uicc hpv and cervical cancer curriculum chapter 6.c.3. methods of treatment - radiation prof. achim...

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UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

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Page 1: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

UICC

HPV andCERVICALCANCERCURRICULUM

Page 2: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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01 Chapitre 6.c.3

Méthodes de traitement – Radiation

Prof. Achim Schneider, MD, MPHCharité Universitätsmedizin Berlin, Germany

Page 3: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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02 Cervical cancer

• Diagnostic

• Staging

• Thérapie

-Chirurgie

-Radiation

-Chimiothérapie

• Prognostic

• Suivi

Page 4: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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03 Radiothérapie

Radiothérapie externe = téléthérapie

Radiothérapie combinée avec la chimiothérapie = chimioradiation

Radiothérapie interne= brachythérapie ou endocuriethérapie

Page 5: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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04 Indications de la radiothérapie

• Radiothérapie initiale

- Irradiation associée à la chimiothérapie

-Brachythérapie et téléthérapie associées donnent de meilleur résultats

Radiothérapie post opératoire

-Seulement en cas de facteurs de risque tels que une tumeur de grande taille, des paramètres infiltrés des ganglions positifs ...

-Si possible on associera à l’irradiation une chimiothérapie simultanée

• Radiothérapie des récidives

-Efficace en absence de radiothérapie préalable

-Toujours si possible en association avec une chimiothérapie simultanée

Page 6: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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05 Chimioradiation

• Survie globale dans 11 essais randomisés: radiothérapie vs. chimioradiation en traitement primaire

• et en adjuvant chez 2856 patientes atteintes de cancer du col

• La chimioradiation est supérieure à la radiothérapie seule, dans les deux cas

Page 7: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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06 Préservation d’organe sparing

Page 8: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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07 Systèmes de brachythérapie

Page 9: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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08 Brachythérapie

Page 10: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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09 Chimioradiation adjuvante après chirurgie • Indication pour:

-R1 (envahissement microscopique des marges d’exérèse)

-pN1 (envahissement ganglionnaire)

-pT2b

-V1 and L1 (envahissement des espaces lympho-vasculaires)

Page 11: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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10 Toxicité

• Toxicité aigue

-Dans les 90 jours après le début du traitement

-Peut être efficacement traité

• Toxicité tardive

-Au de là de 90 jours après le début du traitement

-Souvent chronique

Page 12: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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11 Toxicité aigue

• Erythéme

• Hyperpigmentation

• Pollakiurie

• Mucite

• Diarrhée

• Fistule

• anémie

• Toxicité rénale

• surdité

Page 13: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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12 Toxicité tardive

• Rectite chronique

• Cystite

• Rétrécissement vésical

• Sténoses du rectosigmoide, de l’urètre, des uretères et/ou du vagin

• Défaut auditif

• Insuffisance rénale

• Lymphoedème

Page 14: UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - Radiation Prof. Achim Schneider, MD, MPH UICC HPV and CERVICAL CANCER CURRICULUM

UICC HPV and Cervical Cancer Curriculum Chapter 6.c.3. Methods of treatment - RadiationProf. Achim Schneider, MD, MPH

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Merci

Cette présentation est disponible sur: www.uicc.org/curriculum