voluntary recall of jack rabbit
DESCRIPTION
FDA posts the announcement of Jack Rabbit Inc. regarding its voluntary recall of “Jack Rabbit” on 12th Aug 2013.TRANSCRIPT
Voluntary Recall of Lot 2510 of Jack Rabbit
P.Naina MohamedPharmacologist
Introduction The Food and Drug Administration (FDA) posts the
announcement of Jack Rabbit Inc. regarding its voluntary recall of one lot of the company's dietary supplement product sold under the name “Jack Rabbit” on 12th Aug 2013.
The lab analysis by Food and Drug Administration (FDA) for Lot 2510 found that the product contains sildenafil and Tadalafil.
Sildenafil and Tadalafil are not listed on the product label. The undeclared ingredients may interact with nitrates found in
some prescription drugs such as nitroglycerin and may lower blood pressure to dangerous levels.
Consumers with diabetes, high blood pressure, high cholesterol, or heart disease often take nitrates.
The product may cause side effects, such as headaches and flushing.
Possible Mechanism of ActionJack Rabbit
Contains undeclared Sildenafil and Tadalafil
Inhibition of Phosphodiesterase 5 (PDE 5)
Inhibition of Breakdown of cGMP
Increase the concentration of cGMP in smooth muscle of corpus cavernosum and penile arteries
Smooth muscle relaxation
Increase the blood flow to corpus cavernosum
Penile Erection
Interaction with Nitrates
Undeclared ingredients (Sildenafil and Tadalafil)
Interact with prescription drugs like nitrates (Nitroglycerin)
Excessive dilation of smooth muscle of blood vessels
Lower blood pressure to dangerous levels
Hypotension
Heart Attack
Interaction with Antihypertensives
Undeclared ingredients (Sildenafil and Tadalafil)
Interact with Alpha adrenergic blockers and other antihypertensives
Lower blood pressure to dangerous levels
Hypotension
Interaction with CYP3A4 inhibitors
Undeclared ingredients (Sildenafil and Tadalafil)
Interact with CYP3A4 enzyme inhibitors like Ketoconazole, Erythromycin, Ritonavir
Lower blood pressure to dangerous levels
Hypotension
Adverse Effects
Jack Rabbit may cause side effects, such as headaches and flushing.
Jack Rabbit
Contains undeclared Sildenafil and Tadalafil
Inhibition of Phosphodiesterase 5 (PDE 5)
Vasodilation
Headache and Flushing
Conclusion Jack Rabbit Pack is marketed as a dietary supplement for sexual
enhancement. Customers who have this product in their possession should stop using
it immediately and contact their physician if they have experienced any problems that may be related to taking this product.
FDA announces to the public of a growing trend of dietary supplements or conventional foods with hidden drugs and chemicals. These products are typically promoted for sexual enhancement, weight loss, and body building, and are often represented as being “all natural.”
FDA claims that they are unable to test and identify all products marketed as dietary supplements on the market that have potentially harmful hidden ingredients.
FDA advises the Consumers to exercise caution before purchasing any product in the above categories.
References http://www.fda.gov/Safety/Recalls/ucm365720.htm?source=govd
elivery&utm_medium=email&utm_source=govdelivery Goodman & Gilman's The Pharmacological Basis of
Therapeutics, 12e Laurence L. Brunton, Bruce A. Chabner, Björn C. Knollmann
Harrison's Online Featuring the complete contents of Harrison's Principles ofInternal Medicine, 18e Dan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, J. Larry Jameson, Joseph Loscalzo, Eds.
Hurst's The Heart, 13eValentin Fuster, Richard A. Walsh, Robert A. Harrington
Basic & Clinical Pharmacology, 12e Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor
Clinician's Pocket Reference, 11eLeonard G. Gomella, Steven A. Haist
References http://www.nlm.nih.gov/medlineplus/druginfo/
meds/a604008.html http://www.rxlist.com/cialis-tadalafil/drug-2.ht
m http://
www.medicinenet.com/tadalafil/article.htm http://www.drugs.com/tadalafil.html