Vaccination Experience in AI Control in Indonesia

Elly Sawitri SiregarCoordinator, HPAI-Campaign Management Unit

Ministry of Agriculture

Seminar 5-”Vaccination against AI: Issues and Strategies Within the Context of an Overall Control Program”

Organized byWorld Bank, FAO, OIE and Tokyo Development Learning Center

March 19, 2008

Overview

• Background

• Current HPAI situation

• Control programme

• Vaccination policy and implementation

• Vaccine efficacy

• Summary

Poultry Numbers

• Standing population:

– Native/village 317m (~630m annually)– Layer 106m– Broiler 175m (~1b annually) – Duck 35m

Total >620m (plus others – quail, pigeon, goose…)

Source : Livestock Statistic (2007)

The Poultry Industry

• Total investment US$ 35b

• Turnover US$ 30b pa

• People employed >10m

• Feed production 7.5m MT pa

• DOC broiler >1b pa

• DOC layer >100m pa

• Markets 13,000 markets daily

• Abattoir processing <20%Source : Indonesian Association of Poultry Companies (2004)

Disease Situation

• First identified in 2003• 31/33 provinces have confirmed cases (286/444

districts)• Incidence varies across the country

– Endemic in Java, Bali, Sumatra and South Sulawesi

– Lower incidence in eastern provinces– Based on limited surveillance

• Both commercial and village poultry• Chickens, quails and ducks affected• Human cases since July 2005

Poultry density and human cases

Districts with confirmed infection PDS, dinas and DIC data – 2007 (incomplete)

9 Strategies for Control - 2004

1. Improvement of bio-security2. Vaccination in infected and suspected areas3. Depopulation (selective culling) and

compensation4. Control movement of live poultry, poultry

products and farm waste5. Surveillance and tracing back6. Restocking7. Stamping out in newly infected areas8. Public awareness9. Monitoring and evaluation* Decree of DG of Livestock Services, Feb 2004

National Strategic Plan

• National Strategic Work Plan for the Progressive Control of HPAI in Animals 2006-2008

• 9 elements :• Campaign Management Unit• Enhancement of HPAI Control

• Including vaccination• Surveillance and epidemiology• Diagnostic laboratory services• Animal quarantine services• Regulation• Communication• R & D• Poultry Industry Restructuring

• Reviewed in June 2007 – no substantive change, but recognised need to intensify campaign

Workplan

1. Improve the management, planning and capacity for HPAI control

2. Reduce risk / Improve HPAI prevention

3. Improve detection and response

Reducing Risk

• There are many high risk practices along the production and market chain

• These must be identified and the risk eliminated or reduced

• But this will take time, so… Vaccination of high risk populations will be

necessary until risks reduced

Duck farms incl grazing

By-products Chicken farms Other birdsIncl. wild

Duck farms

Collector Yards

Chicken farms

Wholesale market

Retail markets

Wholesale market

Quail farms

2007 Indonesia, after Sims

Risk

Slaughterhouse

DOC DealersRice,crops

Dealers

Risk Pathways

Risk Reduction

Target:• Vaccine• Farm biosecurity• Ducks• Transport/dealers• Traditional markets• Hatcheries• Information, education and communication

Vaccination Policy

Rationale

• In mid 2003, AI was detected in Central Java and has spread to West Java and East Java…. and 2004 spread to Lampung, North Sumatera, Bali and South Sulawesi.

• Poultry industry was infected and movement of commercial poultry might be the cause of spread to other islands.

• Limited compensation fund was available for Sector 4 and Sector 3 (small scale)

• Sector 1 and 2 no compensation• Mid 2004, vaccination policy was implemented by

Government.

Vaccination Strategy

• Mass vaccination in mid 2004:• 300 M doses available• Inactivated H5N1 local isolate• Free of charge• Backyard and small farmers of any species

• Mass vaccination continued in 2005 and early 2006• Vaccination in sectors 1, 2 and 3 (breeders and layers)

• at their own cost • with coverage estimated to be 90% in commercial layer and

100% in breeding flocks• Mid 2006 due to limited vaccines – targeted vaccination:

• Inactivated LPAI vaccine (H5N2)• 2007 – continued targeted vaccination of some

populations in high risk provinces

AI VaccinesVaccine use (GoI):• 2004 : 132m doses• 2005 : 143.4m doses• 2006 : 102.9m doses• 2007 : 98.5m doses

Registered seed strains:• H5N1: A/Chicken/Legok/2003• H5N2: A/Turkey/England/N28/73

A/Chicken/Mexico/232/94/CPA• H5N9: A/Turkey/Wisconsin/68

Vaccination problems

• Complex programme management in the autonomy era• Limited resources against scale of task

• Staff, equipment, operating, vaccine• Low vaccination coverage in Sector 4 (wide area, large

population, free range)• A range of species infected - native chicken, commercial

chicken, duck, quail• Poor biosecurity/Sector 4• Vaccination in poultry industry – re-occurrence of

outbreaks by end 2005 • And vaccine efficacy issues (results of SEPRL-DGLS-

AAHL-FAO)• Review of antigenic variability of AI viruses in Indonesia • Virus isolates required for further assessment…

Collaborative Vaccine Efficacy Project in 2007

• MoA Indonesia

• AAHL Australia

• FAO

• USDA-APHIS and SEPRL, USA

Summary of Challenge Studies

• PWT-WIJ/06 resistant to most vaccines

• SMI-HAMD/06 was susceptible to most vaccines

• Papua/06 was intermediate

Source: Swayne, 2007

Question?

• What is the significance of PWT-WIJ/06 ?

• Need representative viruses– Spatial, enterprise, species– Epidemiological information: vaccination

status, clinical signs etc– Collected overtime

Available isolates - region

Region 2003200

4200

5200

6200

7 Total

Sumatra 1 18 9 28

West Java, Banten, Jakarta 28 28

Central, East Java, Yogya 3 3 6 38 15 65

Other 10 11 21

Total 3 4 6 94 35 142

Summary of Sequence Analysis

• Isolates from Indonesia fall within one clade

• There are 3 other isolates that group with the PWT-WIJ/06

• These 4 isolates appear to be somewhat different from the majority of isolates so far submitted

Source: Peter Daniels, AAHL

OFFLU Project in Indonesia Oct 2007-Sept 2008

• Concerns over vaccine efficacy– Challenge tests results at SEPRL (USDA)– Outbreaks in commercial industry

• OFFLU project “Monitoring AI virus variants in Indonesia Poultry and defining an effective and sustainable vaccination strategy” – MoA-Indonesia– FAO Rome, Bangkok and Jakarta – OIE – AAHL, Australia – VLA, UK – SEPRL, USA, – Erasmus, The Netherlands

Objectives

– Antigenic mapping– Increased collection of representative isolates

and mapping– Challenge tests/strain selection– Recommend Vaccination strategy

Identify efficacious current vaccinesIdentify new seed strains, if requiredOngoing monitoring

Work already carried out/on-going

• Virus characterization by DNA sequencing (AAHL, Bbalitvet, VLA)

• Efficacy testing of vaccine (SEPRL)• HI tests (SEPRL, VLA, Bbalitvet)• Antigenic cartography (Erasmus)• Under progress- vaccine construction (rev

genetics) and autogenous vaccine (SEPRL)

• Isolate sharing need to be increased

Summary• HPAI remains endemic in many areas• Long term approach to risk reduction is required• Improved surveillance with better understanding

of disease epidemiology• Commercial industry support is critical• Vaccination can be an important tool to reduce

circulating H5N1 virus– Needs adequate resources and management– Monitoring of vaccination program critical– Is only component of successful disease control