tracking cancer development and movement interim presentation february 19, 2005 team 004 albuquerque...

Tracking Cancer Tracking Cancer Development and Development and

Movement Movement Interim PresentationInterim PresentationFebruary 19, 2005February 19, 2005

Team 004Team 004Albuquerque AcademyAlbuquerque Academy

Team Members: Punit Shah

Karalyn Baca

Teacher: Jim Mims

Mentor: Dr. Gene Wong

22 February 19, 2005February 19, 2005 Tracking Cancer Development and Tracking Cancer Development and

MovementMovement

ContentsContents

Project ObjectivesProject Objectives

ResearchResearch

Math ModelMath Model

Code & ProgramCode & Program

To DoTo Do

QuestionsQuestions


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Project ObjectivesProject Objectives

To model the development and To model the development and propagation of melanoma skin cancerpropagation of melanoma skin cancer

To see the patterns in the movement of To see the patterns in the movement of the melanoma cancer through the bodythe melanoma cancer through the body


MovementMovement

ResearchResearchBasic anatomy of skin

LayersEpidermis, outermost layer of skin

Germinal layer, where new skin is produced

Dermis, where blood vessels, hair follicles, and such are

MelanocytesBetween germinal layer and dermis

Make the pigment that in turn makes the skin whatever color it is


MovementMovement

ResearchResearchWhat causes skin cancer On a cellular level

Cells are genetically changed by UV rays

As they are unnatural, they thrive and continue to grow

They make greater and greater pigment in the melanocytes

There are predetermined factors and environments that increase the change of getting cancer

Ways to protect from UV rays


MovementMovement

ResearchResearch

How malignant melanocytes develop Their effect on the germinal layer and epidermis The movement of malignant cells at a local region The movement of malignant melanocytes through the

body Their effect on organs

The symptoms of melanoma The effects of malignant melanocytes on other cells

and tissues


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Initially, tumor growth Initially, tumor growth is exponentialis exponential

As competition As competition increases, cells start increases, cells start to dieto die

Cancer growth follows Cancer growth follows a sigmoidal curvea sigmoidal curve

A sigmoidal curveA sigmoidal curve


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Cancer starts as a sphereCancer starts as a sphereWhen cancer spreads, tends to spread When cancer spreads, tends to spread horizontally rather than verticallyhorizontally rather than verticallyWhen it continues, smaller tumors are created When it continues, smaller tumors are created that continue the cyclethat continue the cycleTo compute, we must look at many tumors’ To compute, we must look at many tumors’ development at oncedevelopment at onceUses great computing power, must be simplifiedUses great computing power, must be simplifiedResource burdening will not be incorporated Resource burdening will not be incorporated initiallyinitially


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Will start with taking few factors into Will start with taking few factors into accountaccount

Will look at a simple, spherical growth and Will look at a simple, spherical growth and may have possible lateral spread in initial may have possible lateral spread in initial versionversion

When diameter exceeds 5mm, new When diameter exceeds 5mm, new tumors created around old tumortumors created around old tumor

Old tumor will then dieOld tumor will then die


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Microsoft Visual Basic 6.0 Microsoft Visual Basic 6.0 will be usedwill be used

Basic code has been Basic code has been developed and windows developed and windows have been setuphave been setup

Plan to have two output Plan to have two output windowswindows Skin Model with Skin Model with

cancercancer Time to Cancerous Time to Cancerous

Cell count graphCell count graph

Program’s splash screen


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Plan to have procedures of classes be the Plan to have procedures of classes be the different properties of a cell in the modeldifferent properties of a cell in the modelProperties includeProperties include Cancerous on non-cancerousCancerous on non-cancerous Location in respect to different cancer tumorsLocation in respect to different cancer tumors

An array will hold the different cells of the An array will hold the different cells of the modelmodelThe GUI of the model will be updated The GUI of the model will be updated periodically to show progressperiodically to show progress


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The cancer modelThe cancer model

Time

Can

cero

us C

ell

Cou

nt

The cancerous cell The cancerous cell count graphcount graph

The cancer tumor


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To DoTo Do

Complete program Develop code to properly graph number of cancerous

cells Add variables of growth such as partial treatment and

random growth Show the cancer’s effect on other body parts Add the growth of satellite nodules Track general movement and growth throughout the

body

Thoroughly benchmark and test the programThoroughly benchmark and test the program

Tracking Cancer Tracking Cancer Development and Development and

Movement Movement Interim PresentationInterim PresentationFebruary 19, 2005February 19, 2005

Team 004Team 004Albuquerque AcademyAlbuquerque Academy

Team Members: Punit Shah

Karalyn Baca

Teacher: Jim Mims

Mentor: Dr. Gene Wong

tracking cancer development and movement interim presentation february 19, 2005 team 004 albuquerque...

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