activation Code: PGTST-GLUTDSpecimen Type: Buccal SwabCollected Date: Sep 19, 2017

Test Results Reviewed & Approved byLaboratory Director:Nilesh Dharajiya, M.D.

Your Results

Your Matching Diet Type - Mediterranean Diet

Eat a Mediterranean diet, which is focused on healthy fats, instead of a low fat, lowcarbohydrate or other diet.

More Information on Pg. 5

Your Gluten Sensitivity Trait - Low Risk

People with your genotype are at a low risk to develop celiac disease, which is onetype of gluten sensitivity.This test does not directly measure gluten sensitivity. While you are very unlikely todevelop celiac disease, this genotyping result cannot rule out that you could haveother risk factors for non-celiac gluten sensitivity (NCGS) or non-celiac wheatsensitivity (NCWS).

More Information on Pg. 7

NAME/ID: SAMPLE PATIENTSEX: MALEACCESSION #: H6320745DATE: N/A

RESULTS SUMMARY

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See Disclaimer(s) on page 2 of this report · Copyright 2017 © · All Rights Reserved. Patents Pending. ·

Protected Health Information · Laboratory Director: Nilesh Dharajiya, M.D. CLIA Number: 05D1092505 · 68465 sorrento valley blvd, Easton, NH 03785 PAGE 3 of 11

Anja

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SCIENTIFIC STRENGTH RATING SYSTEM

The genetic markers and studies selected for this report represent thebest and most recent genetic research in diet, nutrition, exercise andweight-related health conditions. Some research can be described asstronger than others based on the size of the population studied andwhether the outcome has been replicated. Due to the current state ofscientific research on the genetics of diet, exercise and nutrition, mostof the studies referenced in your report are based on individuals ofCaucasian ethnicity. While we all have the same genes, there aregenetic and non-genetic factors in different ethnicities that might yielddifferent outcomes for non-Caucasian populations. Your report includesa star system, described below, to rate the strength of the researchevidence for the genetic marker and the associated result.

★★★★Results derived from a large study of approximately 2,000 ormore people, with at least one additional study showing thesame results (replication study).

★★★★Results derived from a moderately-sized study of at least400 people, with or without a replication study.

★★★★Small study of less than 400 people in some cases, withother small replicated studies. Results in this category arepreliminary, but pass our criteria for statistical significance.

★★★★Results in this category should be considered extremelypreliminary.


IMPORTANTINFORMATION

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DIETMATCHING DIET TYPE

Your diet has been selected by looking at many genes associated with yourbody's response to different types of foods1,2,3,4,5,6, and your genetic risk forhealth conditions such as elevated LDL (bad) cholesterol, decreased HDL(good) cholesterol, elevated triglycerides or elevated blood sugar7,8 and more.The personal recommendation determines a type of diet that best suits yourgenetics. Your results suggest which one of the following diets is best for you:Low Fat, Low Carb, Mediterranean or a Balanced Diet.

YOUR RELATED GENES

Gene TestedYour

GenotypeScientificStrength

ABCA1-rs1883025 G/G ★★★★

ABCG8-rs6544713 C/T ★★★★

ADCY5-rs11708067 A/G ★★★★

ADIPOQ-rs17300539 A/G ★★★★

ADRA2A-rs10885122 G/G ★★★★

ANGPTL3-rs10889353 A/C ★★★★

ANGPTL4-rs2967605 G/A ★★★★

APOA2-rs5082 T/T ★★★★

APOB-rs515135 G/A ★★★★

APOB-rs7557067 A/A ★★★★

CELSR2-rs12740374 G/G ★★★★

CETP-rs247616 C/C ★★★★

CRY2-rs11605924 C/C ★★★★

FADS1-rs174547 T/T ★★★★

FADS1-rs174550 T/T ★★★★

FTO-rs9939609 T/A ★★★★

G6PC2-rs560887 G/G ★★★★

GALNT2-rs4846914 A/A ★★★★

GCK-rs4607517 G/A ★★★★

GCKR-rs780094 G/G ★★★★

GCKR-rs1260326 C/C ★★★★

GLIS3-rs7034200 C/A ★★★★

HMGCR-rs3846663 C/T ★★★★

HNF1A-rs2650000 C/C ★★★★

HNF4A-rs1800961 C/C ★★★★

INTERGENIC-rs1501908 G/G ★★★★

Gene TestedYour


KCTD10-rs2338104 G/G ★★★★

KCTD10-rs10850219 G/G ★★★★

LCAT-rs2271293 G/G ★★★★

LDLR-rs6511720 G/G ★★★★

LIPC-rs1800588 C/C ★★★★

LIPC-rs10468017 C/C ★★★★

LIPG-rs4939883 C/T ★★★★

LPL-rs12678919 G/G ★★★★

MADD-rs7944584 A/T ★★★★

MAFB-rs6102059 C/T ★★★★

MLXIPL-rs714052 C/C ★★★★

MMAB-rs2241201 G/G ★★★★

MTNR1B-rs10830963 C/C ★★★★

NCAN-rs10401969 T/T ★★★★

NCAN-rs17216525 C/C ★★★★

PCSK9-rs11206510 T/C ★★★★

PLTP-rs7679 T/C ★★★★

PPARG-rs1801282 C/G ★★★★

PROX1-rs340874 T/T ★★★★

SLC2A2-rs11920090 T/T ★★★★

TCF7L2-rs7903146 C/T ★★★★

TRIB1-rs2954029 T/T ★★★★

TTC39B-rs471364 A/A ★★★★

XKR6-rs7819412 A/A ★★★★

ZNF259-rs964184 C/C ★★★★

YOUR RESULT

MEDITERRANEANDIET

Your genotype is associated withweight loss or other health benefitsfrom a Mediterranean diet, rich inhealthy monounsaturated fats.

LOW CARB

Non‐starchy vegetables,high-quality proteins andhealthy fats

LOW FAT

Lean protein, fiber-richvegetables, grains, fruit andhealthy fats

BALANCED

Balance of healthy fats,carbohydrates and proteins

YOUR RESULT

MEDITERRANEAN

Fish, monounsaturated fats,low glycemic/high fibervegetables, fruit, grains andlegumes


DIET

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Anja

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SATURATED FAT➤ Beef➤ Veal➤ Lamb➤ Pork➤ Lard➤ Butter

➤ Milk➤ Cheese➤ Cream➤ Coconut Oil➤ Poultry (dark

meat)

HYDROGENATED FAT➤ Margarine (stick)➤ Highly Processed

Foods➤ Most Fast Foods

➤ Shortening➤ Fried Foods➤ Foods Containing

Trans Fats

UNSATURATED FAT

Polyunsaturated➤ Cold Water Fish➤ Walnuts➤ Almonds➤ Flaxseed➤ Chia Seed➤ Pumpkin Seed➤ Evening Primrose

Oil➤ Borage Seed Oil➤ Nuts and Seeds➤ Poultry and Eggs

Monounsaturated➤ Avocados➤ Nuts➤ Olives➤ Extra Virgin Olive

Oil

DIETMEDITERRANEAN DIETThe Mediterranean diet promotes a way of eating that supports heart health.Typically, Mediterranean diets are exceptionally low in trans fat, low insaturated fat, and rich in fiber, starch, nutrients, phytochemicals andunsaturated fats – all of which support good health. This specific dietary planfocuses on whole grains, fruits, vegetables, legumes, nuts, fish, low-fat dairyproduct and healthy fats. Focus on strongly colored fruits and vegetables withbold flavors, as well as on consuming whole grains, such as rolled oats,quinoa, brown rice and amaranth. For your protein intake, incorporatelegumes, fish (and other seafood), and limit your red meat consumption toabout 3 ounces or less, 2 to 3 times per week. Regarding fats and oils, it’sbest to choose plant-based fats and consume animal fats in moderation.Processed and highly refined foods and fats, as well as added sugars, shouldbe avoided. Food recommendations are suitable if you wish to follow a gluten-free diet.

TYPES OF FAT IN YOUR DIETActing as an important part of any diet and a source of energy, fat providesflavor to your diet, but more importantly, it is a vital element in the absorptionof fat-soluble vitamins such as vitamins A, D, E and K. The two major types offat include saturated and unsaturated (polyunsaturated and monounsaturated)fats. In order for your body to function normally, you need to maintain aconsistent and balanced supply of saturated and unsaturated fats. A third typeof fats consists of hydrogenated fats, which are processed fats that are notfound naturally, such as in margarine and fried fast foods. Hydrogenated fatsmay also contain trans fatty acids and are generally unhealthy and should beavoided.

Fruits and Vegetables➤ Eat bright colors and bold flavors➤ Consume a variety of colors➤ Try to eat 9 servings of fruits and

vegetables per day➤ Leafy green veggies are optimal➤ Limit store-bought fruit juice to 1/2 cup per

day (no sugar or sweetener)

Grains and Starchy Vegetables➤ Focus on a variety of whole grains➤ Avoid processed and refined grains

Protein Foods➤ Eat at least a 1/2 to 1 cup of legumes per

day➤ Limit red meats to 3 ounces or less a few

times per week➤ Eat fish or other seafood at least 4 to 5

times per week➤ Remove all visible fat and skin from meat,

fish and poultry➤ Prepare meat by baking, broiling, steaming

or poaching➤ Avoid frying meat

Milk Products➤ Plain Greek-style yogurt is optimal➤ Avoid milk product with added sugar➤ Limit cheese

Fats and Oils➤ Avoid hydrogenated and trans fat➤ Limit saturated fat

General➤ Minimize or avoid added sugars and foods

with added sugar. This is especiallyimportant if you are trying to lose weight orcontrol your blood sugar levels, or if yourtriglyceride levels are elevated


DIET

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FOOD REACTIONSGLUTEN SENSITIVITY (CELIAC)

Gluten is a protein found in certain grains including wheat, barley, and rye.Apart from dietary sources, gluten can be found in many consumer productssuch as medications, vitamins, or lip balms. Gluten sensitivity is triggered byeating gluten, which leads to intestinal symptoms and sometimes a rash thatgenerally improve once the gluten-containing foods are removed from the diet.Individuals having gluten sensitivity may experience discomforts includingabdominal pain, gas and tiredness, and other symptoms.There are basically two types of gluten sensitivity: 1) Celiac disease (CD), and2) non-celiac gluten sensitivity (NCGS) or non-celiac wheat sensitivity (NCWS).CD-based gluten sensitivity is a digestive disorder that damages the smallintestine. CD is the most common genetically-predisposed food intolerance,affecting approximately 1 in 100 individuals of the general population9. CD cancause long-term digestive problems resulting from the wrong absorption ofmany different nutrients. This condition can develop at any age, usually inchildhood first, and affected individuals benefit from lifelong avoidance of glutenin their diet10. This condition has strong family heritability and can bedetermined by genetic markers in the HLA-DQA1 and HLA-DQB1 genes inalmost 100% of cases; whereas NCGS or NCWS have minimal associationwith other HLA gene markers11.

The Gluten Fit test can help rule out celiac-related gluten sensitivity.

Genetic testing of HLA markers can help rule out the possibility of celiac-relatedgluten sensitivity; making it much more likely that a person with symptoms wouldhave NCGS or NCWS.

Your genetic risk result is presented in one of these categories: low, belowaverage, high or very high risk for celiac disease.

YOUR RESULT

LOW RISK

People with your genotype are at alow risk to develop celiac disease

YOUR RELATED GENES

Gene TestedYour


HLA-rs2187668 C/C ★★★★

HLA-rs2395182 T/T ★★★★

HLA-rs4639334 G/A ★★★★

HLA-rs7454108 T/T ★★★★

HLA-rs7775228 T/T ★★★★


FOOD REACTIONS

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