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Wednesday, September 10, 201412 noon Eastern, 9 a.m. Pacifc, 5 p.m. UK, 6 p.m. Central Europe

Register Now!webinar.sciencemag.org

Speakers

Ulrich Broeckel, M.D.

Medical College ofWisconsin

Milwaukee, WI

Audrey Papp

Ohio State University,Columbus, OH

Expandingthe Scope ofRNA-Seq:From Stem

Cells

to FFPE

Brought to you by theScience/AAAS Custom

Publishing Ofce

@SciMagWebinars

During the webinar, viewers will:ï Hear about current approaches using RNA-seq for biomarker discovery

ï Discover novel techniques using NGS for differential gene expression

ï Learn what bioinformatics tools are being used in RNA-seq applications

ï Have their questions answered live by our expert panel!

As next generation sequencing (NGS) platforms advance in theirspeed, ease-of-use, and cost-effectiveness, many researchers are tran-sitioning from microarrays to RNA sequencing (or RNA-seq) for theirgene expression analysis needs. RNA-seq goes beyond differentialgene expression to provide fundamental insights into how genomesare organized and regulated. Some RNA-seq platforms also offerhigher sensitivity, increased sample number fexibility, and the abilityto analyze highly degraded or rare samples from as little as 10 ng ofinput RNA. During this webinar, our expert speakers will discuss howNGS and RNA-seq can be broadly applied, including for the analysisof gene regulation through allelic expression and long non-codingRNAs, particularly in pharmacogenomics; for identifcation of novelmicroRNAs and transcript isoforms in stem cells; or for the discoveryof new tumor biomarkers in archived formalin-fxed, paraffn-embed-ded samples.

Webinar sponsored by

698 8 AUGUST 2014 • VOL 345 ISSUE 6197 sciencemag.org/products SCIENCE

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cient uptake of the oligonucleotide by the

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for therapeutic applications.

Link Technologies

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�� �������� ���������������The new enzyme-linked immunosorbent

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and is especially critical for many analytes in early diagnosis and

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assays for important metabolic and

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sequencing has enabled the discovery

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provide high-quality, long oligos.

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The Leading Journal for Cell Signaling

CANCER BIOLOGY

Vemurafenib Potently Induces EndoplasmicReticulumStress–Mediated Apoptosis inBRAFV600EMelanoma CellsD. Beck et al. (F. Meier), Sci. Signal. 6, ra7 (2013)

NEUROSCIENCE

Requirement for Nuclear CalciumSignaling inDrosophila Long-TermMemoryJ.-M. Weislogel et al. (H. Bading), Sci. Signal. 6, ra33 (2013)

CELL AND MOLECULAR BIOLOGY

ANontranscriptional Role for HIF-1α as a DirectInhibitor of DNAReplicationM. E. Hubbi et al. (G. L. Semenza), Sci. Signal. 6, ra10 (2013)

IMMUNOLOGY

Monovalent andMultivalent Ligation of theB Cell Receptor Exhibit Differential Dependenceupon Syk and Src Family KinasesS. Mukherjee et al. (A. Weiss), Sci. Signal. 6, ra1 (2013)

COMPUTATIONAL AND SYSTEMS BIOLOGY

Cross-Species Protein InteractomeMappingReveals Species-SpecificWiring of StressResponse PathwaysJ. Das et al. (H. Yu), Sci. Signal. 6, ra38 (2013)

Join the ranks of high-profile paperspublished in Science Signaling:

Publishing key findings of broadrelevance in the multidisciplinaryfield of cell signaling

[email protected]

Chief Scientif ic Editor

Michael B. Yaffe, M.D., Ph.D.Massachusetts Institute of Technology

Editor

Nancy R. Gough, Ph.D.

AAAS, Washington, DC

Submit your researchScienceSignaling.org

Recommend to your libraryScienceOnline.org/recommend