troubleshooting in optia...11 presentation title, month #, year. confidential aim components to take...

TROUBLESHOOTING IN OPTIA

Presentation title, Month #, Year. Confidential1

JENNIFER ARMSTRONG TERUMOBCT6TH JUNE 2017 NHSBT CONFERENCE

As a global leader in blood component,therapeutic apheresis and cellular technologies,

we believe in the potential of blood to doeven more for patients than it does today.

This belief unites our organization,inspires our innovation and strengthens

our collaboration with customers.

As a global leader in blood component,therapeutic apheresis and cellular technologies,

we believe in the potential of blood to doeven more for patients than it does today.

This belief unites our organization,inspires our innovation and strengthens

our collaboration with customers.

Topics

� The AIM system and how it works

� Cleaning the centrifuge

� New options on Advanced Control screen from V8-11

� Red Cell Detector, disabling, why and when?

The AIM system provides continuous interface monitoring, interpretation and adjustment for effic ient MNC collection

Monitors interface position up to 25 times per second

Interprets interface information using patented optical detection system

Adjusts pumps and valves to manage the interface position and efficiently remove targeted components

Automated Interface

Management

Interprets

Monitors Adjusts

How it Works – AIM

AIM System Control of Collection

� The AIM system controls the concentration of cells (collection preference) flowing through the collect port by adjusting the plasma pump flow rate.

� The CP will default to a value from 20 to 60 depending on the patient’s WBC and platelet counts.

Buffy coatto chamber

Plasmato patient

RBCto patient

Collect port

The AIM system can only interpret what it sees.........


AIM imagecorrect cleaning

AIM image after “cleaning” with detergent wipes

The AIM image affects the collection process, provi des information to the operator and advice and collection efficienc y is affected if the AIM system information to the operator is not c orrect

� Analysis of the dlog and associated images suggests a film or dirt on the AIM system glass cover and/or the aperture plate likely resulted in the challenges experienced during this procedure. If there is a film or dirt on the aperture plate in the filler or the glass cover of the AIM system, the light used to illuminate the connector will be diffused around the collect port making the contents in the collect port appear lighter to the AIM system than they actually are. Consequently, the system will try to darken the collection to achieve the targeted CP because it “thinks” the contents are too light. This can then result in a high hematocrit in the collected product bag because the system is darkening the collection too far. When this occurs, the green diamonds tend to track at or above the target CP while the contents of the collect line exiting the centrifuge may appear very dark. Furthermore, chambers may fill too fast, triggering the ‘Red blood cells were detected in too soon’ and the ‘Red blood cells were still detected too soon’ alarms. A haze or film can occur if any of the AIM system camera or lighting components, or the aperture plate on the filler is cleaned with a disinfectant wipe or detergent that leaves a soap film. Unfortunately, it may be difficult to see this film through visual inspection the basin; therefore, it is important to clean these components with water and a lint-free cloth.


BEFORE reacting to RBC seen too soon alarms

� Verify AIM system message is correct (debris on AIM system will cause this alarm)

� Clean the AIM system (see notes)

� Look through the viewport and verify the collect port image is as expected

BEFORE disabling RBC seen too soon alarms

� Confirm that patient WBC count is rising (that the chamber is filling quicker than expected as your initial data entry is no longer correct)

� Remember if you disable this alarm� The system will still collect when it sees red cells AND the

chamber is predicted to be 50% full if you stay in SYSTEM control (so the valve won’t open before that)

� If you change to RBC detector control the system will collect regardless of how full the chamber is calculated to be at the time

� You may have a higher collection volume than predicted at the start (more chambers)

� Using Inlet control is an option

Operation StatusMaking Changes – Run Menu

Be sure to choose the correct button, you should not need to disable the RBC detector on MNC collections

Cleaning the Centrifuge

� Reference No. 274 PN 306611274 (available to order)

� Cleaning Centrifuge Chamber Components Dirt or debr is on the optical reference or aperture plate on the f iller, or on the covers of the lights can affect the performance of the AIM system.

� 1. Wipe the surfaces of the components with water and a gauze pad or other lint-free cloth. To avoid damaging the components, do not use an abrasive brush, scrub material, or a sharp object for cleaning.

� Note: If you are unable to remove the dirt using wa ter, you may wipe the components with an alcohol pad. Then w ipe the components again with water to remove any resid ue that was left by the alcohol.

� 2. Dry the components with a gauze pad.

�


AIM components to take care to clean correctly


Larger top light

Smaller bottom light (behind the gear shroud)

New screens in v8 and v11 software

� Advanced control screen

� Using RBC detector as the Collection Phase Control

� Decrease Inlet AC Ratio

� Operation Status Screen

� Disable red cells seen too soon alarm


Advanced ControlMaking Changes – Run Menu

Clumping in the Collect Port

1. The collect port image alternates between dark and light

2. Viewport(2.1) Collect port(2.2) Interface

Troubleshooting

2.1

2.2

2.1

2.2

1

Operation StatusMaking Changes – Run Menu

Be sure to choose the correct button, you should not need to disable the RBC detector on MNC collections

Disabling the RBC detector, when and why?

� TPE procedures (most usual TTP)

� Use this button when the following conditions apply� You have established there is not an air bubble in the

line

� You see haemolysis and you think it is related to the patient’s condition

� You have this confirmed by a physician


We touch a patient’s life every second of every day .

Christy Cassidy and Laura Fraser, patientsNon-Hodgkin’s Lymphoma

OUR IMPACT

THANK YOU


[email protected]

troubleshooting in optia...11 presentation title, month #, year. confidential aim components to take...

Documents