Surface Recontamination ShieldingFrom Patient to worker… Exams Rooms to MRI’s

Total Protection…Total Protection…

The WorkerThe Patient

Soft GoodsHard GoodsSurfaces

All Surfaces Protected

Topic Agenda

Surface Recontamination Shield

(SRS) Certifier

Affiliations & Resources

CLEANING PROTOCOLS

• Antimicrobials are designed to enhance cleaning protocols not replace them.

• The technology allows for protection between cleanings.• Environmentally safe providing a “GREEN” application and

removing the need for chemical cleaning. (soap and water)• Cost effective, reduces the need to buy expensive chemicals

and decreased cleaning time for staff (as much as 66%).

WilkinsSolutions

NEW Technology Enables this Anti-Microbialto be applied via a Electro Static System

that is TRULY Remarkable

It’s Delivery System

http;//www.youtube.com/watch?v=pn0J05v1Jzk

NANO Technology

Mark Shaw ‘s Demonstration atTED Forum in Long Beach CA

February 2013

WARNING: This Video my inspire thoughts of themultitude of ways this product can be used…

Hand Sanitization / Protection

FACTS

• 95% of facial infections are caused by hand to face contact.

• Contact sports provide 8x more exposure to virus and bacterial infections.

• 97 million cases of the flu are reported annually resulting in 126 million “sick” days impacting school attendance and the work place.

FACTS

• Infection control in public venues is people dependent. Only 48% of people wash their hands after using the restroom.

• In the USA currently, 271 people per day, will die from healthcare-associated infections (HAIs) such as Methicillin-resistant Staphylococcus

aurous (MRSA) infections.

4 Layers of Infection Prevention 1. Hand Sanitization / 24 hour Continuous Protection

2. Clothing Disinfection / 100 washings or 90 days of Protection

3. Surface Cleaning / Disinfection

4. Surface Continuous Protection

Not all Non-Alcohol based sanitizers are the same…

•The Active Ingredient in many other Non-Alcohol based sanitizers is Triclosan which is rated as a level 7 high hazard in the Safety Database

•Triclosan has been shown to accumulate biosolids in the environment, one of the top seven organic contaminants in waste water according to the National Toxicology Program. Triclosan leads to various problems with natural biological systems. Triclosan, when combined with chlorine e.g. from tap water, produces dioxins, a probable carcinogen in humans. •Triclosan is currently under review by the FDA due to possible health hazards.

Hand Sanitizing Protection

Why Switch?

Drying effect on the finger tips from winter use of alcohol based sanitizer

Skin from the hands under the scope after regular use of alcohol based products

Check out YouTube to see how teen’s are using hand sanitizer and the possible harm.

Hands of a 32 year old nurse after regular use of alcohol based hand sanitizer

Hand Sanitizer: Benefits• Cutting edge technology for personal health

protection…. schools, fitness gyms, offices, anywhere.• Cost effective protection: .005 cents per application.

With budgets deciding how many employees it takes to perform a job, being healthy and able to work is more important then ever.

• NON-TOXIC: Does not require poison control reporting.• NON-FLAMMABLE: does not pose a safety risk• WATER BASED: NO ALCOHOL; No drying out of skin• LONGEST LASTING: 24 hour protection sanitizer longest

on the market.

Hand Sanitizer: Benefits

• NON-DRYING: promotes healthy skin care• Kills 99.9% of Germs (Including Staph, MRSA, C

Diff, influenza, H1N1, etc…)• Mechanical compound (nano technology

creates microscopic 2nd skin)• Tests show a 72% decrease in absence of Pre

School Students. • Germ free protection for cuts, scrapes and

abrasions.

Clothing & Soft Goods Protection• Antimicrobial technology provides a high

performance, non-leaching, proactive and continual prevention of odor, staining and fabric deterioration.

• Application must be done separately from normal washing. Do not mix with regular detergent or bleach. New model washing machines have the capacity to integrate solutions.

• Creates and environmentally friendly, Invisible, hypoallergenic and non-toxic antimicrobial coating on fabrics.

• Will not create adaptive organisms or “super bugs”.• One application lasts 90 days.

Surface Disinfectant• Hospital Grade Disinfectant is part ONE of the Cleaning

System• 3 minute kill time• Antibiotic-Resistant Bactericidal• Tuberculocidal• Virucide• Bactericidal • Mildew stat/Fungicide • Eliminates odors• Cuts Grease & Grime• Meets OSHA Blood borne Pathogen Standard for HIV,

HBV & HCV

Surface Cleaning / Disinfection

• Antibiotic-Resistant Bactericidal Activity:• Community Associated Methicillin Resistant Staphylococcus aureus (CA-MRSA) (NRS 123) Genotype USA

400 (NRS384) Genotype USA 300, Methicillin resistant staphylococcus aureus (MRSA), (ATCC 33593), Vancomycin resistant Enterococcus faecalis (VRE), (ATCC 51575), Vancomycin intermediate resistant Staphylococcus aureus (VISA), (CDC Isolate 99287), Methicillin resistant Staphylococcus epidermidis (MRSE), (ATCC 51625)

• Bactericidal Activity:• Staphylococcus aureus, (ATCC 6538), Pseudomonas aeruginosa, (ATCC 15442), Salmonella choleraesuis,

(ATCC 10708), Escherichia coli, (ATCC 11229), Escherichia coli O157:H7, (ATCC 43895), Listeria monocytogenes, (ATCC 35152), Salmonella typhi, (ATCC 6539), Streptococcus pyogenes (Necrotizing Fasciitis-Group A) (V.A. Medical Center Isolate 04001), Yersinia enterocolitica, (ATCC 23715), Enterococcus faecium, (ATCC 6569), Corynebacterium ammoniagenes, (ATCC 6871)

• Virucidal Activity:• Avian Influenza A Virus (H3N2), (Avian Reassortant) (ATCC VR-2072), Avian Influenza Virus Type A

(Turkey/WIS/66), (H9N2), SARS Associated Coronavirus (ZeptoMetrix), Paramyxovirus (Mumps) (ATCC VR-1438), Hepatitis A Virus (HAV), Rhinovirus Type 39 (ATCC VR-340), Rotovirus

Disinfectants are Temporary

SRS Attributes

SRS Surface Protection

• Antimicrobials are designed to enhance cleaning protocols not replace them.

• Deactivates ALL dangerous microbes and restrains proliferation by damaging their components through radical oxidation.

• This broad spectrum photo-mineralization of pathogens is continuous.

• Does not cause resistant strains of microbes because its killing mechanism is strictly oxidative, not enzymic or antibiotic.

SRS Surface Protection• Antimicrobial coatings are protectants not

disinfectants…they work continuously between cleanings.

• Environmentally safe “GREEN” application, removing the need for chemical cleaning. (soap and water)

• Reduces the need to buy expensive chemicals. Decreases staff cleaning time (as much as 66%).

• This coating is an energetic trap for microbes and Volatile Organic Compounds (VOCs) at a molecular level, completing their destruction through photo catalytic oxidation (PCO).

What is the residual kill time of most disinfectants?

• “Perceived Cleanliness”

• Spot Cleaning when visible fluid or dirt appears

• Temporarily Disinfecting the surfaces based on protocol

• Toxic Shields – frequently reapplied

Common practices for reducing the exposure to pathogens on surfaces?

What is the residual kill time of most disinfectants?

Anti-Corrosive

Superhydrophilic

Self-Cleaning

SRS’s UV ProtectionVOC & Odor Reduction

Antifouling and anti-adhesive surface coatings

• Poly(ethylene glycol) coatings (PEG)• Self-Assembled Monolayer (SAM)• Diamond-like carbon (DLC) films• Easy clean surfaces

• Pilkington Active <10 degrees contact angle• Pilkington Hydrotech >130 degrees contact angle

• BUT: It merely moves them elsewhere, where they will have to be dealt with by other microbicidal techniques.

Zwitterionic polymer biomimetic surfaces

• Mimic properties found in the lipid bilayers of biological membranes

• Zwitterionic surfaces are biocompatible and non-thrombogenic discouraging adhesion of cells, both mammalian and microbial

• BUT: Still do not fully address the problem of microbial contamination as they have no antimicrobial functionality.

Antimicrobial coatings and surface technologies

• The 6 core technologies are:

1.Microbicide-releasing surfaces2.Silver and silver-containing surfaces3.Copper and copper alloy surfaces4.Bacteriophage-modified surfaces5.Polycationic antimicrobial surfaces6.Light Activated Antimicrobial Agents (LAAAs)

1. Microbicide-releasing surfaces• The most well known is Microban • Microban incorporates Triclosan (chloro-dichlorophenoxy-

phenol) a broad spectrum phenolic antimicrobial. • BUT: It is only active against Bacteria, not virus, spores, or

Volitile Organic Compounds (VOCs). It is toxic in aquatic systems and is an endocrine disruptor. Most concerning is that it degrades to Dioxin which is extremely hazardous to man.

2. Silver and silver-containing surfaces• To date, few organisms have developed resistance towards

the silver ion as an antimicrobial.

• BUT besides “expense” there are a couple of drawbacks: 1. They are non-permanent (leaching), relying on diffusible

antimicrobials to which microbes can develop resistance. 2. Possible Ag ion cytotoxicity towards mammalian cells

3. Copper and copper alloy surfaces• Brass is less effective than pure copper but still exhibits

antimicrobial activity

• Alloys have improved aesthetic and mechanical properties and may be more suited to real world applications

• Door plates, handles and other surfaces could employ copper alloys, but it’s a relatively expensive solution

4. Bacteriophage-modified surfaces• Bacteriophages are viruses that infect prokaryotic cells. • Phages usually target individual species of bacteria, bind to

their surface, inject their genetic material and replicate within the bacterial host.

• BUT they are not practical in general settings where specific targets may not be few enough and viruses, spores etc. are not addressed at all. Also of concern is Phage resistant strains.

5. Polyatomic Antimicrobial Surfaces

• Polyethyleneimines (PEIs)• A positively charged moiety is required—this keeps the

hydrophobic chains separated and erect from the surface, and also electrostatically attracts microbes, due to the net negative charge on their surface.

• BUT, their mechanical stability and longevity have not been described and it is still yet to be seen how well they might respond to the rigors of use and indeed cleaning in a clinical setting.

6. Light Activated Antimicrobial Agents (LAAAs)

• Photosensitiser (PDT Refinement)• PDT is a form of indirect phototherapy, in which light is used as a

means of activating the curative agent.• Titanium Dioxide Photocatalysis

• (Effective with UV or visible spectrum though doping. eg. With Nitrogen or Tungsten oxide)

• Shown to be benign to the environment and humans, animals, birds, and aquatic systems. (No Toxicity)

• Highest binding, permanent, unless removed through abrasion• Active against: Bacteria, Viruses, Spores (i.e. mold, mildew), VOCs and

odors!

What is the residual kill time of most disinfectants?

WSE Available Alternatives

Active Component(s) Zinc, Titanium Dioxide Ammonium Chloride Silver Ions Phenoxy Phenols (PCPP)Mode of Action Contact Photo-Oxidation Contact Dilute Chloride Salts Leaching Heavy Metal in H2O Leaching PoisonEffective Against:

Bacteria Active Bactericide Bacteriostatic Bactericide BactericideViruses Active Virucide Ineffective Against Non-

enveloped VirusesVirucide No

Spores Active Sporicide Fungistatic Sporicide NoVOCs All No No NoOdors All Bacterial only Bacterial Only Bacterial Only

Toxicity Risks To:Humans No High Toxicity to Skin and Eyes Bio-Accumulative Endocrine Disruptor

Animals & Birds No High Toxicity to Skin and Eyes Bio-Accumulative Endocrine DisruptorAquatic Systems No High Toxic, Zero Discharge

AllowedHighly Toxic, Bio-Accumulative

Toxic

Environmental Fate Risk None 5-Year Degradation Time Very High Degrades to DioxinResistant Bacteria Promotion No No Yes YesUV Damage Protection 95% No No NoMetal Corrosion Protection Yes Corrosive No NoHydrophilic Self-Cleaning Yes No No NoApplication Method Water based spray Spray Epoxy Paint Incorporated at ManufactureTreatable Surfaces All Substrates and Textiles

New or ExistingHard Surface or Textile Paintable Incorporated at Manufacture

Durability Very High Binding Removed by Surfactants (Detergents or Soap)

Incorporated Incorporated at Manufacture

Service Interval 6 mo. - 3 Years 1-3 months unless cleaned Repaint Item ReplacementRegulatory Guidance US EPA FIFRA 25B

Minimum Risk Pesticide Exempt From Registration

US EPA FIFRA Registered

US EPA Registered Currently Restricted for Review

US EPA Registered Under Regulatory Review EU banned

Antimicrobial Surface Coatings ComparisonSurface Photocatalyst Quaternary Ammonium Silver TriclosanCoating Class

What is the residual kill time of most disinfectants?

The best combinative surface solution available

Surface Recontamination Shield (SRS)

SRS removes odors and breaks down dangerous VOCs and pollutants in the air.

This safe, persistent cleansing of the air occurs using both natural sunlight and, most importantly, visible light indoors.?

VOC & Odor Reduction

How long does the protection last?

• The coating can only be removed by taking part of the substrate off through high friction polishing or abrasions.

• One treatment will last up to 1 year.

• Once the surface is dry (30 seconds) the coating becomes one with the substrate and cannot be removed without removing the substrate.

How is SRS applied?Original Sphere

Professional Electrostatic Spray System

Ensures efficacy of coverage

70 Times more coverage than conventional sprayers.

Treated surface dries in less than 30 seconds

40 Times greater than the force of gravity

Electrostatic OFF

Electrostatic

ON

SRS Application Methods:• Self Application: 800 sq/ft per gallon.• HVLP Application: 1200 sq/ft per gallon• ESS Application: 3000 sq/ft per gallon• Due to the droplet size, each application process administers

a different amount of surface coverage. This causes a considerable cost variance based on volume of product.

• *ESS is recommended for cost savings.

How is SRS Monitored? PCO™ Verification Ink

•A quick and easy visible quality check!•Safe, water soluble, reaction dye.•The ink will change in a few minutes or less from blue to pink.•Color change is proof that the SRS is protecting the surface, killing bacteria, virus and breaking down VOCs (the odor reduction is self evident).

Messaging your facility:

Portion of the pathogen Kill list:

• Antibiotic-Resistant Bactericidal Activity:• Community Associated Methicillin Resistant Staphylococcus auras (CA-MRSA) (NRS

123) Genotype USA 400 (NRS384) Genotype USA 300, Methicillin resistant staphylococcus auras (MRSA), (ATCC 33593), Vancomycin resistant Enterococcus faecalis (VRE), (ATCC 51575), Vancomycin intermediate resistant Staphylococcus aureus (VISA), (CDC Isolate 99287), Methicillin resistant Staphylococcus epidermidis (MRSE), (ATCC 51625)

• Bactericidal Activity:• Staphylococcus auras, (ATCC 6538), Clostridium difficile, Pseudomonas aeruginosa,

(ATCC 15442), Salmonella choleraesuis, (ATCC 10708), Escherichia coli, (ATCC 11229), Escherichia coli O157:H7, (ATCC 43895), Listeria monocytogenes, (ATCC 35152), Salmonella typhi, (ATCC 6539), Streptococcus pyogenes (Necrotizing Fasciitis-Group A) (V.A. Medical Center Isolate 04001), Yersinia enterocolitica, (ATCC 23715), Enterococcus faecium, (ATCC 6569), Corynebacterium ammoniagenes, (ATCC 6871)

• Virucidal Activity:• Avian Influenza A Virus (H3N2), (Avian Reassortant) (ATCC VR-2072), Avian Influenza

Virus Type A (Turkey/WIS/66), (H9N2), SARS Associated Coronavirus (ZeptoMetrix), Paramyxovirus (Mumps) (ATCC VR-1438), Hepatitis A Virus (HAV), Rhinovirus Type 39 (ATCC VR-340), Rotovirus

US INDEPENDENT TESTING:

Tests were designed to determine the efficacy of the antimicrobial coatings in the most adverse conditions by giving bacteria the optimal growth environment.

ALL LAB TESTS USED ONLY TYPICAL ARTIFICIAL ROOM LIGHTING. The

presence of natural light or greater artificial lighting will increase the efficacy of the coating in bacterial, virus and VOC reduction.

Tests by leading US laboratories show strong, persistent and protective cleaning power in real world conditions: 98% reduction of deadly VRE bacteria in 15 minutes; prolonged virus reduction of 89% over 24 hours and strong reductions of MRSA and Staph; 91% reduction of C. difficile spores over 24 hours and 99% reduction of hydrogen sulfide over 24 hours.

More Information on Selecting Antimicrobials:• Household Cleaning - University of Nebraska- Lincoln• Selecting an Appropriate Sanitizer or Disinfectant - National

Resource Center for Health and Safety in Child Care and Early Education

• Cleaning Up Antimicrobial Hand Soaps - Johns Hopkins School of Public Health

• Disinfection and Remediation Guidelines for Pools and Spas - Centers for Disease Control and Prevention

• Healthy Swimming - Centers for Disease Control and Prevention

• Cleaning, Sanitizing, and Disinfecting in Child Care Settings - National Resource Center for Health and Safety in Child Care and Early Education

Surfaces and antimicrobial surface coatings in the epidemiology of HAIs

*Hospital Acquired Infections - HAIs)

1. Hospital Grade Cleansing/Disinfectant2. Non-Alcohol Based Hand Sanitizer/Protectant3. Disinfection/Antimicrobial Clothing

Protection4. Continuous Antimicrobial Surface Protection

For More INFORMATION in how OXYTITAN can be of benefit to your CommunityChris.Beckman@WilkinsSolutions.com / 888-460-4050 / www.wilkinssolutions.com

For For Information Information ContactContact

Chris BeckmanChris BeckmanCommercial Account Commercial Account ManagerManager615-669-3481615-669-3481www.wilkinssolutions.com

Email: Chris.Beckman@wilkinssolutions.com