tss

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5’ 3’ 3 3 1* 1* TSS 15 15 DNA of Ct-OATP1B3 12 4 12 5 12 4-2 mRNA of Ct-OATP1B3 3 3 1* 1* 15 15 12 4 12 5 12 3 3 1* 1* 15 15 12 4 12 5 12 12 4-2 Alternative Splicing Start Codon Stop CodonStart CodonStop Codon Mature Protein of Ct-OATP1B3 (674 amino acid) Immature Protein (91 amino acid) Translation Translation Transcription Supplemental Figure 1. Alternative splicing of Ct- OATP1B3. Exons of Ct-OATP1B3 are indicated by open boxes. TSS, transcription start site. The mature Ct-OATP1B3 is a 674-amino acid polypeptide, while another variant possesses the terminal codon in the exon 4-2, producing immature 91-amino acid polypeptide.

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1*. 1*. 1*. 3. 3. 3. 15. 15. 15. 1*. 1*. 1*. 3. 3. 3. 15. 15. 15. 4-2. 4-2. 5. 5. 4. 5. 4. 4. 12. 12. 12. 12. 12. 12. 12. 12. 12. 12. TSS. DNA of Ct-OATP1B3. 5’. 3’. Transcription. Alternative Splicing. Start Codon. Stop Codon. Start Codon. Stop Codon. - PowerPoint PPT Presentation

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Page 1: TSS

5’ 3’331*1*

TSS

1515DNA of Ct-OATP1B3 124 125124-2

mRNA of Ct-OATP1B3 331*1* 1515124 125 12 331*1* 1515124 125 12124-2

Alternative Splicing

Start Codon Stop Codon Start Codon Stop Codon

Mature Protein of Ct-OATP1B3(674 amino acid)

Immature Protein(91 amino acid)

Translation Translation

Transcription

Supplemental Figure 1. Alternative splicing of Ct-OATP1B3.Exons of Ct-OATP1B3 are indicated by open boxes. TSS, transcription start site. The mature Ct-OATP1B3 is a 674-amino acid polypeptide, while another variant possesses the terminal codon in the exon 4-2, producing immature 91-amino acid polypeptide.