unnecesary medication use in long term care facilites
DESCRIPTION
Meds are a key component in the clinical process. The guidelines are intended to insure medication use is of value and necessary. T Significant emphasis is placed on preventing and recognizing adverse drug reactions ASAP. Consequently, surveyors will expect to see: Rationale for use, Parameters for monitoring Prompt recognition and evaluation of new onset problems and conditions worsening Consideration for dose reduction and discontinuance as appropriate.TRANSCRIPT
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Meeting Professional Standards of Practice
Debbie Ohl RN, NHA, M.Msc.Ohl & Associates
Consultant and Educator
MDSCAREPLANBUILDER.comTHINKTHETHOUGHTS.com
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What are Unnecessary Medications?
Excessive doses Excessive duration Without adequate monitoring Without adequate indications for use Presence of adverse consequences
indicating dose should be reduced or discontinued.
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Question
In your own words, what do you
consider to be unnecessary drugs?
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UNNECESSARY MEDS ARE
D2UM
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Regulatory Interrelationships
• Unnecessary Drug Use• Antipsychotic Drugs• Medication Errors• Drug Regimen Review• Comprehensive assessment • Care planning• Professional standards of practice
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1. Do the target symptoms warrant medications?
2. Are non-pharmacological interventions in place and relevant?
3. Is medication appropriate to manage the symptoms or condition?
4. Do the intended or actual benefits justify the risk of use?
5. Is there a system in place to insure these criteria are adhered to?
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Key TermsLinked to Unnecessary Med Use
1. ADE: Adverse Drug Effect
2. ADR: Adverse Drug Reaction
3. Poly-pharmacy
4. Predictability
5. Medication Errors
6. Beers List
7. Immediate Jeopardy
8. Professional standards of practice
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Failure to protect from undue adverse medication consequences and/or failure
to provide medications as prescribed.
1. Administration of medication to an individual with a known history of allergic reaction to that medication.
2. Lack of monitoring and identification of potential serious drug interaction, side effects and adverse reactions.
3. Administration of contraindicated medications.4. Pattern of repeated medication errors without
intervention.5. Lack of timely and appropriate monitoring
required for drug titration.
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Degree of the Problem
Isolated Pattern Wide-spread
Immediate Jeopardy J K L
Actual Harm G H I
Potential for Harm D E F
No harm likely A B C
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Adverse Drug Events
• Pharmacodynamics: drugs with similar or opposing effects
• Pharmacokinetics: what the body does to a drug
AD ME• Absorption • Distribution • Metabolism • Elimination
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Preventable Adverse Drug Effects
Occur at Ordering Wrong drug choice Failure to consider drug interactions Transcription errors
Occur at Monitoring Failure to order specific monitoring needs Delayed response or failure to respond to signs &
symptoms of toxicity or lab evidence of toxicity
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ADE Drugs in Elderly
• Analgesics– Opioid
– NSAIDS
Anti-psychotics Anti-coagulants Anti-histamines Anti-convulsants
Cardiovascular Diabetic medications
– Insulins
– Oral agents
JAMA 2006; 296:1858-1866; AGS 2004;52:1349-1354; NEJM 2003;348:1556-64
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Surveyor Assessment
1. Indications / reasons for use.2. Effectiveness, dose.3. Monitoring: drug regimen, response to
irregularities.4. Duplication of drug therapy.5. Presence of Adverse Drug Events6. Weight history of note.7. Hydration / intake records of note.
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Regulator’s Looking For:
• Comprehensive Assessment• Quality of Care• ADL decline• Urinary Incontinence’• Mental and Psychosocial function• Physician Services and Visits• Medical Director• Pharmacy Services
– Medical Regimen Review
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Predictability
PREDICTABLE • Usually dose dependent. • Most identified prior to
marketing.• Can be due to
concomitment disease, drug/drug, and food/drug interactions.
• Rarely life threatening but can produce significant disability.
UNPREDICTABLE • Usually not an extension
of the known drug properties.
• Generally independent of dose and route of administration.
• Includes idiosyncratic reactions, immunologic or allergic reactions.
• Tend to concentrate in certain body systems: liver, kidneys, and nervous system.
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Types of Adverse Drug Reactions
1. Drug / Drug Interactions
2. Drug / Nutrient Interactions
3. Allergic Reactions / Hypersensitivity
4. Drug Toxicity
5. Idiosyncratic Reaction
6. Complications
7. DRUG / DISEASE INTERACTIONS
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Minimizing Occurrence
• Understand pharmacokinetic and pharmacodynamics.
• Monitor drugs with narrow therapeutic range.
• Avoid polypharmacy.
• Know, convey, and document baseline status.
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Factors that Produce/ Contribute to Inappropriate Drug Use
1. Under use of medications 2. Over use of medications 3. Poly pharmacy 4. Excessive dose or duration5. Lack of assessment 6. Lack of monitoring 7. Lack of recognition of ADR’s 8. Lack of adherence to drug therapy
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Assessing a Possible ADR
1. Review the current medications in use for associations with symptoms or condition change.
2. Assess other possible causes for signs and symptoms.
3. Validate the drug ordered is the drug given. 4. Verify that the onset of the event was AFTER
drug administration initiated.5. Determine the time interval between the
beginning of drug treatment and the onset of the event.
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Safeguards Prevention of Adverse Drug Reactions
1. Consider any new symptom as a possible ADE before requesting/ administering new medication for the symptom.
2. Monitor medication orders for wrong drug choices (high-risk inappropriate medications, drug–disease and drug–drug interactions), wrong dosages, or admin errors.
3. Improve prescribing practices by documenting:+ indication for initiation of new drug therapy+ maintaining a current medication list+ documenting response to therapy.
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Polypharmacy
• Concomitant use of multiple drugs, done by simply drug counting.
• Administration of more medications than is
clinically-indicated.• 34% of all drugs prescribed in the United States
are considered unnecessary.
References:Stewarb RB. Polypharmacy in elderly: a fair accompli? DICP 1990; 24; 321-323. Montamat SC, Cusack B. Overcome the problems with polypharmacy and drug misuse. Clin Geriatr Med 1992; 8: 143-158. LeSage J. Polypharmacy in the geriatric patient. Nurs Clin North Am 1991; 26: 273-
287.
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Possible Impacts of Polypharmacy
• Adverse drug reactions
• Drug-drug interactions
• Medication errors made up of non-compliance
• Link to 5% of hospital admission
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Preventing Polypharmacy
Gather information
• Determine all medications being used.
• Identify meds by generic name & drug class.
• Identify the clinical indication of each medication.
• Know the side effect profile of each medication.
• Identify risk factors for an adverse drug reaction.
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Resident Medication Profile
Medications(brand and
generic)
Drug Class
Clinical indication
Common Side
Effects
Expected Response
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Preventing Polypharmacy
Eliminate, Substitute and Simplify
• Eliminate medication with no therapeutic benefit.• Eliminate medication with no clinical indication.• Substitute a safer medication.• Avoid treating an adverse drug reaction with a
drug.• Use a single drug with an infrequent dosing
schedule.
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Medication Errors
• Any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in control of the health professional.
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Pharmaceutical Process Where Drug Errors are Most Likely to Occur
• Prescribing
• Transcribing
• Dispensing
• Administering
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ProcessCausative Problems
& Reasons For Potential Solutions
Prescribing
Transcribing
Dispensing
Administering
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Citations for violations of drug-misuse rules have
increased by nearly 40% since 2004, according to
CMS.
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beers
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Psychoactive MedicationsTHINK
• Why are you using them?
• Consider:– Interpretive guidelines criteria for use– Potential benefits– Potential adverse effects– Impact on other health conditions
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Causes of Behavior Disturbances
• Altered cognition
• Altered emotions
• Mood disturbances
• Physical illness
• Drug toxicity
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Behavioral Disturbance Prompting PA Med Use
Aggression
• Is it offensive or defensive?
• Stimulus internal or external?
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Cognitive Compromise
• Amnesia
• Aphasia
• Apraxia
• Agnosia
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ALTERED MENTAL STATUS
Delirium• Acute confusion that
is reversible.
Dementia
Decline in multiple cognitive functions:
OrientationAttentionmemory language
occurring in clear consciousness.
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Mood Disturbances
1. Emotionally Labile 2. Pathological Emotions 3. Catastrophic Reactions
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Treatment Principles Psychoactive Medications
1. Rule out and/or stabilize medical problems
2. Check critical lab work
3. Create a list of behavior disturbances that need to be improved.
4. Augment therapy if needed.
5. Set realistic goals
6. Establish routine
7. Provide physical clues
8. Talk before touch
9. 1 step commands
10. Allow adequate time for medications trial
11. Specify and quantify improvement
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Behavior Questions
1. What is the behavior; how long does it lasts?
2. Are psychoactive medications used?
3. Is behavior creating care resistance or is care creating behavior problem?
4. What do you believe are the potential causes or contributors to the behavior problem?
5. Can the behavior be easily altered?
6. If not, why not?7. Has the use of
medication been considered?
8. Have you evaluated the triggered RAPs and triggered Quality Indicators?
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Questions for Behavior & PA Meds
What are the symptoms?
What is the frequency?
What is the severity?
What is the ease of alterability?
If easily altered• Are they receiving psychoactive
meds?• How long?• Are side effects present?• Is a reduction program needed or
underway?
If not easily altered• Have physical causes been ruled
out?• Might there be drug interactions
creating the problem? How do you know?
• Are they receiving Psych meds? How long? Has behavior improved? If not, why not? What now?
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Questions for Depression & PA Meds
What are the symptoms ? If you don’t think these
symptoms are mood related, why?
How have you come to this decision?
How pervasive? How serious? How easily altered? Are psychoactive, anti-
anxiety, hypnotics in use?
If easily altered & receiving antidepressant are they a candidate for reduction?
• If NOT easily altered and receiving antidepressant
how long has med been given?
If NOT easily altered and NOT receiving antidepressant are they a candidate?
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Antipsychotic MedsCan you justify use?
High Risk: Cognitive Impairment
Criteria: Harm to self or others; symptoms so distressing impacts ability to function
Low Risk: major mental illness, psychosis, schizophrenia, manic depression
Criteria: Supporting Diagnosis
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Anti-Anxiety Med Questions
Is this a resident demand or clinical need?
What attempts have been made to address this?
Is there a risk plan in place?
Are there adverse effects that can be tied to other problems?
Is it clinically indicated? If so what are risks, concerns?
Is documentation in place?
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Beers Criteria Anticholinergic Medications
Drug classes• Tricyclic antidepressants• Antihistamines• Antispasmodics and
muscle relaxants
Adverse Effects• Urinary retention
• Constipation
• Confusion, delirium, behavior changes
• Exacerbation of dementia
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Beers Criteria Antihypertensives
Principle• Select agents which
act peripherally and are not highly lipophilic
Preferred• ACE inhibitors, ARBs,
CC blockers, atenolol
Avoid• Agents which act
centrally or are highly lipophilic– Methyldopa, clonidine,
propranolol– Short-acting nifedepine
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Beers Criteria Antianxiety/ Sedative Agents
Principle• •Select short-acting
agents, without activemetabolites
• Lowest possible dose• Shortest possible time• Evaluate need for therapy
frequently
Preferred• Lorazepam, Triazolam,
Zolpidem, Zopiclone
Avoid• Diazepam, • Chlordiazepoxide
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Beers Criteria Antipsychotics
Principle• Use least sedating agents• Minimal anticholinergic
effectsPreferred
• Atypical antipsychotics– Risperidone,- Olanzapine- Ziprasidone- Quetiapine,- Aripiprazole
Avoid• Chlorpromazine• Perphenazine
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Beers Criteria Antidepressants
Principles• Use least sedating agents• Minimal cardiotoxicity• Minimal anticholinergic S/E
Preferred• SSRIs (Except Fluoxetine)• SNRI, NRTIs or adrenergic
blockers• Venlafaxine, Duloxetine or
mirtazapine• nortriptyline
Avoid• Amitriptyline• Imipramine
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Minimize Unnecessary Drug Use
• Drug protocols • Quality assurance• Communication• Initial and ongoing
assessment • Care Plan
development and implementation
• Gait keeper
• Staff training: meds used, dose
ranges, side effects, potential complications
implication of cognitive compromise
catastrophic responses leading to unnecessary med orders.
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Assessment Tools for Benchmarking Behavior
• Behavior Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD), Measures agitation/anxiety, psychosis, aggression, depression, and activity disturbance.
• Cohen-Mansfield Agitation Inventory (CMAI), a questionnaire evaluating agitation.
• Clinical Global Impressions (CGI), a rating system used to evaluate the overall and severity of clinical change in a patient with various diseases affecting the brain.
• Functional Assessment Staging (FAST), a diagnosis tool for determining the stage of dementia
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Assessment Tools for Benchmarking Behavior Cont’
• Mini-Mental State Examination (MMSE), used to evaluate cognition.
• AIMS abnormal involuntary movements associated with antipsychotic drugs.
• NPI neuropsychiatric inventory assessment of psychopathology for dementia and other neuro-psychiatric disorders.
• CAM: instrument screens for overall cognitive impairment.
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REASONS FOR MEDICATION USE
• Cure acute illness• Arrest or slow disease process.• Decrease or eliminate symptoms.• Prevent a disease or symptom.• Therapeutic or enabling for a resident with chronic mental or physical problems.
The FUNDAMENTAL ISSUES to be addressed in
CMS guidelines the lack of clear,
solid clinical rational for use of the specific medication identified.