university of michigan school of dentistry russell s ......research in the school of dentistry fall...
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UNIVERSITY OF MICHIGAN School of Dentistry
RUSSELL S. TAICHMAN
CURRICULUM VITAE BUSINESS ADDRESS: Department of Periodontics and Oral Medicine. University of Michigan School of Dentistry. 1011 North University Avenue. Ann Arbor, MI. 48109-1078 Faculty Office Tel: (734) 764-9952 Deans Office Tel: 734-764- 8216 Fax: (734) 763-5503 Email: [email protected] EDUCATION: 1982 B.S. Villanova University. 1986 D.M.D. University of Pennsylvania, School of Dental Medicine. 1990 D.M.Sc. Harvard University, School of Dental Medicine. POSTDOCTORAL TRAINING: 1986-1990 Certificate in Periodontology Harvard University School of Dental Medicine. Boston, MA. 1990-1992 Postdoctoral Fellowship in Molecular Immunology Department of Pathology & Laboratory Medicine. University of Pennsylvania School of Medicine. Philadelphia. PA. Mentor: John C. Reed, M.D., Ph.D. 2009 Essentials and Entrepreneurship of an MBA Program University of Michigan, Ross School of Business. Ann Arbor, MI. ACADEMIC APPOINTMENTS:
1986-1990 Fellow in Periodontology Harvard University, School of Dental Medicine. Boston, MA. 1986-1987 Surgical Research Fellow Department of Surgery, Brigham and Women's Hospital. Boston, MA. 1987-1990 Orthopedic Research Fellow Department of Orthopedics, Children's Hospital Corp. Boston, MA
Curriculum Vitae Russell S. Taichman 1990- 1992 Postdoctoral Research Fellow
Department of Pathology & Laboratory Medicine. University of Pennsylvania School of Medicine. Philadelphia PA.
1991-1992 Consultant, Dental Service Philadelphia VA Medical Center. Philadelphia, PA.
1992-1998 Assistant Professor Department of Periodontics, Prevention & Geriatrics University of Michigan School of Dentistry. Ann Arbor, MI.
1998-2005 Associate Professor Department of Periodontics, Prevention & Geriatrics
University of Michigan School of Dentistry. Ann Arbor, MI. 2001-2014 Staff Periodontist Ann Arbor VA Medical Center. Ann Arbor, MI. 2004-2014 Co-Director - Scholars Program in Dental Leadership (UM-SPDL) University of Michigan School of Dentistry. Ann Arbor, MI. 2005-Present Professor of Dentistry Department of Periodontics & Oral Medicine University of Michigan School of Dentistry. Ann Arbor, MI. 2005-2014 Adjunct Professor College of Literature, Science &Arts, University of Michigan. Ann Arbor, MI. 2011- Present Major McKinley Ash Collegiate Professor Department of Periodontics & Oral Medicine. University of Michigan School of Dentistry. Ann Arbor, MI.
2014-Present Associate Dean for Research University of Michigan School of Dentistry. Ann Arbor, MI.
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Curriculum Vitae Russell S. Taichman INDUSTRIAL APPOINTMENTS: 8/2015- 8/2016 President Genesis Regeneration & Diagnostics LLC Wilmington, DE. CERTIFICATES AND LICENSES: 1992 - Present Dentistry License, State of Michigan. 1986 - Present DEA Licensure. 1992 - Present Cardiac Life Support and Advanced Cardiac Life Support. DENTAL BOARDS: Northeast Regional Boards HONORS AND AWARDS:
Alpha Epsilon Delta Predental/Medical Honor Society (1981-1982).
National Research Service Award, National Institute of Health (1986-1990).
Veteran’s Administration Medical Ctr. Career Development Award (1992-1994).
Dental Hygiene Class - Instructor of the Year (1997).
Dean’s Award for Research Excellence (2001).
OKU Honor Society Faculty Member (2002).
Dean’s Award for Research Excellence (2002).
UROP Faculty Recognition Award for Outstanding Research Mentorship (2003).
ADEA Leadership Institute (2010-2011).
ADEA /Alpha Omega Foundation / Leonard Abrams Scholar (2010-2011).
UROP Faculty Recognition Award for Outstanding Research Mentorship (2011).
Bone Key Investigator Spotlight: Cancer stem cells and the hematopoietic stem cell niche: an
interview with Russell Taichman (April 3, 2012).
http://www.nature.com/bonekey/community/2012/04/cancer-stem-cells-and-the-
hematopoietic-stem-cell-niche-an-interview-with-russell-taichman/
Honorary Professor Jilin University, China (2012).
Vice-President Elect OKU Honor Society (2014).
President OKU Honor Society (2016-2017)
Fellow, American Collage of Dentists (2015)
Cancer Research - Editorial Board (2016)
2016 MICHR Distinguished Clinical and Translational Research Mentor Award
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Curriculum Vitae Russell S. Taichman MEMBERSHIPS:
American Association of Dental Research (1987-Present).
American Association for the Advancement of Science (1986-Present).
American Bone & Mineral Society (1994-Present).
American Society of Hematology (1992-2014).
American Dental Association (1992-1996, 2010-Present).
American Dental Education Association (2004-Present).
International Society for Stem Cell Research (2007-2014).
Honorary Member- Stem Cell Research Italy Association (2010-Present).
American Association for Cancer Research (Invited member) (2010-Present).
American Collage of Dentists (2015-Present)
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Curriculum Vitae Russell S. Taichman TEACHING ACTIVITIES (Selected):
I. COURSES TAUGHT:
1986-1990 Periodontics Lecture. Harvard School of Dental Medicine (1 lecture/year).
1990-1992 Seminar leader. University of Pennsylvania. Department of Pathology.
1992-2006 Lecturer: Etiology of Periodontal Diseases (626) (2 lectures/year).
1992-Present Periodontics Case Conference (1 presentation/year).
1993-Present Seminars in Periodontics (1-2 presentations/year).
1993-1999 Geriatric Dentistry (2 seminars/year).
1993-Present Periodontal Therapy 789 (1 lectures/year).
1995-2005 Course Director: Clinical Periodontics for Dental Hygiene Program.
1995-2010 Course Director: Adv. Topics in Periodontics for Dental Hygiene Program.
1997-1999 Mineralized Tissue Core Course (2 lectures/year).
1997 Research Methods (2 lectures).
1998 Organogenesis of the Hematopoietic System, University of Michigan
Medical School
1998 Cell and Molecular Biology (2 hours).
2000-2014 Course Director: LS&A UC151- 05 Science and Practice of Dentistry in the
21st Century.
2001 Preclinical Periodontal Surgery Course (Pig Jaw).
2003 Organogenesis of Complex Tissues (2 hours).
2010-Present Director – Leadership Pathway for Dental Students.
2013, 2014
2014-Present
2015, 2016
2016-Present
2017
2017
Molecular Cell and Developmental Biology (2 hours).
University of Michigan Collage of Literature, Arts & Science.
Research in the School of Dentistry Fall Term 524 Pathways Course.
University of Michigan Medical School CANCER BIOLOGY 553
Responsible Conduct in Research and Scholarship (RCRS)
ORALHEAL 995 Candidate Research
ORALHEAL 811 Seminar Series and Journal Club - Stem Cell Niche
Module Director.
2017 –
In Development:
DENTISTRY 101. Development of a University of Michigan, Massive
Online Course (MOOC) to be hosted by Coursera (Est. Launch Date Dec 1,
2018). Directors: R.S. Taichman & Rogerio Castilho.
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Curriculum Vitae Russell S. Taichman II. CLINICAL TEACHING:
1989-1990 Periodontology Surgical Clinics. Harvard School of Dental Medicine.
1992-2004 Clinical Instructor. University of Michigan School of Dentistry (1 day/week).
2000-2001 Attending Dentist. Oral Dermatology Clinic. Univ. of Michigan Hospital (1 day/month).
2001-2014 Attending Periodontist. Ann Arbor Veteran’s Administration Medical Center (1/2 day/week). Occasionally after 2004.
2004-2014 Clinical Instructor. University of Michigan School of Dentistry (½day/week).
III. STUDENT RESEARCH:
Student Years Degree Role
Erica DeBover DDS. 1994 Ph.D. Oral Health Science PhD Laboratory Rotation
Somjin Ratanasathien D.D.S. 1995 Ph.D. Oral Health Sciences PhD Laboratory Rotation
Jim Papp D.D.S 1996 M.S. Thesis Committee Member
Maria Korsnes M.S. 1998 M.S. Thesis Advisor
Taylor Huong D.D.S 1998 M.S. Thesis Committee Member
Chris Kazor D.D.S. 1999 Ph.D. Oral Health Sciences PhD Laboratory Rotation Thesis Committee Member
Hamed Harian D.D.S 1999 Ph.D. Thesis Committee Member
Abraham Schnider D.D.S. 2000 Ph.D. Oral health Science PhD Laboratory Rotation
Sandra Chang 2000 D.D.S Mentor: Summer Research Fellowship
Zheng Fu M.D. 2000 Ph.D. Thesis Committee Member (Immunology)
Yong-Hee Chun D.D.S. 2001 M.S. Thesis Committee (Periodontics)
Maria Concii D.D.S 1999- 2001 Ph.D. Dental Public Health Thesis Committee
Bina Park D.D.S. 2001-02 M.S. Thesis Committee (Orthodontics)
Kevin Cook 2002-03 UROP Faculty Mentor
Nadir Osman, M.D. 2003-2004 Post-Doc Post-Doctoral Fellowship
Aaron Havens D.M.D., M.S. 2002-2006 UROP Faculty Mentor
2006-2010 D.M.D. Faculty Mentor at Harvard School of Dental Medicine
2010-2013 M.S. Master’s Thesis Chair
Debby Hwang D.D.S. 2003 M.S. Thesis Committee (Periodontics)
Greg Johnson M.D. 2003 UROP Faculty Mentor
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Curriculum Vitae Russell S. Taichman Younghun Jung Ph.D. 2003-04 Post-Doc Post-Doctoral Fellowship
Mayra Esparza
Sheila Larabell
Tanya Sherrell
2004
2004
2004
B.S.
B.S.
B.S.
Table Clinic Mentor
Table Clinic Mentor
Table Clinic Mentor
Yan Xi Sun, M.D. 2003-05 Post-Doc Post-Doctoral Fellowship
Razina Khayat D.D.S. 2000 Ph.D. Thesis Committee Member (Dental Public Health)
Connie Pagedas 2004-2009 Ph.D. Thesis Committee (Biomedical Engineering)
Katleen Neiva D.D.S 2004 Ph.D. Oral Health Sciences Ph.D. Laboratory Rotation
Janet Kinney 2004-06 M.S. Thesis Committee (Dental Hygiene)
Hui-Chen Chan D.D.S. 2005-2008 M.S. Thesis Committee (Pedodontics)
Jian Hua Wang M.D., Ph.D. 2005-2009 Post-Doc Post-Doctoral Fellowship
Geeta Mehta, Ph.D. 2006-08
2010-2012
Ph.D. Thesis Committee (Biomedical Engineering)
Post-Doctoral Fellowship
Yusuke Shiozawa M.D.,Ph.D. 2006-2010 Post-Doc Post-Doctoral Fellowship
Jr. Research Track Faculty
Elizabeth E. Pedersen 2006-2010 B.S. Faculty Mentor
Zhao Lin 2008-2010 Ph.D. Thesis Committee (Oral Health Sciences)
Amy Hsiao 2008-2011 Ph.D. Thesis Committee (Biomedical Engineering)
Chad Novince D.D.S. 2009-2011 Ph.D. Thesis Committee (Oral Health Sciences)
Lalit Patel 2009-2012 M.S. Faculty Co-Mentor (Biomedical Engineering)
Elizabeth van Tubergen
D.D.S.
2009-2014 Ph.D. Thesis Committee (Oral Health Sciences)
Sudha Krishnamurthy D.D.S 2008-2011 Ph.D. Thesis Committee (Oral Health Sciences)
Jeena Joseph, Ph.D. 2010-2012 Post-Doc Post-Doctoral Fellowship
Anjali Mishra, Ph.D. 2010-2011 Post-Doc Post-Doctoral Fellowship
Jin Koo Kim, Ph.D. 2010-2011 Post-Doc Post-Doctoral Fellowship
Alexandra Forest D.M.D. 2010-2014 DDS Research Pathway Mentor
Samantha McGee 2010-2014 UROP Faculty Mentor
Daniel Wang 2011-2011 UROP Faculty Mentor
Monika Verma, Ph.D. 2012-2013 Post-Doc Post-Doctoral Fellowship
Biao Nie, M.D., Ph.D. 2012 Post-Doc Post-Doctoral Fellowship
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Curriculum Vitae Russell S. Taichman Kenji Yamato, Ph.D. 2012-Present Post-Doc Post-Doctoral Fellow
Janet Zalucha 2012-2016 D.D.S. Research Pathway Mentor
Sylvia Lee 2012-Present B.S. UROP and Research Mentor
Baxter Jones
Lulia Kana
Sarah McDermott D.D.S.
Xu Quan D.D.S.
2012-2016
2012–2016
2013–2015
2014- 2015
D.D.S.
B.S.
M.S.
Ph.D.
Research Pathway Mentor
UROP Faculty Advisor
Thesis Committee (Orthodontics)
Thesis Committee (Oral Health Sciences)
Moo Hyun Kim B.S. 2013-2015 D.D.S. Leadership Pathway Research Project
Sammuel Upton 2013-2015 D.D.S. Leadership Pathway Research Project
Fabiana Soki D.D.S. 2012-2015 Ph.D. Thesis Committee (Oral Health Sciences)
Elizabeth E. Pederson 2014-2016 Ph.D. Thesis Committee, Molecular and Cell
Biology, School of Medicine.
Jia Chang D.D.S. Ph.D.
Megan Michaski D.D.S.
2013-2014
2015
M.S.
Ph.D.
Thesis Committee (Periodontics)
Preliminary Exam Committee
Frank Cacowski M.D. Ph.D. 2014-Present Hem/Onc
Fellowship
Hematology/Oncology Research
Faculty Track Research Mentor
Nicholas Szerlip M.D. 2014-Present M.D. Clinical Associate Professor,
Neurological Surgery
James Rhee 2015-Present B.S. UROP Research Mentor
Ann Decker D.D.S. 2014-Present Ph.D. Oral Health Sciences Ph.D. Mentor
Layla Hek 2016-Present B.S. UROP Research Mentor Tareina Rodgers 2017-Present M.S. Cancer of Chemical Biology
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Curriculum Vitae Russell S. Taichman Student Awards: Aaron Havens DDS, MS 2013 Milo Hellman Research Award from the American Association of Orthodontists ("AAO") 2013 Hatton Research Award 2nd Place – American Association of Dental Research – Seattle, WA. 2010 Cum laude in research – Harvard School of Dental Medicine 2004 Grand Prize Basic Science – Research Table Clinic Day University of Michigan School of Dentistry Eunsohl Lee 2015 University of Michigan School of Dentistry Research Day 2016. 2nd Place Undergraduate, Dental Hygiene, DDS candidates- Basic Science Category. 2016 University of Michigan School of Dentistry Research Day 2016. 1st Place Undergraduate, Dental Hygiene, DDS candidates- Basic Science Category. Janet Zalucia, BS. 2011, 2015 AADR Student Research Fellowship 2010, 2011 Student Research Program Fellowship Award 2011 School of Dentistry Research Day Audience Choice Award “Determining the role of osteoclasts in metastasis based on their ability to participate in hematopoietic stem cell mobilization” 2012 School of Dentistry Research Day Audience Choice Award “Determining osteoclasts’ role in hematopoietic stem cell mobilization and metastasis” Baxter Jones, BS. 2016 American Association of Oral Biologists (AAOB) Award Ann M. (Sagstetter) Decker, DMD 2015-2016 Tissue Engineering and Regeneration Grant (T32) Position Award 2016 Rackham Pre-Candidate Graduate Student Research Grant Award 2016 First Place: Midwest Society of Periodontology Annual Meeting Poster Competition 2016 American Association of Periodontics Foundation Educator Scholarship Recipient 2016 Henry M. Thornton/SCADA Fellowship Award Recipient 2016 Rackham Pre-Candidate Graduate Student Research Grant Award 2016 2016 Midwest Society of Periodontology Annual Meeting Poster Competition 2017 Duff Endowed Scholarship for Excellence in Periodontics Recipient
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Curriculum Vitae Russell S. Taichman SERVICE: I. ADMINISTRATIVE:
DEPARTMENTAL:
Human Subjects Committee (1992-1995).
Selection of Graduate Periodontal Students (1993-2000).
Dental Hygiene Periodontal Curriculum Review Committee (1994-1995).
Task Force for Clinical Coverage (1995).
Chairperson - Ramfjord Symposium CE Committee (1998-1999).
Chairperson - Faculty Recruitment Committee (1997-1998).
Chairperson - Faculty Recruitment Committee (1998-1999).
Chairperson - Faculty Mentoring Committee (2000-2006).
Faculty Mentoring Committee Member (2006-2010t).
Director of Research, Periodontics and Oral Medicine (2004-2014).
Departmental Advisory Board (2004-2014).
Chairperson - Departmental Faculty Search Committee (2008-2009).
Chairperson – Departmental Faculty PreTenure Review Committee (2014).
Committee Member- POM Faculty PreTenure Review (2015)
SCHOOL:
Dental Faculty Associates (1995-2000).
DDS-Ph.D. Planning Committee (1996).
Ethics & The Curriculum Dean’s Committee (1999).
Research Day Organizing Committee (1998-2002).
Library Advisory Committee (1999-2005).
Institutional Review Board (2000-2001).
Advancement, Promotion, Tenure Committee (2001-2003, 2004-2007).
Orthodontic Faculty Search Committee (2004- 2006).
Departmental Chair Search Committee. Department of Cariology, Restorative Sciences
and Endodontics (2004- 2005).
Clinical Design Committee (2006-2008).
School of Dentistry Grievance Panel (8/2008-7/2011).
Search Committee for Cancer Biology, School of Dentistry (2009-2010).
Vision Track Team, School of Dentistry (2009).
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Curriculum Vitae Russell S. Taichman
Oral Health Sciences Program Seminar Committee (1995-2006) (2012-Present)
Research Day Table Clinic Judge (1996-Present).
Research Committee Member (1998-2000, 2004-2014).
Oral Health Sciences Program Faculty (1994-Present).
Director: Scholars Program in Dental Leadership (UM-SPDL) (2004-2014).
CVI Lectures for Scholars Program in Dental Leadership (2006-2014).
Director – Leadership Pathway for Dental Students (2010-2014).
Orthodontics Tenure Track Faculty Search Committee (2012-2013)
MCOHR Review Committee Chair (2013-2014).
Orthodontic Faculty Mid-Term Review Committee (2014).
School of Dentistry AWARDS Committee (2014-2016).
Swartz Professorship in Special Care Dentistry Search Committee (2015-2017)
CVI Lectures for Office of Research and Research Training at SOD (2014-Present).
Research Day Committee Chair (2014-Present).
O.K.U. Vice President (2013-2016).
O.K.U. President (2016-2017).
Integrated Special Care Program in Dentistry Search Committee (2014-Present).
Steward for Domain 3 of School of Dentistry Strategic Plan: Research and Discovery
Domain (2014-Present).
Chair of Search Committee for Chair, Department of Biologic and Materials Sciences &
Division of Prosthodontics (2016-Present)
Oral Health Sciences Program Committee (Ex Officio)(2016-Present).
UNIVERSITY:
Cancer Center Member (1992-Present).
Organogenesis Core Member (1994-Present).
Connective Tissue Oncology –Bone Metastasis Program (1998-2006).
Prostate Oncology Program Steering Committee (2010-Present).
Biomedical Research Council (BMRC) (2011-2014).
University Research Opportunity Program (UROP) Faculty Advisory Committee (2012-
Present).
University Committee on Use and Care of Animals (UCUCA renamed IACUC in 2016)
Advisory Council (UAC) (2012-2016).
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Curriculum Vitae Russell S. Taichman
Michigan Department of Community Health Innovation Fund Proposal Review Panel
(September 2014).
Research Associate Deans Committee Member (2014-Present)
University Committee Evaluating Post-Doctoral Fellows (2014-Present)
2015 UM-Israel Partnership for Research Grant and Fellowship Applications Grant Reviewer
McKay Research Award Committee (2016) Grant Reviewer.
SPORE in Prostate Cancer Small Grant Reviewer (2016)
University of Michigan Health Innovation Grants Internal Competition Reviewer (8/2016)
University of Michigan NIH Bridges to the Doctorate (R25) Grants Internal Reviewer (8/2016)
University of Michigan Office of Research Compliance Review Advisory Committee (ORCR) (2016-2018)
University of Michigan Office of Research IACUC Strategy Committee (2016-Present)
University of Michigan-Israel Partnership Grant Reviewer (2016, 2017)
University of Michigan Office of Research Laboratory Research Safety Committee (LRSC) (2016-Present)
University of Michigan Committee on Disclosure of Individual Research Results (2016-
Present).
Research Administration Advisory Council (RAAC) Faculty Advisory Council (FAC) (2017-
Present).
SPORE in Prostate Career and Pilot Review Committee (2017)
NATIONAL / INTERNATIONAL:
Mineralized Tissue Group Member, American Association of Dental Research (1992-Present).
Periodontics Group Member, American Association of Dental Research (1992-Present).
American Association of Dental Research Hatton Award Committee (1995-1998).
Chairperson - American Association of Dental Research Hatton Award Committee (1997-1998).
Journal of Dental Research Editorial Board (1998-2001)
International Association of Dental Research Fellowship Committee (2000-2003).
Chairperson - International Association of Dental Research Fellowship Taskforce (2002-2003).
Harnessing the Potential of Adult Stem Cells, National Institute of Diabetes and Digestive and
Kidney Diseases (NIDDK). NIDDK Special Emphasis Review Panel
(2001,2002).
Journal of Periodontology Editorial Board (2001-2007).
International Association of Dental Research Gies Award Committee (2004-2007).
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Curriculum Vitae Russell S. Taichman
Committee – Chair International Association of Dental Research Gies Award (2006-2007).
National Institute of Dental and Craniofacial Research (NIDCR). Special Grants Review
Committee (2005-2009).
Hematopoietic Microenvironment Program Committee of the American Society of Hematology
(2006, 2008).
Founding Editor. Journal of Healthcare Leadership (2009).
http://www.dovepress.com/journal-of-healthcare-leadership-journal
Editor–In-Chief; Journal of Healthcare Leadership (2009-Present).
http://www.dovepress.com/journal-of-healthcare-leadership-journal
Editorial Board: American Journal of Translational Research Editorial Board (2010-Present).
Special Emphasis Panel/Scientific Review Group, National Cancer Institute (NCI). (2010).
Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01).
Grant Review Panel for NCI (7-2010).
Conference Grant SEP-Review Panel for NIDCR (2010).
Journal of Dental Education Editorial Review Board Committee (2012-2015).
Comprehensive Ph.D. Examiner for Drew Howard, Van Andel Research Institute Grand Rapids,
MI 49503 (March 4, 2013).
Editor in Chief for Journal of Cancer Stem Cell Research. Trends a Head Medical Publishing
Company. Launch Date 7/2013.
Provocative Questions Special Emphasis Panels (ZCA1 SRLB-9 and SRLB-D) (2013). National
Cancer Institute, National Institute of Health.
Delaware Center for Neuroscience Research (COBRE) Project – Mentoring Program
Committee (2012-Present)
Co-Chairperson. Scientific Program Committee. 13th International Conference on Cancer-
Induced Bone Disease (CIBD) Nov., 2013 in Miami FL.
Chairperson. American Association of Dental Research Annual Session Committee.
2011-2014
Reviewer: 2012-Present. Prostate Cancer Foundation (PCF) Challenge Award Research
Program.
Reviewer for Prostate Cancer UK’s 2013 Spring Grant Round (Project Grants, Pilot Awards &
PCUK/CSO Clinical Research Grants). (2013).
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Curriculum Vitae Russell S. Taichman
Reviewer: Faculty Review Requested by the Dean for Academic Affairs, Columbia University
Medical Center (2014).
National Cancer Institute (NCI) Provocative Question Review Panel ZCA1 GRB(A1)S 2014
National Cancer Institute (NCI) Provocative Question Workshop Member November 13, 2014
National Science Foundation of Poland (OSF) Grant Reviews (Nov 2014)
AADR Nominating Committee (2016-2019).
Cancer Research Editorial Board (February 1, 2016 -December 31, 2017).
W.M. Keck Foundation Grant Reviewer (February – March 2017).
Swiss National Science Foundation Grant Review (October 2017)
AAAS. Secretary Dentistry and Oral Health Sciences (R) (2018-2022).
II. CLINICAL AND PATIENT CARE
1990-1992 Part Time Practice Limited to Periodontics in association with Dr. Richard
Barton, D.M.D. 1025 N. Providence Road. Media. Pennsylvania
1995-2000 Dental Faculty Associates. University of Michigan School of Dentistry
2000-2001 Oral Dermatology Clinic. University of Michigan Hospital
2002-Present Attending Periodontist. Ann Arbor Veteran’s Administration Medical Center
2004-2005 Medical Incident Report Task Force – Sierra Club of North America
III. CONTINUING EDUCATION:
October 1994: Periodontics Alumni Update: Osteoblasts and the Hematopoietic
Microenvironment. University of Michigan. Ann Arbor, MI.
January 1995: Current Issues in the Management of the Periodontal Patient. University of
Michigan. Ann Arbor, MI.
November 1996:Current Issues in the Management of the Periodontal Patient: HIV
Periodontitis. University of Michigan. Ann Arbor, MI.
November 1997: Current issues in Management of the Periodontal Patient. University of
Michigan. Ann Arbor, MI.
November 1998: Current issues in the Management of the Periodontal Patient HIV Disease.
University of Michigan. Ann Arbor, MI.
November 1998: Management of the Periodontal Patient with Systemic Diseases
University of Michigan. Ann Arbor, MI.
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Curriculum Vitae Russell S. Taichman
January 2000: Systemic Diseases and their Impact in Periodontics.
University of Michigan. Ann Arbor, MI.
April 2001: Oral Health, Systemic Health a Two Way Street.
Ohio State Post College Assembly. Columbus, OH.,
August 2002: Systemic Diseases and Periodontitis.
University of Michigan. Ann Arbor, MI..
April 2003: Systemic Health a Two Way Street.
University of Michigan. Ann Arbor, MI.
April 2004: Oral-Systemic Interactions in Periodontics.
University of Michigan. Ann Arbor, MI.
September 2006: Web Design for Dentists.
University of Michigan. Ann Arbor, MI.
April 2005: An Up Date: Systemic Disease and Periodontitis.
University of Michigan. Ann Arbor, MI.
March 2009: The Focal Infection Theory Revisited - The Ramfjord Symposium.
University of Michigan. Ann Arbor, MI.
IV. INVITED SEMINARS:
October 20, 1993. Invited Lecture Series. Osteoblasts and Their Role in Hematopoiesis. State
University of New York, Stony Brook NY. November 7, 1993.
HA Douglas Memorial Symposium. Effect of Diabetes on Periodontal Disease. Flint MI.
February 8, 1995.
Aastrom Biosciences. Invited Lecture Series. Hematopoiesis Supported by Osteoblasts. Ann Arbor, MI.
February 16, 1996.
Keystone Conference. Hematopoiesis Supported by Osteoblasts, Taos NM
January 15, 1997. Invited Lecture Series. Osteoblasts and hematopoiesis. Oral Health Sciences University of Michigan. Ann Arbor, MI.
May 1, 1997.
Invited Lecture Series. Osteoblasts and Their Functional Role in Hematopoiesis. University of Pennsylvania. Philadelphia PA.
June 9, 1997.
Invited Lecture Series. Osteoblasts and Hematopoiesis. University of Toronto. Toronto, Canada
February 5, 1999.
Invited Lecture Series. The Arctic, its Land and People. University of
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Curriculum Vitae Russell S. Taichman
Michigan. Michigan Materials Society Ann Arbor, MI. October 31, 1998.
Of Blood and Bones. American Blood Bank Society. Philadelphia, PA
April 15, 2000.
Bone Regeneration at the University of Michigan. Kaohsiung Dental College. Kaohsiung, Taiwan.
April 16, 2000.
Role of Osteoblasts in Hematopoietic Stem Cell Regulation. Republic of China (ROC) Dental Research Society Annual Meeting. Kaohsiung, Taiwan.
May 3, 2001.
Michigan Public Health Association. The link between gingival health and systemic health. Lansing MI.
October, 2002.
Osteoblasts and the Hematopoietic Microenvironment. Winship Cancer Institute, Emory University, Atlanta GA.
May 22, 2003
Bone and the Hematopoietic microenvironment in health and disease. University of Connecticut School of Dental Medicine, Farmington CT. International Symposium on Extracellular Matrix (SEMIC).
September 29, 2004. Osteoblasts And Stem Cell Regulation. Angra dos Reis, Brazil.
September 13, 2005.
Brown Cancer Center Keynote Address – Cancer Retreat. The Stem Cell Niche in Health and Disease. Brown Cancer Center. University of Louisville, Louisville, TN.
October 1, 2005.
Prostate Cancer Foundation. Tumors And Stem Cell Homing. Scottsdale, AZ.
November 28, 2005.
The Role Of Annexin II In Stem Cell Homing. Hematology/Oncology. Department of Internal Medicine. University of Michigan Medical School. Ann Arbor, MI.
December 5, 2005.
University of Michigan SPORE in Prostate Cancer. Polymorphism in CXCR4 and SDF-1 Leading To Prostate Cancer. Ann Arbor, MI.
February 28, 2006.
Homing Of Stem Cells to Tumors. University of Minnesota Cancer Center. Minneapolis MN.
May 20, 2006.
Symposium Cell-Cell- and Cell-Matrix-Interactions in Tumor Progression and Immunity. The Stem Cell Niche. Bamberg, Germany.
June 1, 2006.
The Stem Cell Niche In Health And Disease. National Institute of Dental and Craniofacial Research, Bethesda, MD.
October 12, 2007.
Paget’s Society Conference on Skeletal Complications of Metastatic
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Curriculum Vitae Russell S. Taichman
Disease. Metastatic Prostate Cancer As Parasites Of The Stem Cell Niche. Philadelphia. PA.
November 14, 2007.
Metastatic Prostate Cancer as Parasites of the niche. University of Delaware. Newark Delaware.
January 28, 2007.
PCa As Parasites Of The Hematopoietic Stem Cell Niche. Joint prostate cancer P01 meeting. Atlanta, Ga.
January 14, 2008.
PCa as a Parasite of the Niche. McGill Dental School. Montreal, Quebec.
March 6, 2008.
Niche Ecology - A Tail of Normal Residents and Parasites. Oral Health Sciences University of Michigan. Ann Arbor, MI.
March 14, 2008.
Molecular Mechanisms Of Tumor Parasitism Of The Stem Cell Niche. Brady School of Medicine. Greenville, NC.
April 15, 2008.
Invited Lecture Series. Metastatic PCa as Molecular Parasites of the HSC Niche. University of Maryland Dental School. Baltimore MD.
April 4, 2008.
Advances In Treating Metastatic Bone Cancer - Second Cambridge Conference. Biology Of Metastasis- Stem Cells Interactions With Bone. Cambridge, MA.
September 13, 2008. ASBMR Molecular Biology and Pathology Working Group. Modeling of the Hematopoietic Stem Cell Niche Under Basal and Diseased Conditions. Montreal, Quebec.
January 8, 2009.
National Institute of Dental and Craniofacial Research. Molecular Interactions In the Stem Cell Niche. Bethesda MD.
September 15, 2009.
The Hematopoietic Stem Cell Niche in Health and as a Target of Metastatic Disease. University of North Carolina, Chapel Hill, N.C.
October 1, 2009.
Prostate Cancer Targeting the Pre-Metastatic Niche in Bone. Karmanos Cancer Institute, Detroit, MI.
October 29, 2009.
Solid Tumors Target the Hematopoietic Stem Cell Niche for Metastasis. Cancer Associated Bone Disease Meeting. Washington, DC.
September 13, 2010.
The Metastasis Research Society and the American Association for Cancer Research. Solid Tumors Target the Stem Cell Niche During Metastasis. Philadelphia, PA.
November 12, 2010.
Prostate Cancers Target The Hematopoietic Stem Cell Niche During Metastasis.
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Curriculum Vitae Russell S. Taichman
Society for Basic Urologic Research Symposium: The Inflammation/Immunity Axis in Urologic Disease. Atlanta, GA.
April 27, 2011.
Prostate Cancers Target The Hematopoietic Stem Cell Niche During Metastasis. Outstanding Scientist Seminar Series. MD. Anderson Cancer Center. Houston. TX.
May 10, 2011. Prostate Cancers Target The Hematopoietic Stem Cell Niche During Metastasis. University of Rochester. Rochester, NY.
September 23, 2011.
Special Lecture: Prostate Cancer Targets The Hematopoietic Stem Cell Niche During Metastasis to Bone. Lake Tahoe, NV. Prostate Cancer Foundation.
November 5, 2011.
“The Hematopoietic Stem Cell Niche is the Target of Metastatic Cells from Solid Tumors. American Association for Cancer Research Conference on Tumor Microenvironment: Complexity and Emerging Roles in Cancer Therapy. Orlando, Florida.
December 1, 2011.
The Hematopoietic Stem Cell Niche is the Target of Metastatic Cells from Solid Tumors. 11th Annual Cancer-Induced Bone Disease Conference. IBMS and the Cancer and Bone Society (CABS). Chicago, IL
March 19, 2012. Engaging the Next Generation of Leaders in Oral Health: Innovative Models for Student Leadership Development. 2012 ADEA Annual Session & Exhibition, Orlando, Florida.
April 1, 2012.
Is There A Premetastatic Niche? 2012 AACR Meeting. Invited Seminar. Chicago IL.
April 19-20, 2012.
Keynote The stem cell niche in cancer metastasis & treatment. Session: The Hematopoietic Stem Cell Niche as a Mechanism to Induce Session Dormancy of Metastatic Cells from Solid Tumors. MSCs play a role in metastasis. Bonus 7 Bone and the Oncologist New Updates. Ottawa ON Canada
July 10, 2012. The bone marrow in health and disease. GHSU, Augusta Georgia. May 10, 2012.
Solid Tumors Target The Hematopoietic Stem Cell Niche For Metastasis. 1st Head & Neck Cancer Stem Cells. Ann Arbor MI.
October 30, 2012.
The Future of Clinical & Translational Research. Invited Seminar, UKMC Kansas City.
February 28, 2013.
The Role of the HSC niche in Dormancy. Workshop on Cancer Latency and
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Curriculum Vitae Russell S. Taichman
Dormancy: February 28-March 1, 2013 Arizona State University, March 7, 2013.
Multipotency of Human and Murine VSEL cell. Mountain View CA. NeoStem
April 7, 2013. April 17, 2013 August 5, 2013 October 4, 2013 October 9, 2013 October 13, 2013 November 8, 2013 November 21, 2013 February 13, 2014 April 23, 2014
Niche targeting: A mechanism for metastasis and dormancy. AACR, Washington D.C. Niche Parasitism - How Tumors Take Over The Bone Marrow. 14th Annual Yale Core Center for Musuloskeletal Disorders Research Day New Haven CT The HSC Niche Regulates Metastasis and Tumor Dormancy of Solid Tumors. 43rd Sun Valley Workshop: Musculoskeletal Biology. Sun Valley, ID Cancer cells and their Bone Marrow Niche. Greg Mundy Memorial Session: Malignancy and Bone. 2013 ASBMR Baltimore MD Parasitic invasion of the hematopoietic stem cell niche by solid tumors. Harvard School of Dental Medicine, Boston MA Molecular Mechanisms of Niche Parasitism by Solid Tumors. School of Dentistry, University of Utah, Salt Lake City, UT The HSC niche Regulates Metastasis and CSC Phenotype of Solid Tumors. 13th Cancer Induced Bone Disease (CIBD), Miami FL Disseminated Tumor Cells Hijack The Hematopoietic Stem Cell Niche. Department of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE Mechanisms of Prostate Cancer Dormancy in the Bone Marrow Niche. TMEN NCI Investigators Meeting, MD Anderson, Houston TX. VSEL Cells: From Regeneration to Metastasis. University of Louisville Cancer Center, Louisville TN.
October 29-30, 2014
Evaluation of Murine and Human VSEL Cells Ability to Regenerate Skeletal Defects, In Vitro and In Vivo. Novel Stem Cells and Vesicles Symposium, Providence Rhode Island
February 12, 2015 Parasitic interactions of DTCs in the HSC niche. Hem/Onc Research Conference, University of Michigan Medical School
February 27, 2015 Regulation of Disseminated Tumor Cell Fate by the Bone Marrow Niche The Tisch Cancer Center
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Curriculum Vitae Russell S. Taichman
Mount Sinai Medical Center, New York, NY.
March 5, 2015 Nature Vs. Nurture. The role of the niche in regulating DTCs. Spore in Prostate Cancer, University of Michigan Cancer Center
March 12, 2015
The challenges dental students face when they try to take a year off NSRG and AADR Member Stakeholder Relations Committee (MSRC)
May 10, 2015
Tumor Dormancy: Hematopoietic Stem Cell Niches Regulates Dormancy Society for Basic Urologic Research / The Society of Urologic Oncology (SBUR / SUO) Joint Session: Tumor Dormancy.
January 18-20, 2016 March 28-Apri1 1, 2016
Mechanisms of Prostate Cancer Dormancy NCI TMEN Steering Committee Meeting, Co-sponsored by Oregon Health & Science University, Portland Oregon. Niche Interactions in Regulating Metastatic Growth Cancer Pathophysiology: Integrating the Host and Tumor Environments (C3) Organizer(s) Sheila A. Stewart, Sandra S. McAllister and Lisa M. Cousens March 28—April 1, 2016 Beaver Run Resort • Breckenridge, Colorado USA
May 6, 2016 BI/CCC NextGen Technologies of Cancer Therapies Seed Fund Challenge Panel Discussant. Cancer Metabolomics. University of Michigan, Ann Arbor MI
May 25, 2016 Niche Interactions Regulating Metastatic Prostate Cancer Growth Center for Molecular Medicine and Genetics; Pathology Department. Wayne State University School of Medicine Detroit, MI 48201.
June 3, 2016 September 8, 2016 March 5, 2017 March 27, 2017
Mechanisms regulating the dormancy of DTCs. Keynote Lecture. Symposium of the DFG-FOR 2127 "Selection and adaptation during metastatic cancer progression" June 1-3, 2016. Herzogssaal, Regensburg, Germany. Planned as an in person presentation, delivered by SKYPE. Niche –DTC interactions in the HSC niche. Prostate Cancer Foundation Scientific Working Group Meeting for Radium Memorial Sloan Kettering Cancer Center New York, NY Identifying DTCs in marrow and how they become dormant. MultiSPORE in Prostate Cancer Retreat. Fort Lauderdale. Florida. Role of CXCL12gamma in Prostate Cancer Progression. Brady Research Institute, John Hopkins School of Medicine Baltimore MD.
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Curriculum Vitae Russell S. Taichman November 9, 2017 November 10, 2017 May 18, 2018 June 21, 2018
The stem cell niche and metastasis. ULAM Research Conference: University of Michigan Unit for Lab Animal Medicine University of Michigan School of Medicine, Ann Arbor ,MI. Finding Franklin – A Scientific And Personal Journey Into One Of The Greatest Mysteries of Arctic Exploration. MEND Research Conference University of Michigan School of Medicine, Ann Arbor ,MI. The future of Academic Dentistry. University of Connecticut School of Dental Medicine Farmington CT. Pathways regulating tumor dormancy by the hematopoietic stem cell niche AACR Conference: Cancer Dormancy and Residual Disease Montreal, Quebec, Canada.
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Curriculum Vitae Russell S. Taichman V. GRANT SUPPORT:
CURRENT/ACTIVE: 3P01CA093900-06 (PI: Keller) (PI Project 3: Taichman) The Biology of Prostate Cancer Skeletal Metastases Project 3: Regulation of the PCa Metastatic Phenotype by the HSC Niche 05/1/15-04/30/20 NIH/NCI Direct Cost Budget: 180,000/Yr 0.6 Cal Annual Direct Cost Budget: $138,381 Total Annual Budget: $212,707 Aim 1: Characterize the biology of CD133+/CD44+ DTC cells isolated from the marrow. Aim 2: Elucidate the mechanisms regulating the conversion of CD133-/CD44- into CD133+/CD44+ cells. Aim 3: Identify the extent to which DTCs in humans express CD133, CD44 and GAS6 receptors. Sponsor Contact Information: Dr. Suresh Mohla Chief, Tumor Biology and Metastasis Branch 6130 Executive Blvd., EPN 5038 Bethesda, MD 20892 (301) 435-1878 Phone (301) 480-0864 Fax [email protected] Targeting quiescence in prostate cancer PI: L. Buttitta, Co-PI: Taichman CDMRP, W81XWH-15-1-0413 8/28/2015-9/30/2018 Effort: 0.2 Cal. No Salary Support. $167,486/Total. Aim 1. Examine DTC quiescence using fluorescent cell cycle sensors in a xenograft model of prostate cancer metastasis, tumor dormancy and recurrence. Aim 2. Measure the effects of disrupting quiescence on cancer dormancy, recurrence and treatment outcomes. Sponsor Contact Information: Lance Nowell Contract Specialist US Army Medical Research Acquisition Activity Phone: 301-619-1357 Email: [email protected] 22
Curriculum Vitae Russell S. Taichman Sympathetic Nervous System Control of Disseminated Tumor Cell (DTCs) Dormancy PI: Taichman CDMRP/ DOD, PC140665 9/1/15-9/31/18 Effort: 0.3 Annual Direct Cost Budget: $121,587, Total Annual Cost Budget: $189,068 Aim 1: Delineate the role of SNS signaling in regulating the cell cycle status of DTCs in the niche. Aim 2: Determine the impact of adrenergic receptors on DTC retention in marrow. Aim 3: Establish the neural network of bone metastases in man. Sponsor Contact Information: Kenneth Grenier Contract Specialist US Army Medical Research Acquisition Activity Phone: 301-619-2728 Email: [email protected] Mechanisms of PCa Relapse in Marrow 2016CHAL1503 Prostate Cancer Foundation (Russell Taichman, PI) 07/01/2016 – 06/30/2019 Total Budget: $1,000,000 Direct. The aim of this project is to define the mechanisms that regulate DTC proliferation and ultimately relapse by comparing the biology of human DTCs with the emerging cancer model Drosophila melanogaster. Contact Information: Prostate Cancer Foundation Audrey Gardner [email protected] 310 570 4792
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Curriculum Vitae Russell S. Taichman
Prior Awards To Mentees w/o Effort. PI: Shiozawa 01/2012-01/2015 Young Investigator Award $225,000/Total Prostate Cancer Foundation Molecular dissection of the premetastatic niche in prostate cancer The goal of this project is to identify the molecular mechanisms of premetastatic niche constituted by
hematopoietic progenitor cells evicted from bone marrow hematopoietic stem cell niche in prostate cancer bone metastasis.
PI: Todd Morgan Young Investigator Award 01/2014-01/2017. Prostate Cancer Foundation $225,000/Total Defining the role of androgen receptor signaling in regulating c-MET through proteasome-
mediated degradation.
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Curriculum Vitae Russell S. Taichman
PAST SUPPORT:
“The Potential Role of Osteoblast Synthesized Growth Factors During Blood Formation.”
PI: Taichman 1992-1993 Biomedical Research Support Grant $5,000/Total School of
Dentistry, University of Michigan. “Role of the C-Raf-1 Proto-Oncogene in Mechanisms of Interleukin-2 Action.”
PI: Taichman 1993-1994 Dental Scientist Career Development Award Salary Support Veteran’s Administration Medical Center.
“Role of Osteoblast Synthesized Cytokines in Hematopoiesis.”
PI: Taichman 1993-1995 Rackham Grants and Fellowships $15,000/Total Rackham School of Graduate Studies, University of Michigan.
“Osteoblast/Hematopoietic Cell Adhesion Mechanisms”
PI: Taichman 6/3/96-6/1/97 University of Michigan Cancer Center $7,380/Total
“Development of Murine/Human Bone-Hematopoietic Cell Implant”
PI: Taichman 5/7/97-5/7/00 Center for Oral Health Rehabilitation $4,783/Total University of Michigan Dental School
“Stem Cell Adhesions to Osteoblasts"
PI: Taichman. 9/1/97-9/1/99 NIDCR RO3 DE12122 $50,000/Total
“Osteoblasts and the Hematopoietic Microenvironment.”
PI: Taichman 4/1/94 -4/1/01 NIDCR R29-DK48102 $350,000/Total
“CXCR4 and Prostate Cancer”
Project PI: Taichman 9/1/2001-9/1/2002 P30 PI: SA Goldstein. $30,000/Total Seed Award: Core Centers for Musculoskeletal Disorders NIH/NIAR Type: P30-AR46024
“Anabolic Mechanisms of PTH Action in Bone” PI: LK McCauley: Co-I: RS Taichman 08/01/98-07/31/02 NIH/NIDDK Type: R 01 DK53904 $200,000/Yr
“Hematogenous Metastasis of Prostate Cancer”
PI: Taichman 8/1/00-8/1/01 $45,000/Total
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Curriculum Vitae Russell S. Taichman
Seed Grant. University of Michigan SPORE in Prostate Cancer
“Molecular Mechanisms of Prostate Cancer Metastasis” PI: Taichman 8/1/01-8/1/04 Department of Defense IDEA Award $375,000/Total
“Bone & The Hematopoietic System” PI: Taichman 9/1/2001-8/31/2006 NIDCR R01 DE13701 $200,000/Yr
“Regulation of Metastatic Prostate Cancer by Annexin II (AX-II) & AXL/GAS6”
PI: Taichman 2/1/06-2/1/07 Prostate Cancer Foundation $100,000/Total
“Identifying Genetic Markers of Incident and Metastatic Prostate Cancer”
PI: Taichman 2/1/06-2/1/07 Co-PIs K Cooney, J Douglas, J Beebe-Dimmer. $50,000/Total P50 CA69568 SPORE in Prostate Cancer Pilot
“Molecular Profiles for Human Periodontal Diseases”
PI: Taichman 6/30/06-6/30/07 Delta Dental $27,536/Total
“Induction of Integrating NF-kB by P gingivalis LPS”
PI: CY Wang. 3/1/05-3/1/09 Co-PIs RS Taichman, WV Giannobile $159,480/Yr NIDCR R01 DE015973.
“Prostate Cancer Parasitism of the Stem Cell Niche”
PI: Taichman. 3/1/07-3/1/08 Prostate Cancer Foundation $99,935/Total
“Bone Marrow Stromal Cells (BMSCs) for Skeletal Regeneration.”
PI: Krebsbach, Co-PI: Taichman 9/1/2001- 8/31/2006 NIH/NIDCR R01 DE1385 (renewed in 2009) $175,000/Yr
“Mechanisms of Hematogenous Spread of Prostate Cancer to Bone”. PI Project 1: Taichman 12/1/2003-4/31/2009 Principal Investigator: Evan T. Keller, Ph.D. $157,000/Yr PO1-CA-93900 (Keller) (renewed in 2009)
“The Role of PGK1 in Prostate Cancer.”
PI: Taichman 3/1/08-2/15/10 Department of Defense PC060857 $125,000/Yr
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Curriculum Vitae Russell S. Taichman
“Hematopoietic Stem Cells Regulate the Osteogenic Phenotype in Metastatic Prostate Cancer.”
PI: Taichman 3/1/07-4/1/10 Department of Defense: PC073952 $124,444/Yr Type: IDEA Award
“Bone Marrow Microenvironmental Control of Prostate Cancer Skeletal Localization” McCauley (PI), Taichman (Co-I) 01/01/08 – 12/31/10 Department of Defense: $124,444/Yr Type: IDEA Award
“Integral role of hematopoietic cells in PTH actions in bone”
McCauley (PI), Taichman (Co-I) 09/01/08 – 08/31/10 NIH R21 $275,000/Total
“Repair of Bony Defects by Human Stem” 3/01/10-10/31/11 R43-AR056893-01A1 $70,001/Total
SBIR Phase I: Univ. MI PI: Taichman, Neostem Corp PI: Rodgerson
“Role of AXII/AXIIR in Myeloma Cell Lodgment and Mobilization in the Marrow.” PI: GD Roodman, University of Pittsburgh Agency 9/1/09-2/29/12 Co-I: Russell Taichman $200,000/Total NHLB R21 CA141426-02
“Mechanisms That Regulate Dormancy & Reactivation of Disseminated Tumor
Cells” PI: Taichman 6/1/11- 5/31/12
Fund for Cancer Research $75,000/Yr “The Use of Erythropoietin (Epo) to Reprogram Oral and Craniofacial Stem Cells”
1RC1DE020721-01 (PI: Taichman) 09/22/09-09/30/11 NIDCR $327,204/Yr
“Functional Characterization of the Stem Cell Niche”
R01DK082481-01A1 07/01/09 – 11/30/13 NIH (PI, Paul Krebsbach, Co-PI Taichman) $250,000/Yr
“Probing the CXCR6/CXCL 16 Axis: Targeting Prevention of the Prostate Cancer
Metastasis” R03 MH095589-01 (PI: Roth, Co-I Taichman) 9/01/11-8/31/13 NIH $10,000/Total
“The Biology of Prostate Cancer Skeletal Metastases+
2P01CA093900-06 (PI: Keller) (PI Project 2: Taichman) 05/1/09-04/30/14 NIH $173,564/Yr
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Curriculum Vitae Russell S. Taichman
“Mechanisms That Regulate Dormancy & Reactivation of Disseminated Tumor Cells” W81XWH-11-1-0636 (PC100829) (PI: Taichman) 9/30/11-10/29/14 Department of Defense $450,000/3 years “Finding Nessy: Unlocking the secrets of the dormant monster within its nest.” MCubed Research Program U036731 08/01/12-8/1/14PI: Taichman. Co PI: Buttitta and Morgan. $60,000 Total
“Osteoporosis Bone Regeneration Using Human VSEL Cells” W81XWH-11-1-0684 Neostem (University of MI PI: Taichman, Co-I McCauley) Department of Defense 04/01/11-11/30 Budget $237,765/yr “Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic Like (VSEL) Cells.” Neostem (PI: Rodgerson), U. Michigan (PI: Taichman, Co-I McCauley) 9 R44 DE022493-02 NIDCR 01/01/13-12/30/15 Total: $1,200,000 Total “Annexin II and clotting factors regulate hematopoietic stem cell homing & proliferation.” University of Michigan – Israel Partnership For Research. 04/01/14-4/1/16 Weizmann Institute. of Science (Co-PIs: Lapidont & Kollet) University of Michigan (PI: Taichman) $25,000 “Mechanisms Of Prostate Cancer Dormancy In The Bone Marrow Niche” 1U54CA163124-01 (Taichman) NIH/NCI 09/16/2011-07/31/2016 1.8 Calendar $166,667/Year Project Description: The global hypothesis of this TMEN application is that disseminated tumor cells (DTCs) target the hematopoietic stem cell (HSC) niche during metastasis. Once in the niche the niche regulates dormancy of DTCs. When DTCs are able to overcome the growth regulatory effects of the HSC niche, metastatic foci develop. Our TMEN addresses three fundamental gaps in our knowledge; how do CTCs/DTCS traffic to the bone (Project 1: Shiozawa, Pienta), become dormant (Project 2: Taichman, Krebsbach), and ultimately begin to proliferate.
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Curriculum Vitae Russell S. Taichman VI. PATENTS:
Hematopoietic cells: compositions and methods.
Abstract: Processes, compositions and uses of hematopoietic cells are disclosed. Hematopoietic cells are cells which can differentiate into mature blood cells when co-cultured with osteoblasts. Specifically, a process for propagating and maintaining the immature morphology of a hematopoietic cell by co-culturing with osteoblasts is disclosed. The osteoblasts provide cytokines and/or a microenvironment which propagates and maintains the immature morphology of a hematopoietic cell. Hematopoietic cells are useful in the treatment of certain blood related disorders and are useful for treatment of patients in need of hematopoietic cells.
CXCR4 Antagonists And Methods Of Their Use. Pub. No.:
WO/2004/087068 International App No.: PCT/US2004/009570
Publication Date: 14.10.2004 International Filing Date: 26.03.2004
IPC: A61K 38/00 (2006.01) Applicants: EMORY UNIVERSITY [US/US]; 1784 North Decatur Road, Suite 130, Atlanta, GA 30322 (US) (For All Designated States Except US) SHIM, Hyunsuk; (US) LIANG, Zhongxing; (US) UMBREIT, Jay; (US) TAICHMAN, Russell; (US) GOODMANN, Mark; (US)
Abstract: Compositions and methods for the treatment or prevention of a chemokine- related or chemokine-receptor-related pathology are provided. In one aspect, the pathology is cancer. It has been discovered that CXCR4 antagonists, in particular CXCR4 peptide antagonists such as TN14003, inhibit or reduce tumor metastasis in a host.
PCT Patent Application Serial No. PCT/US2012/032807 entitled "Autologous Human Adult Pluripotent Very Small Embryonic-Like (hVSEL) Stem Cell Regeneration of Bone Tissue and Cartilage" filed 04/09/12. Exclusive License NeoStem.Inc.
Inventors: Taichman; Russell S. (Ann Arbor, MI), Emerson; Stephen G. (Wayne, PA) Assignee: The Regent of the University of Michigan (Ann Arbor, MI) Appl. No. : 08/426,792 United States Patent No. 5,733,541. Filed: April 21, 1995 Award Date: March 31, 1998.
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Curriculum Vitae Russell S. Taichman
VII. F. Media Coverage 1. Undergrads explore dental careers by way of extraterrestrial relations
http://www.ns.umich.edu/new/releases/5211-undergrads-explore-dental-careers-by-way-of-extraterrestrial-relations Nov 24, 2003
2. Dental School Researcher Awarded $100,000 for Prostate Cancer Research
http://www.webdentistry.com/Article2484-fra.html
3. Neil A Andrews: Discovery of new role for calcium-sensing receptor strengthens link between formation of bone and formation of new blood cells BoneKEy-Osteovision (2006) 3, 5–7 (2006) doi:10.1138/20060201
4. Theresa A Guise. How metastases home to bone: The attraction of chemokines
5. BONEKEY-OSTEOVISION | COMMENTARY. Commentary on: Taichman RS, Cooper C, Keller ET, Pienta KJ, Taichman NS, McCauley LK. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 2002 Mar 15;62(6):1832-7.
6. Jim Erickson. U-M scientists win $6.8 million in federal stimulus-fund grants for stem cell research http://ns.umich.edu/new/releases/7377 Oct 26, 2009
7. NeoStem, Inc. Enters into SRA with University of Michigan; Funding from National Institutes of Health (NIH) Stem Cell Research Grant. http://careers.biospace.com/News/neostem-inc-enters-into-sra-with-university-of/172875. 3/4/2010
8. BoneKEy-Osteovision (2002) (2002) doi:10.1138/2002052Ryohichi Sugimura & Linheng L. iAffiliations Bone Metastasis Targets The Endosteal Hematopoietic Stem Cell Niche. Commentary on: Shiozawa Y, Pedersen EA, Havens AM, Jung Y, Mishra A, Joseph J, Kim JK, Patel LR, Ying C, Ziegler AM, Pienta MJ, Song J, Wang J, Loberg RD, Krebsbach PH, Pienta KJ, Taichman RS. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in marrow. IBMS BoneKEy (2011) 8, 381–384 (2011) doi:10.1138/20110526 August 2011.
9. Bailey University of Michigan Press Prostate cancer spreads to bones by overtaking the home of blood stem cells http://ns.umich.edu/new/releases/8319-prostate-cancer-spreads-to-bones-by-overtaking-the-home-of-blood-stem-cells
Mar 23, 2011
10. Laura Bailey University of Michigan Press. Cells culled from adults may grow human bone Apr 02, 2013 http://www.ns.umich.edu/new/releases/21346-cells-culled-from-adults-may-grow-human-bone
11. NeoStem Announces Receipt of Hellman Research Award by Academic Collaborator for VSEL(TM) Research. January 15, 2013 http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=379969
12. Laura Bailey University of Michigan Press. Decoded: Molecular messages that tell prostate and breast cancers to spread. http://www.ns.umich.edu/new/releases/21432-decoded-molecular-messages-that-tell-prostate-and-breast-cancers-to-spread
Apr 30, 2013.
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Curriculum Vitae Russell S. Taichman
13. NeoStem Receives Notification of $1.2 million NIH Grant Award for First Clinical Study of VSEL Technology in Humans. http://www.caladrius.com/press-release/neostem-receives-notification-of-1-2-million-nih-grant-award-for-first-clinical-study-of-vsel-technology-in-humans/ November 20, 2012
14. RUSSELL TAICHMAN - AUGUST 2012. AADR STRIDES IN SCIENCE http://www.iadr.org/AADR/About-Us/News/Strides-in-Science/ArtMID/134923/ArticleID/323/Russell-Taichman-August-2012
15. C Cheng Up date: Researchers Aim To Regrow Teeth Using Adult Cells http://www.counselheal.com/articles/4667/20130402/researchers-aim-regrow-teeth-using-adult-cells.htm. Apr 02, 2013
16. Very Small Embryonic-Like Stem Cells Grow Human Bone https://beyondthedish.wordpress.com/tag/russell-taichman/ April 16, 2013
17. November 20, 2012 A Bersenev, Is human VSEL stem cells a real thing? on APRIL 21, 2012 · 8 CORD BLOOD, OTHER ADULT STEM CELLS
18. Christine Gorman on July 25, 2013 Has Mariusz Ratajczak Found the Holy Grail of Stem Cells? Scientific American. https://blogs.scientificamerican.com/observations/has-mariusz-ratajczak-found-the-holy-grail-of-stem-cells/
19. Alison Abbott. Doubt cast over tiny stem cells. Studies refute the existence of very small embryonic-like cells endorsed by the Vatican. 24 July 2013 http://www.nature.com/news/doubt-cast-over-tiny-stem-cells-1.13435
20. Knoepfler P Stem Cell Blog /: https://ipscell.com/tag/russell-taichman/
Are VSELs the Sasquatch of the Stem Cell Field? July 24, 2013
21. A Bersenev A new turn in VSEL controversy. OPEN SCIENCE, OTHER ADULT STEM CELLS SEPTEMBER 21, 2013 http://stemcellassays.com/2013/07/vsel-controversy-new-turn/
22. Vatican-backed stem cell research gets $1.2 mln US grant https://medicalxpress.com/news/2013-09-vatican-backed-stem-cell-mln-grant.html#nRlv Vatican-backed stem cell research gets $1.2 mln US grant 9/13/2013
23. Cancer Latency and Dormancy .Arizona State University. February 27, 2013 – February 28, 2013 all-day http://cancer-insights.asu.edu/event/cancer-latency-and-dormancy-feb-28th-march-1st-tempe-az/
24. Sam Gringlas, University discovery may change way doctors treat cancer https://www.michigandaily.com/news/university-discovery-may-change-way-doctors-treat-cancer The Michigan Daily. May 3, 2013.
25. Meeting report from the 35th Annual Meeting of the American Society for Bone and Mineral Research, Baltimore, MD, USA, 4–7 October 2013 Cancer and bone disease (ASBMR 2013) IBMS BoneKEy 492 (2014) 22 January 2014 doi:10.1038/bonekey.2013.226
26. A Bersenev in Other Adult Stem cells VSEL controversy: Ratajczak’s response to criticism. https://www.michigandaily.com/news/university-discovery-may-change-
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way-doctors-treat-cancer May 3, 2013 yttp://stemcellassays.com/2013/09/vsel-controversy-ratajczaks-response-criticism/ Update on VSEL controversy. JANUARY 11, 2014 ·
27. Knoepfler lab stem cell blog. Wild History of VSELs Predicts Future of STAP Cells? https://ipscell.com/tag/vsel/ April 4, 2014
28. University of Michigan SOD, Johns Hopkins Team Receives PCF Funding https://www.dentalaegis.com/news/2014/10/31/University-of-Michigan-SOD-Johns-Hopkins-Team-Receives-PCF-Funding October 31, 2014
29. A Bersenev VSEL in translation APRIL 15, 2014 in CELL PRODUCT, OTHER ADULT STEM CELLS.
30. G Parker. First evidence that very small embryonic-like stem cells from human adult tissues are multipotent. https://phys.org/news/2014-04-evidence-small-embryonic-like-stem-cells.html April 1, 2014. Stem Cells and Development
31. A Bersenev Divesting of VSEL in OTHER ADULT STEM http://stemcellassays.com/2015/07/divesting-vsel-2/ JULY 9, 2015.
32. Post to Twitter Send Gmail Post to LinkedIn Meeting report from the IX international meeting on cancer induced bone disease IBMS BoneKEy 7, 32–46 20 May 2015 http://www.nature.com/bonekey/index.html
33. Dr. Russell Taichman receives $1 million grant for cancer research http://www.dent.umich.edu/news/2016/08/02/dr-russell-taichman-receives-1-million-grant-cancer-research#sthash.cM9WJacK.dpuf Aug. 2, 2016
34. http://www.dent.umich.edu/news/2016/08/02/dr-russell-taichman-receives-1-million-grant-cancer-research#sthash.cM9WJacK.dpbs
35. IN THE LAB: First Look: How jangled nerves could potentially trigger cancer relapse By MEGHANA KESHAVAN @megkesh DECEMBER 9, 2016. STAT (https://www.statnews.com/2016/12/09/cancer-relapse-bone-marrow/)
36. Professor's love of Arctic leads to new research. http://www.dent.umich.edu/news/2017/07/13/professors-love-arctic-leads-new-research#sthash.d7DR03ad.dpbs
37. A Dentist Weighs in On What Really Doomed the Franklin Expedition. Smithsonian.com. August 22, 2017.
http://www.smithsonianmag.com/science-nature/dentist-weighs-in-what-really-doomed-the-franklin-expedition-180964594/#HvP00rdWcJPIjRXL.99
38. Doomed 19th-Century Arctic Expedition Wasn't Brought Down by Lead Poisoning, Study Finds George Dvorsky 8/27/18.
https://gizmodo.com/doomed-19th-century-arctic-expedition-wasnt-brought-dow-1828632856
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VIII. PUBLICATIONS: R.S. Taichmnan Orcid ID: orcid.org/0000-0002-7890-0020 Scopus Author ID: 6701662790
A. Peer-Reviewed Basic and Clinical Research.
1. RS Taichman, T Torigoe, S Tanaka, T Miyashita, JC Reed . Gene transfer investigations of P56-LCK function in IL2-dependent T-cell lines: Implications for mechanisms of IL-2 -signal transduction. Cytokine 4:441-453, 1992. Pubmed #: 1292628.
2. RS Taichman, V Hauschka. The effects of interleukin-1ß and tumor necrosis factor-α on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. Inflammation 16:587-601, 1992. Pubmed #: 1459694.
3. RS Taichman, I Merida, T Torigoe, G Gaulton, JC Reed. The P56 Lck tyrosine kinase
activates and physically associates with the PI-3 kinase in T-cells during IL-2 signal transduction. J Biol Chem 268:20031-20036, 1993. Pubmed #: 8397196.
4. JC Reed, T Torigoe, BC Turner, I Merida, G Gaulton, HU Saragovi, RU Rapp and RS
Taichman. Proto-oncogene-encoded protein kinases in interleukin-2 signal transduction. Seminars in Immunology 5:327-336, 1993. Pubmed #: 8260649.
5. RS Taichman, T Torigoe, JC Reed. A strategy for constructing inducible expression
plasmids for T-lymphocytes. BioTechniques 14:180-182, 1993. Pubmed #: 8094284 6. T Torigoe, JA Millan, S Takayama, RS Taichman, T Miyashita, JC Reed. Bcl-2
inhibits T-cell-mediated cytolysis of a leukemia cell line. Cancer Res 54(18):4851-4, 1994. Pubmed #: 8069851
7. T Torigoe, JA Millan, KWH Chan, RS Taichman, AA Bram, JC Reed. Protein
tyrosine kinase p56-Lck regulates lymphocyte function-associated adhesion molecule expression, granule exocytosis, and cytocytoxic effector function in a cloned T cell. J Exp Med 180:1115-1127,1994. Pubmed #: 7914906
8. RS Taichman, SG Emerson. Human osteoblasts support hematopoiesis through the
production of granulocyte colony stimulating factor. J Exp Med 179:1677-1682, 1994. Pubmed #: 7513014
9. RS Taichman, SG Emerson. Human osteosarcoma cell lines MG-63 and SaOS-2
produce G-CSF and GM-CSF: Identification and partial characterization of cell-associated isoforms. Experimental Hematology 24:509-517, 1996. Pubmed #: 8608800
10. RS Taichman, MJ Reilly, SG Emerson. Human osteoblast support human
hematopoietic progenitor cells in in vitro bone marrow cultures. Blood 87:518-524, 1996. Pubmed #: 8555473
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Curriculum Vitae Russell S. Taichman
11. MR Nassiri, SG Emerson, LB Townsend, JC Drach, RS Taichman. Evaluation of a
potent inhibitor of human CMV replication, BDCRB, on human bone marrow colony formation and proliferation in vitro. British Journal Hematology 93:273-279, 1996. Pubmed #: 8639416
12. RS Taichman, MR Nassiri, MJ Reilly, SG Emerson, JC Drach. Infection and
replication of human cytomegalovirus in bone marrow stromal cells: effects on the production of IL-6, MIP-1α, and TGF-β1. Bone Marrow Transplantation 19:471-480, 1997. Pubmed #: 9052914
13. RS Taichman, MJ Reilly, SG Emerson. Augmented production of interleukin-6 by
normal human osteoblasts in response to CD34+ hematopoietic bone marrow cells in vitro. Blood 89:1165-1172, 1997. Pubmed #:9028938
14. RS Taichman, MJ Reilly, SG Emerson. Human osteosarcomas inhibit hematopoietic
colony formation: partial reversal by antibody to transforming growth factor-β1. Bone 21:353-361, 1997. Pubmed #: 9315339
15. T Takata, JA D’Errico, KB Atkins, JE Berry, CL Strayhorn, RS Taichman, MJ
Somerman. Protein extracts of dentin affect proliferation and differentiation of osteoprogenitor cells in vitro. J Periodontol 69:1247-1255, 1998. Pubmed #: 9848534
16. MR Nassiri, J Gilloteaux, RS Taichman, JC Drach. Ultrastructural aspects of
cytomegalovirus-infected stroma cells of human bone marrow. Tissue & Cell 30(4) 398-406. 1998. Pubmed #: 9787473
17. RS Taichman, MJ Reilly, SG Emerson. The hematopoietic microenvironment:
Osteoblasts and the hematopoietic microenvironment. Hematology 4:421-426. 2000. Pubmed #: 11399584
18. RS Taichman, MJ Reilly, LS Matthews. Human osteoblast-like cells and osteosarcoma
cell lines synthesize macrophage inhibitory protein-1α in response to interleukin-1ß and tumour necrosis factor-α stimulation in vitro. British Journal of Haematology. 108:275-283. 2000. Pubmed #: 10691855
19. TG Hullinger, RS Taichman, MJ Somerman. Secretory products from PC-3 and MCF-
7 tumor cell lines up-regulate osteopontin in MC3T3-E1 cells J. Cell Biochem 78:607-616. 2000.Pubmed #: 10861858
20. PG Eipers, S Skale, RS Taichman, GG Pipia, NA Swords, KG Mann, MW Long. Bone
marrow accessory cells regulate human bone precursor cell development. Experimental Hematology 28:815-825. 2000. Pubmed #: 10907643
21. RS Taichman, MJ Reilly, RS Verma, K Ehrenman, SG Emerson. Hepatocyte growth
factor is secreted by osteogenic cells and cooperatively supports hematopoiesis. British Journal of Haematology. 112(2):438-448, 2001. Pubmed #: 11167845
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Curriculum Vitae Russell S. Taichman
22. T Ponomaryov, A Peled, I Petit, RS Taichman, L Habler, J Sandbank, G Arenzana-Seisdedos, A Nagler, M Lahav, M Szyper-Kravitz, D Zipori, T Lapidot. Increased production of SDF-1 following treatment with DNA damaging agents: relevance for human stem cell homing and repopulation of NOD/SCID Mice. Journal of Clinical Investigation. 106(11):1331-1339, 2000. Pubmed #: 11104786
23. RS Taichman, C Cooper, ET Keller, KJ Pienta, NS Taichman, and LK McCauley.
Use of the Stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res 62: 1832-1837. 2002. Pubmed #: 11912162
24. I Petit, M Szyper-Kravitz, A Nagler, M Lahav, Peled A, L Habler, T Ponomaryov, S
Samira, RS Taichman, J Sandbank, D Zipori, T Lapidot. G-CSF induces stem cell mobilization by decreasing the chemokine SDF-1 and up regulating its receptor CXCR4 in the bone marrow. Nature Immunology 2002 3(7): 687-694. Pubmed #: 12068293
25. CR Cooper, CH Chay, JD Gendernalik, H-L Lee, J Bhatia, RS Taichman, LK
McCauley, ET Keller, and KJ Pienta. Stromal factors involved in prostate cancer metastasis to the bone. cancer 2003. (Supplement Feb 1) p739-747, Pubmed #: 12548571
26. Y-X Sun, J Wang, CE Shelburne, DE Lopatin, AM Chinnaiyan, KJ Pienta, MA
Rubin, RS Taichman. The expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. J Cell Biochem. 2003 (89) 462-473. Pubmed #: 12761880
27. A Havens, Y-X Sun, G Heresi, RS Taichman. The Role of CD164 in metastatic
cancer. University of Michigan Research Forum Fall Inaugural Issue. 2003 (1) 20-24. 28. SM Crean, JP Meneski, TG Hullinger, MJ Reilly, EH De Boever, RS Taichman. N-
Linked sialyated sugar receptors support hematopoietic cell-osteoblast adhesions. British Journal of Haematology, 2004: 124(4):534-546. Pubmed #: 14984505
29. J Dai, Y Kitagawa, J Zhang, J Yao, A Mizokami, S Cheng, J Nor, LK McCauley, RS
Taichman, ET Keller. Vascular endothelial growth factor contributes to the prostate cancer-induced osteoblast differentiation mediated by bone morphogenetic protein. Cancer Res 2004 64 (3): 994-999. Pubmed #: 14871830
30. Z Liang, T Wu, H Lou, X Yu, RS Taichman, S Lau, S Nie, J Umbreit and H Shim.
Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4 chemokine receptor. Cancer Res 2004. 64(12):4302-8. Pubmed #: 15205345
31. Y-X Sun, A Schneider, Y Jung, JH Wang, J Dai, J Wang, K Cook, NI Ishag-Osman,
Z Liang, AJ Koh-Paige, H Shim, KJ Pienta, ET Keller, LK McCauley, and RS Taichman. Use of the skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo. J Bone Miner Res. 2005 20(2):318-29. Pubmed #: 15647826
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Curriculum Vitae Russell S. Taichman
32. GA Heresi, J Wang, RS Taichman, JA Chirinos, JJ Regalado, DM Lichtstein, JD
Rosenblatt Expression of the chemokine receptor CCR7 in prostate cancer presenting with generalized lymphadenopathy: Report of a case, review of the literature and analysis of chemokine receptor expression Urologic Oncology: Seminars and Original Investigations 2005 23:261–267. Pubmed #: 16018941
33. JH Wang, J Wang, Y-X Sun, W Song, J Nor, CY Wang, and RS Taichman.
Signaling through SDF-1/CXCR4 in prostate cancer cell lines leads to altered patterns of cytokine secretion & angiogenesis. Cellular Signaling. 2005. 17; 1578-1592. Pubmed #: 16005185
34. S Miwa, A Mizokami, ET Keller, RS Taichman, J Zhang, M Namiki. The
bisphosphonate YM529 inhibits osteolytic and osteoblastic changes and CXCR-4-induced invasion in prostate cancer. Cancer Res. 2005; 65:8818-8825. Pubmed #: 16204052
35. H Zhang, JK Kim, CA Edwards, Z Xu, RS Taichman R, CY Wang. Clusterin inhibits apoptosis by interacting with activated Bax. Nature Cell Biology. 2005 Sep;7(9):909-15. Pubmed #: 16113678
36. AJ Koh, B Demiralp, K Neiva, J Hooten, RM Nohutcu, H Shim, NS Datta, RS Taichman, and LK McCauley. Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in bone. Endocrinology. 2005 Nov; 146(11):4584-96. Pubmed #: 16081645
37. Y Jung, J Wang, A Havens, Y Sun, J Wang, T Jin, RS Taichman. Cell–to-cell contact
is critical for the survival of hematopoietic progenitor cells on osteoblasts. Cytokine. 2005 Nov;32(3-4):155-62. Pubmed #: 16256361
38. Y Jung, J Wang, A Schneider, YX Sun, AJ Koh-Paige, NI Osman, LK McCauley, RS
Taichman. Regulation of SDF-1 (CXCL12) production by osteoblasts in the hematopoietic microenvironment and a possible mechanisms for stem cell homing. Bone. 2006 Apr;38(4):497-508. Pubmed #: 16337237
39. J Wang, W Song, RS Taichman, PH Krebsbach. Osteogenesis study of 5-
flurouracil-enriched bone marrow osteoprogenitor cells. Stem Cells. 2006 24(6):1573-82. Pubmed #: 16769762
40. M da Conceição Pereira Saraiva, RS Taichman, T Braun, J Nriagu, SA Eklund, BA
Burt. Lead exposure and periodontitis in US adults. J Periodontal Res. 2007 Feb;42(1):45-52. Pubmed #: 17214639
41. AM Havens, Y Jung, Y-X Sun, J Wang, JR. Shah, HJ Bühring, KJ Pienta and RS
Taichman. The role of sialomucin CD164 (MGC-24v or Endolyn) in Prostate Cancer. BMC Cancer. 2006 6:195. Pubmed #: 16859559
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Curriculum Vitae Russell S. Taichman
42. Y-X Sun, M Fang, JH Wang, CR Cooper, KJ Pienta, RS Taichman. expression and activation of αvβ3 Integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells. The Prostate. (2007) 67: 61-73. Pubmed #: 17034033
43. J Zhu, R Garrett, Y Jung, Y Zhang, N Kim, J Wang, GJ Joe, E Hexner, Y Choi, RS
Taichman, and SG Emerson. Osteoblasts support B lymphocyte commitment and differentiation from hematopoietic stem cells published online 16 January 2007, 10.1182/blood-2006-08-041384. Pubmed #: 17227831
44. J Wang, J Wang, J Dai, Y Jung, C-L Wei, Y Wang, A Havens, PJ Hogg, ET Keller,
KJ Pienta, JE Nor, CY Wang, RS Taichman. A glycolytic mechanism regulating an angiogenic switch cancer research 2007 Jan 1;67(1):149-59. Pubmed #: 17210694
45. Y Jung, J Wang, J Song, Y Shiozawa, J Wang, A Havens, Z Wang, YX Sun, SG
Emerson, PH Krebsbach and RS Taichman. Annexin II expressed by osteoblasts & endothelial cells regulates stem cell adhesion, homing & engraftment following transplantation. Blood, 2007 Jul 1;110(1):82-90. Pubmed #: 17360942
46. AH Havens, E Chiu, M Taba Jr., J Wang, Y Shiozawa, Y Jung, LS Taichman, NJ
D’Silva, R Gopalakrishnan, CY Wang, WV Giannobile, RS Taichman. Stromal derived factor-1α (CXCL12) levels increase in periodontal disease. J Periodontol. 2008 May; 79 (5):845-853. Pubmed #: 18454663.
47. JH Wang, Y Shiozawa, J Wang, Y Wang, Y Jung, KJ Pienta, R Medra, R Loberg, RS
Taichman. The role of RDC1 as a chemokine receptor for CXCL12 (SDF-1) in prostate cancer. J Biol Chem. 2008 Feb 15; 283(7):4283-94. Epub 2007 Dec 5. Pubmed #: 18057003.
48. Lu Y, JH Wang, Y Xu, AE Koch, Z Cai, X Chen, DL Galson, RS Taichman, J
Zhang. CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro. Mol Cancer Res. 2008 Apr; 6(4):546-54. Epub 2008 Mar 14. Pubmed #:18344492.
49. AM Havens, EA Pederson, Y Shiozawa, C Ying, Y Jung, Y Sun, C Neeley, J Wang,
R Mehra, ET Keller, LK McCauley, RD Loberg, KJ Pienta, RS Taichman. An in vivo mouse model for human prostate cancer metastasis. Neoplasia. 2008 Apr; 10 (4):371-80. Pubmed #:18392141
50. Y Shiozawa, AM Havens, KJ Pienta, RS Taichman. The bone marrow niche: habitat
to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites. Leukemia. 2008 May; 22(5):941-50. Epub 2008 Feb 28. Pubmed #: 18305549
51. Y Shiozawa, AM Havens, Y Jung, AM Ziegler, EA Pederson, J Wang, G Lu, GD
Roodman, RD Loberg, K Pienta, RS. Taichman. Annexin II regulates prostate cancer metastasis. J Cell Biochem. 2008 Oct 1;105(2):370-80. Pubmed 18636554
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Curriculum Vitae Russell S. Taichman
52. Y Jung, J Song, Y Shiozawa, J Wang, Z Wang, B Williams, A Havens, A Schneider, LK McCauley, PH Krebsbach, RS Taichman. Hematopoietic stem cells regulate development of their niche. Stem Cells. 2008 Aug;26(8):2042-51. Epub 2008 May 22. PMID: 18499897.
53. YX Sun, EA Pedersen, Y Shiozawa, A Havens, J Wang, J Wang, KJ. Pienta. RS
Taichman. CD26/Dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12. Clinical Experimental Metastasis, 2008;25(7):765-76. Epub 2008 Jun 18. Pubmed #: 18563594
54. J Wang, Yi Lu, J Wang, AE Koch, J Zhang, RS Taichman. CXCR6 induced prostate
cancer progression by The AKT/mTOR signaling pathway. Cancer Res. 2008 Dec 15;68(24):10367-76. PMID: 19074906
55. AY Hsiao, Y Torisawa, Y-C Tung, S Sud, RS Taichman, KJ Pienta, S Takayama.
Microscale system for formation of PC-3 Prostate cancer co-culture spheroids. Biomaterials. 2009 Jun;30(16):3020-7. Epub 2009 Mar 21. PMID: 19304321. PMCID: PMC2675053
56. J Gao, S Graves, U Koch, S Liu, V Jankovic, S Buonamici, A El Andaloussi, SD
Nimer, B Kee, R Taichman, S Nimer, F Radtke, I Aifantis. Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell. 2009 Jun 5;4(6):548-58. PMID: 19497283. PMCID: PMC2914688.
57. D. Zieker, I. Königsrainer, I. Tritschler, S Beckert, F. Traub, K. Nieselt, S. Bühler, M.
Löffler, M. Hauth, M. Weller, RS. Taichman, H. Northoff, B. L.D.M.Brücher, A. Königsrainer. PGK1 a promoting enzyme for peritoneal dissemination in gastric cancer. International Journal of Cancer. 126(6):1513-20, 2010 PMID: 19688824. PMCID: PMC2811232.
58. Y Jung, Y Shiozawa, J Wang, Jingcheng Wang, Z Wang, EA Pedersen, CH Lee, CL
Hall, PJ Hogg, PH Krebsbach, ET Keller RS Taichman. Expression of PGK1 by prostate cancer cells induces bone formation. Molecular Cancer Research: MCR. 7(10):1595-604, 2009 Oct. PMID: 19825988. PMCID: PMC2771860
59. J Song, MJ Kiel,, Z Wang, RS Taichman, SJ Morrison, PH Krebsbach An In vivo
model to study the hematopoietic stem cell niche Blood. 2010 Apr 1;115(13):2592-600. PMID: 20110425. PMCID: PMC2852363.
60. Y Shiozawa, EA Pedersen, AM Ziegler, AM Havens, Y Jung, J Wang, S Zalucha, RD
Loberg, KJ Pienta, RS Taichman. GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. Neoplasia (2010) 12, 116–127. PMID: 20126470. PMCID: PMC2814350.
61. Y Shiozawa, EA. Pedersen and RS Taichman. GAS6/Mer axis regulates the homing
and survival of the E2A/PBX1 positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp Hematol. 2009 Nov 14. [Epub ahead of print] PMID: 19922767. PMCID: PMC2815170.
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Curriculum Vitae Russell S. Taichman
62. J Wang, G Ying, J Wang, Y Jung, J Lu, J Zhu, KJ Pienta, RS Taichman.
Characterization of PGK1 expression by stromal cells derived from the tumor microenvironment in prostate cancer progression. Cancer Research. 70(2):471-80, 2010. PMID: 20068185. NIHMSID # 285306 PMCID: PMC3086494.
63. RS Taichman, Z Wang, Y Shiozawa, Y Jung, J Song, A Balduino, J Wang, AM
Havens, M Kucia, MZ. Ratajczak, PH Krebsbach. Prospective identification and skeletal localization of mesenchymal stem cells capable of multi-lineage differentiation in vivo. Stem Cells Dev. 2010 Oct;19(10):1557-70. PMID: 20446812. PMCID: PMC3089003.
64. Y Shiozawa, Y Jung, AM Ziegler, EA. Pedersen, Z Wang, J Song, J Wang, S Sud, KJ
Pienta, PH Krebsbach, RS Taichman. Erythropoietin couples hematopoiesis with bone formation. PLoS One. 2010 May 27;5(5):e10853.PMID: 20523730. PMCID: PMC2877712.
65. Jung, Y Shiozawa, J Wang, LR Patel, AM. Havens, J Song, PH. Krebsbach, GD
Roodman RS Taichman. Annexin 2 is a regulator of SDF-1/CXCL12 function in the hematopoietic stem cell endosteal niche. Exp Hematol. 2011 Feb;39(2):151-166.e1. Epub 2010 Nov 22. PMID: 21108988. PMCID: PMC3026087.
66. S Liu, C Ginestier, SJ Ou, SG. Clouthier, S Patel, F Monville, H Korkaya, A Heath, J
Dutcher, C Kleer, Y Jung, G Dontu, RS Taichman, MS. Wicha. Mesenchymal stem cells regulate breast cancer stem cells defining a cancer stem cell niche. Cancer Res. 2011 Jan 15;71(2):614-24. Epub 2011 Jan 11. PMID: 21224357. PMCID: PMC3100554.
67. Y Shiozawa, EA Pedersen, AM Havens, Y Jung, AM Ziegler, M J Pienta, J Song, J
Wang, RD Loberg, PH. Krebsbach, KJ Pienta, RS Taichman. Metastases target the hematopoietic stem cell niche to establish footholds in bone. J. Clinical Investigation, 2011:121(4) 1298-1312. PMID: 21436587. PMCID: PMC3069764.
68. CM. Novince, AJ. Koh, MN. Michalski, JT. Marchesan, J Wang, Y Jung, JE. Berry,
MR. Eber, TJ. Rosol, RS. Taichman, Laurie K. McCauley. Proteoglycan 4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells. Am J Pathol. 2011 Nov;179(5):2431-42. Epub 2011 Sep 21.PMID:21939632. PMCID: PMC3204095.
69. J Kim, Y Jung, H Sun, J Joseph, A Mishra, Y Shiozawa, J Wang, P Krebsbach, RS
Taichman. Erythropoietin mediated bone formation is regulated by mTor signaling J Cell Biochem. 2012 Jan;113(1):220-8. doi: 10.1002/jcb.23347. PMID:21898543. PMCID: PMC3237787.
70. AJ Koh, CM Novince, X Li, T Wang, RS Taichman, LK McCauley. An irradiation
altered bone marrow microenvironment impacts anabolic actions of PTH. Endocrinology. 2011 Dec;152(12):4525-36. Epub 2011 Nov 1. PMID:22045660. PMCID: PMC3230047.
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Curriculum Vitae Russell S. Taichman
71. S D’Souza, N Kurihara, Y Shiozawa, RS Taichman, DL. Galson, G. D Roodman.
Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment. Blood. 2012 Feb 23;119(8):1888-96. Epub 2012 Jan 5. PMID: 22223826. PMCID: PMC3293642.
72. J Joseph, Y Shiozawa, Y Jung, JK Kim, E Pedersen, A Mishra, J Wang, ET. Keller,
KJ. Pienta, RS Taichman. Disseminated Prostate Cancer Cells Have The Ability To Instruct Hematopoietic Stem and Progenitor Cells To Regulate Bone Phenotype. Mol Cancer Res. 2012 Mar;10(3):282-92. Epub 2012 Jan 12. PMID:22241219. PMCID: PMC3307952.
73. A Mishra, J Wang, Y Shiozawa, S McGee, J Kim, Y Jung, J Joseph, A Havens, KJ
Pienta, RS. Taichman. Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer. Cells Mol Cancer Res. 2012 Jun;10(6):703-12. Epub 2012 Apr 19. PMCID: PMC3378814.
74. Y Jung, Y Shiozawa, J Wang, N McGregor, J Dai, SI Park, AM Havens, J Joseph, JK
Kim, L Patel, P Carmeliet, S Daignault, ET Keller, LK McCauley, KJ. Pienta & RS Taichman. Prevalence of Prostate Cancer Metastases Following Intravenous Inoculation Provides Clues into the Molecular Basis of Dormancy in the Bone Marrow Microenvironment. Neoplasia. 2012 May;14(5):429-39. PMID: 22745589. PMCID: PMC3384430.
75. HL Sun, Y Jung, Y Shiozawa, RS Taichman, PH Krebsbach. Erythropoietin
Modulates the Structure of Bone Morphogenetic Protein 2-Engineered Bone. Tissue Eng Part A. 2012 Jun 16. [Epub ahead of print] PMID: 22703029. PMCID: PMC3463277.
76. A Balduino, VM Coelho, Z Wang, RS Taichman, PH Krebsbach, AT Weeraratna,
KG Becker, R Borojevic. Molecular Signature and In Vivo Behavior of Bone Marrow Endosteal and Subendosteal Stromal Cell Populations and their Relevance to Hematopoiesis Exp Cell Res. 2012 Nov 15;318(19):2427-37. PMID: 22841688. PMCID: PMC3445703.
77. C.M. Novince, P. Entezami, C.G Wilson, J. Wang , A.J. Koh , M.N. Michalski, B.P.
Sinder, K.M. Kozloff, R.S. Taichman, M.L. Warman, L.K. McCauley. The impact of proteoglycan-4 and parathyroid hormone on articular cartilage degeneration (In Press: J. Orthopaedic Res). PMID: 22898906. PMCID: PMC3502647.
78. FN Soki, X Li, J Berry, A Koh, BP. Sinder, X Qian, KM Kozloff, RS Taichman LK
McCauley. The effects of zoledronic acid in the bone and vasculature support of hematopoietic stem cell niches. J Cell Biochem. 2013 Jan;114(1):67-78. PMID: 22833499. PMCID: PMC3593195.
79. AM Havens, Y Shiozawa, Y Jung, H Sun, J Wang, S McGee, A Mishtra, LS
Taichman, T Danciu, Y Jiang, G Yavanian, E Leary, PH Krebsbach, D Rodgerson, RS Taichman. Human Very Small Embryonic-Like (VSEL) Cells Generate Skeletal
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Curriculum Vitae Russell S. Taichman
Structures, In Vivo. Stem Cells Dev. 2012 Sep 28. PMID: 23020187. PMCID: PMC3564465.
80. Holoshitz J1, Liu Y, Fu J, Joseph J, Ling S, Colletta A, Sharma P, Begun D,
Goldstein S, RS Taichman An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity. J Immunol. 2013 Jan 1;190(1):48-57. doi: 10.4049/jimmunol.1202150. Epub 2012 Nov 23. PMCID: PMC3529776
81. P Katarzyna, SJ Borkowska, B Wiszniewska, M Laszczyńska, S Słuczanowska-
Głąbowska Sylwia, M Kucia, JJ. Kopchick, A Bartke, AM Havens, RS Taichman and MZ Ratajczak. The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs—studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice. J. Histology and Histopathology. 2013 April 24 PMID: 23613169. PMCID: PMC3988530
82. Y Jung, JK Kim, Y Shiozawa, J Wang, A Mishra, J Joseph, H Sun, J Wang, T Jin, H
Zhang, PH Krebsbach, ET Keller, KJ Pienta, RS Taichman. CXCL16/CXCR6 Signaling Promotes Prostate Cancer Metastasis by Recruiting and Converting Mesenchymal Stem Cells into Cancer-Associated Fibroblasts. Nature Communications | 4:1795 | DOI: 10.1038/ncomms2766. April 30, 2012. PMID: 23653207. PMCID: PMC3649763.
83. RS. Taichman, LR. Patel, R Bedenis, J Wang, S Weidner, T Schumann, Y Shiozawa, KJ Pienta. GAS6 Receptor Status Is Associated With Dormancy And Bone Metastatic Tumor Formation. Plos One April 2013 | Volume 8 | Issue 4 | e61873. PMID: 23637920. PMCID: PMC3634826.
84. Y Shiozawa, S McGee, M Pienta, N McGregor, Y Jung, K Yumoto, J Wang, J
Berry, K Pienta, RS Taichman. Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis. J Cell Biochem. 2013 May 20. doi: 10.1002/jcb.24592. [Epub ahead of print]. PMID: 23696192. PMCID: PMC3978144.
85. JK Kim, Y Jung, J Wang, J Joseph, A Mishra, EE Hill, PH Krebsbach, KJ Pienta, Y
Shiozawa, RS Taichman. TBK1 Regulates Prostate Cancer Dormancy through mTOR Inhibition. Neoplasia. 2013 Sep;15(9):1064-74. PMID: 24027431 PMCID: PMC3769885.
86. K Yumoto, JE Berry, RS. Taichman, Y Shiozawa. A novel method for monitoring
tumor dormancy using fluorescent dye DiD. Cytometry A. 2014 Jun;85(6):548-55. doi: 10.1002/cyto.a.22434. Epub 2014 Apr 3. PMID: 24700602. (Pubmed in process). PMCID: PMC4143457.
87. AM Havens, H Sun, Y Shiozawa, Y Jung, J Wang, A Mishra, Y Jiang, DW O’Neill,
PH Krebsbach, DO. Rodgerson, RS. Taichman. Human and Murine Very Small Embryonic-Like (VSEL) Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo. Stem Cells Dev. 2014 Apr 1;23(7):689-701. doi: 10.1089/scd.2013.0362. Epub 2014 Feb 4. PMID: 24372153. PMCID:PMC3967374. [Available on 2015/4/1]
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Curriculum Vitae Russell S. Taichman
88. CP Soves, JD Miller, DL Begun, RS Taichman, KD Hankenson, SA Goldstein.
Megakaryocytes are mechanically responsive and influence osteoblast proliferation and differentiation. (Bone, In Press). 2014 May 29. pii: S8756-3282(14)00190-2. doi: 10.1016/j.bone.2014.05.015. [Epub ahead of print] PMID: 24882736. PMCID: PMC4125454. [Available on 2015/9/1]
89. S Krishnamurthy, KA. Meyers, Z Dong, A Imai, BB. Ward, JI. Helman, RS
Taichman, E Light, LK. McCauley, PJ. Polverini, ME. Prince, MS. Wicha, JE. Nör. Endothelial interleukin-6 defines the tumorigenic potential of primary human cancer stem cells. Stem Cells. 2015. 32:2845-2857. PMID: 25078284. PMCID: PMC4198458 [Available on 2015/11/1].
90. Y Jung, J Wang, E Lee, S McGee, JE Berry, K Yumoto, J Dai, ET Keller, Y Shiozawa, RS Taichman. Annexin 2-CXCL12 Interactions Regulate Prostate Cancer Growth in the Bone Marrow. Mol Cancer Res. 2015 Jan;13(1):197-207. doi: 10.1158/1541-7786.MCR-14-0118. Epub 2014 Aug 19. PMCID: PMC4297714 [Available on 2016-01-01]
91. C Li, C Shi, Y Chen, S Ni, L Jiang, J Hou , J Kim, C Zheng, RS Taichman, H Sun.
Roles of erythropoietin in bone regeneration through ephrinB2/Eph4 signal pathway (In Press, J. Dental Research). J Dent Res. 2015 Mar;94(3):455-63. doi: 10.1177/0022034514566431. Epub 2015 Jan 13. PMCID: PMC4336159
92. FP Seib, JE Berry, Y Shiozawa, RS Taichman, DL Kaplan. Tissue engineering a surrogate niche for metastatic cancer cells. Biomaterials 2015 May;51:313-9. doi: 10.1016/j.biomaterials.2015.01.076. Epub 2015 Mar 4.PMID: 25771021 PMCID: PMC4367489 [Available on 2016-05-01]
93. J.L. Zalucha, Y. Jung, J. Joseph, J. Wang, J.E. Berry, Y. Shiozawa, and R.S. Taichman. The Role of Osteoclasts in Early Dissemination of Prostate Cancer Tumor Cells J Cancer Stem Cell Res. 2015; 3: e1005. PMCID: PMC4469294
94. Y Qiao, F Feng, Y Wang, X Cao, S Han, K Wilder-Romans, N Navone, C Logothetis, RS Taichman, ET Keller, G Palapattu, A Alva, D Smith, S Tomlins, T Morgan, A Chinnaiyan. Mechanistic support for combined MET and AR blockade in castration-resistant prostate cancer. Neoplasia. 2016 Jan;18(1):1-9. doi: 10.1016/j.neo.2015.11.009. PMCID: PMC4735600
95. Y Jung, AM Decker, J Wang, El Lee, LA Kana, K Yumoto, F Cackowski, J Rhee, P
Carmeliet, L Buttitta, TM Morgan, and RS. Taichman. Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow. Oncotarget 2016 Mar 25. doi: 10.18632/oncotarget.8365. [Epub ahead of print] PMCID: PMC5041937
96. Y Shiozawa, JE. Berry, MR. Eber, Y Jung , K Yumoto , FC. Cackowski , HJ Yoon, P Parsana, R Mehra, J Wang, S McGee, E Lee, S Nagrath , KJ. Pienta , RS. Taichman.
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Curriculum Vitae Russell S. Taichman
The Marrow Niche Controls The Cancer Stem Cell Phenotype Of Disseminated Prostate Cancer. Oncotarget. 2016 Mar 25. doi: 10.18632/oncotarget.8365. PMCID: PMC5173053
97. E Lee, AM. Decker, FC Cackowski, LA Kana1, L Yumoto, Y Jung, J Wang, L
Buttitta, TM Morgan and RS Taichman. Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G1 Arrest/S Phase Delay and Inhibition of Apoptotic Pathway During Chemotherapy in Bone Marrow. J. Cellular Biology J Cell Biochem. 2016 May 5. doi: 10.1002/jcb.25582. [Epub ahead of print] PMCID: PMC5031902.
98. E Lee, J Wang, K Yumoto, Y Jung, FC. Cackowski, KJ Pienta, and RS. Taichman. DNMT1 Participates in the Primary Prostate Cancer Metastasis by Associating with Epithelial-Mesenchymal Transition and Cancer Stem Cells. Neoplasia. 2016 Sep; 18(9): 553–566. doi: 10.1016/j.neo.2016.07.007 PMCID: PMC5031902
99. D Collins, K Mulka, M Hoenerhoff, RS. Taichman, J Villano. Clinical Scoring System Accurately Identifies Estrogen Supplementation. Comparative Medicine Comp Med. 2017 Feb 1;67(1):11-21.PMID: 28222835
100. K. Yumoto, MR Eber, J Wang, FC Cackowski, E Lee, AR Nobre, JA Aguiree-Ghiso, Y Jung, RS. Taichman. Axl is required for TGF-ß2-induced dormancy of prostate cancer cells in the bone marrow. Scientific Reports. 2016 Nov 7;6:36520. doi: 10.1038/srep36520. PMID: 27819283 PMCID: PMC5098246
101. F Cackowski, MR. Eber, J Rhee, K Yumoto, A Decker, JE. Berry, A Pearson, Y
Shiozawa, Y Jung, JA. Aguirre-Ghiso, and RS. Taichman. Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cell Dormancy. J Cellular Biochemistry. 2016 Oct 18. doi: 10.1002/jcb.25768. [Epub ahead of print] PMID: 27753136. PMCID: PMC5296338
102. A.M. Decker, Y. Jung, F.C. Cackowski1, K. Yumoto, J. Wang, R.S. Taichman.
Sympathetic Signaling Reactivates Quiescent Disseminated Prostate Cancer Cells in the Bone Marrow. Mol Cancer Res. 2017 Aug 16. pii: molcanres.0132.2017. doi: 10.1158/1541-7786.MCR-17-0132. [Epub ahead of print]. PMCID: PMC5712273
103. EL Lee, J Wang, Y Jung, FC Cackowsk, RS Taichman. Reduction of Histone
Marks, H3K9me3 and H3K27me3 by Epidrug Induces Neuroendocrine Differentiation in Prostate Cancer J. Cell. Biochem.,2018. DOI: 10.1002/jcb.26586
104. Y Jung, FC Cackowski, K Yumoto, AM. Decker, J Wang, JK Kim, E Lee, Y Wang,
JS Chung, AM. Gursky, PH Krebsbach, KJ Pienta, TM Morgan, and RS Taichman. CXCL12γ promotes development of metastatic castration resistant prostate cancer by induction of cancer stem cell and neuroendocrine phenotypes. Cancer Res; 78(8) April 15, 2018 2026-2039. (Cancer Research, In Press). DOI: 10.1158/0008-5472.CAN-17-2332 Published April 2018
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Curriculum Vitae Russell S. Taichman
105. U Singhal, Y Wang, J Henderson, YS Niknafs, Y Qiao, A Gursky, A Zaslavsky, JS Cheung, DC. Smith, RJ Karnes, LS. Chang, FY. Feng, GS. Palapattu, RS. Taichman, AM. Chinnaiyan, S Tomlins, TM. Morgan. Multigene profiling of circulating tumor cells in mCRPC identifies a clinically relevant prognostic signature driven by noncanonical Wnt signaling. (In Press. Molecular Cancer Research).
106. EE Hill, JK Kim, Y Jung, CK Neeley, KJ Pienta, RS Taichman, JE. Nor, JR. Baker, Jr., PH Krebsbach. Integrin alpha V beta 3 targeted dendrimer-rapamycin conjugate reduces fibroblast-mediated prostate tumor progression and metastasis. J Cell Biochem. 2018 Jan 30. doi: 10.1002/jcb.26727.
B. Peer-Reviewed Academic Leadership Papers.
107. TT Le, EL Scheller, HM Pinsky, SJ Stefanac, RS Taichman. Ability of dental students to deliver oxygen in a medical emergency: a simulation study. J. Dental Education 2009, 73(4) 497-506. PMID: 19339437. PMCID: PMC2908296.
108. RS. Taichman, TG. Green & PJ. Polverini. Creation of a scholars program in dental
leadership (SPDL) for dental and dental hygiene students. J. Dental Education. 2009 Oct;73(10):1139-43. PMID: 19805778.
109. HM Pinsky, RS Taichman, DP Sarment. Adaptation of airline crew resource
management (CRM) principles to dentistry Adaptation of airline crew resource management principles to dentistry JADA 2010;141(8):1010-1018. PMID: 20675428.
110. RA Bagramian, RS Taichman, LK McCauley, TG Green, MR Inglehart. Mentoring
of dental and dental hygiene faculty – a case study, J Dent Education. 2011 Mar;75(3):291-9. PMID:21368253
111. M.Barber, R. Wiesen, S Arnold, RS Taichman and L.S. Taichman. Perceptions of
business skill development by graduates of the University of Michigan Dental School. J Dent Educ. 2011 Apr;75(4):505-17. PMID: 21460271
112. RS Taichman, JW Parkinson, BA Nelson, B Nordquist, DC Ferguson-Young, JF
Thompson. Leadership training for oral health professionals: a call to action. J Dent Educ. 2012 Feb;76(2):185-91. PMID:22319083
113. RS Taichman, JW Parkinson, BA Nelson, B Nordquist, DC Ferguson-Young, JF
Thompson. Program design considerations for leadership training for dental / dental hygiene students. J Dent Education. 2012 Feb;76(2):192-9. PMID: 22319084. PMCID: PMC3296954
114. RS Taichman, JW Parkinson. Where is leadership training being taught in U.S. dental
schools? J Dent Education. 2012 Jun;76(6):713-20. PMID: 22659699. PMCID: PMC3616398.
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Curriculum Vitae Russell S. Taichman
115. E Kalenderian, RS Taichman, A Skoulas, N Nadershahi, KZ Victoroff. Developing the Next Generation of Leaders in Oral Health. J Dent Educ. J. Dent Education J Dent Educ. 2013 Nov;77(11):1508-14. PMID: 24192416
116. HM Pinsky, RE Dufff, RM Eber, RS Taichman, DJ Pinsky. The “Predictable
Surprise.” Case Report. Academy For Academic Leadership (In Press). 117. A Forest, RS Taichman, MR Inglehart. Dentists’ Leadership-related Perceptions,
Values, Experiences, and Behavior – A National Survey. J Am Dent Assoc. 2013 Dec;144(12):1397-405. PMID: 24282270 [PubMed - in process]
118. P Owtad1, RS Taichman, J H Park1, S Yaibuathes3, J Knapp. An Idea for the
Future of Dental Research: A Cloud-based Clinical Network and Database. Journal of Curriculum and Teaching Vol. 2, No. 2; 2013.
119. LS Taichman, RS Taichman, MR Inglehart. "Dentists’ Leadership-related
Educational Experiences, Attitudes, and Past and Current Behavior" J Dent Educ. 2014 Jun;78(6):876-85. PMID: 24882773
120. AL Niemchick, J Delgado, RS Taichman, MR Inglehart. Student Evaluations of
Teaching: Dental and Dental Hygiene Students’ and Faculty Members’ Perspectives on Leadership Development. J. Dent Educ. January 1, 2017 vol. 81 no. 1 44-53.
C. Peer-Reviewed Exploration Papers.
121. RS. Taichman, T Gross & M MacEachern. A Critical Assessment of the Oral Condition of the Crew of the Franklin Expedition. Arctic. Journal of the North American Arctic Institute. 2017. Vol 70 (1) 25-36
DOI: http://dx.doi.org/10.14430/arctic4629 PID: http://hdl.handle.net/10515/sy5862bv4 122. T Gross & RS. Taichman. A Comparative Analysis of the Su-pung-er and Bayne
Testimonies Related to the Franklin Expedition., Polar Record. First View https://doi.org/10.1017/S0032247417000535 Published online: 26 October 2017, pp. 1-19
D. PubChem Reports.
123. Hershberger, S. Peddibhotla, E Sugarman, P Maloney, D. Key, E Suyama, K Nguyen, S Vasile, M Kraft, D Stonich, A Mangravita-Novo, M Vicchiarelli, P Gosalia, M Milewski, L Li, M Hedrick, Q Sun, E Sergienko, A Cheltsov, S Salanawil, J Diwan, LH Smith, RS. Taichman, TDY Chung, AB. Pinkerton, S Malany, and GP Roth. Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis. PubChem Summary Bioassay Identifier (AID): 602249
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Curriculum Vitae Russell S. Taichman
E. Review Papers 1. JC Reed, T Torigoe, BC Turner, I Merida, G Gaulton, HU Saragovi, UR Rapp, RS
Taichman. Proto-oncogene-encoded protein kinases in interleukin-2 signal transduction. Seminars in Immunology 5:327-336, 1993. Pubmed #: 8260649
2. RS Taichman, SG Emerson. The role of osteoblasts in the hematopoietic
microenvironment. Stem Cells 16:7-15, 1998. Pubmed #: 9474743 3. ET Keller, J Zhang, CR Cooper, PC Smith, LK McCauley, KJ Pienta, RS
Taichman. Prostate carcinoma skeletal metastases: Cross-talk between tumor and bone. Cancer and Metastasis Reviews; 20(3-4):333-349, 2001. Pubmed #: 12085970
4. RS Taichman. Bone and Blood. Two tissues who’s fate are intertwined. Blood:
105(7):2631-2639. 2005. Pubmed #: 15585658. 5. CR Cooper, CH Chay, JD Gendernalik, H-L Lee, J Bhatia, RS Taichman, LK
McCauley, ET Keller, and KJ Pienta. Stromal Factors involved in Prostate Cancer Metastasis to the Bone. Cancer (Supplement Feb 1) p739-747, 2003. Pubmed #: 12548571
6. RD Loberg, Y Fridman, BA Pienta, ET Keller, LK McCauley, RS Taichman, and
KJ Pienta. Detection and isolation of circulating tumor cells in urologic cancers: a review. Neoplasia. Vol. 6, No. 4, July/August 2004, pp. 302 – 309. Pubmed #: 15256052. PMCID: PMC1502117
7. CR Cooper, RA Sikes, BE Nicholson, Y-X Sun, KJ Pienta, RS Taichman. Cancer
cells homing to bone: the significance of chemotaxis and cell adhesion. Cancer Treatment & Research.118:291-309. 2004. Pubmed #: 15043197
8. K Neiva, Y-X Sun, RS Taichman. The Role of Osteoblasts in Regulating
Hematopoietic Stem Cell Activities and Tumor Metastasis. The Brazilian Journal of Medical and Biological Research. 2005 Oct;38 (10):1449-54. Pubmed #: 16172737
9. J. Wang, R. Loberg, RS Taichman. The pivotal role of CXCL12 (SDF-1)/CXCR4
axis in bone metastasis. Cancer and Metastasis Reviews 2006 25:573-587. Pubmed #: 17165132
10. ET Keller, J Dai J, J Escara-Wilke J, CL Hall, K Ignatoski K, RS Taichman, J
Keller. New trends in the treatment of bone metastasis. J Cell Biochem. 2007 Dec 1;102(5):1095-102. Review. PMID: 17955492
11. RS Taichman, R Loberg, Mehra R, KJ Pienta. The biology and treatment of
localized and metastatic prostate cancer. Journal Clinical Investigation. 2007 Sep;117 (9):2351-61. Pubmed #: 17786228. PMCID: PMC1952634
12. RE Coleman, TA Guise, A Lipton, GD Roodman, JR Berenson, JJ Body, BF Boyce,
LM Calvi, P Hadji, EV McCloskey, F Saad, MR Smith, LJ Suva, RS Taichman, RL Vessella, K Weilbaecher. Advancing Treatment for Metastatic Bone Cancer,
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Curriculum Vitae Russell S. Taichman
Consensus Recommendations from the Second Cambridge Conference Clinical Cancer Research 2008 14: 6387-6395.
13. AM Havens, EA Pedersen, Y Shiozawa, RS Taichman. Innovative Mouse Models
for Metastatic Disease. Drug Discovery Today: Disease Models, doi:10.1016/j.ddmod. 2008.11.001. Vol. 6, No. 1. 2009 Pages 27-31.
14. EA Pedersen, Y Shiozawa, RS Taichman. Meeting Report from the IX International
Meeting on Cancer Induced Bone Disease. IBMS BoneKEy;2010 January;7(1):32-46. DOI: 10.1138/20100426
15. X Sun, G Chen, M Hao, J Zheng, X Zhou, J Zhang, RS Taichman, J Wang.
CXCL12/ CXCR4/ CXCR7 Axis and Cancer Progression. Cancer and Metastasis Reviews 2010 Dec;29(4):709-22.PMID: 20839032. PMCID: PMC3175097
16. EA. Pedersen, Y Shiozawa, A Mishra, RS. Taichman. Structure and function of the
solid tumor niche. Frontiers in Bioscience (Scholars Edition): 2012 Jan 1;4:1-15. PMID:22202039. PMCID: PMC3594847
17. Y. Shiozawa, KJ Pienta, RS Taichman. CCR Molecular Pathways: Hematopoietic
stem cell niche is a potential therapeutic target for bone metastatic tumors. Clin Cancer Res. 2011 Sep 1;17(17):5553-8. Epub 2011 Jun 15. PMID:21676926. PMCID: PMC3593121
18. A. Mishra A, Y. Shiozawa Y, KJ. Pienta KJ, RS Taichman Homing of Cancer
Cells to the Bone. Cancer Microenvironment. Cancer Microenvironment. 2011 Dec;4(3):221-35. Epub 2011 Aug 9. PMID: 21826451. PMCID: PMC3234327
19. LR Patel, DF Camacho, Y Shiozawa, KJ Pienta, RS Taichman. Mechanisms of
cancer cell metastasis to the bone: a multistep process. Future Oncol. 2011 Nov;7(11):1285-97. PMID:22044203. PMCID: PMC3258525.
20. SJ McGee, AM Havens, Y Shiozawa, Y Jung, RS Taichman. Effects of
Erythropoietin on the Bone Microenvironment Growth Factors. 2012 Feb;30(1):22-8. (Epub 2011 Nov 28.). PMID: 22117584. PMC3295609
21. EA Pedersen Y Shiozawa, KJ Pienta, RS Taichman. Perspective on the Prostate
Cancer Niche in Bone Marrow. The Prostate Cancer Bone Marrow Niche: More than Just “Fertile Soil”. Asian J Androl. 2012 Feb 27. doi: 10.1038/aja.2011.164. [Epub ahead of print] PMID:22367179. PMCID: PMC3602965
22. C Yu, Y Shiozawa, RS Taichman, LK McCauley, KJ Pienta, ET Keller. Prostate
cancer and parasitism of the bone hematopoietic stem cell niche. Critical Reviews in Eukaryotic Gene Expression. 2012.. PMID: 22856431. PMCID: PMC3615416.
23. Y Shiozawa, RS Taichman. Cancer stem cells and the bone marrow
microenvironment. BoneKEy Reports (Invited Review) 2012 Volume:1, Article number:48 DOI:doi:10.1038/bonekey.2012.48. PMID: 23745167. PMCID:
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Curriculum Vitae Russell S. Taichman
PMC3671623. (http://www.nature.com/bonekeyreports/2012/120321/bonekey201248/full/bonekey201248.htm).
24. Y Shiozawa, RS Taichman. Getting blood from bone: an emerging understanding of
the role that osteoblasts play in regulating hematopoietic stem cells within their niche. Exp Hematol. 2012 Sep;40(9):685-94. doi: 10.1016/j.exphem.2012.05.004. Epub 2012 May 26. PMID: 22640993. PMCID: PMC3419274.
25. Y Shiozawa, RS Taichman, ET Keller. Detection and isolation of human
disseminated tumor cells in the murine bone marrow stem cell niche. Methods Mol Biol. 2013;1035:207-15. doi: 10.1007/978-1-62703-508-8_18.PMID: 23959994
26. Y. Shiozawa, B Nie, K Pienta, T.Morgan, RS Taichman. Cancer Stem Cells and
their Role in Metastasis. Pharmacology & Therapeutics. Pharmacol Ther. 2013 May;138(2):285-93. doi: 10.1016/j.pharmthera.2013.01.014. Epub 2013 Feb 4. PMID: 23384596. PMCID: PMC3602306.
27. KJ Pienta, B Robertson, D Coffey , RS Taichman. The Cancer Diaspora:
Metastasis beyond the seed and soil hypothesis. Clin Cancer Res. 2013 Oct 7. [Epub ahead of print] PMID:24100626 PMCID: PMC3835696
29. E Cordeiro-Spinetti, W de Mello, L Siqueira Trindade, DD. Taub, RS. Taichman,
A Balduino. Human Bone Marrow Mesenchymal Progenitors: Perspectives on an Optimized In Vitro Manipulation. Frontiers in Cell and Dev. Biology Front. Cell Dev. Bio., 27 March 2014 | doi: 10.3389/fcell.2014.00007. PMID: 25364715. PMCID:PMC4207019 http://journal.frontiersin.org/Journal/10.3389/fcell.2014.00007/abstract#sthash.tUvkAJ7k.dpuf.
30. KR Yang, S Mooney, JC. Zarif. D S. Coffey, RS Taichman, KJ Pienta. Cancer
cells as ecosystem engineers at primary and metastatic sites. J. Cellular Biochemistry (2014) PMID: 24700698. PMCID: PMC4143896
31. K Yumoto, M Eber, J Berry, Y Shiozawa, RS Taichman. Molecular Pathways:
Niches in metastatic dormancy. Clin Cancer Res. 2014 Apr 22. [Epub ahead of print] PMID: 24756372. PMCID: PMC4079737 [Available on 2015/7/1]
32. JC. Zarif, RS. Taichman, KJ Pienta. TAM macrophages promote growth and
metastasis within the cancer ecosystem Oncoimmunology. 2014 Jul 3;3(7):e941734. eCollection PMCID: PMC4341447.
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33. E. Cordeiro-Spinetti, RS. Taichman, A. Balduino. The bone marrow endosteal niche: how far from the surface? J Cellular Biochemistry 2015: 116(1) 6-11. PMCID: PMC4229422 [Available on 2015/4/1].
34. Y. Shiozawa, MR Eber, JE. Berry, RS Taichman Bone marrow as a metastatic
niche for disseminated tumor cells from solid tumors. BoneKEy Reports 4: 2015. International Bone & Mineral Society 2047-6396/15 (www.nature.com/bonekey).
35. A. Decker, Y. Jung, C. Cackowski, RS Taichman The Role of Hematopoietic
Stem Cell Niche in Prostate Cancer Bone Metastasis. Journal of Bone Oncology. (2016), http://dx.doi.org/10.1016/j.jbo.2016.02.005i PMCID: PMC5063229 36. A.M.Decker, F.C. Cackowski, Y.Jung, R.S. Taichman. Biochemical Changes in
the niche following tumor cell invasion. J Cell Biochem. 2016 Dec 16. doi: 10.1002/jcb.25843 PMID:27982511
36. FC Cackowski & RS Taichman. Parallels Between Hematopoietic Stem Cell and
Prostate Cancer Disseminated Tumor Cell Regulation. 26 February 2018. https://doi.org/10.1016/j.bone.2018.02.025
37. AM Decker, LS Taichman, NJ D’Silva, & RS Taichman. Periodontal Treatment in
Cancer Patients: An Interdisciplinary Approach (Current Oral Health Reports, In Press).
F. Invited Editorials/Commentary/Reviews
1. Y. Shiozawa, RS Taichman. Dysfunctional niches as a root of hematopoietic malignancy. Dysfunctional niches as a root of hematopoietic malignancy. Cell Stem Cell. 2010 May 7;6(5):399-400.PMID: 20452309.
2. Y. Shiozawa, RS Taichman. HSCs & Niche Relations Marked by CD166. Invited
commentary/review on: CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche by Chitteti et al, Blood, July 24, 2014. 124(4) 472.
3. RS Taichman. Expanding the scholarship on leadership training in dental education. J Dent Educ. 2014 Jun;78(6):811-2.
4. Y Shiozawa and RS. Taichman. Elucidating which cell erythropoietin targets in
bone. Invited commentary/ review on Hiram-Bab, S. et al. Erythropoietin directly stimulates osteoclast precursors and induces bone loss. FASEB J. http://dx.doi.org/10.1096/fj.14 259085. Nature Reviews Endocrinology. 2015 May;11(5):263-4. doi: 10.1038/nrendo.2015.32. Epub 2015 Mar 10.
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G. Letters to the Editor
1. Y Shiozawa, RS Taichman. Erythropoietin and Bone Remodeling. [e-Letter], Blood (http://bloodjournal.hematologylibrary.org/content/117/21/5631.full/reply#bloodjournal_el_2584). Published July 25, 2011.
H. Book Chapters
1. RS Taichman, SG Emerson. The hematopoietic microenvironment. In:
High-dose cancer therapy: pharmacology, hematopoietins, stem cells. Armitage JO, Antman KH, editors. Baltimore: Williams & Wilkins, pp.151-158, 1995.
2. SG Emerson, RS Taichman, S Adams. The role of osteoblasts in
hematopoietic stem cell biology. In. Hematopoiesis. Zon, LI Editor. New York: Oxford University Press, pp 476-483. 2001.
3. CR Cooper, RA Sikes RA, BE Nickolson, YX Sun, KJ Pienta and RS Taichman.
Cancer cells homing to bone: the significance of chemotaxis and cell adhesion. In: The Biology of Bone Metastases Editors Evan T. Keller and Leland W. Chung. Kluwer Academic Publishers 291-310, 2004.
4. ET Keller, J Zhang, CR Cooper, PC Smith, LK McCauley, KJ Pienta, RS
Taichman. Prostate carcinoma skeletal metastases: Cross-talk between tumor and bone Prostate carcinoma skeletal metastases In New Horizons in Research and Treatment. Michael L. Cher (Edt) Kluwer Academic Pub 179-214, 2003.
5. AM Havens, Y Shiozawa, RS Taichman. Blood-Bone Axis and Bone Marrow
Microenvironment Chapter 1: Bone and Cancer (Volume 5, Topics in Bone Biology Series) Edited by Felix Bronner and Mary C Farach-Carson.
6. K Mizutani, RS Taichman, KJ Pienta. Prostate Cancer Metastasis: Thoughts on
biology and therapeutics. Cancer Metastasis: Biologic Basis and Therapeutics Cambridge University Press. Edited by Dan Welch, David Lyden.
7. E. Forest, Y. Shiozawa, KJ. Pienta, RS. Taichman. The Hematopoietic Stem Cell
Niche & Bone Metastasis In Metastatic Cancer: Molecular and Translational Perspectives Springer/Landes Bioscience. R. Jandial & K. Hunter, Editors. The Hematopoietic Stem Cell Niche and Bone Metastasis. http://www.landesbioscience.com/curie/chapter/5326/ Publication date: March 1, 2012.
8. Y Shiozawa, RS Taichman, ET Keller. Detection and Isolation of Human
Disseminated Tumor Cells in the Murine Bone Marrow Stem Cell Niche. Kursed Turksen (ed) In: Stem Cells Niche, Methods and Protocols. Methods in Molecular Biology, Springer Publishing. Vol 1035. Chapter 18. (In Press).
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Curriculum Vitae Russell S. Taichman
9. A Balduino, ME Leite Duartey, RS Taichman. Chapter 7: Skeletal Resident Stem Cells. In: Resident Stem Cells and Regenerative Therapy. Edited by Regina Coeli dos Santos Goldenberg and Antonio Carlos Campos de Carvalho. DOI: http://dx.doi.org/10.1016/B978-0-12-416012-5.00010-4. 2013 Elsevier Inc.
10. G. Mehta, Y Shiozawa, RS Taichman. Hematopoietic Stem Cells and their Niches.
“Biomaterials and Regenerative Medicine” Edited by P X. Ma. 2013. Cambridge University Press.
I. Papers Submitted & Under Review
1. FC Cackowski, J. Wang, Y Jung, Y Shiozawa, K Yumoto, AM Decker, Y Mishina, RS Taichman. Cxcl12 Expression in Mouse Marrow is Responsive to GFP – Implications for CAR Cell Detection and Biology (Stem Cell).
2. H Takahashi, K Yumoto, K Yasuhara, ET Nadres, RS Taichman and K Kuroda Anticancer polymers designed for killing dormant prostate cancer cells (Submitted to Angewandte Chemie)
J. Other Publications
1. RS Taichman. Polycytokine Modulation of Osteoblast Metabolism. Doctoral Dissertation. Harvard University Press. 183 pages. 1990.
2. RS Taichman, editorial comment National Geographic Magazine January 2000,
Special Millennium Issue. Pg 23.
K. Non-Academic Book Chapters
1. RS Taichman. Bring Me The Oil Can, or Adventures Of The Modern Day
Tin Man. In: No ****, There I Was. A Collection of Wild Stories From Wild People. Edited by Michael Hodgson. ICS Books. Merrillville, IN. pg.77-81, 1997. ISBN-10: 0934802971.
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