weeks ohm 2012 (final)

The Weeks Clinic for Corrective Medicine and Psychiatry © 2011

The War is Overso

Don’t Kill the Messenger!

OHMSan Francisco CA Feb 25th 2012

Bradford S. Weeks, M.D.www.weeksclinic.com [email protected]


Appreciation and

Congratulations!


Tenzin Choedrak

Jonathan Wright Abram Hoffer David Horrobin

Otto Wolff Richard Kunin


““The Pioneer The Pioneer is the fellow is the fellow with all the with all the arrows in his back”arrows in his back”


Distinguished Professor Peter Duesberg: “Aneuploidy”Distinguished Professor Peter Duesberg: “Aneuploidy”

This lectureThis lectureis dedicatedis dedicatedto my to my Friend and Friend and Source of Source of InspirationInspiration


"A physician once told me that nothing arouses so much bitter enmity and heated arguments among his colleagues, as the subject of cancer. This may be due to the guilty recollections of cancer victims expiring who might have been saved; or of the memories of patients pronounced hopelessly ill who recovered under the treatment of a 'quack,' or who miraculously lived without further treatment. Possibly these guilt reactions and the remorse over exhausting the money of patients and their relatives in futile cancer treatments, account for some of these psychological manifestations which are expressed in hostility and attack."

Nat Morris (written in 1958)


GOALS for this Presentation

1) Consider the nature of cancer as confused and not aggressive; i.e. “Cellular ADHD”

2) understand the futility of killing cancer without enhancing vitality of the person within which the cancerous process is occurring;

3) understanding the pros and cons of conventional chemotherapy and radiation;

4) understand the importance of addressing cancer

STEM cells in addition to cancer TUMOR cells,

5) understand the theoretical and practical aspects of Corrective Cancer Care ™

The next 55 minutes…


• Definition of Terms towards a Reconsideration of the Nature of Cancer

• Problems with the Standard of Care • Introducing Cancer STEM Cells

• The Revolution In Oncology 2009-present • New Directions in Oncology • Improving the Standard of Care: Corrective Cancer Care • Doctoring the Cancer STEM Cells

• Clinical Case Studies

Part 1

Definition of Termstowards a

Reconsideration of the Nature of Cancer



1) What is “cancer”?&

2) What is a “dog”?


Which box are you thinking outside of?


A Common Understanding of a “DOG”


RORY


New Puppy Syndrome


What means “Cancer”

• Is cancer aggressive?• Is cancer simply confused?• Should we kill the cancer or should we doctor

(“lead or teach”) the cancer? • “To understand something, we must study

from whence it derives.” Goethe 1749-1832

(scientist, poet, writer, philosopher)


Reconsideration: The Nature of Cancer

1) Is cancer aggressive, or is cancer simply confused?

2) Metaphor: “Molecular ADHD”


The Mechanisms of Malignancy

““Malignancy is an anti-social Malignancy is an anti-social expression, on the cellular expression, on the cellular level, which is free from any level, which is free from any ““higherhigher”” level of level of ““integratedintegrated”” control…”control…”

Rudolf SteinerRudolf Steiner


Should these ADHD kids be hit… Should these ADHD kids be hit… or should they be taught? or should they be taught? (Note: that is a rhetorical question!)(Note: that is a rhetorical question!)


The Problem? or The Potential?”The Problem? or The Potential?”


‘‘When a plant is sick, When a plant is sick, treat the soil, not just the plant.”treat the soil, not just the plant.”

““When a child is misbehaving, When a child is misbehaving, assess the environment assess the environment before medicating the patient.”before medicating the patient.”

““When you discover cancer, When you discover cancer, don’t treat the cancer cell, don’t treat the cancer cell, instead treat the cancerous process.”instead treat the cancerous process.”


“Nature abhors a vacuum.”

Empty or unfilled spaces are unnatural as they go against

the laws of nature and physics.


““Cancer is not aggressive. Cancer is not aggressive. It simply moves into It simply moves into

abandoned etheric spaces.”abandoned etheric spaces.”

Rudolf Steiner.Rudolf Steiner.


Cancer is not the problem.

Cancer is an adaptive response to the problem.

Toxic blood and tissue (the mesenchyme) is the problem.

Metaphor: Every town has a garbage dump.Solution: make less trash, recycle.

To avoid cancer: eat non-toxic foods and eat less!


Removing the tumor is the least Removing the tumor is the least important step in curing cancer.important step in curing cancer.


““The symptom is a healing gesture.” The symptom is a healing gesture.” Samuel Hahnemann, M.D. (Ab)Samuel Hahnemann, M.D. (Ab)

Symptoms represent the body's efforts to heal itself. Symptoms represent the body's efforts to heal itself. Therefore they are stimulated to complete the curative Therefore they are stimulated to complete the curative process. process.

The totality of symptoms is considered. The totality of symptoms is considered. The individual’s complete symptom picture is taken The individual’s complete symptom picture is taken into account: mental, emotional and physical into account: mental, emotional and physical complaints.complaints.


“Don’t kill the messenger”

Cancer brings the message of systemic toxicity.


Part 2:Part 2:

Problems with Problems with the Standard of Care the Standard of Care


Pros and Cons of Conventional Chemotherapy

Pros:Powerful drugsEffective at killing cancer TUMOR cells

Cons: -Powerful drugs-Effective at killing patients while killing cancer -Cost (average oncologist mark up = 400%) - Low effectiveness rate = 2.1% (!)- … but NOT effective in killing cancer STEM cells!


Problems with Conventional Chemotherapy

1) Adequate intra-cellular concentrations requires high dose, systemic administration of these drugs.

2) Lack of tissue specificity for drugs.

3) Consequence: Multiple tissue and organ toxicity (“side-effects”).

4) Note the tragic and little reported facts that 1) chemotherapy and radiation do NOT kill stem cells and 2) 99% of the cells in a cancerous tumor are NON-cancerous


FACT: ~ 2% of all cancers respond to chemotherapy (!!!??)FACT: Conventional Chemotherapy hurts more than it helps.

OPINION: “The overall contribution of curative and adjuvant cyto-toxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA . . . chemotherapy only makes a minor contribution to cancer survival. To justify the continued funding and availability of drugs used in cytotoxic chemotherapy, a rigorous evaluation of the cost-effectiveness and impact on quality of life is urgently required.”

Morgan G, Ward R, Barton M. in his article: The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. See Clin Oncol (R Coll Radiol). 2004 Dec;16(8):549-60.)

Problems with Conventional Chemotherapy Problems with Conventional Chemotherapy (cont.)(cont.)


Why Do Cancer Cells Resist Chemotherapy?

1. resistant cells survive and reproduce “survival of the fittest”; 2. cancer cells mutate and replicate3. gene amplification: hundreds of copies of genes which produce

chemo-inactivating proteins (inc. MDR gene expression).4. P-glycoprotein pump which pumps drug out of cells (inc. MDR

expression).5. cancer cells inactivate the pump which brings the drugs into the

cells (e.g. decreased expression folate transporter with MTX).6. cancer cells “learn” to repair DNA damage caused by some

chemo drugs (inc. nucleoside excision repair with alkylating agents and platinum drugs; inc. O alkyl-guanine alkyl transferase with nitrosureas, procarbazine, and temozolamide).

7. cancer cells “learn” to inactivate chemo drugs or decrease their activation (decreased folypolyglutamyl synthetase with MTX or decreased deoxycytidine kinase with cytosine arabinoside, fludarabine phosphate, and cladrabine).

8. increased detoxification (increased glutathione or GSH tranferase)

Answer:

“It’s the cancer STEM cells,

stupid!”



What would be the Elements of an Ideal

Solution to this Chemotherapy Dilemma?

1) To develop a method of differentiating the cancer cell population from the normal cell population.

2) To deliver lowered doses of drug more specifically into this differentiated cancer cell population.

3) To maintain and /or enhance chemotherapy’s cell-killing effectiveness in cancer cells.

4) To reduce / avoid chemo side effects in normal cells.

5) To doctor the cancer STEM cells and not just the cancer TUMOR cells.


Part 3:Part 3:

Introducing Introducing Cancer STEM CellsCancer STEM Cells


Stem cells vs. Germ cells Stem cells vs. Germ cells

Definition of terms: Definition of terms:

1908: The term "stem cell" was proposed for scientific use by 1908: The term "stem cell" was proposed for scientific use by the Russian histologist Alexander Maksimov (1874–1928) at the Russian histologist Alexander Maksimov (1874–1928) at congress of hematologic society in Berlin. It postulated congress of hematologic society in Berlin. It postulated existence of haematopoietic stem cells.existence of haematopoietic stem cells.

1911 “germ cells” John Beard. D.Sc., 1911 “germ cells” John Beard. D.Sc., The Enzyme The Enzyme Treatment of Cancer and its Scientific BasisTreatment of Cancer and its Scientific Basis. .

“The physical martyrdom was lacking; but there are, as I can testify from experience, many

more ways than one of burning a scientific man at the stake.”

John Beard. D.Sc., The Enzyme Treatment of Cancer and its Scientific Basis. 1911


Scientists spotted the first cancer stem cell in 1994, in a form ofScientists spotted the first cancer stem cell in 1994, in a form ofleukemia, and during the past decade, reports of cancer stem cells in leukemia, and during the past decade, reports of cancer stem cells in diverse solid tumors have proliferated, although much of the latest diverse solid tumors have proliferated, although much of the latest research has yet to be replicated and confirmed. What's more, the research has yet to be replicated and confirmed. What's more, the cancer-stem-cell hypothesis-even the idea that such cells exist in most cancer-stem-cell hypothesis-even the idea that such cells exist in most cancers-is far from universally accepted.cancers-is far from universally accepted.

"There are lots of ideas about which cancers follow the model and "There are lots of ideas about which cancers follow the model and which don’t. Dogmas are being created at a furious rate, with ideas which don’t. Dogmas are being created at a furious rate, with ideas that people find intuitively attractive getting repeated to the point that that people find intuitively attractive getting repeated to the point that nobody remembers that they've never actually been tested.”nobody remembers that they've never actually been tested.”Sean Morris Sean Morris www.lsi.umich.edu/facultyresearch/labs/morrison/pi

Modern “discovery of cancer STEM cellsModern “discovery of cancer STEM cells

http://www.lsi.umich.edu/facultyresearch/labs/morrison/pi


Once again… What Once again… What isis Cancer? Cancer?

Cancer is understood to be unregulated Cancer is understood to be unregulated cells proliferating autonomously within cells proliferating autonomously within the human being – either in humoral or the human being – either in humoral or tumorous form. tumorous form.

(Remember: Are these (Remember: Are these aggressive or confused cells? aggressive or confused cells? Molecular ADHD?)Molecular ADHD?)


What is a Tumor?What is a Tumor?

A tumor, benign or malignant, A tumor, benign or malignant, is a proliferation of cells of is a proliferation of cells of which, in the case of a malignant which, in the case of a malignant cancer, cancer, less than 1% of which are less than 1% of which are dangerous.dangerous.


Only cancer STEM cells metastasizeOnly cancer STEM cells metastasize

99.1% - 99.6% of the tumor cells are NOT 99.1% - 99.6% of the tumor cells are NOT dangerous (aside from steric, obstructive dangerous (aside from steric, obstructive factors). factors).

““Similarly, usually less than 1% of primary Similarly, usually less than 1% of primary tumor cells cultured tumor cells cultured in vitroin vitro can give rise to can give rise to colonies.colonies.”” Diehn, M Diehn, M Therapeutic Implications of the Cancer Stem Cell Therapeutic Implications of the Cancer Stem Cell HypothesisHypothesis S Semin Radiat Oncolemin Radiat Oncol. 2009 April; 19(2): 78–86.. 2009 April; 19(2): 78–86.


What metastasizes?… Stem cellsWhat metastasizes?… Stem cells!!

““… … For For in vivoin vivo tumor transplantation, this is reflected in the tumor transplantation, this is reflected in the large numbers of tumor cells that must usually be large numbers of tumor cells that must usually be transplanted to form a tumor. transplanted to form a tumor. For primary human and For primary human and mouse tumors,mouse tumors, this number often resides in the this number often resides in the thousands or millions. thousands or millions. (ibid Diehn et al) (ibid Diehn et al)

““Considerable evidence suggests Considerable evidence suggests that tumors contain that tumors contain only a minority of cells which are capable of only a minority of cells which are capable of regrowing the tumor (ie. tumor stem cells).regrowing the tumor (ie. tumor stem cells).

Hill RP The proportion of stem cells in murine tumors. Int J Radiat Oncol Hill RP The proportion of stem cells in murine tumors. Int J Radiat Oncol

Biol Phys. 1989 Feb;16(2):513-8Biol Phys. 1989 Feb;16(2):513-8..


Normal TissueNormal Tissue Stem Cells resist Chemotherapy Stem Cells resist Chemotherapy

““A large number of the most frequently used A large number of the most frequently used therapies for cancer induce cell death by therapies for cancer induce cell death by inducing DNA damage. These agents are also inducing DNA damage. These agents are also toxic to normal stem cells and their progeny.toxic to normal stem cells and their progeny.Fortunately, normal stem cells have Fortunately, normal stem cells have evolved multiple mechanisms to evolved multiple mechanisms to protect themselves from toxins and protect themselves from toxins and genotoxic stress, which make them genotoxic stress, which make them relatively resistant to cell killing with relatively resistant to cell killing with cytotoxic agents.cytotoxic agents.”” (ibid Diehn et al) (ibid Diehn et al)


CancerCancer stem stem cells are resistant to chemotherapycells are resistant to chemotherapy

““The apparent similarities between normal stem cells The apparent similarities between normal stem cells and CSC led to the hypothesis that CSC may be and CSC led to the hypothesis that CSC may be relatively resistant to common chemotherapeutic relatively resistant to common chemotherapeutic agents compared to their more differentiated non-agents compared to their more differentiated non-tumorigenic counterparts and that improvements in tumorigenic counterparts and that improvements in patient outcomes might be achieved by directly patient outcomes might be achieved by directly targeting CSC. Mounting evidence suggests that this is targeting CSC. Mounting evidence suggests that this is the case. Recent studies have shown thatthe case. Recent studies have shown that ““cancer cancer stem cell-like cellsstem cell-like cells”” present in some established present in some established cell lines and in long-term xenograftscell lines and in long-term xenografts appear to be appear to be relatively resistant to cytotoxic relatively resistant to cytotoxic chemotherapeutics.chemotherapeutics.”” (ibid Diehn et al)(ibid Diehn et al)


Cancer Stem Cells resist Chemotherapy

Baker, M Stem cells: Fast and furious.Nature. 2009 Apr 23;458(7241):962-5.


……and Cancer STEM Cells are and Cancer STEM Cells are resistant to resistant to Radiation TherapyRadiation Therapy also also

““Thus, CSC in some tumors appear to be resistant to Thus, CSC in some tumors appear to be resistant to cytotoxic chemotherapies. As is discussed elsewhere cytotoxic chemotherapies. As is discussed elsewhere in this issue, in this issue, CSC in some tumors also CSC in some tumors also appear to be resistant to radiotherapy.appear to be resistant to radiotherapy. These findings suggest the overcoming CSC These findings suggest the overcoming CSC resistance mechanisms to cytotoxic therapies may resistance mechanisms to cytotoxic therapies may result in higher cure rates.result in higher cure rates.”” (ibid Diehn et al)(ibid Diehn et al)


Part 4:Part 4:

The Revolution The Revolution in Oncology in Oncology

2009-present2009-present


Chemotherapy increases Chemotherapy increases cancer stem cell cancer stem cell proliferationproliferation

…… colon cancer stem cells were colon cancer stem cells were enrichedenriched in xenografts that had been in xenografts that had been treated with treated with cyclophosphamidecyclophosphamide compared to untreated control compared to untreated control tumors.tumors.

Diehn, M Diehn, M Therapeutic Implications of the Cancer Stem Cell Therapeutic Implications of the Cancer Stem Cell HypothesisHypothesis S Semin Radiat Oncolemin Radiat Oncol. 2009 April; 19(2): 78–86.. 2009 April; 19(2): 78–86.


Chemotherapy increases Chemotherapy increases cancer STEM cell cancer STEM cell number & number & virulencevirulence

““Enrichment was documented both as anEnrichment was documented both as an increased increased percentage of cancer stem cellspercentage of cancer stem cells as as measured by measured by flow cytometry and asflow cytometry and as higher tumor forming higher tumor forming capacitycapacity in limiting dilution assays.in limiting dilution assays.””

Li X, Lewis MT, Huang J, et al. Li X, Lewis MT, Huang J, et al. Intrinsic resistance of Intrinsic resistance of tumorigenic breast cancer cells to chemotherapytumorigenic breast cancer cells to chemotherapy. . J Natl J Natl Cancer InstCancer Inst. 2008;100:672–9.. 2008;100:672–9.


Max Wicha, M.D.Distinguished Professor of Oncology

Director, University of Michigan Comprehensive Cancer Center

• “The problem is, when we treat cancer cells with chemotherapy, the cancer stem cells are being stimulated to grow too.”

• “When we take mesenchymal stem cells and mix them with tumor cells, the tumors grow much more quickly in animals.”


Cancer expert tells how treatment can be problem

Wednesday, February 24, 2010 By Mark Roth, Pittsburgh Post-Gazette

Max Wicha: Hopes cancer treatments can avoid general chemo altogether and just use targeted therapies against the stem cells.

Max Wicha is coming to Pittsburgh today to deliver a startling message. Standard cancer treatments not only often fail to eradicate cancer, but can make it worse.

That argument isn't coming from a fringe proponent of alternative medicine, but from the founder of the University of Michigan's Comprehensive Cancer Center and a pioneer in research on why cancers recur and spread to other parts of the body.


..treatment is a problem (cont.)

The reason breast cancer and other malignancies often return aggressively after treatment is that when tumor cells die under assault from chemotherapy and radiation, they give off substances that can reactivate a special set of master cells known as cancer stem cells, Dr. Wicha said in an interview Tuesday….

Dr. Wicha's lab has found that inflammatory molecules secreted by dying tumor cells can hook up with the stem cells and cause them in effect to come out of hibernation.



• Adult stem cells exist in most tissues, and go into action to repair damage from wounds or infections.

• In cancer, they can mutate and no longer obey normal bodily signals to stop growing, Dr. Wicha said.

• He and other researchers say that even when chemotherapy and radiation cause tumors to shrink dramatically, these stem cells can stay alive, living under the radar until they are once again spurred into action.



• They also believe stem cells are probably the ones that break away from an original tumor and cause cancer to spread elsewhere in the body.

• Chemo and radiation kill off the fastest-growing cells in the body, which applies to most cancer cells, but the cancer stem cells that create those rapidly dividing tumor cells actually grow much more slowly themselves, and are less susceptible to those therapies, he said.

• One tactic to address this problem is to kill off both types of cancer cells at once, Dr. Wicha said.



• A recent experimental trial with advanced breast cancer patients at the University of Michigan, Baylor University in Texas and the Dana-Farber Cancer Institute at Harvard University used standard chemotherapy along with a substance designed to block one of the biochemical pathways of stem cells.

• The approach killed off more than 90 percent of the cancer stem cells, Dr. Wicha said, and researchers now hope to expand the treatment to a much larger group of patients.



• Ultimately, he hopes cancer treatments can avoid general chemo altogether, with its debilitating side effects, and just use targeted therapies against the stem cells.

• There is still a long road ahead, he said, and "my feeling is, to really knock these stem cells out, we're probably going to have to use multiple inhibitors.“

You Tube http://weeksmd.com/?p=5014 and http://wn.com/professor_max_wicha__breast_cancer_stem_cell_regulation

http://weeksmd.com/?p=5014

http://wn.com/professor_max_wicha__breast_cancer_stem_cell_regulation

http://wn.com/professor_max_wicha__breast_cancer_stem_cell_regulation


The Public “retraction”

“Cancer patients, follow recommended care!

An article published by the Post-Gazette claimed that our research suggests cancer treatments "not only often fail to eradicate cancer, but can make it worse" This statement has been misinterpreted by patients currently receiving radiation or chemotherapy treatments. I have been contacted by both my own patients and Pittsburgh-area patients who have questioned whether they should continue with their chemotherapy. In fact, these treatments are lifesaving for many patients.


…Retraction (cont.)

• Our work does suggest that the resistance of a small population of tumor cells to these treatments may account for some of their limitations. Based on this, we are working to develop new approaches to target this specific cell population -- treatments that could augment chemotherapy and radiation therapy. New treatments based on this theory are in their early testing stages. Only through the conduct of rigorous clinical trials will we be able to determine whether addition of these new therapies improves the outcome for patients with cancer.

• In the meantime, patients diagnosed with cancer need to follow their doctors' recommendations for treatment according to the current standards of care and inquire whether they are eligible for a clinical trial.

MAX WICHA, M.D.Distinguished Professor of OncologyDirector, University of Michigan Comprehensive Cancer CenterAnn Arbor, Mich.”

Chemotherapy stimulates cancer STEM cells

Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance

Women with late-stage ovarian cancer usually develop chemotherapeutic-resistant recurrence. It has been theorized that a rare cancer stem cell, which is responsible for the growth and maintenance of the tumor, is also resistant to conventional chemotherapeutics. …….These results suggest that

chemotherapeutics may be stimulative to cancer stem cells and that selective inhibition of these cells by treating with MIS or targeting LIN28 should be considered in the development of therapeutics.

PNAS 2012 109 (7) 2358-2363; pub 1-27-12


Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

Antiangiogenic therapy has been thought to hold significant potential for the treatment of cancer. However, the efficacy of such treatments, especially in breast cancer patients, has been called into question, as recent clinical trials reveal only limited effectiveness of antiangiogenic agents in prolonging patient survival. New research using preclinical models further suggests that antiangiogenic agents actually increase invasive and metastatic properties of breast cancer cells….. These studies demonstrate that hypoxia-driven cancer stem cell stimulation limits the effectiveness of antiangiogenic agents, and suggest that to improve patient outcome, these agents might have to be combined with cancer stem cell-targeting drugs.

http://www.pnas.org/content/early/2012/01/18/1018866109.full.pdf+html?sid=0e0bafe1-8d4e-434a-b046-d8f394719e2b Sarah J. Conley, Max S. Wicha et al


Chemotherapy stimulates cancer STEM cells Chemotherapy stimulates cancer STEM cells (cont.)(cont.)

http://www.pnas.org/content/early/2012/01/18/1018866109.full.pdf+html?sid=0e0bafe1-8d4e-434a-b046-d8f394719e2b



Is tumor shrinkage the gold standard?

"If the cancer-stem-cell hypothesis is true, treating the majority of dividing cancer cells will shrink a tumor but won't cure the cancer unless we can target the cancer stem cells themselves. That could explain why tumor shrinkage-the gold standard for measuring a drug's effectiveness-doesn’t always translate into longer survival for patients.” Daniel Haber, M.D. Director Massachusetts General Hospital Cancer Center.

<http://www.hms.harvard.edu/dms/bbs/fac/haber.htm>


http://www.hms.harvard.edu/dms/bbs/fac/haber.html


““Chemotherapy and radiation make cancer Chemotherapy and radiation make cancer worse.”worse.” Distinguished Professor Max Wicha, M.D. Distinguished Professor Max Wicha, M.D. Director, U. Michigan Director, U. Michigan

Comprehensive Cancer Center Comprehensive Cancer Center

““When discussing potential targets for the When discussing potential targets for the treatment of cancer today, the conversation will treatment of cancer today, the conversation will generally lean towards targeted therapy of generally lean towards targeted therapy of cancer stem cells (CSCs).” cancer stem cells (CSCs).”

Professor Max Diehn, M.D. Stanford U. Professor Max Diehn, M.D. Stanford U.

The Revolution in Oncology 2012The Revolution in Oncology 2012


Part 5:Part 5:

New DirectionsNew Directionsin Oncology in Oncology


““Recent insights into tumor biology….indicate that in Recent insights into tumor biology….indicate that in many cancers many cancers only a subset of malignant cells only a subset of malignant cells has the potential to proliferate indefinitelyhas the potential to proliferate indefinitely and therefore to give rise to macroscopic metastases and therefore to give rise to macroscopic metastases or to cause tumor recurrence after treatmentor to cause tumor recurrence after treatment””

““It is this subset of cells, often called It is this subset of cells, often called cancer cancer stem cells (CSC), that needs to be targeted stem cells (CSC), that needs to be targeted and eliminated in order to achieve curesand eliminated in order to achieve cures, , since the remaining cancer cells (called non-since the remaining cancer cells (called non-tumorigenic cells) are destined to stop dividing or to tumorigenic cells) are destined to stop dividing or to die.die.”” (ibid Diehl et al)(ibid Diehl et al)

New Directions in Cancer New Directions in Cancer TreatmentTreatment


Furthermore, classic mechanisms of treatment Furthermore, classic mechanisms of treatment resistance, such as clonal selection and the resistance, such as clonal selection and the tumor microenvironment, will continue to tumor microenvironment, will continue to present obstacles for achieving cure.present obstacles for achieving cure. It is therefore It is therefore likely that combinations of cytotoxic, likely that combinations of cytotoxic, biologicbiologic, and CSC-, and CSC-directed therapies will ultimately allow the largest possible directed therapies will ultimately allow the largest possible improvements in patient outcomes.improvements in patient outcomes.

IPT and CCC docs are leading the way, IPT and CCC docs are leading the way, but the key to preventing recurrence is the but the key to preventing recurrence is the ADJUVANT therapies and addressing cancer ADJUVANT therapies and addressing cancer STEM cells. STEM cells.

New Directions New Directions (cont.)(cont.)


“The goal of all our existing therapies has been to kill as many cells within the tumor as possible. This study suggests that the current model may

not be getting us anywhere, because we have been targeting the wrong cells with the wrong treatments. Instead, we need to develop drugs targeted tat the tumor’s stem cells. If we are to have any real cures in advanced breast cancer, it will be absolutely necessary to eliminate those cells.”

Professor Max Wicha, M.D.

June 18th 2008 www.cancer.med.umich.edu/news/stemcell.htm

http://www.cancer.med.umich.edu/news/stemcell.htm


The 3 Questions The 3 Questions your patients must ask their oncologist: your patients must ask their oncologist:

•““What will your proposed treatment do to my cancer What will your proposed treatment do to my cancer stem cells?” stem cells?”

1)1)““How are you planning to interrupt the Interleukin 8 How are you planning to interrupt the Interleukin 8 “SOS” message my targeted and dying cancer TUMOR “SOS” message my targeted and dying cancer TUMOR cells will emit in response to your chemotherapy and cells will emit in response to your chemotherapy and radiation? radiation?

•““What chemosensitivity testing will you do to What chemosensitivity testing will you do to determine which chemotherapy agent to use?” determine which chemotherapy agent to use?”


TAKE HOME MESSAGETAKE HOME MESSAGE

1) There is an Earthquake at the Foundation of 1) There is an Earthquake at the Foundation of Oncology today;Oncology today;

2) Killing the tumor is the standard of care (using 2) Killing the tumor is the standard of care (using chemo and radiation) BUT… chemo and radiation) BUT…

3) Leaders in oncology are advising new directions !3) Leaders in oncology are advising new directions !

4) And the 4) And the ““newnew”” direction is what we have offered direction is what we have offered all along:all along: ““When the plant is sick, treat the soilWhen the plant is sick, treat the soil””..

5) The time is NOW to offer Corrective Cancer Care 5) The time is NOW to offer Corrective Cancer Care to people with cancer.to people with cancer.


IPT IPT isis better than conventional better than conventional Chemotherapy – no doubt.Chemotherapy – no doubt.

““Those wicked creatures yet do look well-Those wicked creatures yet do look well-favored, when others are more wicked; not favored, when others are more wicked; not being the worst stands in some rank of being the worst stands in some rank of praise – praise –

II’’ll go with thee: thy fifty yet doth double ll go with thee: thy fifty yet doth double five and twenty, and thou art twice her five and twenty, and thou art twice her love…love…”” Lear, speaking to daughter Goneril when insulted by daughter Regan - Act 2 Lear, speaking to daughter Goneril when insulted by daughter Regan - Act 2 scene 1scene 1


IPT alone, being chemotherapy IPT alone, being chemotherapy (albeit low dose and targeted (albeit low dose and targeted ““kinder and gentlerkinder and gentler””), ), nevertheless nevertheless still worsens prognosisstill worsens prognosis since it still kills ONLY cancer tumor cellssince it still kills ONLY cancer tumor cells (not the cancer STEM cells): (not the cancer STEM cells):

The resulting IL-8 The resulting IL-8 ““SOSSOS”” signal still goes out to signal still goes out to muster reinforcements from the mesenchymal stem muster reinforcements from the mesenchymal stem cells which increase the number and virulence of cells which increase the number and virulence of cancer stem cells.cancer stem cells.

However ….However ….


Part 6:Part 6:

Improving the Improving the Standard of Care: Standard of Care:

Corrective Corrective CancerCancerCareCare


Stem cell Stem cell ““re educationre education”” Adjunctive therapies Adjunctive therapies along with IPTalong with IPT to to entice cancer stem cells to differentiate and entice cancer stem cells to differentiate and become either normal tissue stem cells or become either normal tissue stem cells or normal tissue cells or tumor cells which are normal tissue cells or tumor cells which are vulnerable to chemotherapy or radiation.vulnerable to chemotherapy or radiation.

RX: IPT RX: IPT withwith Adjuvant Therapies Adjuvant Therapies


Corrective Cancer Care (CCC)As a branch of

Corrective Medicine and Psychiatry

The Logo of the Weeks Clinic

Serving the 4 human bodies:Physical, Etheric, Soul and Spirit with a Heart of Compassion

“The Violin Concert”


Corrective Cancer Care™

“The Cordelia Effect”-The Four Steps -

1) Take down the “cancer welcome” sign2) Enhance immune system 3) Reduce or kill cancer TUMOR cells4) re-educate cancer STEM cells

Metaphor: Bailing a sinking boat vs. plugging the hole


When your car breaks down, When your car breaks down, you have an important you have an important

choice.choice.

Call a tow truck or….Call a tow truck or….

Correct the Problem!Correct the Problem!


Correct the Problem!Correct the Problem!

Fill up the gasoline tank!Fill up the gasoline tank!

Put air back in flat tire!Put air back in flat tire!


Pain in Buttock (Standard of Care)

• Prescribe pain medications• If problem persists, increase dosage.• If problem persists, refer to psychiatrist.• Eventually, refer to rehabilitation if patient

becomes addicted to pain medication. • Rarely, check to see if the patient is sitting on

a tack


Pain in Buttock? (Corrective Health Option)

• Delay prescribing pain medications • Check to see if the patients sitting on a tack!• If so , teach about tacks (empower the patient)• If so, teach to avoid tacks(preventive care)


Take Down the “Cancer Welcome” Sign

• Eliminate Toxins• Replenish Deficiencies• Reduce INFLAMMATION • Lifestyle Changes• Belief Changes• The NET (Nutrition Exercise Thought)



Corrective Cancer Care ™

• The Health Pyramid• The “NET” • Nutrition • Exercise • Thought

LIFESTYLE FACTORS (85%)

Repair the “NET”Nutrition (get it) Exercise (use it) Thoughts (manage it)

Supplementand / or

Detoxify

Drugs Surgery

Hospital


Nutrition

• What comes in – all 7 senses• Quality – organic, fresh, • Adequate protein • Fermented Soy (Haelan)• Supplements: MVMM, O3/O6 EFA• Soul food “It’s the little sins that kill

you.”

Otto Wolff 1982


Exercise

• Activity• Doing justice to what comes in• Processing• Digesting• Expression• Creativity (our birthright!)


Thought

• CorThot• Thoughts create feeling • Feelings are transient• Thoughts are directable• Reason for living• Quality of life

Enhance the Immune System

• Psychoneuroimmunology• Beliefs• Actions• No Fear• Supplements• Sleep



SupplementsPrevent cancer cells from repairing themselves

(caffeine)Force apoptosis (curcumin, tumeric)Support immune system

1. Theanine (increases interferon gamma)2. Arginine (increases NKC and T-cell function)3. American ginseng (increases T-cell function)4. Melatonin (increases IL-2, epidermal growth

factor)5. Thymrevit (increases T-cell function)6. Vitamin A, C and others7. Aromatase inhibitors: BioDim, Myomin

Prevent Metastases - Modified Citrus Pectin, Heparin, Thalidomide.

All of the above and more: try fermented soy

Chemo Potentiating Agents

• Insulin• Fasting• Metformin• Sulforafane• Aspirin• Fish oil • Vit C (Zaizen, et al)

• Many more….



Insulin Potentiation Therapy

Utilizes Insulin to Modify Endogenous Mechanisms of Malignancy

Selectively Targets Cancer CellsEnhances Anti-cancer Drug EffectsVery Low Doses of Chemotherapeutic AgentsAlmost Completely Eliminates Dose Related

Side Effects.BUT, being as it is, chemotherapy (albeit

“gentler”)does NOT selectively kill cancer STEM cells !


Physiologic Effects After IV Insulin:

Membrane Effect

Improved drug penetration into cancer cells

Use lower doses to reduce side effects

Shorten treatment cycle intervals

Metabolic Effect

Increased proportion in S phase.

Increase rate of cell kill per cycle

Cellular Differentiation Effect

Excess IR & IGF-R on cancer cells

Specifically targets cancer “smart bomb”

Relative sparing of normal tissue from toxicity


In vitro, after adding insulin to an asynchronous population of breast cancer cells, the S phase fraction was 66% compared to only 37% in the controls.


From Treating Cancer with Insulin Potentiation Therapy p 84by Ross Hauser, M.D. 2002 Pub: Beulah Land Press


Rapidly growing tumors are more sensitive to chemotherapy than slow-growing tumors.

Studies at George Washington University, National Cancer Institute and

M.D. Anderson Hospital & Tumor Institute tested and proved that insulin does potentiate the effects of chemotherapy.


“…Hence, the results of our experiments indicate that tumor-specific growth stimulatory hormones can be utilized to overcome the cyto-kinetic drug resistance. …thereby render subpopulations of tumor cells vulnerable to the lethal effects of cell cycle-active drugs that otherwise would have remained inert to their effects and might have constituted a potential source of late treatment failure.”


Summary: Biochemistry of Insulin and Cancer

Glucose is the ONLY fuel cancer cells can useCancer cells have 6 to 17x > IRs than regular cells Cancer cells have 10 x > IGF-1 Rs than regular

cellsINS+IR increases delta-9-desaturase which makes

cancer cells become permeable IGF-1 doubles number of cancer cells in S-phase;

increasing vulnerability to chemotherapy drugsCancer cells are selectively targeted so lower

doses of chemo drugs preserves immune function

Appetite improves, weight and euphoria increase


IPT is a chemotherapy-based protocol using insulin as a biologic response modifier of the endogenous mechanisms of malignancy.

In IPT, insulin is used to selectively target cancer cells with lowered doses of chemotherapy drugs, enhancing drug effects on these cells and, at the same time, effectively reducing dose-related chemotherapy side effects on host normal tissues.

Summary: Insulin Potentiation Summary: Insulin Potentiation TherapyTherapy

Fasting

"fasting can actually make cancerous cells more susceptible to chemotherapy”

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8215-20. Epub 2008 Mar 31.

Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD.

“Stop eating while still hungry and do not continue until you are satisfied." St. John Cassian


http://www.ncbi.nlm.nih.gov/pubmed/18378900

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Raffaghello%2520L%2522%255BAuthor%255D

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Raffaghello%2520L%2522%255BAuthor%255D

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Lee%2520C%2522%255BAuthor%255D

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Safdie%2520FM%2522%255BAuthor%255D

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Wei%2520M%2522%255BAuthor%255D

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Madia%2520F%2522%255BAuthor%255D

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Bianchi%2520G%2522%255BAuthor%255D

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Longo%2520VD%2522%255BAuthor%255D


Sulforaphane (broccoli) enhances chemotherapy

Sulforaphane protects against cisplatin-induced nephrotoxicity.

Guerrero-Beltrán CECalderón-Oliver MTapia E Pedraza-Chaverri J. et al Toxicol Lett. 2010 Feb 15;192(3):278-85. Epub 2009 Nov 12.

Sulforaphane (SFN) attenuated CDDP-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion, enhanced urinary hydrogen peroxide excretion and the decrease in antioxidant enzymes (catalase, glutathione peroxidase and glutathione-S-transferase).

The renoprotective effect of SFN on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes.

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Pedraza-Chaverri%2520J%2522%255BAuthor%255D




Fermented Soy This raw, fermented, organic, non-GMO,

whole soyproduct contains all 5 of the super foods

discoveredin 1991 by the National Cancer institute

after thei$20 million study searching for anti-cancerproperties in fruits and vegetables:

1) Isoflavones 2) Protease Inhibitors 3) Saponins 4) Phytosterols 5) Phytic Acid Compounds


Curcumin, the yellow pigment found in the spice turmeric and a

key ingredient in yellow curry inhibits melanoma cell growth

and stimulates tumor cell death via apoptosis

“potent antioxidant, anti-inflammatory and cancer

terminating effects…”

CANCER August 15, 2005


Proteolytic Enzymes (away from food):

1) selectively attack and kill cancer cells2) clean up after themselves (debris)3) unmask cancer cells (membrane effect)

4) prevent metastatic disease5) offer systemic immune enhancement6) compelling scientific /clinical record7) excellent risk/benefit ratio


Vitamin C plus Vitamin K3

1. Vitamin K3 alone has demonstrated anti-tumor activity against multiple rodent and human cancer cell lines.

2. Synergism noted with doxorubicin, 5 FU, vinblastine, vincristine, mitomycin, bleomycin, cisplatin, mitoxanthrone, MTX, and many others.

3. Phase I trials in humans 400-500 mg/day showed no toxicity in combination with mitomycin. Phase II trials of IV K3 (2.5 gms/m2) with mitomycin showed objective response but 30% showed hemolysis (Gold, Cancer Treat Rep, 1986)


Vitamin C Plus Vitamin K3 (cont)

1) Vit C and K3 combination showed synergistic activity in a 100/1 ratio in breast, endometrial and oral epidermoid carcinoma cell lines in concentrations 10-50 times lower than for the individual vitamins (Noto, et al, Cancer, 1989).

2) Co administration of C plus K3 with adriamycin, bleomycin, mitomycin C, vincristine or cisplatin increased growth inhibitory effect by 3-14 fold (Buc Calderone, et al., Curr. Med. Chem. 2002).


Vitamin C: Cancer’s “silver bullet”

1. Vitamin C alone has been found to have cytotoxic effects against most cancer cell lines in vitro. These in vitro concentrations are easily achievable in vivo with IV C. The mechanism appears to be intracellular accumulation of H2O2 with low catalase enzyme activity native to cancer cells. (Dr. Mark Levine, NIH division of Diabetes and Kidney diseases).

2. Vit C has also been found to potentiate the effects of chemotherapy drugs (Zaizen, et al., J cancer Res Lin Oncol, 1986; Prasad, et al, Pol J Pharmacol and Pharm, 1992; Koch and Biaglow, J Cell Physiol, 1978) and radiation therapy (Hanck, Prog Clin Biol Res, 1988).


Oxygen breathing may be a cheaper and safer alternative to exogenous erythropoietin (EPO)

Recently discovered “normobaric oxygen paradox” demonstrates that renal tissue can be stimulated to increase EPO production via a simple pattern of oxygen breathing at normal atmospheric pressures. This leads directly to the hypothesis that oxygen breathing may provide chemotherapy patients with a convenient and inexpensive alternative to ESAs. Stimulating endogenous EPO production eliminates the small risk of immune system reaction associated with ESAs. Further, the endogenous physiological EPO doses provided by this method may be safer, in terms of cancer mortality, than the exogenous pharmacological doses inherent in ESA administration.

R. Burk Medical Hypothesis published on line 5/ 11/ 07


Current Approach: Current Approach: Killing the Messenger (Cut, Burn, Killing the Messenger (Cut, Burn, Poison)Poison)

Better Approach: Better Approach: Entice the cancer stem cells to Entice the cancer stem cells to ““behavebehave”” (i.e to differentiate) (i.e to differentiate)

““The Cordelia EffectThe Cordelia Effect””


The goal of the The goal of the ““Cordelia EffectCordelia Effect”” (Corrective (Corrective Cancer Care) is to control the variables including Cancer Care) is to control the variables including the local tumor environment so as to shift the the local tumor environment so as to shift the cancer stem cellscancer stem cells’’ metabolism away from metabolism away from proliferation and towards differentiation, in order proliferation and towards differentiation, in order to decrease tumor size, growth and virulence.to decrease tumor size, growth and virulence.

““Treat the soil, not the plant.Treat the soil, not the plant.””

The Cordelia EffectThe Cordelia Effect (cont.) (cont.)


1) Proteolytic Enzyme Therapy (pancreatic enzymes, 1) Proteolytic Enzyme Therapy (pancreatic enzymes, trypsin)trypsin)2) MEBO (moist exposed burn ointment, GIC)2) MEBO (moist exposed burn ointment, GIC)3) Anti-inflammatory agents (tumeric, resveratrol, propolis, 3) Anti-inflammatory agents (tumeric, resveratrol, propolis, etc.)etc.)4) Pro-apoptotic agents (iodine, soy 4) Pro-apoptotic agents (iodine, soy [Genistein, Daidzein] [Genistein, Daidzein] etc.)etc.)5) ER beta > ER alpha (Fermented Soy products , BioDim)5) ER beta > ER alpha (Fermented Soy products , BioDim)6) Target cancer STEM cells (Haelan 951, Metformin, etc.)6) Target cancer STEM cells (Haelan 951, Metformin, etc.)7) Minimize fear and anxiety (stop the war, correct the 7) Minimize fear and anxiety (stop the war, correct the problem)problem)8) Enhance sense of purpose and appreciation of life and 8) Enhance sense of purpose and appreciation of life and lovelove

The Cordelia EffectThe Cordelia Effectre-educating the re-educating the confusedconfused cancer cancer

STEM cells STEM cells

Adjuvants with Corrective Cancer CareAdjuvants with Corrective Cancer Care


“Tumors are wounds, that do not heal. Every cancer medication should improve wound healing."

- Rudolph Virchow, 1865

Today we know that cytokines (inflammation) inhibit cell differentiation and wound healing.

Reconsideration: The Nature of Cancer Reconsideration: The Nature of Cancer

http://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPG


Goal: To interrupt the IL-8 cytokine Goal: To interrupt the IL-8 cytokine ““SOSSOS”” and allow and allow differentiation of cancer stem cellsdifferentiation of cancer stem cells

1) Reprotaxin -CXCR1 receptor blocker- (per Dr. Max Wicha)1) Reprotaxin -CXCR1 receptor blocker- (per Dr. Max Wicha)2) Soy (hits ERb not ERa !) See 2) Soy (hits ERb not ERa !) See Is Soy Safe?Is Soy Safe? by O. Rodriguez, by O. Rodriguez, Life Extension Magazine July 2010Life Extension Magazine July 20103) Aspirin Lancet 20113) Aspirin Lancet 20114) Many more: Oxygen (hypoxemia stimulates CSCs), 4) Many more: Oxygen (hypoxemia stimulates CSCs), Tumeric, Vitamin D3, Carotenoids, Propolis, MEBOTumeric, Vitamin D3, Carotenoids, Propolis, MEBOIodine (Iodolactones => induction of apoptosis in 80% of breast Iodine (Iodolactones => induction of apoptosis in 80% of breast cancer cell lines tested - per JVW: Askin, BAcancer cell lines tested - per JVW: Askin, BA

Anti-Inflammatory AgentsAnti-Inflammatory Agents


Anti-Inflammatory Agents in Corrective Cancer CareAnti-Inflammatory Agents in Corrective Cancer Care


“Regular aspirin use at low doses may reduce the risk of fatal colon cancer. Whether this is due to a direct effect of aspirin, perhaps mediated by the inhibition of prostaglandin synthesis, or to other factors indirectly associated with aspirin use is unclear.” (N Engl J Med 1991;325:1593—6.)

“600 mg aspirin per day for a mean of 25 months substantially reduced cancer incidence after 55·7 months in carriers of hereditary colorectal cancer. Further studies are needed to establish the optimum dose and duration of aspirin treatment.”(The Lancet, Volume 378, Issue 9809 Pages 2081 - 2087, 17 December 2011)

Aspirin: A Centsible Option Aspirin: A Centsible Option


ERalpha vs. ERbeta

Prostate cancer growth depends, in its earlier stages, on androgens and is usually pharmacologically modulated with androgen blockade. However, androgen-ablation therapy may generate androgen-independent prostate cancer, often characterized by an increased invasiveness.

We have shown that the dihydrotestosterone metabolite 5alpha-androstane-3beta,17beta-diol (3beta-Adiol), a steroid which does not bind androgen receptors, but efficiently binds the estrogen receptor beta (ERbeta), exerts a potent inhibition of prostate cancer cell migration through the activation of the ERbeta signaling.


GENE EXPRESSION IN CIRCULATING TUMOR CELLS WITH FERMENTED SOY

Rohr et al. Horm Mol Biol Clin Invest 2010;3(2):391–409


Apoptosis is allowed to proceed.• Clinical Implication: Apoptosis is the healthy, appropriate

cells death which occurs at the right times after a cell has lived it full normal life. In contrast, cancer cells resist apoptosis and live eternally thereby killing the cancer patient.

DNA Repair is enhanced.• Clinical Implication: DNA damage is the hallmark of cancer.

If DNA is repaired a cell can stop being cancerous. Reactivates P-53 Tumor Suppressor Gene • Clinical Implication: This raises levels of P-21 in breast,

ovarian and prostate cancer cell and thereby suppresses cancer and allows apoptosis.

P21 gene activity is increased• Clinical Implication: This lifesaving gene is derived from the

anti-cancer gene P53 and allows to cancer call death

Scientific and Clinical Benefits of Fermented Soy


Scientific and Clinical Benefits of Fermented Soy (cont.)

Reduces Estrogen Levels • Clinical Implication: This is an anti-cancer effect since it also reduces ER-a.Increased Estrogen receptor-beta receptors – ER-b • Clinical Implication: These kill cancers by increasing the amount of natural

chemotoxic agents like 2-methoxyestradiol as well as their delivery to the cancer cell.

Decreased Estrogen receptor-alpha receptors – ER-a • Clinical Implication: These receptors allow cancer cells to thrive and metastasize so

they must be suppressed for your health.Improves Ratio- ER-a/ER-b• Clinical Implication: This allows for appropriate apoptosis and restoration of low

cancer risk.Decreases the matrix metalloproteinases enzyme • Clinical Implication: This enzyme erodes collagen surrounding the tumor and frees

cancer stem cells to spread through out the body creating metastatic disease.Produces Anti-Cancer metabolites • Clinical Implication: Some of the most important of these are 3-Beta Adiol and 2-

methoxyestradiol which hunt down and kill cancer stem cells. Note the tragic and little reported facts that 1) chemotherapy and radiation do NOT kill stem cells and 2) 99% of the cells in a cancerous tumor are NON-cancerous



Prevents Protein Calorie Malnutrition (cachexia or starvation)• Clinical Implication: This reversal of cachexia is life-saving since cachexia kills

80% of cancer patients. We must at all costs avoid the situation where you starve (no appetite!) while the cancer gorges itself.

Shuts Down NF-kB Mutation Pathway• Clinical Implication: Cancer cells are smart and they try to mutate using the NF-kB

pathway in order to escape death when the immune system or the chemotherapy is applied.

Enhances tumor necrosis factor (TNF)• Clinical Implication: TNF is a pillar of our immune system required to fight

cancer.Increases function of GADPH gene expression• Clinical Implication: This gene expression is one way to measure cancer die off.Overcomes depression and improves quality of life• Clinical Implication: When the soul and spirit are less troubled, the immune

system thrives. Non-Specific Immune Stimulation Increased 400%• Clinical Implication: the symbiosis of taking a product offering the 5 super foods

and the myriad benefits described above amount to a huge immune boost. It increases macrophage phagocytosis by three-fold and double the number of active macrophages.



Anti-angiogenesis • Clinical Implication: Angiogenesis is the creation of a blood supply to tissues low

in oxygen – like cancer. Without this new blood supply, cancer cells can not grow. The drug Avastin stops blood coming to the tumor by destroying the angiogenesis signal VEGF (vascular endothelial growth factor) however this is fatal as your healthy blood vessels (to your heart and brain etc) need VEGF! - stops angiogenesis without destroying VEGF.

Reduces exosomes • Clinical Implication: These are particles that inhibit immune defense against

cancer, they inhibit both NK cell function and gamma interferon.Increases BAX 500% compared with Doxorubicin (re breast cancer)• Clinical Implication: This is a gene which kills cancer cells via allowing apoptosis.Decreases BCL2 200% - in comparison to Doxorubicin (in cases of

breast cancer)• Clinical Implication: This is a gene which allows cancer cells to thrive by evading

apoptosis.Improves Anti-apoptotic Ratio of BAX/BCL2• Clinical Implication: This means that the genes are now fighting cancer by

enhancing apoptosis.


Scientific and Clinical Benefits of Fermented Soy

Why you may want to stop drinking fermented soy at 4oz twice a day despite its life-saving benefits:

• Hold your nose! Chase with water or juice.• The bitter taste is not pleasant! But we have a

solution: we have found that mixing fermented soy (1/2 bottle) with Stevia/Xylitol and Ola Loa Orange (1 packet) and whatever amount of cold water you desire is a workable solution to the taste issue!

• Option: fermented soy retention enema


Part 7 Part 7

Doctoring Doctoring thethe

Cancer STEM CellsCancer STEM Cells


1) Soy decreases cytokines (including IL-8)Handayani, R Soy Isoflavones Alter Expression of Genes Associated with Cancer Progression, Including Interleukin-8, in Androgen-Independent PC-3 Human Prostate Cancer Cells1 J. Nutr. 136:75-82, January 2006

2) Fermented soy promotes cell differentiation“Inhibited leukemia cell growth by inducing cell differentiation“ Kanatani 1993“Induced differentiation in human medulloblastoma cell lines“ Matsumoto 1991“Induced differentiation in HL-60 cells“ Han 1994“Induced differention in B16 melanom cells“ Jing and Han 1992 “Induced differentiation in five human melanoma cell lines“ Kiguchi 1990

CANCER STEM CELLS AND SOYCANCER STEM CELLS AND SOY


“Fermented soy transformed circulating cancer stem cells (in vivo, human) into more differentiated and therefore more targetable treatable cancer tumor cells.“

This mechanism may be the reason for dramatic increase in survival we see in clinic.

An example of the “Cordelia Effect“

CANCER STEM CELLS AND FERMENTED SOY


CANCER STEM CELLS AND FERMENTED SOY

Anti-Angiogenesis Anti-Angiogenesis

Stabilizing blood capillaries in cancer patients is the Stabilizing blood capillaries in cancer patients is the new goal in severe diseases.new goal in severe diseases.

Adiol (and/or Fermented Soy) inhibits stem cell Adiol (and/or Fermented Soy) inhibits stem cell metastastasis by this anti-inflammatory mechanism.metastastasis by this anti-inflammatory mechanism.


Metformin selectively kills the chemotherapy resistant cancer

STEM cells Metformin decreases the dose of chemotherapy for prolonging

tumor remission in mouse xenografts involving multiple cancer cell types.

Cancer Res. 2011 May 1;71(9):3196-201. Epub 2011 Mar 17. Iliopoulos D, Hirsch HA, Struhl K

Metformin, the first-line drug for treating diabetes, selectively kills the chemotherapy resistant subpopulation of cancer stem cells (CSC) in genetically distinct types of breast cancer cell lines.

In mouse xenografts, injection of metformin and the chemotherapeutic drug doxorubicin near the tumor is more effective than either drug alone in blocking tumor growth and preventing relapse.


Metformin for CSC “Here, we show that metformin is equally effective when given orally together with paclitaxel, carboplatin, and doxorubicin, indicating that metformin works together with a variety of standard chemotherapeutic agents. In addition, metformin has comparable effects on tumor regression and preventing relapse when combined with a four-fold reduced dose of doxorubicin that is not effective as a monotherapy. Finally, the combination of metformin and doxorubicin prevents relapse in xenografts generated with prostate and lung cancer cell lines.”

“These observations provide further evidence for the CSC hypothesis for cancer relapse, an experimental rationale for using metformin as part of combinatorial therapy in a variety of clinical settings, and for reducing the chemotherapy dose in cancer patients.”


Mo’ MetforminMetformin and cancer: new applications for an old drug. Kourelis TV, Siegel R Med Oncol. 2011 Feb 8.

Metformin, one of most widely prescribed oral hypoglycemic agents, has recently received increased attention because of its potential anti-tumorigenic effects that are thought to be independent of its hypoglycemic effects. Severalpotential mechanisms have been suggested for the ability of metformin tosuppress cancer growth in vitro and vivo: (1) activation of LKB1/AMPKpathway, (2) induction of cell cycle arrest and/or apoptosis, (3) inhibition of protein synthesis, (4) reduction in circulating insulin levels, (5) inhibition of the unfolded protein response (UPR),

(6) activation of the immune system, and(7) eradication of cancer stem cells.


Mo’ Metformin (cont.)Solving the Mystery of an Old Diabetes Drug That May Reduce

Cancer Risk

“Exposure to metformin reduces the cellular mutation rate and the accumulation of DNA damage which is well known to be directly involved in carcinogenesis.”

“It is remarkable that metformin, an inexpensive, off-patent, safe and widely used drug, has several biological actions that may result in reduced cancer risk — these latest findings suggest that it reduces mutation rate in somatic cells, providing an additional mechanism by which it could prevent cancer.”

“The drug seems to selectively prevent ROS production from altered mitochondria such as those found in cells with oncogenic mutations.”

http://weeksmd.com/2012/01/7849/


Fish oil compound kills cancer STEM cells

Possible Cure for Leukemia Found in Fish Oil

A compound produced from fish oil that appears to target leukemia stem cells could lead to a cure for

the disease. The compound — delta-12-protaglandin J3, or D12-PGJ3 — targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, said The compound is produced from EPA — Eicosapentaenoic Acid — an Omega-3 fatty acid found in fish and in fish oil. The fish oil compound kills cancer-causing STEM cells in the mice’s spleen

and bone marrow. Specifically, it activates a gene — p53 — in the leukemia stem cell that programs the cell’s own death.

“Research in the past on fatty acids has shown the health benefits of fatty acids on cardiovascular system and brain development, particularly in infants, but we have shown that some metabolites of Omega-3 have the ability to selectively kill the leukemia-causing stem cells in mice….The important thing is that the mice were completely cured of leukemia with no relapse.” Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences, Penn State

REFERENCE http://weeksmd.com/2011/12/now-alas-expect-the-fda-to-declare-fish-oil-a-drug-psttt-it-kills-cancer-stem-cells/


Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice.

“Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse…..”

“Given the potency of ω-3 polyunsaturated fatty acid-derived CyPGs and the well-known refractoriness of LSCs to currently used clinical agents, Δ(12)-PGJ(3) may represent a new chemotherapeutic for leukemia that targets leukemia STEM cells (LSCs).”

Source: Blood. 2011 Dec 22;118(26):6909-19. Epub 2011 Oct 3. Hegde S, Prabhu KS. Et al

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Hegde%2520S%2522%255BAuthor%255D

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Hegde%2520S%2522%255BAuthor%255D

http://www.ncbi.nlm.nih.gov/pubmed?term=%2522Prabhu%2520KS%2522%255BAuthor%255D


Herceptin targets breast cancer STEM cells

A gene that is overexpressed in 20 percent of breast cancers increases the number of cancer STEM cells, the cells that fuel a tumor's growth and spread, according to a new study from the University of Michigan Comprehensive Cancer Center.

The gene, HER2, causes cancer stem cells to multiply and spread, explaining why HER2 has been linked to a more aggressive type of breast cancer and to metastatic disease, in which the cancer has spread beyond the breast, the researchers say. Herceptin, which is used to treat HER2-positive breast cancer, was found to target and destroy the cancer stem cells. Results of the study appear online in the journal Oncogene.

"This work suggests that the reason drugs that target HER2, such as Herceptin and Lapatanib, are so effective in breast cancer is that they target the cancer stem cell population. This finding provides further evidence for the cancer stem cell hypothesis," says study author Max S. Wicha, M.D., Distinguished Professor of Oncology and director of the U-M Comprehensive Cancer Center.

"We are now studying what pathways are activated by HER2 overexpression. Our hope is that we could develop inhibitors of these pathways that might be effective in targeting cancer stem cells in women whose tumors do not overexpress HER2 or those who are resistant to Herceptin," says study author Hasan Korkaya, Ph.D., a U-M research fellow in internal medicine.

Source: University of Michigan, July 9, 2008


Chrysin kills cancer STEM cells

Chrysin Reverse the Drug Resistance by Targeting Breast Cancer Stem Cell Related Subpopulation

Conclusions:

1)Chrysin can reverse drug resistance of MCF-7/MX cells by targeting BCRP.

2) Chrysin influences breast cancer stem cell subgroup in MCF-7/MX cell lines

Synthetic Analogue of Chrysin

New synthetic anti-inflammatory chrysin analog, 5,7-dihydroxy-8-(pyridine-4yl)flavone.Eur J Pharmacol. 2011 Nov 30;670(2-3):617-22. Epub 2011 Sep 21.

Lim H, Jin JH, Park H, Kim HP.

C-721 inhibited TNF-α and IL-6 production at 10-50 μM. An in vivo study revealed that oral and intraperitoneal administration of C-721 showed 25.2%-44.3% inhibition against λ-carrageenan-induced paw edema in mice at 10-100mg/kg. Furthermore, this compound significantly inhibited collagen-induced arthritis in mice when administered by intraperitoneal injection at 50mg/kg three times/week. Taken together, these results suggest that C-721 has the potential for use as a synthetic lead compound for development of a new anti-inflammatory agent.



Summary: Cancer Stem Cells and Summary: Cancer Stem Cells and CancerCancer

1) Cancer mortality is directly related to cancer stem cell 1) Cancer mortality is directly related to cancer stem cell activity (metastatic and proliferative processes)activity (metastatic and proliferative processes)

2) Chemotherapy and radiation do 2) Chemotherapy and radiation do notnot kill cancer stem kill cancer stem cells;cells;

3) Chemotherapy and radiation make cancers grow 3) Chemotherapy and radiation make cancers grow faster and more virulent; faster and more virulent;

4) Treatment of (people with) cancer requires 4) Treatment of (people with) cancer requires adjunctive care and not just chemotherapy or radiation;adjunctive care and not just chemotherapy or radiation;

5) Treatment which fails to address the toxicity of 5) Treatment which fails to address the toxicity of cancer stem cells is futile and irresponsible. Time to cancer stem cells is futile and irresponsible. Time to “doctor” the cancer cells.“doctor” the cancer cells.


6) IPT, while “kinder and gentler”, must not be 6) IPT, while “kinder and gentler”, must not be given unless adjunctive care is taken to given unless adjunctive care is taken to minimize cancer stem cell stimulation minimize cancer stem cell stimulation

7) Adjunctive treatment modalities represent a 7) Adjunctive treatment modalities represent a significant improvement over traditional IPT.significant improvement over traditional IPT.

• It is time to “doctor” the cancer cells: both It is time to “doctor” the cancer cells: both TUMOR and STEM cells;TUMOR and STEM cells;

8)8) This is a therapeutic message which our This is a therapeutic message which our patients, as well as our oncology colleagues, patients, as well as our oncology colleagues, are are ready to hear.ready to hear.

Summary: Stem Cells and CancerSummary: Stem Cells and Cancer (cont.)(cont.)


Further Reading on Cancer Stem Cell Treatment

1) Therapeutics formulated to target cancer stem cells: Is it in our future? Stephanie Clayton, Cancer Cell Int. 2011; 11: 7. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073868/

2) Therapeutic Implications of the Cancer Stem Cell Hypothesis Maximilian Diehn, MD/PhD and Michael F. Clarke, MD http://weeksmd.com/?p=5465

3) Eradication of Cancer Cells via Regeneration Xu Rongxiang, M.D. http://en.mebo.com/Achievement/ShowInfo.asp?InfoID=262

4) Soy isoflavones increase quinone reductase in hepa-1c1c7 cells via estrogen receptor beta and nuclear factor erythroid 2-related factor 2 binding to the antioxidant. EB Froyen… - The Journal of Nutritional Biochemistry, 2010 - Elsevier

5) Powerpoint on Proteolytic Enzymes Bradford S. Weeks, M.D. Presentation at 2010 IPT Conference www.

6) The Enzyme Treatment of Cancer and its Scientific Basis John Beard, D. Sc. 1911

7) The Trophoblast and the Origins of Cancer Nicholas Gonzalez, M.D. New Spring Press 2009

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073868/

http://weeksmd.com/?p=5465

http://en.mebo.com/Achievement/ShowInfo.asp?InfoID=262


Part 8

CLINICAL CASE STUDIES


Case#1: Hodgkin’s Lymphoma stage IV

• 65 year old male, otherwise healthy• Lump on neck – no other symptoms• PET results February 2010: “Multiple areas of

abnormal metabolic activity seen in head and neck. Abnormal metabolic activity seen along retroaortic thoracic lymph node. L3-L4 skeletal lesions.

• Impression: stage IV Hodgkin’s lymphoma with multiple stations of adenopathy in head and neck, chest, abdomen and pelvis”.


Proposed Treatment

• Meds: Bleomycin

• Assurance: “Don’t worry. We have an excellent success rate with Hodgkin’s Lymphoma: 6 months of Hell and then 2 years of recovery, but after that, you will be cancer free.”


Conventional Treatment Course

• 2 treatments of conventional chemotherapy: Vinblastine, Cytoxan, Adriamycin, Prednisone, Procarbazine, Omeprazole, Prochlorperazine

• Side effects: nausea, vomiting, anemia, fatigue• “Never again. I’d rather die.”


CCC starting April 2010

1) IPT chemotherapy: Bleomycin 1 unit, Adriamycin 6mg, Dacarbazine 20mg, Vinblastine 1mg.

2) HDVC: 50g /450cc sterile water w/ 2cc Magnesium SO4

3) Alpha Lipoic Acid 600mg in 50cc nl saline4) Homeopathics: Au Stibium Hyoscyamus Hepar Stannum

6/10 Lien Cichorium Lymphocytes 8 Thrombocytes 6 Erythrocytes 6

Oral Supplements: Haelan 951, MVMM, Niacin, Selenium, CoQ 10, vitamin D3, LDN 4.5mg, Metformin 500mg BID


Clinical Progress

• PET/CT 4-14-10: “IMPRESSION: remarkable improvement since 2-2-10 with near complete response.”

• Prior Oncologist: “My treatment has kicked in.”

• Patient goes off protocol: eats alcohol, sugar

• PET/CT 6-11-10: “enlarged nodes on both sides of the neck, supraclavicular space and the mediastinum, retrocrural lymph nodes, skeletal lesions at L3—L4. Disease progression seen compared to 2-2-10 PET/CT.

• Patient leapt back on CCC protocol.


PET: 8/6/10

• Head and Neck “no evidence of adenopathy” “no focal lesions to suggest recurrence in the head and neck.”

• Chest “no abnormal metabolic activity seen in nodes” “no new lesions” “no suspicious pulmonary nodes”

• Abdomen: “no organomegaly, no adenopathy”

• Skeleton: “No focal suspicious lytic or blastic skeletal lesions seen.”

• Impression: “No PET CT evidence for residual or recurrent lymphoma.”


Case #2 Triple Negative (ER, PR, Her2-Nu) Infiltrating Ductal Carcinoma with

DCIS• 69 yr old female banker, life-long cystic

process: breast, ovaries and fibroids, was on HRT (unopposed estrogen)

• Hypothyroid but never assessed for serum iodine or serum 25-OH D3

• Lumpectomy, refused chemo and radiation because of what she saw her friend go through


Triple negative breast cancer (cont)

1) Chemosensitivity testing www.biofocus.de 2) IPT Chemotherapy: Taxol 30mg Vincristine

0.2mg Cytoxan 100mg ALTERNATE Mitomycin 4mg, Doxorubicin 6mg Vinblastine 1mg

3) HDVC: 75g /400cc ST water w/ MagO4 and Cal Gluconate

4) Alpha Lipoic Acid 600mg in 50cc nl saline5) Homeopathics: Au Stibium Hyoscyamus Hepar Stannum 6/10 Lien Cichorium Lymphocytes 8 Thrombocytes 6 Erythrocytes 6

Oral Supplements: Haelan 951, Ioderal, MVMM-Ola Loa, Niacin, Selenium, CoQ 10, vitamin D3, LDN 4.5mg, Metformin 500mg BID,

http://www.biofocus.de/


Pre and Post PET/ CT

• PET/CT “metabolically active lesions in left breast and axillary nodes consistent with metastatic disease”

• PET/CT after 6 treatments “prior lesions in breast and lymph nodes are not visualized”


The original “Come Hither” look….


Case #3 Primary Lung & Breast Cancer

• 54 yr old woman, happily married, 5 kids, Chemist who had worked as field sampler at Hanford nuclear site when 24 yr old – burned samples in non-vented room;

• Stage 3A breast cancer 6/20 nodes positive• Lung adenoCA, stage 3B (TTF1 positive)–with mets• Rx #4 28 days cycles of Gemzar, Pimitrex, Avastin• CTscan “The tumors grew despite standard of care” • Per oncologist “This is bad” - offered higher dosage • Patient read Suzanne Sommers “Knockout”


Two Primary Cancers (cont.)

1) Chemosensitivity testing www.biofocus.de 2) IPT Chemotherapy: Vinrelobine 10mg, Topotecan

4mg 3) HDVC: 75g /400cc ST water w/ MagO4 and Cal

Gluconate 4) Alpha Lipoic Acid 600mg in 50cc nl saline5) Homeopathics:

Au Stibium Hyoscyamus Hepar Stannum 6/10

Lien Cichorium Lymphocytes 8 Thrombocytes 6 Erythrocytes 6

Oral Supplements: Haelan 951, Ioderal, MVMM-Ola Loa, Niacin, Selenium, CoQ 10, vitamin D3, LDN 4.5mg, Metformin 500mg BID,



Results: two primary cancers

• PET/CT after #6 IPT treatments “the mass previously seen in the posterior aspect of the left upper lung is no longer present; no evidence of progression or new malignancy”

• Per her oncologist “You are cancer free”• 6 month follow-up PET CT, Biofocus CTC =

“no sign of cancer” on CCC taper


““The capacity to playThe capacity to play reflects the capacity for life.”reflects the capacity for life.”


Case # 4 Pancreatic Adenocarcinoma

• 55 yr old former alcoholic, obese, chronic pancreatitis, IDDM, Hep C, prostatitis, cirrhosis, sleep apnea, headaches, DJD/OA

• Work: medical disability (talented wood worker -furniture),

• Mother died of “pancreatic cancer”

• He attends NA and has loving family

• Diagnosis re Pain: “ulcer” “pancreatitis” “psychosomatic”

• PET “mass in head of pancreas most consistent with adenocarcinoma, swelling diffuse and metastatic disease to 1 lymph node.”

• Per oncologist: “You are not a surgical candidate and have 3-6 weeks to live.” (November 2, 2011)

• Patient refused all conventional treatment and elected CCC


Pancreatic Adenocarcinoma (cont.)

1) Chemosensitivity testing www.biofocus.de 2) IPT Chemotherapy drugs: Gemzar 200mg 5-FU 150mg3) HDVC: 75g /400cc ST water w/ MagS and Cal Gluconate 4) Alpha Lipoic Acid 600mg in 50cc nl saline5) Homeopathics: Pancrease Hepar Stannum 6/10 Lien Cichorium Lymphocytes 8 Thrombocytes 6 Erythrocytes 6

Oral Supplements: Haelan 951, Thymrevit, Ola Loa, Selenium, CoQ 10, vitamin D3, Metformin 500mg BID (on opiates, so no LDN), castor oil pack,




Follow –up after 4 weeks of CCC with 6 IPT treatments:

PET/CT 1-13-12 - per radiologist: “mild avidity on his PET/CT very atypical of advanced metastatic pancreatic cancer” … “quite heartening” “very surprising” lesion is 1/3rd size of original scan”

“I would have expected more uptake if the cancer were growing.”

“We thought he would be dead by now.”

What was NOT asked by radiologist: “What did you do for him?”



Also RESOLVED as of 2-20-12:

-Sleep disturbance (sleeping through the night)

-Hot flashes at night (blood sugar stabilized)

-Restless legs (magnesium also helped chronic constipation)

-Leg cramps (these were “horrible” –he loves the magnesium)

-Blood sugar stabilized: diet and 2 of the original 4 medications

-Headaches (rehydration, food allergies, magnesium)

-Constipation (vitamin C and magnesium)

-BPH (sleeping through the night for first time in years)

-Weight loss (280 -> 211 but not cachexia)


Rory reminding us to take the time to stop and smell the flowers!


Case #5 Prostate Cancer (mets to bone)

• 67 yr old nutritional doctor, with elevated PSA at age 62.

• Avid golfer for 57 years, happily married for 55 years,

• Per oncologist: “No matter what, you are dead in 5 years.”

• Treated in NYC with proteolytics – full compliance (up at night for pills, coffee enemas) – but worse in 5 years… Cryosurgery 2006

• Presenting Sx: unable to pee, urological emergency, pain in R hip, gross leg edema, up 6 times a night to urinate; sleep deprived, tired; hydrocele “largest radiologist had ever seen”, PSA 55 % free 10;

• PET/CT mets to bone, L2 fully sclerosed, R iliac crest, mets to lymph nodes; unable to sleep due to pain and frequent urination.


Assessment 7-16-11

• Per oncologist: “you are going to die. Put your affairs in order.”

• “Also, you need to give up golf or you’ll break your back and be paralyzed…”


Prostate cancer protocol

1) Chemosensitivity testing www.biofocus.de “Androgen blockage would not be helpful”2) IPT Chemotherapy drugs: Cytoxan, Taxol, Doxorubicin 3) HDVC: 75g /400cc ST water w/ MagO4 and Cal Gluconate 3) Alpha Lipoic Acid 600mg in 50cc nl saline4) Homeopathics: Au Stibium Hyoscyamus Hepar Stannum 6/10 Lien Cichorium Lymphocytes 8 Thrombocytes 6 Erythrocytes 6

Oral Supplements: Haelan 951 (oral and enema), IP6, Vit K2 4 grams a day, Ola Loa, Selenium, CoQ 10, vitamin D3, LDN 4.5mg, Metformin 500mg BID & Medical Marijuana tar for sleep (See You Tube:

“Run from the Cure” and also Dr. Rob Abrams, Chief Oncology UCSF)



Prostate Cancer (cont.)

“No pain after 1st IPT treatment”

• Nagalase enzymes tested high so started macrophage activator “GCMAF”

• IP6 and high dose vit K2 (4 grams a day)

• Pancreas enzymes before sleep• Medical Marijuana “tar”


Update: after 9 weeks of CCC and #6 IPT treatments

• “Sleeping through the night and awakening refreshed for first time in decades”;

• Urine stream and voiding “vastly improved” • “Edema 80% resolved, increased flexibility”• “Great energy and stamina and mood”• Just back from a week at Pebble Beach (“I parred 6 of the back nine”) • PET / CT pending, • Currently cruising in Mediterranean with wife


Walking on Ebby’s LandingWhidbey Island, with Rory.


Case #6 Metastatic Breast cancer, Stage 4

• 48 year old mother of twins, happily married, strong Christian faith

• No other significant health history, happy and healthy all her life

• “We prayed and God told us not do conventional treatments. Later, he told us to come to you, Dr. Weeks”

• PET/CT: “diffuse metastatic breast cancer invading axilliary nodes”

• Per oncologist: “You waited too long. There is nothing anyone can do to help you now.”

• Presenting Sx: lump and mass in breast, huge left arm lymphedema with pain and limited range of motion.

• Medications: Fentanyl patch 50mg/24 hrs and Dilautid 4mg 5x/day


Case #6 Metastatic Stage 4 Breast cancer

1) Chemosensitivity testing www.biofocus.de 2) IPT Chemotherapy drugs: Cytoxan 100mg, Taxol 30mg and 5-FU 100mg3) HDVC: 75g /400cc ST water w/ MagS and Cal Gluconate 3) Alpha Lipoic Acid 400mg in 50cc nl saline4) Homeopathics: Au Stibium Hyoscyamus Hepar Stannum 6/10 Viscum Mali Lymphocytes 8 Thrombocytes 6 Erythrocytes 6

Oral Supplements: Haelan 951 (oral and enema), Thymrevit, C Statin, Artemisinin, Ola Loa, Selenium, CoQ 10, vitamin D3, DHEAOral Medications: LDN 4.5mg, Metformin 500mg BID, Oxytocin 10U HS, Medical Marijuana tar (see: You Tube “Run from the Cure” and also: Dr. Rob Abrams, Chief Oncology UCSF)


Breast cancer outcomePre PET CT 8-3-11 “extensive locally invasive disease involving much of the superior and lateral aspect of left breast extending left hemi-diaphragm and into left axillary nodes…mediastinal and bilateral hilar metabolically active metastatic lymph nodes … Active foci in sternum, thoracic spine and pelvis.. A few lung lesions…”

6 IPT treatments over 3 weeks (August 30th - October 20th)

Post PET CT 11- 11 “does not identify any focus of FDG activity” “most consistent with complete response to therapy” “no evidence of osseous metastasis” “previously described pulmonary nodules are no longer present” “No evidence of cancer”

Empowered patient comment: “You helped me get rid of my cancer.”


Breast cancer outcome

Oncologist comment: “Dr. Weeks is a fraud and a thief who tells people he can cure cancer. Can we report him to the attorney general?”

3 month follow up: “Aside from limited range of motion due to resolving lymphedema, I have no symptoms of cancer.” (see www.weeksclinic.com testimonials)

5 month follow-up: lymphedema back, suspicions of cancer returning.

Patient admits being off the protocol:

“Maybe I get too casual since I trust so much in God to take care of me.”

We Reaffirmed Therapeutic Contract: NO UNILATERAL CHANGES!


Summary and

Invitation

Corrective Cancer Care with

Insulin Potentiation Therapy


The Standard of Care is sub-

therapeutic.

Only 10% of conventional oncologists say they would take the medication they prescribe if

they had cancer.

In contrast, 100% of IPT doctors would take their own medicine!


Opinion:

Any oncologist not addressing cancer STEM cells while killing cancer TUMOR cells should be

challenged.


Corrective Cancer Care with IPT

Safe EffectiveCost-effective

and…

The longest continuous cancer chemotherapeutic protocol in the western hemisphere (1926-present)


Corrective Cancer Care with IPT cont.

“Smart Bomb” effect: Excess of insulin-sensitive receptors on human cancer cells causes predominance of insulin effect in cancer cells, sparing normal host tissues = INCREASED SAFETY

Synergy of insulin’s membrane and metabolic effects enhances anticancer drug action in cancer cells = INCREASED EFFICACY


Within the Correct Context

• …of a human becoming.

• Treat the patient, not just the cancer.• “The secret of caring for the patient is caring for

the patient.” William Osler, M.D.

• “When in doubt ask the patient.” Alan Tisdale, M.D.


The War against Cancer is Over!

• Doctor the patient.

• Doctor the cancer cell too!

• Don’t kill the messenger.

• Honor the “wisdom of the symptom”.


King Lear and his thirddaughter, the beloved and loyal Cordelia – theonly “truthfulmessenger”.

“Be kind, for everyone you meet is fighting a great battle.” Ian McLaren

“If you can’t be nice, be vague.”Miss Manners



Thank youfor yourkind attention!

weeks ohm 2012 (final)

Documents