UNIVERSITÀ DEGLI STUDI DI PADOVA Ufficio Stampa

Via VIII febbraio 2, 35122 Padova - tel. 049/8273041-3066-3520 fax 049/8273050 e-mail: stampa@unipd.it per la stampa: http://www.unipd.it/comunicati

Padova, 23 novembre 2015

QUANDO LA RICERCA E' GIOVANE PHD STUDENT RESEARCH PROGRAM DAY

MEDICAL AND BIOMEDICAL SCIENCES

I dottorandi dell’Area Medica (2° anno di corso) presenteranno al pubblico le ricerche che stanno conducendo. L’occasione è un convegno in programma Martedì 24 Novembre alle ore 9.00 (Archivio Antico e Aula Magna del Palazzo del Bo), durante il quale i dottorandi dei Corsi di Biomedicia, Medicina dello Sviluppo e Scienze della Programmazione Sanitaria, Oncologia e Oncologia Chirurgica, Scienze Mediche, Cliniche e Sperimentali e del Corso di Dottorato Internazionale di Ipertensione Arteriosa e Biologia Vascolare si succederanno per l’intera giornata a illustrare il loro progetto di ricerca. L’appuntamento è organizzato in collaborazione con l’Associazione Ricerche Cardiopatie Aritmiche.

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Old University

Archivio Antico-Aula Magna Palazzo del Bo

Via 8 Febbraio, 2 - 35122 Padova

University of Padua

PhD Programmes Medical and Biomedical Sciences

Tuesday, November 24, 2015

Organized by Prof.ssa Annalisa Angelini Prof. Gaetano Thiene Department of Cardiac, Thoracic and Vascular Science

In collaboration with: Alessandra Cervellin Department of Cardiac, Thoracic and Vascular Science Tel 049/8272288 – Fax 049/8272294 e-mail: alessandra.cervellin@unipd.it

A.R.C.A. Associazione Ricerche Cardiopatie Aritmiche Via A. Gabelli, 86 35121 Padova sito web: http://anpat.unipd.it/ARCA/

OLD UNIVERSITY “GALILEO GALILEI” AULA MAGNA 9.00 OPENING CEREMONY

9.30 AULA MAGNA

Chairperson: Prof. Paola Zanovello

A U L A

M A G N A

A U L A

M A G N A

A U L A

M A

ONCOLOGY AND SURGICAL ONCOLOGY

Engin BOJNIK – Tutors: Prof.ssa Anita De Rossi, Prof. Paolo Ghia

“COMBINED ERK AND BTK INHIBITION AS A NOVEL THERAPEUTIC APROACH IN CHRONIC LYMPHOCYTIC LEUKEMIA”

Antonella BRUNELLO – Tutors: Dr.ssa Vittorina Zagonel, Dr.ssa Maria Luisa Calabrò

“EVALUATION OF BIOMARKERS IN HIGH GRADE SOFT TISSUE SARCOMAS: PRELIMINARY RESULTS RELATED TO A COHORT OF PATIENTS AFFECTED BY LEIOMYOSARCOMA”

Sara Josè CANOVAS NUNES – Tutor: Dr. Francesco Piazza

“RHOU EXPRESSION CHANGES IN MULTIPLE MYELOMA REVEAL A POSSIBLE CORRELATION WITH BONE MARROW DEPENDENCE”

Maria Vittoria DIECI – Tutor: Prof. Valentina Guarneri

“INTEGRATED TRANSLATIONAL EVALUATION OF MOLECULAR INTRINSIC SUBTYPES AND IMMUNE MODULATION OF PCR IN HER2-POSITIVE BREAST CANCER PATIENTS TREATED WITH CHEMOTHERAPY HER2-TARGETED AGENTS IN THE PROSPECTIVE RANDOMIZED CHERLOB TRIAL”

Alvise FRASSON – Tutor: Prof. Donato Nitti

“ANALISYS OF THE EXPRESSION OF PRO-INFLAMMATORY CYTOKINES AND VASCULAR ADHESION MOLECULES IN CIRROTHIC PATIENTS WITH OR WITHOUT HEPATOCARCINOMA”

Kevin LEONE – Tutor: Dr.ssa Ilaria Marigo

“DAB2 CONTROLS THE MACROPHAGE-ASSISTED METASTATIC PROCESS”

Paolo MACACCARO – Tutor: Dr. Francesco Piazza

“IMMUNOPHENOTYPIC CHARACTERIZATION OF B-LYMPHOPOIESIS IN KO MICE FOR ONCOGENIC SER/THR KINASES BY MULTIPARAMETER FLOW CYTOMETRY”

G N A

Lisa PERILLI – Tutor: Prof.ssa Paola Zanovello

“ROLE OF MIR-182 IN NEOPLASTIC PROGRESSION OF COLORECTAL CANCER”

9.30 ARCHIVIO ANTICO Chairpersons: Prof. Gaetano Thiene, Prof.ssa Annalisa Angelini

A R C H I V I O

A N T I C O

A R C H I V I O

CARDIOVASCULAR SCIENCES

Ahmed Hussien Hussien AL MAMARY – Tutor: Prof. Sabino Iliceto

“SPONTANEOUS CORONARY ARTERY DISSECTION IN SUDDEN DEATH VICTIMS AND SURVIVING PATIENTS: WHICH ARE THE DIFFERENCES?”

Maria Stella BACCILLIERI– Tutor: Prof.ssa Cristina Basso

“THE ANATOMICAL CHARACTERISTICS OF RIGHT ATRIAL CAVOTRICUSPID ISTHMUS CAN AFFECT RADIOFREQUENCY CATHETER ABLATION IN TERM OF SUCCESSFUL AND COMPLICATIONS”

Manuel DE LAZZARI – Tutor: Dr.ssa Martina Perazzolo Marra

“MITRAL VALVE PROLAPSE: ARRHYTHMOGENIC SUBSTRATES BY CARDIAC MAGNETIC RESONANCE IMAGING”

Michela FACCHIN – Tutor: Prof. Giuseppe Tarantini

“PREVALENCE AND IMPACT OF ATRIAL FIBRILLATION IN PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE IMPLANTATION. AN ANALYSIS FROM THE SOURCE XT PROSPECTIVE MULTICENTRE REGISTRY”

Cátia Marisa LOURENÇO FIDALGO – Tutor: Prof. Gino Gerosa

“ASSESSMENT OF STERILISATION AND PRESERVATION METHODS FOR DECELLULARISED SCAFFOLDS”

Massimo NAPODANO – Tutor: Prof. Sabino Iliceto

“DEVELOPMENT AND VALIDATION OF A DISTAL EMBOLIZATION RISK SCORE DURING PRIMARY ANGIOPLASTY IN ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION”

Vera RENIER – Tutor: Prof. Gaetano Thiene

“CARDIAC TUMORS: SURGICAL SERIES AND FOLLOW-UP”

A N T I C O

Maria SILVANO – Tutor: Prof. Domenico Corrado

“BENEFIT AND COMPLICATIONS OF IMPLANTABLE CARDIOVERTER DEFIBRILLATOR THERAPY IN YOUNG PATIENTS WITH CARDIOMYOPATHIES: A LONG-TERM SINGLE CENTER FOLLOW-UP STUDY”

11.00 COFFEE BREAK 11.30 AULA MAGNA

Chairpersons: Prof. Paola Zanovello, Prof. Gian Paolo Rossi

A U L A

M A G N A

A U L A

M A G N A

A U L A

ONCOLOGY AND SURGICAL ONCOLOGY

Giorgia PILOTTO – Tutor: Prof. Alberto Amadori

“METABOLIC AND MOLECULAR PROFILING OF OVARIAN CANCER STEM CELLS AND CANCER NON-STEM COUNTERPART”

Anna TOSI – Tutor: Prof. Antonio Rosato

“IDENTIFICATION OF A HLA-A*0201-RESTRICTED IMMUNOGENIC EPITOPE FROM THE UNIVERSAL TUMOR ANTIGEN DEPDC1”

Carolina VENTUROLI – Tutor: Dr. Stefano Indraccolo

“ANTI-ANGIOGENIC THERAPY AND METABOLIC HETEROGENEITY IN OVARIAN CANCER”

Gianpietro ZANCHETTIN – Tutor: Prof. Stefano Merigliano

“BMP AXIS IN CANCER CACHEXIA”

ARTERIAL HYPERTENSION AND VASCULAR BIOLOGY

Marilisa CITTON – Tutor: Prof. Maurizio Iacobone

“UNILATERAL ADRENALECTOMY FOR LATERALIZED PRIMARY ALDOSTERONISM IMPROVES THE MENTAL HEALTH AND DEPRESSION SCORE AT ONE MONTH”

Paul-Emmanuel VANDERRIELE – Tutor: Prof. Gian Paolo Rossi

“ANGIOTENSIN-(1-7) PEPTIDE IS INVOLVED IN ALDOSTERONE AND CORTISOL PRODUCTION IN HUMAN ADRENOCORTICAL CELL LINE (NCI-H295)”

Giovanni VIEL – Tutor: Prof. Maurizio Iacobobe

“CUSHING AND PREGNANCY”

11.30 ARCHIVIO ANTICO Chairpersons: Prof. Gaetano Thiene, Prof. Roberto Vettor

A R C H I V I O

A N T I C O

A R C H I V I O

A R C H I V I O

CARDIOVASCULAR SCIENCES

Sugat Ratna TULADHAR – Tutor: Prof. Gino Gerosa

“DEVELOPMENT OF A DECELLULARIZED PERICARDIUM PERCUTANEOUS HEART VALVE”

Alessandro ZORZI – Tutor: Prof. Domenico Corrado

“CLINICAL CHARACTERISTICS AND STRATEGIES FOR EARLY DIAGNOSIS OF NON-ISCHEMIC LEFT VENTRICULAR SCAR IN COMPETITIVE ATHLETES”

CLINICAL METHODOLOGY, ENDOCRINOLOGICAL DIABETOLOGICAL

AND NEPHROLOGICAL SCIENCES

Elisabetta BENETTI – Tutor: Prof. Roberto Vettor

“INTERACTION OF CIRCUMFERENCE , LENGTH AND SHAPE OF THE ARM IN BLOOD PRESSURE MEASUREMENT IN THE OBESE”

Lisa GIANESELLO – Tutor: Dr.ssa Dorella Del Prete

“PROTEIN UPTAKE AT GLOMERULAR LEVEL: POSSIBLE INVOLVEMENT OF AN ENDOCYTIC MACHINARY IN CELL CULTURE AND IN PATIENTS WITH PROTEINURIC NEPHROPATHY”

Andrea REBELLATO – Tutor: Prof. Francesco Fallo

“METHYLATION STATUS OF VITAMIN D RECEPTOR GENE PROMOTER IN BENIGN AND MALIGNANT ADRENOCORTICAL TUMORS”

Valentina SCATTOLINI – Tutors: Prof. Angelo Avogaro, Dr. Gian Paolo Fadini

“IN VIVO IMAGING OF THE DIABETIC MICROCIRCULATION”

Giovanna SPIRO – Tutor: Prof. Roberto Vettor

“MUSCLE STEM CELLS AND EXTRACELLULAR MATRIX IN SARCOPENIC OBESITY”

Eva ZABEO – Tutor: Prof. Roberto Vettor

“DYNAMICS OF CIRCULATING MICROPARTICLES IN OBESITY AFTER WEIGHT LOSS”

13.00 LUNCH

14.00 AULA MAGNA Chairpersons: Prof. Stefano Piccolo, Prof. Carlo Giaquinto

A U L A

M A G N A

A U L A

M A G N A

A U L A

M A G N A

MOLECULAR MEDICINE

Giusy BATTILANA – Tutor: Prof. Stefano Piccolo

“YAP/TAZ/TEAD COOPERATE WITH AP-1”

Veronica DI ANTONIO – Tutor: Prof. Ignazio Castagliuolo

“IDENTIFICATION OF SMALL MOLECULES INHIBITING THE DIMERIZATION OF HCMV DNA POLYMERASE PROCESSIVITY FACTOR UL44”

Vittoria RAIMONDI – Tutors: Prof. Stefano Piccolo, Prof. Vincenzo Ciminale

“ROLE AND REGULATION OF MIR-34A IN HTLV-1 INFECTED CELLS”

REGENERATIVE MEDICINE

Francesco PETRELLA – Tutor: Prof. Maria Teresa Conconi

“EXPERIMENTAL AND CLINICAL AIRWAY RESTORATION BY MESENCHYMAL STROMAL CELL AUTOLOGUS TRANSPLANTATION”

PEDIATRIC ONCOHEMATOLOGY, MEDICAL GENETICS, RARE

DISEASES, EPIDEMIOLOGY AND COMMUNITY MEDICINE

Stefania BELLESSO – Tutors: Dr.ssa Rosella Tomanin, Prof. Maurizio Scarpa

“DEREGULATED FGF SIGNALING SUBSTANTIALLY CONTRIBUTES TO EARLY OSTEOGENIC DEFECTS IN MUCOPOLYSACCHARIDOSIS TYPE II”

Annagiulia BONIZZATO – Tutor: Dr.ssa Geertruy Te Kronnie

“PORTRAYING THE TRANSCRIPTIONAL LANDSCAPE OF NORMAL HEMATOPOIESIS”

Biagio CASTALDI – Tutor: Prof. Ornella Milanesi

“INTEGRATED IMAGING TO EVALUATE CARDIAC PERFORMANCE IN FONTAN PATIENTS”

Ilaria DE BARBIERI – Tutor: Prof. Giorgio Perilongo

“RELATIONSHIP-BASED-CARE MODEL IN PEDIATRIA: STUDIO RANDOMIZZATO CONTROLLATO PER IMPLEMENTARE LA QUALITÀ DELLE CURE”

A U L A

Francesca GRANDI – Tutor: Prof. Piergiorgio Gamba

“SHORT BOWEL SYNDROME IN PEDIATRIC AGE: A NEW REGENERATIVE APPROACH”

Elena MARIOTTO – Tutors: Prof. Giuseppe Basso, Prof. Giampietro Viola

“IN VITRO AND IN VIVO PHARMACOLOGICAL STUDY OF EB-3D, A NOVEL CHOLINE KINASE INHIBITOR FOR BREAST CANCER TREATMENT”

14.00 ARCHIVIO ANTICO

Chairpersons: Prof. Elena Pegoraro

A R C H I V I O

A N T I C O

A R C H I V I O

NEUROSCIENCE

Luca BELLO – Tutor: Prof. Elena Pegoraro, Dr. Eric P. Hoffman

“VALIDATION, FUNCTIONAL STUDIES, AND DISCOVERY OF GENETIC MODIFIERS OF DUCHENNE MUSCULAR DYSTROPHY”

Francesca BURGIO – Tutor: Prof. Carlo Semenza

“NADL-FINANCIAL: A NEW TOOL FOR THE ASSESSMENT OF FINANCIAL ABILITIES. A STUDY ON MILD COGNITIVE IMPAIRMENT”

Cinzia BUSSE’ – Tutor: Prof. Carlo Semenza

“PROFILES OF VERBAL MEMORY IMPAIRMENT IN DEMENTIA WITH LEWY BODIES VERSUS ALZHEIMER DISEASE”

Valeria GIANNUNZIO – Tutor: Prof. Angela Favaro

“DECISION MAKING IN ANOREXIA NERVOSA”

Sonia MARCATO – Tutor: Prof. Elena Pegoraro

“EMPATHY AND EXECUTIVE FUNCTIONS IN NEUROMUSCULAR DISEASES”

Lucia NARDETTO – Tutor: Prof. Elena Pegoraro

“HEMATOMA EXPANSION IN ACUTE PRIMARY INTRACEREBRAL HEMORRHAGE”

Davide POGGIALI – Tutor: Prof. Elena Pegoraro

“RELIABLE METHODS FOR MULTIMODALITY IMAGING: FUNCTIONAL VS. ANATOMICAL”

A N T I C O

Claudio SEMPLICINI – Tutor: Prof. Elena Pegoraro

“WIDENING THE CLINICAL AND MUTATIONAL SPECTRUM OF CASQ1-RELATED MYOPATHY”

Marco SOLMI – Tutor: Prof. Angela Favaro

“5-HTTLPR POLYMORPHISM IN EATING DISORDERS”

Filippo VALENTE – Tutor: Prof. Alessandro Martini

“NANOPARTICLES AND STEM CELLS PROTOCOLS AGAINST DRUG OTOTOXICITY”

Marco ZOCCARATO – Tutor: Prof. Elena Pegoraro

“GLUTAMIC ACID DECARBOXYLASE ANTIBODIES IN NEUROLOGICAL DISEASES: CLINICAL RETROSPECTIVE EVALUATION OF DIAGNOSIS PERFORMED BY ENZYME-LINKED IMMUNOSORBENT ASSAY”

16.00 COFFEE BREAK

16.30 AULA MAGNA

Chairperson: Prof. Carlo Giaquinto

A U L A

M A G N A

PEDIATRIC ONCOHEMATOLOGY, MEDICAL GENETICS, RARE

DISEASES, EPIDEMIOLOGY AND COMMUNITY MEDICINE

Francesca MAULE – Tutors: Prof. Giuseppe Basso, Dr. Luca Persano

“ANNEXIN A2 IS A KEY DETERMINANT OF GLIOBLASTOMA AGGRESSIVENESS BY CONTROLLING CANCER CELL DISSEMINATION AND PROLIFERATION”

Silvia ROSSI – Tutor: Prof. Maurizio Clementi

“APPLICATION OF METHODS OF MASSIVE PARALLEL SEQUENCING IN THE DIAGNOSIS OF CERTAIN GENETIC AUTOSOMAL DOMINANT DISEASES”

A U L A

M A G N A

PROGRAMMING SCIENCE

Francesca MENEGAZZO – Tutor: Prof. Paola Facchin

“CODING RARE DISEASES IN HEALTH INFORMATION SYSTEMS: DESIGN, IMPLEMENTATION AND TESTING OF THE PILOT STUDY FOR THE EUROPEAN JOINT ACTION ON RARE DISEASES”

Giulia MENEGHEL – Tutors: Prof. Paola Facchin, Dr. Melissa Rosa Rizzotto

“POISONING IN PATIENTS EVALUATED FOR ALLEGED CHILD ABUSE AND NEGLECT”

Elena RIZZARDI – Tutor: Prof. Paola Facchin, Dr. Monica Mazzucato

“FROM A GENERALIZED CLINICAL DATABASE TO THE CREATION OF REGISTERS OF RARE DISEASES”

16.30 ARCHIVIO ANTICO

Chairpersons: Prof. Paolo Angeli, Prof. Andrea Doria

A R C H I V I O

A N T I C O

HEPATOLOGY AND HEPATOBILIARY SURGERY AND

TRANSPLANTATION

Irene BERTOZZI – Tutor: Prof. Maria Luigia Randi

“VALIDATION OF WHO-2008 CRITERIA IN PEDIATRIC ESSENTIAL THROMBOCYTHEMIA: RELEVANCE OF BIOMOLECULAR AND HISTOLOGICAL CRITERIA”

Riccardo BOETTO – Tutor: Prof. Umberto Cillo

“EXTREME HEPATECTOMIES AND NON-RESECTABILITY TECHNICAL BREAKTHROUGH FOR LIVER NEOPLASIA, FOCUSING ON COLORECTAL METASTASES: EXPERIMENTAL PILOT STUDY ON SAFETY, EFFICACY, AND REGENERATION PATTERNS WITH NEW INSIGHT ON ALLPS-LT HYBRID TECHNIQUES”

Alessandra BROCCA – Tutor: Prof. Paolo Angeli

“CHARACTERIZATION OF MOLECULAR PATHWAYS INVOLVED IN ACUTE AND ACUTE-ON-CHRONIC LIVER DISEASE”

A R C H I V I O

A N T I C O

Paola PESCE – Tutor: Prof. David Sacerdoti

“IDENTIFICATION OF EARLY MARKERS OF EVOLUTIVE NON ALCOHOLIC FATTY LIVER DISEASE”

Marina POLACCO – Tutor: Prof. Umberto Cillo

“RESECTION-BENEFIT IN R1 LIVER RESECTION IN COLO-RECTAL LIVER METASTASES AND IN CHOLANGIOCARCINOMA”

RHEUMATOLOGICAL SCIENCES

Ada AITA – Tutor: Prof. Leonardo Punzi

“THE MEFV R202Q VARIANT: A GENETIC RISK FACTOR FOR SERONEGATIVE SPONDYLOARTHRITIS”

Marianna BEGGIO – Tutor: Prof. Andrea Doria

“IN VITRO EFFECTS OF ESTROGENS ON BLyS mRNA EXPRESSION IN A HUMAN MYELOID CELL LINE”

Rossella TALOTTA – Tutor: Prof. Andrea Doria

“IMMUNOGENICITY DURING TREATMENT OF CHRONIC RHEUMATIC DISEASES: FOCUS ON TH9 LYMPHOCYTES”

18.00 CLOSING REMARKS

PHD PROGRAMMES (XXIX CYCLE)

1.

BIOMEDICINE Coordinator: Prof. Stefano Piccolo Curricula: - MOLECULAR MEDICINE - REGENERATIVE MEDICINE

2.

INTERNATIONAL DOCTORATE PROGRAM ARTERIAL HYPERTENSION AND VASCULAR BIOLOGY Coordinator: Prof. Gian Paolo Rossi

3.

DEVELOPMENTAL MEDICINE AND HEALTH PLANNING SCIENCES Coordinator: Prof. Carlo Giaquinto Curricula: - PEDIATRIC ONCOHEMATOLOGY, MEDICAL GENETICS, RARE DISEASES, EPIDEMIOLOGY AND COMMUNITY MEDICINE - PROGRAMMING SCIENCE

4.

ONCOLOGY AND SURGICAL ONCOLOGY Coordinator: Prof.ssa Paola Zanovello

5.

MEDICAL CLINICAL AND EXPERIMENTAL SCIENCES Coordinator: Prof. Gaetano Thiene Curricula: - CARDIOVASCULAR SCIENCES - CLINICAL METHODOLOGY, ENDOCRINOLOGICAL DIABETOLOGICAL AND NEPHROLOGICAL SCIENCES - HEPATOLOGY AND HEPATOBILIARY SURGERY AND TRANSPLANTATION - NEUROSCIENCES - RHEUMATOLOGICAL SCIENCES