white lesions (2)
TRANSCRIPT
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WHITE LESIONS
Prepared by:Dr. Rea Corpuz
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lesions of the oral mucosa, which are white results from a
thickened layer of keratin
epithelial hyperplasia
intracellular epithelial edema
reduced vascularity of subjacent connective tissue
White Lesions
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white or yellow lesions may also be due to fibrous exudate covering an:
ulcer submucosal deposit surface debris fungal colonies
White Lesions
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(1) Leukoedema
(2) Leukoplakia
(3) Lichen Planus
(4) Candidiasis
(5) White Sponge Nevus
(6) Nicotine Stomatitis
White Lesions
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(7) Geographic Tongue
(8) Hairy Tongue
(9) Dental Lamina Cyst
(10) Fordyce’s Disease
(11) Perleche
White Lesions
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generalized opacification of buccal mucosa that is regarded as a variation of normal
can be identified in majority of population
(1) Leukoedema
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Etiology & Pathogenesis
to date, cause has not been established
smoking chewing tobacco none alcoholo ingestion are bacterial infection proven salivary condition cause electrochemical interactions have been implicated
(1) Leukoedema
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Clinical Features
usual discovered as incidental finding
asymptomatic
symmetrically distributed in buccal mucosa
(1) Leukoedema
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Clinical Features
appear as gray-white, diffuse, filmy or milky surface
more exaggerated cases, whitish cast with surface textural changes
• wrinkling• or corrugations
(1) Leukoedema
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Clinical Features
with stretching of buccal mucosa, opaque changes dissipate
more apparent in non-whites, especially African-American
(1) Leukoedema
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Treatment
NO treatment is necessary
since there is no malignant potential
if there is any doubt about diagnosis, a biopsy can be performed
(1) Leukoedema
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also known as Leukokeratosis; Erythroplakia
Leuko= white
Plakia = patch
defined by World Health Organization (WHO) as a white patch or plaque that cannot be characterized clinically or pathologically as any other disease
(2) Leukoplakia
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clinical term indicating a white patch or plaque of oral mucosa
cannot be rubbed off
cannot be characterized clinically as any other disease
biopsy is mandatory to establish a definitive diagnosis
Leukoplakia(2) Leukoplakia
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Mild or Thin Leukoplakia
Homogenous or Thick Leukoplakia
Granular or Nodular Leukoplakia
Verrucous or Verruciform Leukoplakia
(2) Leukoplakia
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Proliferative Verrucous Leukoplakia (PVL)
Erythroleukoplakia or Speckled Leukoplakia
(2) Leukoplakia
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(2) Leukoplakia
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Mild or Thin Leukoplakia
seldom shows dysplasia on biopsy
may disappear or continue unchanged
(2) Leukoplakia
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Homogenous or Thick Leukoplakia
for tobacco smokers who do not reduce their habit
2/3 of such lesions slowly extend laterally, become thicker + acquire distinctly white appearance
(2) Leukoplakia
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Homogenous or Thick Leukoplakia
affected mucosa may become leathery to palpation
fissures may deepen
become more numerous
most thick, smooth lesions remain indefinitely at this stage
(2) Leukoplakia
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Homogenous or Thick Leukoplakia
some, perhaps as many as 1/3, regress or disappear
(2) Leukoplakia
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Granular or Nodular Leukoplakia
few become even more severe
develop increased surface irregularities
(2) Leukoplakia
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Verrucous or Verruciform Leukoplakia
lesions that demonstrate sharp or blunt projections
(2) Leukoplakia
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Proliferative Verrucous Leukoplakia (PVL)
high risk form of leukoplakia
development of multiple keratotic plaques
with roughened surface projections
(2) Leukoplakia
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Proliferative Verrucous Leukoplakia (PVL)
tend to slowly spread
involve additional oral mucosal sites
gingiva is frequently involved
although other sites may be affected as well
(2) Leukoplakia
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Proliferative Verrucous Leukoplakia (PVL)
as lesions progress, there may go through a stage indistinguishable
transform into full-fledged squamous cell carcinoma (usually within 8 years of initial PVL diagnosis)
(2) Leukoplakia
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Proliferative Verrucous Leukoplakia (PVL)
lesions rarely regress despite therapy
strong female predilection
minimal association with tobacco use
(2) Leukoplakia
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Erythroplakia
leukoplakia may become dysplastic
even invasive, with no change in its clinical appearance
however, some lesions eventually demonstrate scattered patches of redness called erythroplakia
(2) Leukoplakia
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Erythroleukoplakia or Speckled Leukoplakia
such areas usually represent sites in which epithelial cells are so immature or atrophic that they can no longer produce keratin
(2) Leukoplakia
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Erythroleukoplakia or Speckled Leukoplakia
intermixed red-and-white lesion
pattern of leukoplakia that frequently reveals advanced dysplasia on biopsy
(2) Leukoplakia
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Etiology & Prognosis
many cases are etiologically related to use of tobacco in smoked or smokeless forms and may regress after discontinuation of tobacco use
(2) Leukoplakia
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Etiology & Prognosis
other factors, such as • alcohol abuse may have• trauma a role in• C. albicans infection etiology
(2) Leukoplakia
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Etiology & Prognosis
nutritional factors have been cited as important, especially iron deficiency anemia
(2) Leukoplakia
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Clinical Features
associated with middle-aged + older population
vast majority of cases occur after age of 40 years
(2) Leukoplakia
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Site of Occurence
Vestibule Buccal Palate Alveolar Ridge Lip Tongue Floor
(2) Leukoplakia
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leukoplakia of lips + tongue also exhibits relative high percentage of dysplastic or neoplastic change
(2) Leukoplakia
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Treatment & Prognosis
absence of dysplastic or atypical epithelial changes
• periodic examinations + rebiopsy of new suspicious areas are recommended
(2) Leukoplakia
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Treatment & Prognosis
if diagnosis as moderate to severe dysplasia
• excision is obligatory
for large lesions, grafting procedures may be necessary after surgery
may recur after complete removal
(2) Leukoplakia
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chronic mucocutaneous disease of unknown cause
relatively common
typically presents as bilateral white lesions
occasionally with associated ulcers
(3) Lichen Planus
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Pathogenesis
although cause is unknown
generally considered to be a immunologically mediated process
resembles hypersensitivity reaction
(3) Lichen Planus
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Clinical Features
disease of middle age
affects men + women in nearly equal numbers
children rarely affected
(3) Lichen Planus
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Clinical Features
Types:
• Reticular• Erosive (ulcerative)• Plaque• Papular • Erythematous (atrophic)
(3) Lichen Planus
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Clinical Features
Reticular Form
• most common type
• numerous interlacing white keratotic lines or striae
(Wickham’s striae)
produces anular or lacy pattern
(3) Lichen Planus
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Clinical Features
Reticular Form
• buccal mucosa is the site most commonly involved
• may also be noted on:
tongue gingiva – less common lips
(3) Lichen Planus
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Clinical Features
Plaque Form
• resembles leukoplakia
• but has multifocal distribution
• range from slightly elevated to smooth and flat
(3) Lichen Planus
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Clinical Features
Plaque Form
• primary sites are
dorsum of tongue buccal mucosa
(3) Lichen Planus
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Clinical Features
Erythematous Form
• red patches
• with very fine white striae
• attached gingiva commonly involved
(3) Lichen Planus
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Clinical Features
Erythematous Form
• patchy distribution often in four quadrants
• patient may complain of
burning sensitivity generalized discomfort
(3) Lichen Planus
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Clinical Features
Erosive Form
• central area of lesion is ulcerated
• fibrinous plaque or pseudomembrane covers ulcer
• changing patterns of involvement from week to week
(3) Lichen Planus
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Treatment
although it cannot be generally cured
some drugs can provide satisfactory control
corticosteroids are the single most useful group of drugs in the management of lichen planus
(3) Lichen Planus
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Treatment
corticosteroid
• ability to modulate inflammation + immune response
(3) Lichen Planus
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Treatment
topical application + local injection of steroids have been used successfully in controlling but not curing this disease
(3) Lichen Planus
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common oppurtunistic oral mycotic infection
develops in the presence of one of several predisposing factors
• immunodeficiency• endocrine disturbances• hypoparathyroidism• diabetes mellitus• poor oral hygiene • xerostomia
(4) Candidiasis
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caused by Candida albicans
infection with this organism is usually superficial, affecting the outer aspects of involved oral mucosa or skin
(4) Candidiasis
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in severely debilitated + immunocompromised patients such as patients with AIDS
infection may extend into alimentary tract (candidal esophagitis
bronchopulmonary tract
and other organ system
(4) Candidiasis
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Clinical Features
most common form is acute pseudomembranous also known, as thrush
• young infants + elderly are commonly affected
(4) Candidiasis
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Clinical Features
oral lesion of acute candidiasis (thrush)
• white• soft plaques that sometime grow centrifugally + merge• wiping plaques with gauze sponge leaves a painful, eroded, eryhtematous or ulcerated surface
(4) Candidiasis
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Clinical Features
Chronic Erythematous Candidiasis
• commonly seen on geriatric individuals
• who wear complete maxillary denture
(4) Candidiasis
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Clinical Features
Chronic Erythematous Candidiasis
• distinct predilection for palatal mucosa as compared with mandibular alveolar arch
(4) Candidiasis
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Clinical Features
Chronic Erythematous Candidiasis
• chronic low-grade resulting from poor prosthesis fit
• failure to remove appliance at night
(4) Candidiasis
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Clinical Features
Chronic Erythematous Candidiasis
• bright red
• relative little keratinization
(4) Candidiasis
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Clinical Features
Hyperplastic Candidiasis
• may involve dorsum of tongue
• pattern referred to as median rhomboid glossitis
(4) Candidiasis
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Clinical Features
Hyperplastic Candidiasis
• usually asymptomatic
• usually discovered on routine oral examination
(4) Candidiasis
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Clinical Features
Hyperplastic Candidiasis
• found anterior to circumvallate papillae
• oval or rhomboid outline
(4) Candidiasis
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Clinical Features
Hyperplastic Candidiasis
• may have smooth, nodular or fissured surface
• range in color from white to more red
(4) Candidiasis
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Clinical Features
Mucocutaneous Candidiasis
• long standing
• persistent candidiasis of
oral mucosa skin vaginal mucosa
(4) Candidiasis
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Clinical Features
Mucocutaneous Candidiasis
• often resistant to treatment
• begins as a pseudomembranous type of candidiasis
• soon followed by nail + cutaneous involvement
(4) Candidiasis
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Treatment
majority of infections may be simply treated with topical applications of nystatin suspension
• nystatin cream or ointment often effective when applied directly to denture-bearing surface itself
(4) Candidiasis
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Treatment
topical applications of either nystatin or clotrimazole should be continued for at least 1 week beyond disappearance of clinical manifestations of disease
(4) Candidiasis
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Treatment
Hyperplastic Candidiasis
• topical + systemic antifungal agents may not be effective at completely removing lesions
surgical management may be necessary
(4) Candidiasis
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Treatment
Chronic Mucocutaneous Candidiasis associated with immunosuppression
• topical agents may not be effective
(4) Candidiasis
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Treatment
Chronic Mucocutaneous Candidiasis associated with immunosuppression
• systemic administration of medications:
Ketoconazole Fluconazole Itraconazole
(4) Candidiasis
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autosomal-dominant condition
due to point mutations for genes coding for keratin 4 and/or 13.
affects oral mucosa bilaterally
NO treatment is required
(5) White Sponge Nevus
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Clinical Features
• asymptomatic
• folded white lesions
• may affect several mucosal sites
• lesions tend to be thickened + spongy consitency
(5) White Sponge Nevus
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Clinical Features
• presentation intraorally is almost always bilateral + symmetric
• usually appears early in life, typically before puberty
(5) White Sponge Nevus
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Clinical Features
• usually observed in buccal mucosa
• tongue + vestibular mucosa may be involved
(5) White Sponge Nevus
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Treatment
• NO treatment necessary since it is asymptomatic + benign
(5) White Sponge Nevus
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common tobacco-related form of keratosis
typically associated with pipe + cigar smoking
with positive correlation between intensity of smoking + severity of condition
(6) Nicotine Stomatitis
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combination of tobacco carcinogens + heat is markedly intensified in reverse smoking (lit end positioned inside the mouth)
adding a significant risk for malignant conversion
(6) Nicotine Stomatitis
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Clinical Features
palatal mucosa initially responds with an erythematous change follwed by keratinization
(6) Nicotine Stomatitis
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Clinical Features
subsequent to opacification or keratinization of palate
• red dots surrounded by white keratotic rings appear
dot represent inflammation of salivary gland excretory duct
(6) Nicotine Stomatitis
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Treatment
condition rarely evolves into malignancy
except in individuals who reverse smoke
discontinuation of tobacco habit
(6) Nicotine Stomatitis
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also known as erythema migrans, benign migratory glossitis
prevalent among whites + blacks
strongly associated with fissure tongue
inversely associated with cigarette smoking
(7) Geographic Tongue
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emotional stress may enhance the process
(7) Geographic Tongue
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Clinical Features
affects women slightly more than men
children occasionally may be affected
characterized initially by presence of atrophic patches surrounded by elevated keratotic margins
(7) Geographic Tongue
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Clinical Features
desquamated areas appear red + may be slightly tender
followed over a period of days or weeks, pattern changes
appearing to move across dorsum of tongue
(7) Geographic Tongue
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Clinical Features
most patients are asymptomatic
occasionally patients complain of irritation or tenderness
especially in relation to consumption of spicy foods + alcoholic beverages
(7) Geographic Tongue
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Clinical Features
lesions periodically disappear
recur for no apparent reason
(7) Geographic Tongue
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Treatment
NO treatment is required because of self-limiting + usually asymptomatic nature of this condition
(7) Geographic Tongue
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Treatment
when symptoms occur,
• topical steroids especially ones containing antifungal agent
helpful in reducing symptoms
(7) Geographic Tongue
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Treatment
mouth clean using mouthrinse composed of sodium bicarbonate in water
reassure patients that condition is totally benign
(7) Geographic Tongue
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clinical term referring to a condition of filiform papillae overgrowth on dorsal surface of tongue
there are numerous initiating or predisposing factors for hairy tongue
(8) Hairy Tongue
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broad spectrum antibiotics such as penicillin + systemic cortiocosteroids are often identified in clinical history of patients with this condition
(8) Hairy Tongue
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oxygenating mouthrinses containing:
hydrogen peroxide sodium perborate carbamide peroxide
have been cited as possible etiologic agents
(8) Hairy Tongue
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Clinical Features
clinical alteration translates to hyperplasia of filiform papillae; result is
• thick serves to trap• matted surface bacteria, fungi, foreign materials
(8) Hairy Tongue
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Clinical Features
extensive elongation of papillae occurs,
• gagging may be• tickiling sensation felt
(8) Hairy Tongue
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Clinical Features
color may range from white to tan to deep brown depending on:
• diet• oral hygiene• composition of bacteria inhabiting papillary surface
(8) Hairy Tongue
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Treatment
brush/scrape tongue with baking soda
maintain good oral hygiene
emphasize to patients that this process is entirely benign
(8) Hairy Tongue
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Treatment
self-limiting
tongue should return to normal after institution of physical debridement + proper oral hygiene
(8) Hairy Tongue
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also known as Gingival Cyst of New Born or Bohn’s nodules
appear as multiple nodules along alveolar ridge in neonates
(9) Dental Lamina Cyst
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similar epithelial inclusion cysts may occur along midline of palate (palatine cyst of new born or Epstein’s pearls)
developmental origin derived from epithelium included in fusion line between palatal shelves + nasal processes no treatment; resolve spontaneously
(9) Dental Lamina Cyst
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Treatment
not necessary because nearly all spontaneously rupture before patient is 3 months of age
(9) Dental Lamina Cyst
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represents ectopic sebaceous glands or sebaceous choristomas
normal tissue in abnormal location
regarded as developmental
considered a variation of normal
(10) Fordyce’s Granules
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multiple
often seen in aggregates
sites of predilection include
• buccal mucosa• vermillion of upper lip
(10) Fordyce’s Granules
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lesions generally are symmetrical distributed
tend to become obvious after puberty
maximal expression occurring between 20-30 years of age
(10) Fordyce’s Granules
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lesions are asymptomatic
discovered during routine oral examination
(10) Fordyce’s Granules
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Treatment
No treatment is indicated
• glands are normal in character
• do not cause any untoward effects
(10) Fordyce’s Granules
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also known as Angular Cheilitis
inflammation + atrophy of skin of folds at angles of mouth
(11) Perleche
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may be due to:
excessive lip licking
thumb sucking
sagging of facial skin in edentulous or elderly persons
(11) Perleche
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may be due to:
prolonged contact with saliva results in maceration with possible secondary infection by Candida or staphylococci
(11) Perleche
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Clinical Features
skin at angles of mouth has erythematous fissures
often with exudate + crust
further licking to moisten inflamed area exacerbates the problem
(11) Perleche
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Treatment
applying antimicrobial creams
followed by low-potency steroid creams until symptoms resolve
protective lip balm may help prevent recurrence
(11) Perleche
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References:References:
BooksBooks
Cawson, R.A: Cawson’s Essentials of OralCawson, R.A: Cawson’s Essentials of Oral Oral Pathology and Oral Medicine,Oral Pathology and Oral Medicine, 88thth Edition Edition
• (page 165-167 )(page 165-167 ) Neville, et. al: Oral and Maxillofacial PathologyNeville, et. al: Oral and Maxillofacial Pathology 33rdrd Edition Edition
• (pages 388- 397; 590-592; 819-820) (pages 388- 397; 590-592; 819-820) Regezi, et. al: Oral Pathology: Clinical PathologicRegezi, et. al: Oral Pathology: Clinical Pathologic Correlations, 5Correlations, 5thth Edition Edition
• (pages 73-105; 241-242; 296-299; 394)(pages 73-105; 241-242; 296-299; 394)