tms and the_hand-eye_coordination-presentation
DESCRIPTION
Presentation about a study we were planning to do on TMS for the TMS group. Design and half of the content by Ceren Alici.TRANSCRIPT
Group 202 – Stimulate the brain
Tutors: Nina Bien Christianne Jacobs
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Background of our research
Relevance of this study
Intention
Implementation
Expectations of the study/research practical
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Posterior Parietal Cortex cross modal tasks
integration of information from different modalities in the brain
update of visual-spatial information of the hand essential to perform a
hand-eye coordination task
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Repetitive TMS intermittent theta burst stimulation (iTBS)▪ stimulated every 10 seconds for 2 seconds within
190 seconds (50Hz)▪ excitatory effect
continuous theta burst stimulation (cTBS)▪ stimulation lasts 40 seconds without disruption
(50 Hz)▪ inhibitory effect
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Evidence of disruption of motor evoked potentials in humans lasting up to one hour after use of TBS
Handedness plays an important role in finding the
responsible brain area to stimulate it in right handed people eye-hand
coordination is initiated by left hemisphere
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Influence of iTBS and cTBS on complex cognitive tasks?
Is the Nintendo Wii game console a reliable instrument? Can we use it in other studies?
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Find support for the idea that the dorsolateral posterior parietal cortex indeed plays a critical role in the hand-eye coordination
Use TMS in order to indicate a causal relationship
Examine effects of iTBS and cTBS on a complex cognitive task such as the coordination of the hand with the help of visual information 7
MRI get an insight into
anatomical structure of the participant’s brain
precise localization of TMS stimulation
A counterbalanced experimental design with two sessions 8
Session 1 and 2 (each 1 hour) Pre-measurements▪ Nintendo Wii baseball game▪ Motor task
iTBS/cTBS stimulation Post-measurements▪ Nintendo Wii baseball game▪ Motor task
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Both tasks within the measurements
and the TBS protocols will be
applied in a random order
reason: TMS effect decreases over
time and therefore
necessary to reduce the risk of
order effects
Both tasks within the measurements
and the TBS protocols will be
applied in a random order
reason: TMS effect decreases over
time and therefore
necessary to reduce the risk of
order effects
Nintendo Wii game console game: Wii Sports - Baseball hit/miss ratio
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Motor task:
participants will use a normal keyboard to react as fast as possible to a visual stimulus
stimulus is made by the program 'Presentation' → will tell them which letter/number they have to type
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there are 3 keys for each side, 1 key for every finger▪ we cannot use the thumb and little finger
because it is to hard to type with the different conditions are (2x2x2
design):▪ eyes open vs. eyes closed▪ hands crossed vs. hands uncrossed▪ left vs. right hand
on their left side are letters and on their right side numbers
reaction time will be measured12
iTBS/cTBS stimulation intensity of TMS is dosed relative to the
motor threshold (MT)▪ determining the correct MT is important for
determining the proper TMS dose for each subject and is important with respect to safety▪ MT can be determined when muscle groups
are active (aMT) or when they are at rest (rMT)▪ Will be defined by the point at which the
muscle groups aren't active yet, but the stimulation can be felt by the participant
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Implementation (7)
▪ MT determined separately for every participant by applying TMS on the arm▪ We'll take 80% of the Motor Threshold
Stimulation of the posterior parietal cortex leads to an alteration of the task performance cTBS should have an inhibitory effect iTBS should have an excitatory effect
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