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Welcome!
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True Root Causes of Dis-Ease: Functional Medicine Fundamentals
Part 3 (of 4)
This presentation is copyrighted by Purpose Inc. with all rights reserved
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● Quick Reminders
● Hormone Soup: Powerful Interconnectedness
● Estrogen Dominance
On the Menu for Today
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Functional Medicine Tenets
Each person is unique.
Everything in the body/system is interconnected.
The body's natural, default state is one of wellness.
Dis-ease precedes disease and is evidence of imbalance, blockage, and/or impairment in natural functioning.
The root cause and the complaint may be distant from one another (in the body, in time, in the biochemistry).
The collection of root causes of dis-ease in the body is unique for each person. Effective medicine is customized for each person.
Wellness includes the entire patient experience(physical, mental, emotional, spiritual).
The patient's active participation and belief in their healing are central to their ability to get (and remain) well.
All modalities that bring greater balance, ease, and flow to the patient are a key part of their unique healing journey and ongoing “health care”.
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5
Functional Medicine: Making It Simple
G
E
N
E
S ILL-NESS
ENVIRONMENT:
What we Maximize,
Minimize, and
Prioritize
WELL-NESS
InteractiveBiochemistry
Endocrine (Hormones)
Immune (Inflammation)
Nervous (Neurotransmitters)
Digestion(Nutrients)
Metabolism(Energy)
Detoxification(Clearance)
?
Choices
Choices
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All Things are Interconnected
Oxygen Intake and Spiritual Mindset
Stress and Stress Management
Toxins and Detoxification Ability
Sensitivities and Allergies and Immune Health
Energy Generation and Circulation
Nourishment and Absorption Ability
Genetic Predispositions and Infections
Expectation, Association, History, Belief
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The Difference That Matters Most
Mildly (or Un-) Satisfied Patients
Hesitation/Uncertainty
Control –or– Aimless
Diagnosis Management
Delayed benefit
Unsustainable benefit
Fear (nocebo)
Wildly Satisfied Patients
Confidence
Leadership
Functional Dynamics Knowledge
Rapid Relief
Root Cause Resolution
Belief (placebo)
Wildly satisfied patients can fill your practice with their enthusiastic referrals,
freeing you to (1) Do what you love the most and (2) Be wildly successful doing it!
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Most Common True Root Causes of Dis-ease
❖ Dis-ease Begins in the Gut
❖ Insulin Resistance
❖ Estrogen Dominance
❖ Toxicity
❖ Stress
❖ A failure to Maximize, Minimize, and Prioritize the right elements for a unique individual.
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Etiology of Dis-ease in the Gut
Deficiency-Driven Dysfunction
–e.g. anemia, neuropathy, depression, headache
Gastrointestinal Dis-ease
–e.g. IBS, constipation, belching, bloating
GI-origin Inflammation
–e.g. osteoarthritis, asthma, migraine, chronic fatigue, fibromyalgia, eczema, intestinal permeability
Autoimmune Dis-ease
–Hashimoto's thyroiditis, lupus, multiple sclerosis, Crohn's disease, rheumatoid arthritis
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Keepin’ It Simple: Insulin Resistance
Eat Refined (or an excess of)
Carbohydrate Foods
Make lots of insulin
Cells resist the effects of insulin
Excess sugar gets stored as body fat
Feel Hungry, Weak, and Tired
Vicious Cycle of
Insulin Resistance
❖ A Powerful example of where our focus needs to be to give the Greatest Value to our patients and clients: Educate, Educate, Educate!
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Most Common True Root Causes of Dis-ease
❖ Dis-ease Begins in the Gut
❖ Insulin Resistance
❖ Estrogen Dominance
❖ Toxicity
❖ Stress
❖ A failure to Maximize, Minimize, and Prioritize the right elements for a unique individual.
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● Quick Reminders
● Hormone Soup: Powerful Interconnectedness
● Estrogen Dominance
On the Menu for Today
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Hormones 101
Hormones are molecules of communication. Messenger chemicals.– Endocrine (at a distance)
– Exocrine (internal to the cell)
– Paracrine (from one cell to another)
Allow the body to interact with and respond to its environment.
Interact with each other to give the body maximum flexibility in responding to its environment, as it changes.
Levels are shifting all the time. Thus, remember that any test data is just a moment in time.
Estrogen is typically measured in 1,000,000,000,000th of a gram.
Must balance each other for optimal functioning
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Dance of the Hormones
Epinephrine/Norepinephrine
Cortisol
Insulin
Estrogen
Progesterone
ThyroidTestosterone
DihydroTestosterone(DHT)
Note: this diagram was revised from the original webcast to show more intricate and accurate interconnectedness.
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Three Common Hormone Imbalances
1. High insulin-producing diet (e.g. refined carbohydrates, sugars)
increases testosterone in women and increases estrogen in men
• Acne, infertility and anovulation (PCOS), excess body hair growth in
women (e.g. above lip), excess body fat (especially mid-torso, “apple
shape”), head hair loss in women, T2 Diabetes, gynecomastia in men.
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Dance of the Hormones
Epinephrine/Norepinephrine
Cortisol
Insulin
Estrogen
Progesterone
ThyroidTestosterone
DihydroTestosterone(DHT)
Note: this diagram was revised from the original webcast to show more intricate and accurate interconnectedness.
© P
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Three Common Hormone Imbalances
1. High insulin-producing diet (e.g. refined carbohydrates, sugars)
increases testosterone in women and increases estrogen in men
• Acne, infertility and anovulation (PCOS), excess body hair growth in
women (e.g. above lip), excess body fat (especially mid-torso, “apple
shape”), head hair loss in women, T2 Diabetes, gynecomastia in men.
2. High estrogen exposure or absorption overwhelms progesterone
(which may also be low). Often a result of “xenoestrogens”
overload. Creating “estrogen dominance”.
• Anxiety, higher body fat (especially in the lower belly, “the pooch”),
emotional sensitivity, bad PMS, long and heavy menstrual periods,
bloating/cramping, carbohydrate cravings.
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E & P: It’s All About Balance
Table details from Dr. John Lee, “Hormone Balance Made Simple”, Hatchette Book Group, 2006, p. 78-79* Cowan, et al., American Journal of Epidemiology, 1981. http://aje.oxfordjournals.org/content/114/2/209.short
Estrogen Effects Progesterone Effects
Proliferates endometrium Maintains endometrium
Stimulates breast cells Protects against breast fibroids
Increases body fat Helps use fat for energy
Salt and fluid retention Natural diuretic (clinical tip!)
Higher risk of blood clots Normalizes blood clotting
Restrains bone cell loss Stimulates new bone cell growth
Higher breast cancer risk Reduces breast cancer risk.*
Anxiety, headaches Natural antidepressant; calms anxiety
Reduced cellular oxygen Restores cellular oxygen
Creates progesterone receptors Normalizes tissue sensitivity to
estrogen
Slows testosterone clearance Speeds testosterone clearance
(clinical tip!)
Ideally: “Test; don’t Guess” (e.g. DUTCH)
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Menstrual Cycle Overview
From Wikipedia, Open source
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Estrogen Mimickers: Everywhere!
BPAGlyphosate
Oxybenzone
Triclosan
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The Experience of Toxicity is Individual
What is toxic to one person is fine for another person. Our toxin tolerance is particularly individual.
Genetics
Toxic Excretion
Environment
Toxic Exposure
and Absorption Nutrition
Toxic Retention
Inflammation/
DiseaseComfort/
Wellness
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Estrogen Dominance Interventions
1. Choose organic foods. Use EWG’s Clean 15/Dirty Dozen tools.
2. Eliminate all conventionally-raised animal foods and reduce or eliminate dairy foods, especially during luteal phase.
3. Clean up personal hygiene products. Use EWG’s Skin Deep database/guide.
4. Ensure magnesium is optimal (RBC magnesium; ideally upper third RR).
5. Reduce or eliminate caffeine (e.g. green tea vs. coffee).
6. Address insulin resistance (reduce dietary sweeteners/refined carbohydrates).
7. Address any constipation (e.g. low magnesium, low thyroid, low hydration).
8. Support detoxification with supplemental activated B vitamins
9. Increase progesterone with chastetree berry and tangible stress reduction(which may include reducing exercise intensity/frequency).
10. Increase estrogen detoxification with cruciferous vegetables (or supplement with I3C or DIM).
And EPA and iodine and ground flaxseed and ….. ☺
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Looking Ahead
In our fourth webinar Debilitating Overloads: Stress and Toxicity
And Why these are Pearls regarding sustainable Weight Loss (more hormone madness!)
Resolution Clinical Tips
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for this entire webinar series.
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