when aspiration thrombectomy does not work? · when aspiration thrombectomy doesn’t work? when...
TRANSCRIPT
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A A R O N W O N G
N A T I O N A L H E A R T C E N T R E S I N G A P O R E
When Aspiration Thrombectomy Does Not Work?
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Thrombus in STEMI
Over 70% of STEMI patients has angiographic evidence of thrombus
Thrombus increases the risk of: No reflow/Distal embolization and Stent thrombosis
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Thrombus in STEMI
Sianos G et al. JACC 2007;50:573-83
Worse outcome in patients with high thrombus load
5.8%
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Distal Embolization and Mortality
De Luca et al. Journal of Thromb Thrombolysis 2009
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Aspiration Thrombectomy in Primary PCI
Very appealing to interventionists:
Simple concept
Easy to use
Faster procedure
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TAPAS Trial – Mortality at One year
Vlaar et al. Lancet 2008;371:1965
Higher rate of: 1) ST segment
resolution 2) Better MBG
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TASTE Trial – Mortality at One year
Lagerqvist et al. NEJM 2014;371:1111-20
No difference in: 1) Rehospitalization
for MI 2) Stent thrombosis
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TOTAL Trial – Primary Outcome at 1 year
CV death, MI, Shock and CHF
• No difference in efficacy
• Worse outcome with increase risk of stroke
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Recommendation of Aspiration Thrombectomy
“Manual catheter thrombus aspiration should be considered during PCI of the culprit lesion in STEMI.”
“Aspiration thrombectomy is reasonable for patients undergoing primary PCI.”
O’Gara Circulation 2013, Kushner JACC 2009 Steg EHJ 2012, Wijns EHJ 2010, Van de Werf EHJ 2009
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Recommendation of Aspiration Thrombectomy
Levine et al. Circulation. 2016; 133: 1135-1147
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When Aspiration Thrombectomy Doesn’t work?
Routine aspiration thrombectomy in primary PCI is a Class III recommendation
Correct topic?
Shouldn’t the topic be: “When aspiration thrombectomy does work?”
“Why aspiration thrombectomy doesn’t work?”
“When aspiration thrombectomy doesn’t work”
We either: Do not follow the updated guidelines! Or
Still believe that aspiration thrombectomy still works!
I believe most interventionists still believe that aspiration thrombectomy still works for selected cases
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Case 1 – Just aspirate and stent!
After aspiration catheter
Advantages: Removal of thrombus, establish flow and visualization of the vessel for sizing of stent
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Case 1 – Just aspirate and stent!
After stenting
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Case 2 – Just aspirate and stent!
Anterior STEMI Aspiration thrombectomy
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Case 2 – Just aspirate and stent!
Post aspiration thrombectomy Stent placement
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Case 2 – Just aspirate and stent!
Final angiography TIMI 2 flow and good myocardial blush
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When aspiration thrombectomy does not work?
Define “works”
What do we expect aspiration thrombectomy to do?
Reduce thrombus load
Reduce distal embolization
Facilitate PCI – assess lesion size and length
Faster procedure
Reduce mortality Reduce MACE events
Improves microvascular perfusion
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Reasons for failure of Aspiration Thrombectomy
Too little experience with device use
Too little thrombus presence
Too much thrombus
Too little thrombus can be removed
Too late to have a discernable effect against the large background of myocardial necrosis
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Limitation of TASTE and TOTAL Trial
Highly selected patients
60% of patients who met criteria for this study were not randomized into the trial
30-day mortality of 2.9% in randomized versus 10.6% in non-randomized patients
5 thrombectomy catheter use per 2 years and 2.5 patients/month/hospital
Not selective enough
Inclusion of some patients with low thrombus burden
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What does neutral trial means?
Be
ne
fit H
ar
m
1 2 3
3 possible scenarios of a neutral trial
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Stroke and Aspiration Thrombectomy
Inferior STEMI with large conus branch Proximal RCA occlusion
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Stroke and Aspiration Thrombectomy
Transradial approach with difficult guiding
Proximal embolization to conus branch after aspiration thrombectomy
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P R E S E N T A T I O N O F C A S E S
When Aspiration Thrombectomy Doesn’t work?
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Case 3
Anterior STEMI Spontaneous recannalization – TIMI 3
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Case 3
Stenting of LAD with wire in diagonal Final angiography
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When Aspiration Thrombectomy doesn’t work?
When there is nothing to aspirate
Minimal thrombus with TIMI 3 flow
The amount of thrombus make no difference to the outcome
Risk of distal embolization is minimal
When to aspirate?
TIMI 0 – definitely
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Case 4
Inferior STEMI Mid RCA occlusion
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Case 4
After wire crossing but aspiration catheter not able to cross
2 mm balloon failed to dilate lesion proximal to culprit lesion
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Case 4
1.25 mm rotablation burr was used Final angiography after high pressure balloon and 2 DES implanted
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Case 5
Inferior STEMI with mid RCA occlusion
Aspiration catheter not able to go beyond lesion
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Case 5
Post aspiration thrombectomy Final angiography
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When Aspiration Thrombectomy doesn’t work?
When unable to cross lesion
Too tight, calcified or tortuous
Tight lesion usually associated with less thrombus
If unable to cross, aspirate at the site of occlusion may help to establish some flow distally
Different aspiration catheter has different crossing profile and deliverability
Thrombuster® comes with stylet to facilitate delivery
May need pre-dilation but risk of distal embolization
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Aspiration Thrombectomy Catheters
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Case 6
Inferior STEMI with ectactic RCA Large thrombus lodged in distal RCA bifurcation
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Case 6
Aspirated with aspiration catheter but still have large thrombus present Angiojet® used for mechanical aspiration but still have residual thrombus
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Case 6
Final angiography after multiple aspiration thrombectomy, Angioget® and balloon. Glycoprotein 2b3a inhibitors was given as bailout.
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Case 6 – 3 days later
TIMI 3 flow with resolution of thrombus in distal RCA
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Case 7
Inferior STEMI with thrombus laden aneurysmal RCA with multiple critical lesions
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Case 8 – An unusual case
Inferior STEMI with a huge thrombus compressing proximal segment of a dominant LCX with spontaneous recannalization
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Case 8 – An unusual case
Inferior STEMI with a huge thrombus compressing proximal segment of a dominant LCX with spontaneous recannalization
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T
LM
LCX AVM
LM = left main
T = thrombus
LCX = left circumflex
AVM = AV malformation
Case 8 – An unusual case
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When Aspiration Thrombectomy doesn’t work?
When there is too much thrombus
Commonly in large, ectatic and/or aneurysmal artery
AMI in these situations are sometimes due to embolization of thrombus formed in the dilated segment
Usually these vessels have high thrombus load 2 other scenarios usually high thrombus load and
related to poor PCI outcomes despite aspiration or even mechanical thrombectomy – RCA and left main
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Case 9
Inferior STEMI with large thrombus load in RCA and despite aspiration thrombectomy, there was still slow flow in RCA
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Case 9
Filter device was placed in the distal RCA and Angiojet® was used Further balloon dilatation and Angiojet® were used
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Case 9
Repeat angiography 4 days later Final angiography with slow flow
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Case 10
Inferior STEMI with occluded proximal RCA
After multiple aspiration thrombectomy
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Case 10
Despite multiple dilatation with larger balloon, there were still large amount of thrombus in RCA
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Case 10
Final angiography with residual thrombus and occluded right PL branches
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Case – 4 days later
Relook of RCA showed similar findings of thrombus laden RCA
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Case 10 – 4 days later
DES was deployed across right AV groove branch with minimal effect on distal RCA flow
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Rate of Distal Embolization
NHCS in 1998, fifty consecutive primary PCI patient before the use of embolic protection devices
Angiographic appearance of distal embolization:
1. Slow flow
2. No-reflow
3. Macroscopic embolization
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Case 11
“STEMI” with cardiogenic shock with LM occlusion Both LAD and LCX were wired and aspiration thrombectomy was performed
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Case 11
Flow was established in LAD and LCX but slow flow, with a large mobile thrombus sitting at the distal LM bifurcation
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Case 11
LM stenting into LAD with crossover LCX artery No reflow and patient collapsed with
Lucas® device used for CPR
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Case 11
No adequate flow established after LM stenting and patient did not survived
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Case 12
“STEMI” with distal LM occlusion with poor flow to LAD and LCX
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Case 12
Aspiration thrombectomy was performed in both LAD and LCX Crush technique was used for LM bifurcation stenting with FKBT
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Case 12
Final angiography showing poor distal flow in both LAD and LCX despite GP2b3a inhibitors, vasodilators and IABP
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When Aspiration Thrombectomy does not work?
Primary PCI in LM occlusion almost always do poorly
Usually in cardiogenic shock and on multiple inotropic support– poor myocardial perfusion and vasoconstriction
Left main is a large vessel – higher thrombus load
Larger territory at risk of distal embolization commonly post stenting or post dilatation of stent
Usually slow flow or no reflow – edematous myocardium may impede/reduce microvascular perfusion
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Case 13
“STEMI” with LM occlusion and cardiogenic shock RCA was relatively free of disease
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Case 13
LAD was wired and after aspiration thrombectomy there is huge filling defects in LAD and slow flow distally despite IC vasodilators.
Angiojet® was used
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Case 13
Slight improvement of LAD filling defects LCX was wired and thrombus seen after aspiration with thrombectomy catheter
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Case 13
Angiojet® device was used with flow to distal LCA improved but still poor
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Case 13
Both LAD and LCX was predilated with large balloon LM was stented using Crush technique with FKBT
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Case 13 – LM dissection 1/52 post partum
Poor distal flow in both LAD and LCX at final angiography Patient required ECMO and eventual LVAD
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Case 14
Young woman presented few days post partum with chest pain and “STEMI” and coronary angiography showed LM was occluded with filling defects
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Case 14
Different views showed extensive filling defects and flaps RCA was free of disease
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Case 14
LAD and LCX were wired with IVUS guidance After confirming in true lumen stenting to LAD and LM/LCX/LAD using TAP
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Case 14
Final angiography after GP2b3a inhibitors and IC vasodilator
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Case 14 – 3 days later
Repeat angiogram showed improved flow in both LAD and LCX 3 days later
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When Aspiration Thrombectomy doesn’t work?
When the primary cause is not thrombus
Coronary artery dissection (post partum, connective tissue disease, SCAD)
Coronary artery spasm
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Unusual case of STEMI
Chest pain and anterior STEMI Patient had a cath done 4 hours ago with normal coronary artery
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Coronary artery spasm
After aspiration and lots of IC GTN
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Case 15 – Finale
65 year-old woman presented with chest pain, syncope and ECG showed inferior STEMI
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Case 15
RCA showed proximal occlusion and wiring of occlusion was problematic despite using balloon support and multiple guidewires
After attempted with multiple guidewires
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Case 15
Wire eventually crosssed Aspiration thrombectomy and balloon predilation was performed
There was no flow to distal RCA
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Case 15
In view of large thrombus load, Angiojet® was used to aspirate the thrombus mechanically
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Case 15 – Final Angiography
After Angiojet® failed, multiple balloon dilations and aspirations were performed Eventually abandoned the attempt to recannalize RCA
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Case 15 – In retrospect …
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Case 15 – In retrospect …
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Case 15 – CT Aortogram
Ascending aorta Descending aorta
Abdominal aorta Common iliac
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When Aspiration Thrombectomy doesn’t work?
When there is nothing to aspirate - Minimal thrombus with TIMI 3 flow
When lesion cannot be crossed – too tight, calcified or tortuous
When there is too much thrombus– large ectatic and aneurysmal vessel with huge thrombus load or in large vessels like RCA and LM
When the primary problem is not thrombus - aortic dissection, spontaneous coronary artery dissection or spasm
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When Aspiration Thrombectomy doesn’t work ..
Angioget® – in our experience not much more effective
Distal protection device (filter devices)
IABP – may improve coronary flow
M-Guard stent
Glycoprotein 2b3a inhibitors
Intracoronary vasodilators – verapamil, adenosine, GTN, nitroprusside
Defer PCI - provided patient pain free and adequate antegrade or collaterals flow
CABG
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CABG as option for STEMI
• Presented with chest pain and “STEMI” – LM occlusion • After aspiration thrombectomy, TIMI 3 flow was established • Operator decided for CABG as high likelihood of no reflow and demise
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Conclusion
Routine aspiration thrombectomy is not recommendation in primary PCI
However, it may be beneficial in selected patient or bailout situation
Operators need to pay careful attention to the technique of aspiration to prevent complications
Although it does not work well in some situations discussed, it works well in selected STEMI patients
Aspiration thrombectomy is here to stay as it is cheap, simple to use, facilitates equipment selection and probably shorten the time of procedure
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Thank you for your attention!