visceral adipose tissue volume measurement using …...border semi-a presen morph we pe fat, a...

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Visce Cri 1 Facu de C Ponti OBJE [1]. A risk to betwe particu VAT a findin using Circum Radiat relatio relatio METH range: anthro history bioche BMI, (TF), Additi MRI s includ shot tu out-of image sequen and SA border semi-a presen morph We pe fat, A correla RESU showe feature (range 2390c We fo Comp ARFI of adv 0.94 b betwe DISCU indepe popula VAT + Clinic superi liver s amoun CONC used t volum REFE 2011, eral adipose ti stóbal Martín Serr lty of Medicine, Po Chile, Santiago, Re ificia Universidad Metr ECTIVE: Viscer Additionally, it ha o develop NAL en different biom ular, we studied and liver stiffne gs; measuremen MRI; anthrop mference (WC) tion Force Impu on between anth on between the a HODS: 19 pati : 61.5-97) with opometry, ARFI y, physical exa emical workup, WC, body fat bicipital fold ionally, 10 TrE m scans were perfo ding the followi urbo spin-echo, f-phase, T1 grad e sequences. We nce, centered at AT volumes. Th r until below the automatic softw nce of hepatic hological criteria erformed differe ARFI and anth ation statistic. ULTS: Clinical ed that no subj es of liver cirrh e = 22.6-29), an cc ± 801cc, (rang ound a poor corre paring measurem was 0.10 (p=0.6 vanced liver fibro between (VAT+ en (VAT+SAT) USSION: We c endent of the bo ation. However, + SAT. cal diagnosis ind ior to 1.6m/s tha stiffness. This fi nt of VAT to con CLUSION. Bec to study the clin mes, since it has b ERENCES. 1. v 5. Schwenzer et issue volume m rano García 1,2 , Fran ontificia Universid gión Metropolitan Católica de Chile ropolitana, Chile, 6 ral Adipose Tiss as been reported LFD [2]. In this markers and live the association ess. For this purp nts of VAT and ometric indexe ) and Transien ulse) for measuri hropometric ind amount of VAT a ents (mean age DM2 were enro I, and MRI. C am and laborato HbA1c). Anthro percentage (BF (BF), supraili measurements w ormed on a Phil ing sequences: T2 with fat satu dient echo, and e also included t fat, to assess he FOV include e kidneys. VAT ware (Image J [3 c disease wa a over the MRI s ent comparisons hropometry usin l diagnosis an ject had clinica hosis. The BM nd the WC was ge = 1173-2252) elation comparin ments of adipose 66) and between osis [4]), we fou SAT) with ARF and ARFI (p=0 confirmed previ dy phenotype. M in those patient dicated that none at are at a greate inding suggests nfirm whether th cause of the imp nical condition o been demonstrat van der Poorten e t al Invest Radio measurement ncisco Barrera 3 , H Prieto 2,6 , dad Católica de Ch na, Chile, 3 Gastroe , Santiago, Región 6 Electrical Engine sue (VAT) has b d that type 2 diab work, we prop er fibrosis/cirrho of liver fibrosis/ pose, we perform d Subcutaneous es, like Body nt Elastography ing liver stiffnes dexes and MRI and the stiffness : 62 years, rang olled. All patien Clinical evaluat ory data (hemo opometric data F%), brachial cir iac fold (SpF) were made in the llips Intera 1.5T half-Fourier sin uration, in-phase d diffusion weig a spectral excita quantitatively V ed the diaphragm was measured u 3]) (Figure 1). s evaluated u scans. between abdom ng the Pearson nd MRI findin al or biochemic I was 29.3 ± 4 99.7cm ± 9.1 (r and SAT was 3 ng anthropometr tissue with ARF n (VAT+SAT) w und that the corre FI (p=0.001) (Fi .29). ous results [5], Moreover, we did ts with greater l e of the DM2 pa er risk of develo performing furt here is a progres plications of dev f the liver. For t ted that anthropo et al Hepatology ol 2010. using MRI, an diab Hugo Vidal 4 , Carlo Pablo Irarrázaval 2 hile, Santiago, Reg enterology, Pontifi n Metropolitana, C eering, Pontificia U been associated w betic patients (D pose to evaluate osis in type 2 dia /cirrhosis with b med a study that Adipose Tissue Mass Index (B y (TrE) using ss. Furthermore, measurement of the liver. ge: 55-75, mean nts underwent cl tion included c globin, platelet assessed include rcumference (B ) and subscapu right lobe of the T MR ngle- e and ghted ation VAT matic using The using minal n’s ngs cal 4.7 range =85-120). 143cc ± 1298cc ric indexes with FI we found that with ARFI was 0. elation was 0.63 igure 2, right). I indicating that d not find a relat liver stiffness w atients had diagn oping liver fibros her studies of li sion of liver fibr veloping hepatic this, MR images ometric measure y 2008, 2. Luxm Figure 2. adipose ti adipose ti nd its relation betic patients. s Riquelme 4 , Pilar ,6 , Cristián Tejos 2,6 gión Metropolitan icia Universidad C Chile, 5 Nutrition & Universidad Catól with liver fibrosi DM2) are at high e the relationsh abetic patients. I oth the amount o t included clinic e (SAT) volume BMI) and Wai ARFI (Acoust we evaluated th of VAT and th n weight: 77.2k linical evaluatio complete medic count, comple ed weight, heigh C), tricipital fo ular fold (SbF e liver. . The TrE was . measurements o : the correlation .08 (p=0.72). By 3 between VAT a In the group wi BMI and WC a tion between the e found a good nosis of liver fib sis or cirrhosis. iver fibrosis (e.g rosis and begin N c disorders due s do not only pl ments are bad pr mi et al. JLUMH (left) Dispersion g ssue volume. (righ ssue volume. In bl n with liver ela r Labbé 3 , Jessica L 6 , and Sergio Urib na, Chile, 2 Biomed Católica de Chile, & Diabetes, Pontifi lica de Chile, Sant is on patients wi her hip In of cal es ist tic he he kg, on, cal ete ht, old F). 1.65 ± 0.8 m/s, of VAT (Figure between ARFI y analyzing the g and ARFI (p=0. ith ARFI inferio are bad predicto e stiffness of the correlation betw brosis/cirrhosis. W On this group, h g. liver biopsy) o NASH medical t to metabolic dis lay a role in live redictors of this HS 2008 3. http:// Figure 1. adipose tis graph showing the ht) Dispersion grap lue squares data w astography an Liberona 5 , Marco A be 2,4 dical Imaging Cent Santiago, Región icia Universidad C tiago, Región Metr ith Non-alcoholi (range 0.8-3.4 e 2, left) (r=0.13 and VAT was -0 group with ARF 12), 0.66 betwee or to 1.6 m/s the ors of VAT volu e liver and the ad ween ARFI valu We identified a higher VAT vol on those patient therapy. seases, different er fibrosis diagn fat depot. /rsbweb.nih.gov MRI image (a), a ssue (c), and subcu e relation between ph showing the rel with direct correlati nd anthropom Arrese 3 , Francisco ter, Pontificia Uni Metropolitana, Ch Católica de Chile, ropolitana, Chile ic Fatty Liver D m/s). The amou for BMI), and ( 0.01 (p=0.94), be FI superior to 1.6 en SAT and AR e largest correlat ume in type 2 d dipose tissue dep ues and the amo subgroup of pat lume was associ ts with largest A t imaging bioma osis, but can als v/ij/ 4. Nguyen e and binary image utaneous adipose twaist circumferen lation between AR ion. etry, in type 2 Cruz 4 , Claudia versidad Católica hile, 4 Radiology, Santiago, Región isease (NAFLD) unt of VAT was (r=0.56 for WC) etween SAT and 6 m/s (suggestive RFI (p=0.10), and tion was r=0.33 diabetic patients pots in the entire ount of VAT and tients with ARFI iated with higher ARFI and larges arkers should be so measure VAT et al Hepatology (b) visceral issue nce and visceral RFI and visceral 2 ) s . d e d , , e d I r t e T y 4097 Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)

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Page 1: Visceral adipose tissue volume measurement using …...border semi-a presen morph We pe fat, A correla RESU showe feature (range 2390c We fo Comp ARFI of adv 0.94 b betwe DISCU indepe

Visce

Cri

1Facude C

Pontif

OBJE[1]. Arisk tobetweparticuVAT afindinusing CircumRadiatrelatiorelatioMETHrange:anthrohistorybiocheBMI, (TF), AdditiMRI sincludshot tuout-ofimagesequenand SAbordersemi-apresenmorphWe pefat, AcorrelaRESUshowefeature(range2390cWe foCompARFI of adv0.94 bbetweDISCUindepepopulaVAT +Clinicsuperiliver samounCONCused tvolumREFE2011,

eral adipose ti

stóbal Martín Serr

lty of Medicine, PoChile, Santiago, Regificia Universidad

Metr

ECTIVE: ViscerAdditionally, it ha

o develop NALen different biomular, we studied and liver stiffnegs; measuremenMRI; anthrop

mference (WC)tion Force Impu

on between anthon between the aHODS: 19 pati: 61.5-97) with opometry, ARFIy, physical exaemical workup, WC, body fat bicipital fold

ionally, 10 TrE mscans were perfoding the followiurbo spin-echo, f-phase, T1 grade sequences. Wence, centered atAT volumes. Thr until below theautomatic softwnce of hepatichological criteriaerformed differeARFI and anthation statistic.

ULTS: Clinicaled that no subjes of liver cirrhe = 22.6-29), ancc ± 801cc, (rangound a poor correparing measurem

was 0.10 (p=0.6vanced liver fibrobetween (VAT+en (VAT+SAT) USSION: We cendent of the boation. However,+ SAT.

cal diagnosis indior to 1.6m/s thastiffness. This fint of VAT to conCLUSION. Becto study the clin

mes, since it has bERENCES. 1. v

5. Schwenzer et

issue volume m

rano García1,2, Fran

ontificia Universidgión MetropolitanCatólica de Chile,

ropolitana, Chile, 6

ral Adipose Tissas been reported

LFD [2]. In thismarkers and livethe association

ess. For this purpnts of VAT andometric indexe) and Transienulse) for measurihropometric ind

amount of VAT aents (mean ageDM2 were enroI, and MRI. C

am and laboratoHbA1c). Anthropercentage (BF(BF), supraili

measurements wormed on a Philing sequences: T2 with fat satudient echo, ande also included t fat, to assess he FOV includee kidneys. VAT

ware (Image J [3c disease waa over the MRI sent comparisonshropometry usin

l diagnosis anject had clinicahosis. The BM

nd the WC was ge = 1173-2252) elation comparin

ments of adipose 66) and betweenosis [4]), we fouSAT) with ARFand ARFI (p=0

confirmed previdy phenotype. M in those patient

dicated that noneat are at a greateinding suggests nfirm whether thcause of the impnical condition obeen demonstrat

van der Poorten et al Invest Radio

measurement

ncisco Barrera3, HPrieto2,6,

dad Católica de Chna, Chile, 3Gastroe, Santiago, Región6Electrical Engine

sue (VAT) has bd that type 2 diab work, we proper fibrosis/cirrhoof liver fibrosis/pose, we performd Subcutaneous es, like Body nt Elastographying liver stiffnesdexes and MRIand the stiffness : 62 years, rangolled. All patienClinical evaluatory data (hemoopometric data

F%), brachial ciriac fold (SpF)

were made in the llips Intera 1.5Thalf-Fourier sin

uration, in-phased diffusion weiga spectral excitaquantitatively V

ed the diaphragmwas measured u3]) (Figure 1). s evaluated u

scans. between abdomng the Pearson

nd MRI findinal or biochemicI was 29.3 ± 499.7cm ± 9.1 (rand SAT was 3

ng anthropometrtissue with ARF

n (VAT+SAT) wund that the correFI (p=0.001) (Fi.29). ous results [5],

Moreover, we didts with greater l

e of the DM2 paer risk of developerforming furt

here is a progresplications of devf the liver. For tted that anthropoet al Hepatology

ol 2010.

using MRI, andiab

Hugo Vidal4, CarloPablo Irarrázaval2

hile, Santiago, Regenterology, Pontifin Metropolitana, Ceering, Pontificia U

been associated wbetic patients (Dpose to evaluateosis in type 2 dia/cirrhosis with bmed a study that

Adipose TissueMass Index (B

y (TrE) using ss. Furthermore, measurement of the liver.

ge: 55-75, meannts underwent cltion included cglobin, platelet assessed includercumference (B) and subscapuright lobe of the

T MR ngle-e and ghted ation VAT matic using

The using

minal n’s

ngs cal 4.7 range =85-120).143cc ± 1298ccric indexes with FI we found that

with ARFI was 0.elation was 0.63igure 2, right). I

indicating that d not find a relatliver stiffness w

atients had diagnoping liver fibrosher studies of lision of liver fibrveloping hepaticthis, MR imagesometric measurey 2008, 2. Luxm

Figure 2. adipose tiadipose ti

nd its relationbetic patients.

s Riquelme4, Pilar,6, Cristián Tejos2,6

gión Metropolitanficia Universidad CChile, 5Nutrition &Universidad Catól

with liver fibrosi

DM2) are at highe the relationshabetic patients. Ioth the amount ot included clinice (SAT) volumeBMI) and WaiARFI (Acoust

we evaluated thof VAT and th

n weight: 77.2klinical evaluatiocomplete medic

count, compleed weight, heighC), tricipital foular fold (SbFe liver.

. The TrE was . measurements o: the correlation .08 (p=0.72). By

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BMI and WC ation between thee found a good

nosis of liver fibsis or cirrhosis. iver fibrosis (e.grosis and begin Nc disorders due s do not only plments are bad pr

mi et al. JLUMH

(left) Dispersion gssue volume. (righssue volume. In bl

n with liver ela

r Labbé3, Jessica L6, and Sergio Urib

na, Chile, 2BiomedCatólica de Chile,

& Diabetes, Pontifilica de Chile, Sant

is on patients wiher hip In of

cal es ist tic he he

kg, on, cal ete ht,

old F).

1.65 ± 0.8 m/s,

of VAT (Figurebetween ARFI

y analyzing the gand ARFI (p=0.ith ARFI inferio

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brosis/cirrhosis. WOn this group, h

g. liver biopsy) oNASH medical tto metabolic dis

lay a role in liveredictors of this

HS 2008 3. http://

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graph showing theht) Dispersion graplue squares data w

astography an

Liberona5, Marco Abe2,4 dical Imaging Cent

Santiago, Región icia Universidad Ctiago, Región Metr

ith Non-alcoholi

(range 0.8-3.4

e 2, left) (r=0.13 and VAT was -0group with ARF12), 0.66 betwee

or to 1.6 m/s the

ors of VAT volue liver and the adween ARFI valu

We identified a higher VAT volon those patienttherapy. seases, different

er fibrosis diagnfat depot.

//rsbweb.nih.gov

MRI image (a), assue (c), and subcu

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ic Fatty Liver D

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t imaging biomaosis, but can als

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and binary image (utaneous adipose ti

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Cruz4, Claudia

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isease (NAFLD)

unt of VAT was

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6 m/s (suggestiveRFI (p=0.10), and

tion was r=0.33

diabetic patientspots in the entire

ount of VAT and

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arkers should beso measure VAT

et al Hepatology

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4097Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)