xv congreso nacional de virologÍa la de sev...4 queridos amigos y amigas, es un gran placer daros...

VIROLOGÍAX V C o n g r e s o N a c i o n a l d e

1 1 T H I n t e r n a t i o n a l

M e e t i n g

B A R C E L O N A9 / 1 2 J U N I O 2 0 1 9

A U D I T O R I O A X As e v i r o l o g i a . e s

SEVL AD E

INDICE Bienvenida 04Welcome

Comités 08Committees

Ponentes y moderadores 10 Invited speakers and chairpersons

Esquema del programa 11 Programme at a glance

Programa detallado 14 Detailed Programme

Posters 44

Informacion general 72 General information

Empresas colaboradoras 76 Sponsors

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Queridos amigos y amigas,Es un gran placer daros la bienvenida a Barcelona (España) en nombre del Comité Organizador del XV Congreso de la Sociedad Española de Virología (SEV). El Congreso de la SEV tendrá lugar durante los días 9 al 12 de Junio de 2019 en el Auditorio Axa localizado en una las áreas más modernas de la ciudad.

Por primera vez, el Congreso de la SEV será organizado en conjunto con la Red Global de Virus (Global Virus Network, GVN), una alianza internacional de centros de excelencia en el campo de la virología humana y animal (www.gvn.org). El Dr. Christian Bréchot es el presidente de GVN. Esta colaboración aumentará el alcance de nuestro ya consolidado Congreso de la SEV, incrementando visibilidad a nivel internacional.

El Congreso de la SEV comienza con una conferencia de apertura a cargo del Dr. Robert C. Gallo, altamente reconocido por su descubrimiento del primer retrovirus humano, HTLV-1, y el descubrimiento conjunto del VIH como la causa del SIDA y el desarrollo del análisis de sangre del VIH. El Congreso estará organizado en sesiones paralelas (desde el 10 al 12 de Junio de 2019), incluyendo tópicos tan importantes como inmunología y vacunas, antivirales, interacción virus-huésped, epidemiología y diagnóstico viral, morfogénesis y biología estructural, virus emergentes y re-emergentes, los virus como herramientas biotecnológicas y temas novedosos en virología.

En paralelo, y abierto a todos los delegados, la GVN organiza su 11ª Reunión Internacional los días 10 y 11 de Junio de 2019, con un programa muy atractivo orientado a virus relevantes que afectan la salud humana.

Nada de lo antes mencionado sería posible sin la contribución de todos aquellos ponentes, delegados y moderadores, así como compañías promotoras y socios colaboradores. Quisiéramos expresar nuestra mayor gratitud a todos ellos, ya que serán las piezas clave de este Congreso de la SEV-GVN 2019. Además, queremos expresar nuestra gratitud a los miembros del Comité Científico de la asociación SEV-GVN, ya que representan el alma de este Congreso.

España es un país hermoso y magnífico, donde las posibilidades turísticas vacacionales son casi infinitas. Barcelona es una ciudad cosmopolita en la que llegaréis a sentiros como en casa. Podéis elegir desde paseos culturales hasta los más bellos entornos naturales, desde el mar hasta las montañas, contemplar exhibiciones diurnas o disfrutar de la vida nocturna… seguramente encontraréis la opción que mejor se adapte a vuestro gusto ¡Descubre, prueba, experimenta y disfruta!

¡Bienvenidos a Barcelona!

JOAQUIM SEGALÉSPresidente organizador del XV Congreso de la SEV y XI Reunión Internacional GVNEn nombre del Comité Organizador Local

BIENVENIDA

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WELCOME

Dear friends,On behalf of the XV Congress of the Spanish Society of Virology (Sociedad Española de Virología, SEV) Organizing Committee, it is my great pleasure to welcome you to Barcelona, Spain. The SEV congress will take place on June 9-12th, 2019 at the Axa Auditorium located in one of the most modern areas of the city.

For the first time, the SEV Congress will be organized together with the Global Virus Network (GVN), an international alliance of centers of excellence in the field of human and animal virology (www.gvn.org). Dr. Christian Bréchot is the president of GVN. This collaboration will increase the scope of our well consolidated SEV Congress and its international visibility.

The SEV Congress will start on June 9th, 2019, with an opening lecture by one of the co-founders of GVN, Dr. Robert C. Gallo, most notable for his discovery of the first human retrovirus, HTLV-1, and co-discovery of HIV as the cause of AIDS and development of the HIV blood test. The regular structure of the congress will be organized with several parallel sessions (from June 10th to 12th, 2019), including topics as relevant as immunology and vaccines, anti-virals, virus-host interaction, diagnostic virology and epidemiology, morphogenesis and structural biology, emerging and re-emerging viruses, viruses as biotechnological tools and trending topics in virology.

In parallel, but open to all delegates, GVN will organize its 11th International Meeting June 10th and 11th, 2019, with a very attractive program oriented to significant viruses affecting mankind.

None of the above will be feasible without the contribution of speakers, delegates and chairpersons as well as supporters and funding partners. Our deep gratitude to all of them; they will be the core of the SEV-GVN 2019! Moreover, our deep appreciation to Scientific Committee members of the SEV-GVN partnership, since they represent the soul and the spirit of the Congress.

Spain is a magnificent and beautiful country and tourist/vacation possibilities are almost endless. Barcelona is a cosmopolitan city in which you will feel at home. You can choose from culture to environment and nature, from sea to mountains, from exhibitions to partying… you will surely meet up with your match. Discover, taste, experience and enjoy!

Welcome to Barcelona!

JOAQUIM SEGALÉSChair of the XV Congress of the SEV and 11th International GVN Meeting On behalf of the Local Organizing Committee

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CARTA GVN / GVN LETTER

Dear Friends,

It is a pleasure to welcome you to the 11th GVN International meeting organized in partnership with the Spanish Society of Virology.

We are grateful to GVN’s Drs. Segales and Rodríguez of IRTA-CReSA and Drs. Domingo and of Centro de Biologia Molecular, Severo Ochoa. We also thank Albert Bosch, President of the SEV for co-hosting the GVN meeting.

This past year has been especially active, as we not only welcomed new centers, but we developed a growing number of initiatives, partnerships and collaborations.

Several new developments include the launch of GVN’s Anticipation and Preparedness Task Force (A&P TF) and its fellowships, GVN Virus Watch Groups (VWG), Regional GVN Units, the GVN Corporation Partnership Program, the "GVN Academy” and major grants, among others.

The GVN is an organization created by, and for, virologists. Our members have devoted their careers to viral research, delivering outstanding discoveries with high impact to public health. It is our job as an organization to connect GVN members to the next generation of leaders, fostering in every possible way mentorship, research and training opportunities to be better prepared to respond to future epidemics.

We hope this meeting will bring exceptional collaboration and networking opportunities, and continue to inspire the next generation of virologists to take the lead in the discovery of diagnostics, treatments and generation knowledge to improve our understanding of viruses.

I would like to thank the local team, the sponsors and organizers for making this a platform to advance the field.

Sincerely,CHRISTIAN BRECHOT, MD, PHDGVN President

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CARTA SEV / SEV LETTER

On the behalf of the Spanish Society for Virology (SEV), I would like to welcome you to our XV National Congress of Virology that will be held in Barcelona on June 9-12. In this occasion, the event will be a joint venture with the 11th Meeting of the Global Virus Network (GVN). I take the opportunity to give a warm welcome to the President, Dr. Christian Bréchot, and delegates of the GVN to our conference. We look forward to exciting presentations and fruitful interactions in the next days.

I would like to express our appreciation to Drs. Segales and Rodriguez of IRTA-CRESA, extensive to the local organizing committee, for the hard work and efforts in shaping a terrific meeting.

ALBERT BOSCHPresident of the Spanish Society for Virology (SEV)

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COMITÉS

COMITÉ ORGANIZADOR LOCAL (IRTA-CRESA)

Albert Bensaid Núria Busquets Florencia Correa-Fiz Fernando Rodríguez Joaquim Segalés, presidente Júlia Vergara-Alert

COMITÉ CIENTÍFICO

Miguel Aranda, Centro Superior de Investigaciones Científicas, España Albert Bensaid, IRTA-CReSA, España Albert Bosch (presidente de la SEV), Universitat de Barcelona, España Christian Bréchot, GVN Núria Busquets, IRTA-CReSA, España Inmaculada Casas, Instituto de Salud Carlos III, España Florencia Correa-Fiz, IRTA-CReSA, España Juana Díez, Universitat Pompeu Fabra, España Esteban Domingo, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), España Rosina Gironès, Universitat de Barcelona, España Sharon Lewin (GVN), Peter Doherty Institute, Australia Juan José López, Centre de Recerca en Agrigenòmica, España Luis Menéndez-Arias, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), España Natalia Mercer, GVN Johan Neyts (GVN), University of Leuven, Bélgica Tomàs Pumarola, Hospital Universitari Vall d’Hebron, España Josep Quer, Vall d'Hebron Institut of Research (VHIR-HUVH), España Fernando Rodríguez, IRTA-CReSA, España María Paz Sánchez-Seco, Instituto de Salud Carlos III, España Joaquim Segalés (presidente del congreso SEV-GVN), IRTA-CReSA, España Júlia Vergara-Alert, IRTA-CReSA, España Mikel Yoldi, Hospital Clínic- ISGlobal- Universitat de Barcelona, España

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COMMITTEES

LOCAL ORGANIZING COMMITTEE (IRTA-CRESA)

Albert Bensaid Núria Busquets Florencia Correa-Fiz Fernando Rodríguez Joaquim Segalés, Chair Júlia Vergara-Alert

SCIENTIFIC COMMITTEE

Miguel Aranda, Centro Superior de Investigaciones Científicas, Spain Albert Bensaid, IRTA-CReSA, Spain Albert Bosch (president of the SEV), Universitat de Barcelona, Spain Christian Bréchot, GVN Núria Busquets, IRTA-CReSA, Spain Inmaculada Casas, Instituto de Salud Carlos III, Spain Florencia Correa-Fiz, IRTA-CReSA, Spain Juana Díez, Universitat Pompeu Fabra, Spain Esteban Domingo, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Spain Rosina Gironès, Universitat de Barcelona, Spain Sharon Lewin (GVN), Peter Doherty Institute, Australia Juan José López, Centre de Recerca en Agrigenòmica, Spain Luis Menéndez-Arias, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Spain Natalia Mercer, GVN Johan Neyts (GVN), University of Leuven, Belgium Tomàs Pumarola, Hospital Universitari Vall d’Hebron, Spain Josep Quer, Vall d’Hebron Institut of Research (VHIR-HUVH), Spain Fernando Rodríguez, IRTA-CReSA, Spain María Paz Sánchez-Seco, Instituto de Salud Carlos III, Spain Joaquim Segalés (Chair of the SEV-GVN Congress), IRTA-CReSA, Spain Júlia Vergara-Alert, IRTA-CReSA, Spain Mikel Yoldi, Hospital Clínic- ISGlobal- Universitat de Barcelona, Spain

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PONENTESINVITED SPEAKERS

Busquets, Núria. Centre de Recerca en Sanitat Animal (CReSA) – Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Spain – GVN Center

Diez Antón, Juana. Universitat Pompeu Fabra, Spain

Domingo, Esteban. Centro de Bilogía Molecular Severo ochoa (CSIC-UAM), Spain – GVN Center

Figuerola, Jordi. Estación Biológica de Doñana, CSIC, Spain

Gallo, Robert C. University of Maryland, School of Medicine, Institute of Human Virology, USA – GVN Center

Garaigorta, Urtzi. Centro Nacional de Biotecnologia, CSIC, Spain

García, Juan Antonio. Centro Nacional de Biotecnologia, CSIC, Spain

Jee, Youngmee. National Institute of Health, South Korea – GVN Center

Koopmans, Marion. Erasmus MC, Department of Viroscience, The Netherlands – GVN Center

Mateu de Antonio, Enric. Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Spain

Matsouka, Masao. Department of Hematology, Rheumatology, and Infectious diseases, Kumamoto University, Japan – GVN Center

Neyts, Johan. University of Leuven, Belgium – GVN Center

Nieto, Amelia. Department of Molecular and Cellular Biology - CNB-CSIC, Spain

Osterhaus, Albert. Research Centre for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Germany – GVN Center

Pallás, Vicente. Instituto de Biologia Molecular y Celular de PLantas (IBMCP). UPV-CSIC, Spain

Pérez Pérez, María Jesús. Instituto de Química Médica (IQM) Consejo Superior de Investigaciones Científicas (CSIC), Spain

Poon, Leo. The University of Hong Kong, China – GVN Center

Rasmussen, Thomas. Senior Researcher. National Veterinary Institute Virology, Australia – GVN Center

Schinazi, Raymond. Emory Unversity School of Medicine, USA – GVN Center

Vignuzzi, Marco. Institut Pasteur, France – GVN Center

Weaver, Scott. University of Texas Medical Branch, USA – GVN Center

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ESQUEMA DEL PROGRAMAPROGRAMME AT A GLANCE

SUNDAY 9TH

Auditori - Plenary Room16:30 Registration17:30 Inaugural ceremony18:00 Opening lecture: Robert C. Gallo19:00

Robert C. Gallo Award Presentation

Welcome Reception in the Foyer

MONDAY 10TH

Auditori - Plenary Room Room 1 Room 308:00 Registration (Open all day)

08:30

Going viral: preparing for changing disease dynamics: Marion Koopmans

09:00

The Zika Virus Task Force: Activities and Updates on Zika Research: Scott Weaver

09:30

Strategy and pathogenesis of human t-cell leukemia virus type 1 (HTLV-1):

Masao Matsuoka10:00

Use of arbovirus surveillance in

vertebrate hosts and mosquitoes as an early warning system: Núria Busquets

10:30 Coffe break

11:00

New immunotherapeutic approaches to eliminate HIV persistence on antiretroviral

therapy: Thomas A. Rasmussen

11:30 Spatial virus-induced host adaptation to viral codon usage: Juana Díez

12:00

Senior virologist lecture (SEV award): The struggle of viruses for survival in an

always hostile world: Juan Antonio García13:00 Lunch and Posters session

14:30 Diagnostic virology and epidemiology O-EP (1-6)

Anti-virals O-AV (1-6)

GVN Sessions O-GVN (1-6)

16:00 Coffe break

16:30 Flash talk presentations

17:00Virus-host interaction

O-VH (1-5)

Emerging and re-emerging

viruses O-EM (1-6)


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TUESDAY 11TH

Auditori - Plenary Room Room 1 Room 308:00 Registration (Open all day)

08:30 Round table "One health: fact or fiction?" Ab Osterhaus, Jordi

Figuerola and Amelia Nieto10:30 Coffe break

11:00

Antivirals, a lot has been achieved, yet a long way to go: Johan Neyts

Virus-host interaction O-VH (6-13)

Immunology and vaccines

O-IM (1-8)

11:30

Confronting HBV and Emerging viruses with innovative therapeutics:

Raymond Schinazi12:00

Developing of antivirals; the

perspective of a medicinal chemist: María Jesús Pérez-Pérez

12:30 Antivirals and viral evolution: Esteban Domingo

13:00

Lunch and Posters session GVN Group picture

GVN Center Director's closed meeting14:30

Circulating of avian influenza

viruses in wild birds: Leo PoonVirus-host interaction

O-VH (14-19)

Viruses as biotechnological tools O-BT (1-6)

15:00 MERS-coronavirus: Youngmee Jee

15:30

Porcine reproductive and respiratory syndrome virus: Enric Mateu

16:00 Coffe break

16:30 Flash talk presentations 17:00

Virus-host interaction O-VH (20-25)

Emerging and re-emerging

viruses O-EM (7-12)


18:30 General Assembly of SEV

20:30 Congress Dinner - Maritim Restaurant (port)

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WEDNESDAY 12TH

Auditori - Plenary Room Room 1 Room 308:15 Registration

08:45 RNA methylation modulates the infection of a plant RNA

virus: Vicente Pallás

09:15

Diagnostics and Epidemiology

O-EP (7-11)

Trending topics in virology O-TT- (1-5)

Morphogenesis and structural biology

O-MO (1-5)10:30 Coffe break

11:00

Viral evolution and emerging viruses: Marco

Vignuzzi

12:00

Young virologist lecture (SEV award): Host-virus

interactions: a journey from hepatitis C to hepatitis B virus infection: Urtzi

Garaigorta13:00 Concluding remarks, closing ceremony and presentation the following

SEV congress

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DETAILED PROGRAMMESUNDAY, JUNE 9TH 2019

16:30 REGISTRATION (open all day)

17:30 INAUGURAL CEREMONY Auditori – Plenary Room Christian Bréchot (president GVN), Albert Bosch (president SEV), Joaquim Segalés (president of the LOC)

18:00-19:00 OPENING LECTUREAuditori – Plenary RoomRobert C. Gallo, University of Maryland, School of Medicine, Institute of HumanVirology, USA – GVN Center

19:00 ROBERT C. GALLO AWARD PRESENTATIONAuditori – Plenary RoomWelcome Reception. Auditori Foyer

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DETAILED PROGRAMMEMONDAY, JUNE 10TH 2019

08:00 REGISTRATION (open all day)

08:00 - 09:00 SESSION I: Anticipation and preparednessAuditori – Plenary RoomChair: Heinz Ellerbrock. Robert Koch Institute. Center for International Health Protection, Germany

08:30 Going viral: preparing for changing disease dynamics. Marion Koopmans, Erasmus MC, Department of Viroscience, The Netherlands – GVN Center

09:00 The Zika Virus Task Force: Activities and Updates on Zika Research. Scott Weaver, University of Texas Medical Branch, USA – GVN Center

09:30 Strategy and pathogenesis of human T-cell leukemia virus type 1 (HTLV-1). Masao Matsuoka, Department of Hematology, Rheumatology, and Infectious diseases, Kumamoto University, Japan – GVN Center

10:00 Use of arbovirus surveillance in vertebrate hosts and mosquitoes as an early warning system. Núria Busquets, Centre de Recerca en Sanitat Animal (CReSA) – Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Spain – GVN Center

10:30 - 11:00 Coffee break

11:00 - 12:00 SESSION II: Host-pathogen interactionAuditori – Plenary RoomChair: Robert Garry. Tulane University, USA

11:00 New immunotherapeutic approaches to eliminate HIV persistence on antiretroviral therapy. Thomas A. Rasmussen, Senior Researcher. National Veterinary Institute Virology, Australia – GVN Center

11:30 Spatial virus-induced host adaptation to viral codon usage.Juana Díez Antón, Universitat Pompeu Fabra, Spain

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12:00-13:00 SENIOR VIROLOGIST LECTURE (SEV Award) Auditori – Plenary RoomChair: Albert Bosch, Universitat de Barcelona, Spain

The struggle of viruses for survival in an always hostile world. Juan Antonio García, Centro Nacional de Biotecnologia, CSIC, Spain

13:00-14:30 Lunch and Posters session

14:30-16:00 ORAL PRESENTATIONS: Diagnostic virology and epidemiology O-EP (1-6)Auditori – Plenary RoomChair: Inma Casas. Centro Nacional de Microbiologia-ISCIII. Laboratorio de Virus Respiratorios y Gripe, Spain

O-EP-01INGEPLEX ENTERIC MICROARRAY, A NEW DIFFERENTIAL AND SIMULTANEOUS DETECTION TOOL FOR SWINE DISEASES.Luis Rivas1, Jorge Pulido1, Cristina Aira1, Jaime Gómez-Laguna2, Gerard Martín-Valls3, Nuria De La Roja1, Lissett López1, María José Rodríguez1.1INGENASA, Madrid, Spain; 2Departament of Anatomy and Comparative Pathology, University of Córdoba, Córdoba, Spain; 3Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Barcelona, Spain.

O-EP-02REASSORTMENT PATTERNS IN PIGS INVOLVING SWINE INFLUENZA A AND 2009 PANDEMIC H1N1 VIRUSESAna Moreno1, Laura Baioni2, Davide Lelli1, Emanuela Foni2, Alice Prosperi2, Marianna Merenda3, Silvia Faccini3, Andrea Luppi2, G. Loris Alborali1, Cristian Salogni1, Carlo Rosignoli3, Antonio Lavazza1, Chiara Chiapponi2.1Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Brescia, Italy; 2Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Parma, Italy; 3Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Mantova, Italy.

O-EP-03EFFECTS OF PORCINE CIRCOVIRUS 2 (PCV-2) SOW BLANKET VACCINATION ON VIROLOGICAL PARAMETER OF SOWS AND THEIR PROGENYPatricia Pleguezuelos1, Marina Sibila1, Raúl Cuadrado1, Rosa López-Jiménez1, Diego Pérez1, Eva Huerta1, Anna Llorens1, Joaquim Segalés2, Sergio López-Soria1.1IRTA, Centre de Recerca en Sanitat Animal (CRESA, IRTA-UAB), BELLATERRA, Spain; 2UAB, Centre de Recerca en Sanitat Animal (CRESA, IRTA-UAB), BELLATERRA, Spain.

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O-EP-04NO DIFFERENCES IN PCV-3 DNA FREQUENCY IN PIGS WITH RESPIRATORY OR DIGESTIVE DISORDERS COMPARED TO HEALTHY ANIMALSViviane Saporiti1, Taís Cruz2, Florencia Correa-Fiz1, José Núñes1, Marina Sibila1, Joaquim Segalés3.1IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain; 2Department of Immunology and Microbiology, Institute of Biosciences, College of Veterinary Medicine, São Paulo State University (UNESP), Botucatu, SP18618-000, São Paulo, Brazil; 3Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

O-EP-05TOWARDS AN EXPERIMENTAL MODEL IN HORSES FOR MONITORING AHS LABORATORY DIAGNOSTIC METHODSManuel Durán-Ferrer1, Paloma Fernández-Pacheco2, Rubén Villalba1, Cristina Tena-Tomás3, Elena San Miguel1, Javier Castillo-Olivares4, Miguel Ángel Jiménez-Clavero2, Marisa Arias2, Montserrat Agüero1.1Laboratorio Central de Veterinaria (MAPA), Algete (Madrid), Spain; 2Centro de Investigación en Sanidad Animal. (INIA-CISA), Valdeolmos (Madrid), Spain; 3Tecnologías y Servicios Agrarios, S.A. (TRAGSATEC), Madrid, Spain; 4Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

O-EP-06A NOVEL GROUP OF AVIAN ASTROVIRUSES FROM NEOTROPICAL PASSERINE BIRDS BROADEN THE DIVERSITY AND HOST RANGE OF ASTROVIRIDAEIzaskun Fernández-Correa1, Daniel A. Truchado1, Esperanza Gomez-Lucia1, Ana Doménech1, Javier Pérez-Tris1, Daniel Cadar2, Laura Benítez1.1Complutense University of Madrid, Madrid, Spain; 2Bernhard-Nocht-Institut for Tropical Medicine, Hamburg, Germany.

14:30-16:00 ORAL PRESENTATIONS: Anti-virals O-AV (1-6)Room 1 (Level -1)Chair: Juana Díez. Universitat Pompeu Fabra, Spain

O-AV-01CLINICAL AND VIROLOGICAL PREDICTORS OF RESPONSE AFTER ANTIVIRAL THERAPY INTERRUPTION IN HBEAG-NEGATIVE CHRONIC HEPATITIS B Mireia García-López1, Sabela Lens1, Zoe Mariño1, Martín Bonacci1, Sergio Rodríguez-Tajes1, Elena Perpiñán1, Francisco Rodríguez-Frías2, Barbara Testoni3, George Koutsoudakis1, María Buti2, Fabien Zoulim3, Sofía Pérez-Del-Pulgar1, Xavier Forns1.1IDIBAPS, Barcelona, Spain; 2Vall d'Hebron, Barcelona, Spain; 3INSERM, Lyon, France.

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O-AV-02AMIDIC DERIVATIVES OF VALPROIC ACID AS AN ANTIVIRAL IN HSV-1-INFECTED OLIGODENDROCYTES Beatriz Praena1, Raquel Bello-Morales1, Carmen De La Nuez2, Fernando De Castro3, José Antonio López-Guerrero2.1Universidad Autónoma de Madrid/ Fundación Severo Ochoa, Madrid, Spain; 2Universidad Autónoma de Madrid, Madrid, Spain; 3Instituto Cajal CSIC, Madrid, Spain.

O-AV-03POLYANIONIC CARBOSILANE DENDRIMERS AGAINST HUMAN CITOMEGALOVIRUS INFECTION IN VITRO AS NEW TREATMENTIgnacio Relaño-Rodríguez, Raquel Juarez-Sánchez, Mª Ángeles Muñoz-Fernández.Hospital G. U. Gregorio Marañón. IiSGM, Madrid, Spain.

O-AV-04SIRNA-MEDIATED SIMULTANEOUS REGULATION OF THE CELLULAR INNATE IMMUNE RESPONSE AND HUMAN RESPIRATORY SYNCYTIAL VIRUS REPLICATIONMaria Martin-Vicente, Salvador Resino, Isidoro Martínez.Instituto de Salud Carlos III, Madrid, Spain.

O-AV-05PHARMACOLOGICAL INHIBITION OF PROTEIN KINASE C REDUCES WEST NILE VIRUS REPLICATIONAna-Belén Blázquez, Angela Vázquez-Calvo, Miguel A. Martín-Acebes, Juan-Carlos Saiz.INIA, Madrid, Spain.

O-AV-06PERTURBING HOST LIPID METABOLISM TO INHIBIT FLAVIVIRUS INFECTIONNereida Jiménez De Oya, Ana-Belén Blázquez, Estela Escribano-Romero, Juan-Carlos Saiz, Miguel A. Martín-Acebes.INIA, Madrid, Spain.

14:30-16:00 ORAL PRESENTATIONS: GVN Sessions O-GVN (1-6)Room 3 (level -1)Chair: Ramesh Akkina. Colorado State University. Microbiology, Immunology and Pathology, USA O-GVN-01STRUCTURAL BASIS FOR THE MULTIFUNCTIONALITY OF EBOLA VIRUS PROTEINSSara Landeras Bueno1, Hal Wasserman1, Shun-Ichiro Oda2, Michael J. Norris1, Zhe Li Salie1, Erica Ollmann Saphire1.1The Scripps Research Institute, La Jolla, United States; 2University of Cambridge, Cambridge, United Kingdom.

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O-GVN-02THE VIRAL PROTEIN CORONA DIRECTS VIRAL PATHOGENESIS AND AMYLOID AGGREGATIONKariem Ezzat1, Maria Pernemalm2, Sandra Pålsson1, Yevheniia Ishchenko3, Tarja Malm3, Anna-Lena Spetz1.1Stockholm University, Stockholm, Sweden; 2Karolinska Institutet, Stockholm, Sweden; 3University of Eastern Finland, Kuopio, Finland.

O-GVN-03MOSQUITO MOLECULAR RESPONSES TO ARBOVIRUS INFECTIONAna Isabel Núñez1, Anna Esteve2, Jèssica Gómez2, Marco Brustolin3, Sandra Talavera1, Albert Bensaid1, Núria Busquets1.1IRTA-CReSA, Bellaterra, Campus UAB, Spain; 2CNAG-CRG, Barcelona, Spain; 3Department of Entomology, The Pennsylvania State University, Pensilvania, United States.

O-GVN-04RNAI AND ARBOVIRUS INTERACTIONS IN AEDES AEGYPTIKen E. Olson1, Carol D. Blair1, Raul Andino2, Michael Tassetto2, Mark Kunitomi2.1Colorado State University, Fort Collins, CO, United States; 2University California, San Francisco, United States.

O-GVN-05VIROLOGIC DIFFERENCES BETWEEN HISTORICAL AND EPIDEMIC ZIKA VIRUS-MEDIATED INFECTION AND NEUROCYTOTOXICITYGe Li1, Sandra Bos2, Gilles Gadea2, Philippe Desprès2, Richard Zhao1.1University of Maryland School of Medicine, Baltimore, United States; 2Unité Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Université de La Réunion, La Réunion, France.

O-GVN-06MODELING ZIKA VIRAL INFECTION OF HUMAN B CELLS AND HEMATOPOIETIC STEM CELLS IN HUMANIZED MICEKimberly Schmitt, Kinner-Bibeau Kinner-Bibeau, Remling-Mulder Remling-Mulder, Molly Price, Ken Olson, Tawfik Aboellail, Ramesh Akkina.Colorado State University, Fort Collins, United States.

16:00-16:30 Coffee break

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16:30-17:00 FLASH TALK PRESENTATIONSAuditori – Plenary RoomChair: Júlia Vergara-Alert, IRTA-CReSA, Spain

P-EM-05FATAL INFECTION BY CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS IN SPAIN (2018). IDENTIFICATION OF A NEW VIRUSAnabel Negredo1, Rafael Sánchez-Arroyo2, Fernando De Ory1, Marco Antonio Budiño2, Ana Vázquez1, Mª Angeles Garcinuño2, Lourdes Hernández1, César De La Hoz González2, Francisca Molero1, Carmen Grande2, Mª Paz Sánchez-Seco1.1Centro Nacional de Microbiología, Madrid, Spain; 2Hospital Nuestra Señora de Sonsoles, Ávila, Spain.

P-EP-07PREVALENCE OF PORCINE CIRCOVIRUSES 2 (PCV-2) AND 3 (PCV-3) IN FATTENING PIG FARMS OF DIFFERENT EUROPEAN COUNTRIESViviane Saporiti1, Marina Sibila1, Florencia Correa-Fiz1, Bernd Grosse Liesner2, Joaquim Segalés3.1IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain; 2Boehringer Ingelheim Vetmedica GmbH AH Swine, Ingelheim, Germany; 3Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

P-EP-09EVIDENCE FOR POSITIVE SELECTION OF HEPATITIS A VIRUS ANTIGENIC VARIANTS IN VACCINATED MEN-HAVING-SEX-WITH MEN PATIENTS: IMPLICATIONS FOR IMMUNIZATION POLICIESAurora Sabrià1, Josep Gregori2, Damir Garcia-Cehic2, Susana Guix1, Tomàs Pumarola2, Sandra Manzanares-Laya3, Joan A. Caylà3, Albert Bosch1, Josep Quer2, Rosa M. Pintó1.1Universitat de Barcelona, Barcelona, Spain; 2Vall d'Hebron Institut de Recerca, Barcelona, Spain; 3Agència de Salut Pública de Barcelona, Barcelona, Spain.

P-EP-15APPLICATION OF PROBE CAPTURE TARGET ENRICHMENT NGS TO THE CHARACTERI- ZATION OF THE VIROME OF DIFFERENT TYPES OF COMPLEX SAMPLES Sandra Martínez-Puchol1, Natàlia Timoneda2, Xavi Fernández-Cassi1, Marta Itarte1, Marta Rusiñol1, Ayalkibet Hundesa1, Rosina Girones1, Josep F Abril3, Sílvia Bofill-Mas1.1Laboratory of Viruses Contaminants of Water and Food, Department of Genetics, Statistics and Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain; 2Laboratory of Viruses Contaminants of Water and Food and Computational Genomics Lab, Department of Genetics, Statistics and Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain; 3Computational Genomics Lab, Department of Genetics, Statistics and Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain.

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P-EP-17SWINE INFLUENZA VIRUS REASSORTANT H1N2 (WITH AVIAN ORIGIN HEMAGGLUTININ) INFECTION IN REPLACEMENT STOCK AND VACCINATION RESPONSIVENESSSusana Mesonero-Escuredo1, Adam Martínez2, Carlos Casanovas1, Sergio Barrabés1, Joaquim Segalés3.1IDT BIOLOGIKA S.L., Barcelona, Spain; 2VALL COMPANYS, Lérida, Spain; 3IRTA-CReSA and Fac. Veterinària UAB, Barcelona, Spain.

P-IM-11A VACCINE BASED ON A MODIFIED VACCINIA VIRUS ANKARA VECTOR EXPRESSING ZIKA VIRUS STRUCTURAL PROTEINS AND PRODUCING VIRUS-LIKE PARTICLES CONTROLS ZIKA VIRUS REPLICATION IN MICE Patricia Pérez1, María Q. Marín1, Adrián Lázaro-Frías1, Nereida Jiménez De Oya2, Ana-Belén Blázquez2, Estela Escribano-Romero2, Carlos Óscar S. Sorzano1, Javier Ortego3, Juan-Carlos Saiz2, Mariano Esteban1, Miguel Ángel Martín-Acebes2, Juan García-Arriaza1.1Centro Nacional de Biotecnología, Madrid, Spain; 2Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain; 3Centro de Investigación en Sanidad Animal, Madrid, Spain.

17:00-18:30 ORAL PRESENTATIONS: Virus-host interaction O-VH (1-5)Auditori – Pleanary RoomChair: Rosina Gironés. Universitat de Barcelona, Spain

O-VH-01ERLIN-1 PROTEIN IS REQUIRED FOR EFFICIENT HEPATITIS C VIRUS INFECTIONUrtzi Garaigorta1, Andoni Gómez-Moreno1, Christina Whitten-Bauer2, Josan Chung2, Michael D. Huber2, Larry Gerace3, Francis V. Chisari2.1Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain; 2The Scripps Research Institute, La Jolla, United States; 3The Scripps Research Institute, Madrid, United States.

O-VH-02ELUCIDATING THE MECHANISMS OF HDV-INDUCED LIVER DAMAGE IN AN AAV-HBV/HDV COINFECTION MOUSE MODEL Carla Usai1, Sheila Maestro Galilea1, Gracián Camps1, Lester Suárez Amarán2, África Vales1, Cristina Olague1, Rafael Aldabe1, Mirja Hommel1, Gloria González Aseguinolaza1.1Universidad de Navarra, CIMA, IdiSNA, Pamplona, Spain; 2Universidad de Navarra, CIMA, Pamplona, Spain.

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O-VH-03ADENO-ASSOCIATED VIRAL VECTOR-MEDIATED DELIVERY OF SMALL AND LARGE HEPATITIS DELTA ANTIGEN INDUCES LIVER DAMAGE IN MICEGracián Camps1, Carla Usai1, Sheila Maestro Galilea1, Cristina Godoy2, Cristina Olagüe1, África Vales Aranguren1, Lester Suárez1, Rafael Aldabe1, Gloria González Aseguinolaza1.1Universidad de Navarra, CIMA, Pamplona, Spain; 2Hospital Vall d´Hebron, Departamento Microbiología - Patología Hepática, Barcelona, Spain.

O-VH-04ELUCIDATING THE ROLE OF HEPATITIS DELTA COMPONENTS DURING VIRAL CYCLE AND PATHOGENESISSheila Maestro1, Carla Usai1, Gracián Camps1, Léster Suárez1, Cristina Godoy2, Nahia Echarte1, Cristina Olagüe1, África Vales1, Rafael Aldabe1, Gloria González Aseguinolaza1.1Universidad de Navarra, CIMA, Pamplona, Spain; 2Hospital Vall D'hebron, Departamento de Microbiología, Unidad Patología Hepática, Barcelona, Spain.

O-VH-05NS5B PHOSPHORYLATION IS A MOLECULAR SWITCH DURING HCV REPLICATION.Rosario Sabariegos1, Laura Albentosa1, Pilar Clemente-Casares1, Celia Perales2, Esteban Domingo2, Antonio Mas1.1Laboratorio de Virología Molecular,Centro Regional de Investigaciones Biomédicas-Universidad de Castilla La Mancha, Albacete, Spain; 2Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Cantoblanco and CIBERehd, Instituto de Salud Carlos III, Madrid, Spain.

17:00-18:30 ORAL PRESENTATIONS: Emerging and re-emerging viruses O-EM (1-6)Room 1 (level -1)Chair: Maripaz Sánchez, Instituto de Salud Carlos III, Spain

O-EM-01IDENTIFICATION OF DENGUE 1 VIRUS IN THE FIRST OUTBREAK OF AUTOCHTHONOUS DENGUE IN SPAINAna Vázquez1, Antonio Moreno-Docón2, Dolores Navarro3, Elena Escudero4, Fernando De Ory1, Vladimir Salazar2, Rosa Ramos3, Ignacio Borbolla4, Laura Herrero1, Mª Asunción Iborra2, Rosa Blázquez3, Javier Taboada4, Mª Paz Sánchez-Seco1.1Centro Nacional de Microbiología, Madrid, Spain; 2Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; 3Hospital General Universitario Morales Messeguer, Murcia, Spain; 4Hospital Ruber Internacional, Madrid, Spain.

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O-EM-02ZIKA VIRUS REPLICATION IN DORSAL ROOT GANGLIA EXPLANTS FROM INTERFERON RECEPTOR1 KNOCKOUT (IFNR1) MICE CAUSES MYELIN DEGENERATIONIsabel Pagani, Vera Giulia Volpi, Maurizio D'antonio, Elisa Vicenzi.San Raffaele Scientific Institute, Milan, Italy.

O-EM-03AN ALANINE-TO-VALINE SUBSTITUTION IN THE RESIDUE 117 OF ZIKA VIRUS NS2A PROTEIN ENHANCE VIRAL PATHOGENESISGinés Ávila-Pérez1, Aitor Nogales1, Silvia Márquez-Jurado2, Francisco J. Iborra2, Luis Martínez-Sobrido1, Fernando Almazán2.1Department of Microbiology and Immunology. University of Rochester Medical Center, Rochester, United States; 2Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.

O-EM-04USUTU VIRUS NS5: CHARACTERIZATION OF ITS ROLE AS A VIRAL REPLICASE AND AS A MODULATOR OF CELL RESPONSES.Laura Albentosa1, Pilar Clemente1, Armando Arias2, Rosario Sabariegos1, Antonio Mas1.1Laboratorio de Virología Molecular, Centro Regional de Investigaciones Biomédicas (CRIB) Universidad de Castilla-La Mancha, Albacete, Spain; 2Technical University of Denmark, Kemitorvet building 202, Konens Lyngby, Denmark.

O-EM-05NOVEL NUCLEAR FUNCTIONS FOR EBOLA VIRUS VP24 PROTEINSantiago Vidal Freire1, María T Sánchez-Aparicio2, Enrique Vázquez3, Ahmed El Motiam1, Rocío Seoane1, Yanis H Bouzaher1, Sergio Gómez-Medina4, Maite Baz-Martínez1, Manuel S Rodríguez5, Adolfo García-Sastre2, Cesar Muñoz-Fontela4, Carmen Rivas6.1Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS)/Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain; 2Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States; 3Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain; 4Berhard Nocht Institute for Tropical Medicine/German Center for Infection Research (DZIF), Partner Site, Hamburg, Germany; 5Advanced Technology Institute in Life Sciences (ITAV) CNRS-USR3505, Université de Toulouse, UPS/Institut de Pharmacologie et de Biologie Structurale (IPBS) CNRS-UMR5089, Université de Toulouse, UPS, Toulouse, France; 6Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS)/Instituto de Investigaciones Sanitarias (IDIS)/Departamento de Biología Molecular y Celular Centro Nacional de Biotecnología (CNB), CSIC, Santiago de Compostela, Spain.

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O-EM-06A FIELD-BASED TEST OF THE DILUTION EFFECT HYPOTHESIS ON THE WEST NILE VIRUS SEROPREVALENCEMartina Ferraguti1, Josué Martínez-De La Puente1, Miguel Ángel Jiménez-Clavero2, Francisco Llorente-García2, David Roiz1, Santiago Ruiz3, Ramón Soriguer1, Jordi Figuerola1.1Estación Biológica de Doñana (EBD-CSIC), Seville, Spain; 2Centro de Investigación en Sanidad Animal - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CISA), Madrid, Spain; 3Diputación de Huelva. Área de Medio Ambiente. Servicio de Control de Mosquitos, Huelva, Spain.

17:00-18:30 ORAL PRESENTATIONS: GVN Sessions O-GVN (7-12)Room 3 (level -1)Chair: Victor Romanowski. Universidad Nacional de La Plata. IBBM, Facultad de Ciencias Exactas, Argentina.

O-GVN-07THE GLOBAL CENTER FOR HEALTH SECURITY: A MODEL OF GLOBAL PREPAREDNESS FOR EMERGING INFECTIOUS DISEASESChristopher Kratochvil1, Ken Bayles1, James Lawler1, John Lowe1, Shelly Schwedhelm2.1University of Nebraska Medical Center, Omaha, United States; 2Nebraska Medicine, Omaha, United States. O-GVN-08MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-COV) REPLICATES IN ALPACA RESPIRATORY TISSUE EXPLANTSJordi Rodon, Nigeer Te, Mónica Pérez, Joan Pujols, Joaquim Segalés, Albert Bensaid, Júlia Vergara-Alert.Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal (CReSA), Bellaterra (Cerdanyola del Vallès), Spain.

O-GVN-09IDENTIFICATION OF A NOVEL PESTIVIRUS IN A MARINE MAMMALWendy K. Jo1, Niels Van Elk2, Marco Van De Bildt2, Monique Petry1, Ilka Baumann1, Sonja Jesse1, Klaus Jung3, Martin Ludlow1, Thijs Kuiken2, Albert Osterhaus1.1RIZ, TiHo, Hannover, Germany; 2Dept. Viroscience, Erasmus MC Rotterdam, Rotterdam, Netherlands; 3Institute for Animal Breeding and Genetics, TiHo, Hannover, Germany.

O-GVN-10AFRICAN SWINE FEVER VIRUS (ASFV) PROTECTION MEDIATED BY NH/P68 RECOMBINANT LIVE-ATTENUATED VIRUSESCarmina Gallardo1, Elena G. Sánchez2, Daniel Pérez-Núñez2, Marisa Nogal2, Patricia De León2, Ángel L. Carrascosa2, Raquel Nieto1, Alejandro Soler1, María Luisa Arias1, Yolanda Revilla2.1Centro de Investigación en Sanidad Animal (INIA-CISA), Madrid, Spain; 2Centro de Biología Molecular Severo Ochoa (CBMSO-CSIC), Madrid, Spain.

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O-GVN-11THE SENIEUR PROTOCOL AND THE EFFICACY OF HEPATITIS B VACCINATION IN HEALTHY ELDERLY PERSONSMeagan Deming1, Robert Edelman2, Franklin Toapanta3, Marcela Pasetti4, Marcelo Sztein5.1Institute of Human Virology; Center for Vaccine Development and Global Health, Baltimore, United States; 2Institute of Human Virology; Department of Medicine, University of Maryland School of Medicine, Baltimore, United States; 3Center for Vaccine Development and Global Health, Baltimore, United States; 4Center for Vaccine Development and Global Health; Department of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, United States; 5Center for Vaccine Development and Global Health; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, United States.

O-GVN-12ETHICAL REVIEW PREPAREDNESS FOR EPIDEMICS AND PANDEMICSAbigail Lowe, Chris Kratochvil, Bruce Gordon.University of Nebraska Medical Center, Omaha, NE, United States.

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DETAILED PROGRAMMETUESDAY, JUNE 11TH 2019

08:00 Registration (open all day)

08:30-10:30ROUND TABLE: One health: fact or fiction?Auditori – Plenary RoomChair: Joaquim Segalés, IRTA-CReSA, Spain One world-one health: the animal side. Ab Osterhaus, Research Centre for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Germany – GVN Center

One world-one health: the environment side. Jordi Figuerola, Estación Biológica de Doñana, CSIC, Spain

Influenza A virus can directly infect the heart and cause cardiac disorders and sudden death.Amelia Nieto, Department of Molecular and Cellular Biology - CNB-CSIC, Spain

10:30-11:00 Coffee break

11:00-13:00 SESSION III: AntiviralsAuditori – Plenary RoomChair: Johan Neyts. Rega Institute for Medical Research, Universityi of Leuven, Belgium 11:00 Antivirals, a lot has been achieved, yet a long way to go. Johan Neyts, University of Leuven, Belgium – GVN Center

11:30 Confronting, HBV and Emerging viruses with innovative therapeutics. Raymond Schinazi, Emory Unviversity School of Medicine, USA – GVN Center

12:00 Development of antivirals: medicinal chemistry at the beginning of the process... and beyond. María Jesús Pérez-Pérez, Instituto de Química Médica (IQM) Consejo Superior de Investigaciones Científicas (CSIC), Spain

12:30 Antivirals and viral evolution.Esteban Domingo, Centro de Bilogía Molecular Severo Ochoa (CSIC-UAM), Spain – GVN Center

https://www.cnb.csic.es/index.php/es/investigacion/departamentos-de-investigacion/biologia-molecular-y-celular

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11:00-13:00 ORAL PRESENTATIONS: Virus-host interaction O-VH (6-13)Room 1 (Level -1)Chair: Juanjo López. Centre for Research in Agricultural Genomics. Genética Molecular , Spain O-VH-06PEPINO MOSAIC VIRUS RECRUITS A GLUTATHIONE S-TRANSFERASE AND AN RNASE H TO ITS VIRAL REPLICATION COMPLEXESEduardo Mendez-López, Livia Donaire, Fabiola Ruiz-Ramón, Cristina Alcaide, Maria Amelia Sánchez-Pina, Miguel A. Aranda.CEBAS-CSIC, Murcia, Spain.

O-VH-07THE VIRAL-DERIVED HAM1 PYROPHOSPHATASE IS REQUIRED FOR THE IPOMOVIRUS UGANDAN CASSAVA BROWN STREAK VIRUS TO INFECT ITS NATURAL HOST BUT NOT A MODEL PLANTAdrian A. Valli1, Francisco J. Martínez1, María Ribaya1, Fabio Pasin2, Beatriz García1, Juan Antonio García1.1Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain; 2Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.

O-VH-08SPECIFICITY OF THE EGGPLANT LATENT VIROID RNA REPLICATION INTERMEDIATE RECOGNITION BY THE TRNA LIGASEBeltrán Ortolá, José-Antonio Daròs.IBMCP (CSIC-Universitat Politècnica de València), Valencia, Spain.

O-VH-09IDENTIFICATION OF AN IMMUNOSUPPRESSIVE CELL POPULATION ASSOCIATED WITH VIRAL PERSISTENCE: THE CLASSICAL SWINE FEVER MODELJose Alejandro Bohorquez1, Sara Muñoz-González1, Marta Perez-Simó1, Raquel Maeso1, Concepción Revilla2, Javier Dominguez2, Llilianne Ganges1.1IRTA-CReSA, Barcelona, Spain; 2Departamento de Biotecnología, INIA, Madrid, Spain.

O-VH-10AFRICAN SWINE FEVER VIRUS ARMENIA/07 VIRULENT STRAIN CONTROLS IFN-Β PRODUCTION THROUGH CGAS-STING PATHWAYRaquel García-Belmonte1, Daniel Pérez-Núñez1, Marco Pittau2, Juergen Richt3, Yolanda Revilla1.1Centro de Biología Molecular Severo Ochoa. CSIC-UAM, Madrid, Spain; 2Università degli Studi di Sassari, UNISS, Sassari, Italy; 3Department of Diagnostic Medicine/ & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States.

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O-VH-11PATHOBIOLOGY OF TWO HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUSES (H7N1, H5N8) IN CHICKENS, GEESE AND PIGEONSRaúl Sánchez, Miquel Nofrarias, Nabil Wali, Albert Perlas, Rosa Valle, Mónica Pérez, Antonio Ramis, Natalia Majó.IRTA-CReSA, Bellaterra, Spain.

O-VH-12QUANTITATIVE TRANSCRIPTOMIC AND TRANSLATOMIC ANALYSIS TO IDENTIFY KEY DETERMINANTS OF CHIKUNGUNYA VIRUS INFECTION IN MOSQUITO CELLSGemma Perez-Vilaro, Marc Tallo-Parra, René Böttcher, Juana Diez.Universitat Pompeu Fabra, Barcelona, Spain.

O-VH-13CIRCRNAS: A NOVEL PLAYER IN VIRAL-HOST INTERACTIONSMarc Tallo-Parra, René Böttcher, Gemma Perez-Vilaro, Juana Diez.Universitat Pompeu Fabra, Barcelona, Spain.

11:00-13:00 ORAL PRESENTATIONS: Immunology and vaccines O-IM (1-8)Room 3 (Level -1)Chair: Albert Bensaid. IRTA-CReSA, Spain O-IM-01CHARACTERIZATION OF A NEUTRALIZING EPITOPE OF AN EMERGING VIRUSAna Mª Podadera González1, Kevin Paul Dalton1, Inés Nicieza1, Daniel De Llano1, Jose Manuel Martín Alonso1, Juan Ramón De Los Toyos2, Marcos García Ocaña3, Fernando Vázquez-Villa4, Francisco Parra1.1Instituto Universitario de Biotecnología de Asturias, Departamento de Bioquímica y Biología Molecular, Edificio Santiago Gascón, Universidad de Oviedo, Oviedo, Spain; 2Área de Inmunología, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain; 3Servicios Científicos Técnicos, Campus El Cristo, Universidad de Oviedo, Oviedo, Spain; 4Departamento de Cirugía, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain.

O-IM-02SPLENIC TRANSCRIPTOME DYNAMICS REVEALS KEY EVENTS IN VIRUS INFECTION FATE DECISIONJordi Argilaguet1, Valentina Casella1, Mireia Pedragosa1, Eva Domenjo1, Hector Huerta Encabo2, Anna Esteve-Codina3, Cristina López-Rodríguez2, Gennady Bocharov4, Andreas Meyerhans5.1Infection Biology Laboratory, Department of Experimental and Health Sciences (DCEXS), Barcelona, Spain; 2Immunology Unit, Department of Experimental and Health Sciences (DCEXS), Universitat Pompeu Fabra, Barcelona, Spain; 33CNAG-CRG, Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology

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& Universitat Pompeu Fabra, Barcelona, Spain; 4Marchuk Institute for Numerical Mathematics, Russian Academy of Sciences, Moscow, Russian Federation; 5Infection Biology Laboratory, Department of Experimental and Health Sciences (DCEXS) and Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

O-IM-03INFLUENZA VIRUS-BASED VECTOR PLATFORM FOR RESPIRATORY MUCOSAL VACCINATIONAndrey Vasin, Andrey Egorov, Marina Stukova, Maria Sergeeva.Smorodintsev Research Institute of Influenza, Ministry of Health, Saint-Petersburg, Russian Federation.

O-IM-04PESTE DES PETITS RUMINANTS VIRUS FUSION AND HEMAGGLUTININ PROTEINS TRIGGER ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY IN INFECTED CELLSDaniel Rodríguez-Martín, José Manuel Rojas, Miguel Avia, Verónica Martín, Noemí Sevilla.Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos (Madrid), Spain.

O-IM-05SENDAI VIRUS INDUCES PROTECTIVE IMMUNE RESPONSES IN OVINE CELLSLorena De Pablo-Maiso1, Irache Echeverria2, Sergio Rius3, Damián De Andrés1, Estanislao Nistal-Villán3, Ramsés Reina1.1CSIC, Pamplona, Spain; 2CSIC-UPNA-Gobierno de Navarra, Pamplona, Spain; 3Universidad Sab Pablo-CEU, Madrid, Spain.

O-IM-06DISTINCT IMMUNOGENICITY AND EFFICACY AGAINST EBOLA VIRUS OF POXVIRUS-BASED VACCINE CANDIDATES EXPRESSING GP AND VP40 PROTEINSAdrián Lázaro-Frías1, Sergio Gómez-Medina2, Lucas Sánchez-Sampedro1, Karl Ljungberg3, Mart Ustav4, Peter Liljeström3, César Muñoz-Fontela2, Mariano Esteban1, Juan García-Arriaza1.1Centro Nacional de Biotecnología, Madrid, Spain; 2Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; 3Karolinska Institutet, Stockholm, Sweden; 4Icosagen Cell Factory OU, Tartumaa, Estonia.

O-IM-07IMPROVING THE IMMUNOGENICITY OF HIV-1 VACCINE CANDIDATES BY THE HETEROLOGOUS COMBINATION OF VSV AND NYVAC VECTORS Beatriz Perdiguero1, Carmen Elena Gómez1, Juan García-Arriaza1, Carlos Óscar S. Sorzano1, Sarah Wilmschen2, Dorothee Von Laer2, Janine Kimpel2, Ralf Wagner3, Benedikt Asbach3, Song Ding4, Giuseppe Pantaleo5, Mariano Esteban1.1Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain; 2Innsbruck Medical University, Innsbruck, Austria; 3University of Regensburg, Regensburg, Germany; 4Eurovacc Foundation, Amsterdam, Netherlands; 5Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

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O-IM-08GRADUAL RESTORATION OF HCV-SPECIFIC CD8+ T CELL FREQUENCY BUT PERSISTENCE OF ALTERED PHENOTYPE IN CIRRHOTIC HCV-INFECTED PATIENTS AFTER SUCCESSFUL DIRECT-ACTING ANTIVIRAL THERAPY.Elena Perpiñán, Sofía Pérez-Del-Pulgar, María-Carlota Londoño, Patricia González, Zoe Mariño, Sabela Lens, Concepción Bartres, Mireia García-López, Xavier Forns, George Koutsoudakis.Liver Unit, Hospital Clínic, University of Barcelona, IDIBAPS and CIBEREHD, Barcelona, Spain.

13:00-14:30 Lunch and Posters sessionGVN Group pictureGVN Center Director's closed meeting

14:30-16:00 SESSION IV: Respiratory virusesAuditori – Plenary RoomChair: Hideki Hasegawa. National Institute of Infectious Diseases. Department of Pathology, Japan

14:30 Circulating of avian influenza viruses in wild birds. Leo Poon, The University of Hong Kong, China – GVN Center

15:00 MERS-coronavirus. Youngmee Jee, National Institute of Health, South Korea – GVN Center

15:30 Porcine reproductive and respiratory syndrome virus. Enric Mateu, Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Spain

14:30-16:00 ORAL PRESENTATIONS: Virus-host interaction O-VH (14-19)Room 1 (Level -1)Chair: Tomás Pumarola, Hospital Universitari Vall d’Hebron, Spain

O-VH-14HEPATITIS A VIRUS REPLICATION STIMULATES THE EXPRESSION OF GENES CODING FOR PROTEINS INVOLVED IN THE EXOSOME BIOGENESIS AND SECRETIONMontserrat De Castellarnau, Susana Guix, Anna Altisent, Cecilia Martin, Albert Bosch, Rosa M. Pintó.Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, Campus Torribera, University of Barcelona, Barcelona, Spain.

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O-VH-15RESIDENT MEMORY T CELLS ARE A CELLULAR RESERVOIR FOR HIV IN THE CERVICAL MUCOSAJon Cantero-Pérez1, Judith Grau-Expósito1, Carla Serra-Peinado1, Daniela A. Rosero1, Laura Luque-Ballesteros1, Josep Castellví2, Tamara Sanhueza3, Julia G. Prado4, Antoni Tarrats5, Carla Lecumberri6, Laura Mañalich-Barrachina7, Cristina Centeno-Mediavilla7, Vicenç Falcó1, María J. Buzón1, Meritxell Genescà1.1Department of Infectious Diseases, Hospital Universitari Vall d’Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain; 2Department of Pathology, Hospital Universitari Vall d’Hebrón, Universitat Autònoma de Barcelona, Barcelona, Spain; 3Department of Pathology, Hospital Universitari Germans Trias i Pujol (HUGTP), Badalona, Spain; 4AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain; 5Department of Obstetrics and Gynecology, HUGTP, Badalona, Spain; 6Department of Obstetrics and Gynecology, HUGTP, Badalona, Barcelona, Spain; 7Department of Obstetrics and Gynecology, Hospital Universitari Vall d’Hebrón, Universitat Autònoma de Barcelona, Barcelona, Spain.

O-VH-16HIV RESERVOIR SIZE IS CORRELATED TO NK-MEDIATED KILLING OF EFFECTOR MEMORY CD4 CELLS Antonio Astorga-Gamaza, Judith Grau-Expósito, Laura Luque-Ballesteros, Ariadna Torrella, Bibiana Planas, Rosa Badía, Esteban Ribera, Joaquín Burgos, Jordi Navarro, Adrià Curran, Maria Jose Buzón.Infectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

O-VH-17SCHLAFEN 12, A NOVEL HIV RESTRICTION FACTOR THAT PARTICIPATES IN LATENCYMie Kobayashi-Ishihara1, Katarina Smutná1, Jordi Argilaguet1, Jennifer Jungfleisch1, René Böttcher1, Javier P. Martinez1, Anna Esteve-Codina2, Florencia E. Alonso1, Yasuko Tsunetsugu-Yokota3, Juana Díez Antón1, Andreas Meyerhans1.1Universitat Pompeu Fabra, Barcelona, Spain; 2Centre Nacional d’Anàlisi Genòmica, Center for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain; 3Tokyo University of Technology, Tokyo, Japan.

O-VH-18CMV-ENCODED CD48 HOMOLOGS: NEW PLAYERS IN VIRAL IMMUNE EVASION Pablo Martínez-Vicente1, Domènec Farré1, Carolina Sánchez2, Antonio Alcamí2, Pablo Engel1, Ana Angulo1.1Immunology Unit, Department of Biomedical Sciences, Medical School, University of Barcelona, Barcelona, Spain; 2Centro de Biología Molecular Severo Ochoa, Madrid, Spain.

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O-VH-19IDENTIFICATION OF A NOVEL T CELL IMMUNE EVASION STRATEGY USED BY CYTOMEGALOVIRUS DURING INFECTION OF ANTIGEN PRESENTING CELLSGuillem Angulo, Pablo Engel, Ana Angulo.University of Barcelona, Barcelona, Spain.

14:30-16:00 ORAL PRESENTATION: Viruses as biotechnological tools O-BT (1-6)Room 3 (Level -1)Chair: Carlos Briones. Centro de Astrobiología (CSIC-INTA). Evolución Molecular, Spain O-BT-01POTYVIRUS-DERIVED VECTORS TO INDUCE THE PRODUCTION OF HIGHLY APPRECIATED METABOLITES IN ADULT PLANTSMaricarmen Martí, Fakhreddine Houhou, Verónica Aragonés, José-Antonio Daròs.IBMCP (CSIC-Universitat Politècnica de València), Valencia, Spain.

O-BT-02PEGYLATED CATIONIC DENDRIMERS COMPLEX WITH MIRNAS AS NEW GENE DELIVERY THERAPY AGAINST HIV-1 INFECTIONIgnacio Rodriguez-Izquierdo1, Rafael Gómez2, Javier De La Mata2, Mª Ángeles Muñoz-Fernández1, José Luis Jiménez1.1Hospital G.U. Gregorio Marañón. IiSGM, Madrid, Spain; 2Universidad de Alcalá, Madrid, Spain.

O-BT-03ENGINEERING FUNCTIONAL DOMAINS OF THE PARVOVIRUS MVM CAPSID WITH VEGF-R BINDING PEPTIDES: STRUCTURAL, IMMUNE, AND RE-TARGETING IMPLICATIONS FOR CANCER THERAPY.Tania Calvo-López, Esther Grueso, Cristina Sánchez-Martínez, Germán Andrés, José María Almendral.Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain.

O-BT-04NEWCASTLE DISEASE VIRUS (NDV) ONCOLYTIC ACTIVITY IS DEPENDENT ON THE GENETIC CHARACTERISTICS OF PRIMARY HUMAN GLIOMA CANCER STEM CELLS.Susana Estaban-Rubio1, Irina Palacin-Aliana1, Sergio Rius-Rocabert2, Ángel Ayuso-Sacido3, Estanislao Nistal-Villan2.1Instituto de Medicina Molecular Aplicada (IMMA). Escuela Internacional de Doctorado CEINDO. Universidad San Pablo CEU, Madrid, Spain; 2Facultad de Farmacia. Escuela Internacional de Doctorado CEINDO. Universidad San Pablo CEU, Madrid, Spain; 3Instituto de Medicina Molecular Aplicada (IMMA). Escuela Internacional de Doctorado CEINDO. Universidad San Pablo CEU. Fundación de Investigación HM Hospitales, Madrid, Spain.

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O-BT-05A NOVEL FLUORESCENT AND BIOLUMINESCENT BI-REPORTER INFLUENZA A VIRUS (BIRFLU) TO EVALUATE VIRAL INFECTIONSAitor Nogales1, Gines Ávila-Pérez2, Javier Rangel-Moreno2, Kevin Chiem2, Javier Ortego3, Marta Lopez Dediego4, Luis Martínez-Sobrido2.11-University of Rochester, Rochester, New York, USA. 2-Center for Animal Health Research, INIA-CISA, Madrid, Spain; 2University of Rochester, Rochester, New York, United States; 3Center for Animal Health Research, INIA-CISA, Madrid, Spain; 4Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.

O-BT-06A RECOMBINANT RIFT VALLEY FEVER VIRUS (RVFV) EXPRESSING BLUETONGUE VIRUS (BTV) ANTIGENS PROVIDES IMMUNITY AND PROTECTION AGAINST A BTV-4 CHALLENGE IN MICE AND SHEEPSandra Moreno1, Eva Calvo-Pinilla1, Friedemann Weber2, Julio Benavides3, Javier Ortego1, Alejandro Brun1.1Centro de Investigación en Sanidad Animal (INIA-CISA), Madrid, Spain; 2Universidad de Giessen, Giessen, Germany; 3Instituto de Ganadería de Montaña (CSIC-Universidad de León), Leon, Spain.

16:00-16:30 Coffee break 16:30-17:00 FLASH TALK PRESENTATIONSAuditori – Plenary RoomChair: María Ángeles Muñoz. Hospital Gregorio Marañón. Laboratorio Inmunobiología Molecular, Spain

P-AV-01IMAGING AS A POWERFUL TOOL TO STUDY THE MECHANISM OF ACTION OF ANTIVIRALSMoisés García Serradilla, Cristina Risco.Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.

P-EM-04AN ATTENUATED VARIANT OF RIFT VALLEY FEVER VIRUS GENERATED BY A MUTAGENIC DRUG (FAVIPIRAVIR) UNVEILS POTENTIAL VIRULENCE MARKERS Belén Borrego, Sandra Moreno, Alejandro Brun.INIA-CISA, Valdeolmos, Madrid, Spain.

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P-TT-05THE RNA SILENCING SUPPRESSOR ACTIVITY OF CUCURBIT YELLOW STUNTING DISORDER VIRUS (CYSDV) P25 PROTEIN IS NEGATIVELY AFFECTED BY WATERMELON MOSAIC VIRUS (WMV) P1 PROTEINMaria Luisa Domingo-Calap, Ana Beatriz Moreno, Mariona Estapé, Ornela Chase, Juan José López-Moya.Centre for Research in Agricultural Genomics (CRAG), Barcelona, Spain.

P-VH-17DENDRITIC CELLS FROM THE CERVICAL MUCOSA CAPTURE AND TRANSFER HIV-1 VIA SIGLEC-1Daniel Perez-Zsolt1, Jon Cantero-Pérez2, Itziar Erkizia3, Susana Benet1, Maria Pino3, Carla Serra-Peinado4, Alba Hernández-Gallego5, Josep Castellví6, Gustavo Tapia7, Vicent Arnau-Saz8, Julio Garrido9, Antoni Tarrats10, María J. Buzón4, Javier Martinez-Picado11, Nuria Izquierdo-Useros12, Meritxell Genescà2.1IrsiCaixa AIDS Research Institute, Badalona; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; 2Department of Infectious Diseases, Vall d’Hebron Institut de Recerca (VHIR); Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Barcelona, Spain; 3IrsiCaixa AIDS Research Institute, Badalona, Spain; 4Department of Infectious Diseases, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain; 5Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP); Pathology Department, Hospital Universitari Germans Trias i Pujol (HUGTP), Badalona, Spain; 6Pathology Department, Hospital Universitari Vall d’Hebron, Barcelona, Spain; 7Universitat Autònoma de Barcelona (UAB), Barcelona; Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona; Pathology Department, Hospital Universitari Germans Trias i Pujol (HUGTP), Badalona, Spain; 8Universitat Autònoma de Barcelona (UAB); Department of Infectious Diseases, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain; 9Hospital Municipal de Badalona, Badalona, Spain; 10Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Spain; 11IrsiCaixa AIDS Research Institute, Badalona; University of Vic-Central University of Catalonia (UVic-UCC), Vic; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain; 12IrsiCaixa AIDS Research Institute, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Spain.

P-VH-18“HIV-TRANSCRIPTION INDUCES CD20 EXPRESSION AND RENDERS CELLS SUSCEPTIBLE TO RITUXIMAB"Carla Serra Peinado1, Judith Grau-Expósito1, Laura Luque-Ballesteros1, Antonio Astorga Gamaza1, Rein Willekens2, Jordi Navarro2, Adrià Curran2, Joaquin Burgos2, Esteban Ribera2, Josep Castellví2, Meritxell Genescà1, Vicenç Falcó2, María J. Buzón1.1Vall d'Hebron Research Institute, Barcelona, Spain; 2Hospital Universitario de la Vall d’Hebron, Barcelona, pain.

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P-VH-19HAUSP/USP7 AS AN EBOLA VIRUS VP24 PROTEIN TARGETSantiago Vidal Freire1, Ahmed El Motiam1, Rocío Seoane1, Viktorija Preitakaite1, Yanis H Bouzaher1, Sergio Gómez-Medina2, Dolores Rodríguez3, Maite Rejas4, Maite Baz-Martínez1, Manuel S Rodríguez5, César Muñoz-Fontela2, Carmen Rivas6.1Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS)/Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain; 2Berhard Nocht Institute for Tropical Medicine/German Center for Infection Research (DZIF), Partner Site, Hamburg, Germany; 3Departamento de Biología Molecular y Celular Centro Nacional de Biotecnología (CNB), CSIC, Madrid, Spain; 4Centro de Biología Molecular Severo Ochoa (CSIC-UAM)/Universidad Autónoma de Madrid, Madrid, Spain; 5Advanced Technology Institute in Life Sciences (ITAV) CNRS-USR3505, Université de Toulouse, UPS/8Institut de Pharmacologie et de Biologie Structurale (IPBS) CNRS-UMR5089, Université de Toulouse, UPS, Toulouse, France; 6Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS)/Instituto de Investigaciones Sanitarias (IDIS)/Departamento de Biología Molecular y Celular Centro Nacional de Biotecnología (CNB), CSIC, Santiago de Compostela, Spain.

17:00-18:30 ORAL PRESENTATIONS: Virus-host interaction O-VH (20-25)Auditori – Penary RoomChair: Amelia Nieto, Centro Nacional de Biotecnologia, Spain

O-VH-20ENDOGENOUS PARVOVIRUS ELEMENTS IN MAMMALIAN GENOMES: DISTRIBUTION AND GENETIC STRUCTURESCarlos Gallego, Nooshin Bayat, David Abia, José M. Almendral.Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.

O-VH-21HUMAN ASTROVIRUS MLB REPLICATION IN VITRO: PERSISTENCE IN EXTRA-INTESTINAL CELL LINESDiem-Lan Vu, Albert Bosch, Rosa M. Pintó, Enric Ribes, Susana Guix.Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona; Nutrition and Food Safety Research Institute (INSA·UB), University of Barcelona, Barcelona, Spain.

O-VH-22PRESENCE OF BACTERIOPHAGES IN CLINICAL SAMPLES AND THEIR INTERFERENCE IN THE MICROBIOLOGICAL DIAGNOSIS OF INFECTIONSMaite Muniesa1, Maryury Brown-Jaque1, Lorena Rodríguez-Rubio1, Elisenda Miró2, Paula Espinal2, Ferran Navarro2.1Universidad de Barcelona, Barcelona, Spain; 2Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

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O-VH-23ADAR1 FUNCTION REGULATES INNATE IMMUNE ACTIVATION AND SUSCEPTIBILITY TO VIRAL INFECTIONSMaria Pujantell1, Roger Badia1, Sandra Franco1, Iván Galván-Femenía2, Eva A Riveira-Muñoz1, Edurne García-Vidal1, Lucía Gutierrez1, Ifeanyi J. Ezeonwumelu1, Bonaventura Clotet1, Rafael De Cid2, Cristina Tural3, Miguel A. Martínez1, Guillem Sirera3, José A. Esté1, Ester Ballana1.1IrsiCaixa, Badalona, Spain; 2IGTP, Badalona, Spain; 3Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

O-VH-24THE INTERFERON (IFN)-INDUCED PROTEIN 44 (IFI44) INTERACTS WITH THE CELLULAR FK506-BINDING PROTEIN 5 (FKBP5), NEGATIVELY REGULATES HOST ANTIVIRAL RESPONSES AND SUPPORTS VIRUS REPLICATIONMarta L. Dediego1, Aitor Nogales2, Luis Martinez-Sobrido3, David J. Topham4.1Department of Molecular and Cell Biology. Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain, Madrid, Spain; 2Center for Animal Health Research, CISA-INIA, Madrid, Spain; 3Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA, Rochester, NY, United States; 4David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA, Rochester, NY, United States.

O-VH-25MECHANISM OF HISTONE METHYLASE DOT1L IN THE CONTROL OF THE ANTIVIRAL RENPONSE Laura Marcos Villar1, Amelia Nieto Martin1, Estaislao Nistal Villan2, Pablo Gastaminza1.1CNB-CSIC, Madrid, Spain; 2San Pablo CEU, Madrid, Spain.

17:00-18:30 ORAL PRESENTATIONS: Emerging and re-emerging viruses O-EM (7-12) Room 1 (Level -1)Chair: Ana Doménech, Universidad Complutense de Madrid, Spain

O-EM-07EXPRESSION OF CYTOKINES AND PRO-INFLAMMATORY RESPONSE INDUCED IN THE NASAL EPITHELIUM OF MERS-COV INFECTED ALPACAS (VICUGNA PACOS) Nigeer Te1, Jordi Rodon1, Mònica Pérez1, Bart L. Haagmans2, Júlia Vergara-Alert1, Joaquim Segalés3, Albert Bensaid1.1Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal (CReSA), Bellaterra (Cerdanyola del Vallès), Spain; 2Department of Viroscience, Erasmus Medical Centre, Rotterdam, Netherlands; 3Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Spain, Bellaterra (Cerdanyola del Vallès), Spain.

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O-EM-08FROM CLASSIC HUMAN ENTERIC VIRUSES TO EMERGING VIRUSES: THE LLOBREGAT DELTA STUDYAlbert Blanco1, Damir Garcia2, Josep Gregori2, Josep Quer2, Mireia Jané3, Anna Martínez3, Rosa Pintó1, Susana Guix1, Albert Bosch1.1Enteric Virus Laboratory, University of Barcelona, Barcelona, Spain; 2Viral Hepatitis Laboratory, Vall d'Hebrón Research Institute, Barcelona, Spain; 3Public Health Agency of Catalonia, Barcelona, Spain.

O-EM-09A RECOMBINANT SUBVIRAL PARTICLE-BASED VACCINE PROTECTS MAGPIE (PICA PICA) AGAINST WEST NILE VIRUS INFECTION.Estela Escribano-Romero1, María-Cruz Camacho2, Ana-Belén Blázquez1, Miguel A. Martín-Acebes1, Ursula Höfle2, Juan-Carlos Saiz1, Nereida Jiménez De Oya1.1INIA, Madrid, Spain; 2SaBio,IREC, CSIC-UCLM-JCCM, Ciudad Real, Spain.

O-EM-10GENERATION OF A PROTECTIVE BIVALENT BLUETONGUE AND RIFT VALLEY FEVER VIRUS VACCINE BASED ON RECOMBINANT MODIFIED VACCINIA ANKARA VIRUS.Eva Calvo-Pinilla1, Sandra Moreno1, Alejandro Marín-López1, Sergio Utrilla-Trigo1, Aitor Nogales1, Julio Benavides2, Alejandro Brun1, Javier Ortego1.1Centro de Investigación en Sanidad Animal (INIA-CISA), Valdeolmos-Madrid, Spain; 2Instituto de Ganadería de Montaña (CSIC-Universidad de León), León, Spain.

O-EM-11PORCINE CIRCOVIRUS 3 (PCV-3) DETECTION IN ITALIAN AND SPANISH WILD UNGULATES AND RELATED TICKS: WILDER THAN EXPECTED?Giovanni Franzo1, Francini Klaumann2,3, Laura Grassi1, Marina Sibila4, Ewelina Czyzewska-Dors3,4, José Ignacio Núñez3, Oscar Cabezón3, Claudia Maria Tucciarone1, Matteo Legnardi1, MicheleDrigo1, Joaquim Segalés5,6 and Maria Luisa Menandro11Department of Animal Medicine, Production and Health (MAPS), University of Padua, Legnaro (PD), 2CAPES Foundation, Ministry of Education of Brazil, Brasília, 3IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Barcelona, 4National Veterinary Institute, Pulawy, Poland, 5UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Barcelona, 6Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Barcelona

O-EM-12TRANSMISSIBLE VIRAL PROVENTRICULITIS CAUSED BY CHICKEN PROVENTRICULAR NECROSIS VIRUS IN SPANISH POULTRY FARMSNabil Wali1, Miquel Nofrarias1, Antoni Ramis2, Raul Sanchez1, Rosa Valle1, Monica Perez1, Llorence Grau-Roma3, Natalia Majo21IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Barcelona, Spain; 2Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona (UAB), Barcelona, Spain; 3Institute of Animal Pathology, University of Bern, Bern, Switzerland.

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17:00-18:30 ORAL PRESENTATIONS: GVN Sessions O-GVN (13-18)Room 3 (Level -1)Chair: Luis Menéndez-Arias. Centro de Biología Molecular Severo Ochoa, Spain O-GVN-13CIRCULATION OF INFLUENZA VIRUS FROM 2009 TO 2018 IN CAMEROON: 10 YEARS OF SURVEILLANCE DATA Richard Njouom.Centre Pasteur of Cameroon, Yaounde, Cameroon.

O-GVN-14NOROVIRUS EVOLUTION DURING CHRONIC INFECTIONSuliman Qadir Afridi1, Hassan Moeini1, Robert Beck2, Kerstin Haase3, Zainab Usman3, Dmitrij Frishman3, Ulrike Protzer1, Dieter Hoffmann1.1Institute of Virology, Technische Universität / Helmholtz Zentrum München, Munich, Germany; 2Institute for Medical Virology and Epidemiology of Viral Diseases, University Tübingen, Tübingen, Germany; 3Department of Bioinformatics, Technische Universität München, Munich, Germany.

O-GVN-15ANALYSIS AND MOLECULAR DETERMINANTS OF HIV RNASE H CLEAVAGE SPECIFICITY AT THE PPT/U3 JUNCTIONMar Álvarez, Enrique Sapena-Ventura, Joanna Luczkowiak, Luis Menéndez-Arias.Centro de Biologia Molecular Severo Ochoa, Madrid, Spain.

O-GVN-16CONTEMPORARY CIRCULATING EV-D68 STRAINS SHOW DIFFERENTIAL VIRAL ENTRY AND REPLICATION IN HUMAN NEURONAL CELL CULTURES AND MOUSE MODELS OF PARALYSISRichard Scheuermann1, David Brown2, Lauren Oldfield2, Alison Hixon3, Yun Zhang1, Mark Novotny1, Kenneth Tyler3.1J. Craig Venter Institute, La Jolla, United States; 2J. Craig Venter Institute, Rockville, United States; 3University of Colorado, Denver, United States.

O-GVN-173D-CELL CULTURE INFECTION MODELS AS SCREENING TOOLS FOR THE REPURPOSING OF APPROVED CANCER DRUGS AS NEW ANTIVIRALS Robert Koban, Markus Neumann, Philipp Nelson, Heinz Ellerbrok.Robert Koch Institut, Berlin, Germany.

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O-GVN-18A NOVEL MODEL FOR SURVEILLANCE, INTERVENTION AND RESEARCH IN EXTREMELY MARGINALIZED HYPERENDEMIC REGIONS FOR VIRAL INFECTIONShyam Kottilil, Ameer Abutaleb, Jean Clement, Mousumi Khatun, Pratibha Singh, Simanti Datta, Sk Mahiuddin Ahmed, Koshy George, Partha Sarathi Mukherjee, Amal Santra, Abhijit Chowdhury.Institute of Human Virology, University of Maryland, Baltimore, United States.

18:30 GENERAL ASSEMBLY OF SEV

20:30 CONGRESS DINNER AT MARITIM RESTAURANT

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DETAILED PROGRAMMEWEDNESDAY, JUNE 12TH 2019

08:15REGISTRATION

08:45-09:15 PLENARY LECTURE: Plant virusesAuditori – Plenary RoomChair: Jesús Navas. IHSM-CSIC-UMA, Spain

RNA methylation modulates the infection of a plant RNA virus. Vicente Pallás, Instituto de Biologia Molecular y Celular de PLantas (IBMCP). UPV-CSIC, Spain

09:15-10:30 ORAL PRESENTATIONS: Diagnostics and Epidemiology O-EP (7-11)Auditori – Plenary RoomChair: Javier Buesa. Universidad de Valencia. Microbiologia i Ecologia, Spain

O-EP-07INCREASE IN VARIABILITY OF MUMPS VIRUS GENOTYPE G STRAINS IN SPAIN, 2005-2018Ana María Gavilán1, Juan Emilio Echevarría2, Ana María Castellanos2, Juan Carlos Sanz3, Angel Rueda1, Fernando De Ory2, Josefa Masa-Calles4, Noemí López-Perea4, María De Viarce Torres De Mier4, Aurora Fernández-García2.1Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III, Majadahonda, Madrid, Spain; 2Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III. CIBER de Epidemiología y Salud Pública, Majadahonda, Madrid, Spain; 3Laboratorio Regional de Salud Pública de la Comunidad de Madrid. CIBER de Epidemiología y Salud Pública, Madrid, Spain; 4Centro Nacional de Epidemiología (CNE), Instituto de Salud Carlos III. CIBER de Epidemiología y Salud Pública, Madrid, Spain.

O-EP-08DENGUE SEROTYPES AND GENOTYPES INTRODUCED TO EUROPE BY EUROPEAN TRAVELERS BEFORE ZIKA EMERGENCELeticia Franco1, Aldo Rojas2, Francisca Molero1, Lourdes Hernández1, Arancha Potente1, María Paz Sánchez-Seco1, Ana Vázquez1, Tropnet Dengue Study Group1Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain; 2Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain; Universidad San Luis Gonzaga, Ica, Peru.

O-EP-09COMPARISON OF DIFFERENT ROTAVIRUS VP8* GENOTYPE SEROPREVALENCE AMONG CHILDREN AND ADULTS IN VALENCIA, SPAINSusana Vila-Vicent, Roberto Gozalbo-Rovira, Antonio Rubio-Del-Campo, Cristina Santiso-Bellón, Javier Buesa, Jesús Rodríguez-Díaz.University of Valencia, Valencia, Spain.

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O-EP-10DEVELOPMENT OF AN ELASA BASED ON APTAMER/MABS ANTI-NUCLEOPROTEIN FOR THE DETECTION OF INFLUENZA ANTIGEN IN FIELD SAMPLES Cristina Aira Pino1, Víctor Manuel González2, Jose Ignacio Klett Mingo3, Tamara Ruiz1, Gerard Eduard Martín Valls4, Jaime Gómez Laguna5, Paloma Rueda1, Ana Ranz1, María José Rodríguez García1, Lissett López Morejón1.1INGENASA, Madrid, Spain; 2Aptus-BIOTECH, Madrid, Spain; 3Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal, Madrid, Spain; 4Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; 5Department of Anatomy and Comparative Pathology, University of Córdoba, Córdoba, Spain.

O-EP-11APPLICATION OF DIFFERENT NEXT GENERATION SEQUENCING STRATEGIES TO THE CHARACTERIZATION OF SEWAGE VIROMESandra Martínez-Puchol1, Marta Rusiñol1, Xavier Fernández-Cassi1, Natàlia Timoneda2, Rosina Girones1, Sílvia Bofill-Mas1.1Laboratory of Viruses Contaminants of Water and Food, Department of Genetics, Statistics and Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain; 2Laboratory of Viruses Contaminants of Water and Food and Computational Genomics Lab, Department of Genetics, Statistics and Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain.

09:15-10:30 ORAL PRESENTATIONS: Trending topics in virology O-TT- (1-5)Room 1 (Level -1)Chair: Fernando Rodríguez. IRTA-CReSA, Spain O-TT-01SEQUENCE CONSTRAINS IN PLANT VIRUS GENOMES: KEY RELEVANCE OF DINUCLEOTIDE FREQUENCIES IN DETERMINING VIRAL FITNESSAlfonso González1, Adrián Sánchez1, Peter Simmonds2, Juan Antonio García1, Adrián A. Valli1.1Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain; 2University of Oxford, Oxford, United Kingdom.

O-TT-02INACTIVATION OF AFRICAN SWINE FEVER VIRUS INOCULATED IN CONCENTRATED PORCINE PLASMA BY COMMERCIAL SPRAY DRYING CONDITIONS Elena Blázquez Salvador1, Joan Pujols2, Joaquim Segalés3, Carmen Rodríguez4, Jesús Ródenas4, Isabelle Kalmar5, Lourens Herens6, Javier Polo4.1APC Europe S.L.U IRTA CReSA, Barcelona, Spain; 2IRTA CReSA, Barcelona, Spain; 3UAB; IRTA CReSA, Barcelona, Spain; 4APC Europe S.L.U, Barcelona, Spain; 5Veos, Zwevezele, Belgium; 6SONAC/DARLING INGREDIENTS, Son, Netherlands.

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O-TT-03NOVEL CIRCULAR REP-ENCODING SINGLE-STRANDED DNA VIRUSES IN HUMAN RESPIRATORY SPECIMENS.María De La Montaña Iglesias Caballero1, Unai Pérez Sautu2, Michael Wiley2, Francisco Pozo3, Miguel Angel Romera4, Rosario Millan4, María Luz García García5, Cristina Calvo5, Gustavo Palacios2, Inmaculada Casas3.1Instituto de Salud Carlos III. Centro Nacional de Microbiología, Majadahonda, Spain; 2Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, United States; 3Instituto de Salud Carlos III. Centro Nacional de Microbiología, Majadahonda, Spain; 4Hospital Universitario Puerta de Hierro, Majadahonda, Spain; 5Hospital Universitario Severo Ochoa, Leganés, Spain.

O-TT-04ENTEROVIRUSES IN SPLEEN, BLOOD LEUKOCYTES, PANCREAS OF PEOPLE WITH DIABETES OF SHORT AND LONG DURATIONAntonio Toniolo1, Angelo Genoni1, Francesco Broccolo1, Anna Puggioni1, Nastaran Muhammadi1, Cristina Romano2, Lars Krogvold3, Sara Hammerstad3, Knut Dahl-Jorgensen3.1University of Insubria Medical School, Varese, Italy; 2Ospedale di Circolo, Varese, Italy; 3Oslo University Hospital, Oslo, Norway.

O-TT-05CHARACTERIZATION OF THE GUT MICROBIOTA MEMBERS ABLE TO BIND EX VIVO ROTAVIRUS BY FLUORESCENCE-ACTIVATED CELL SORTING AND NEXT GENERATION SEQUENCINGJesus Rodríguez-Díaz1, Antonio Rubio-Del-Campo1, Javier Buesa1, Roberto Gozalbo-Rovira1, Susana Vila-Vicent1, Cristina Santiso-Bellón1, Susana Delgado2, Natalia Molinero2, Abelardo Margolles2, María Carmen Collado3, Vicente Monedero3.1Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain; 2Institute of Dairy Products of Asturias (IPLA-CSIC), Villaviciosa, Spain; 3Department of Biotechnology, Institute of Agrochemistry and Food Technology (IATA-CSIC), Valencia, Spain.

09:15-10:30 ORAL PRESENTATIONS: Morphogenesis and structural biology O-MO (1-5)Room 3 (Level -1)Chair: José Antonio López, Universidad Autónoma de Madrid, Spain O-MO-01EXPLORING THE REQUIREMENTS FOR THE PRODUCTION OF VIRUS-LIKE PARTICLES (VLPS) OF TWO FLEXUOUS PLANT VIRUSES FROM THE GENERA IPOMOVIRUS AND CRINIVIRUS IN PLANTInmaculada Ferriol1, Eric Ros-Moner1, George P. Lomonossoff2, Juan José López-Moya1.1Center for Research in Agricultural Genomics (CRAG-CSIC-IRTA-UAB-UB), Bellaterra, Spain; 2Department of Biological Chemistry, John Innes Centre (JIC), Norwich, United Kingdom.

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O-MO-02VIROID RNA STRUCTURE VISUALIZATION AND ANALYSIS AT SINGLE-MOLECULE RESOLUTION BY ATOMIC FORCE MICROSCOPYMiguel Moreno1, Luis Vázquez2, María Amparo López-Carrasco3, Jose Angel Martín-Gago2, Ricardo Flores3, Carlos Briones1.1Centro de Astrobiologia, Torrejon de Ardoz, Spain; 2Instituto de Ciencia de Materiales de Madrid, Madrid, Spain; 3Instituto de Biología Molecular y Celular de Plantas, Valencia, Spain.

O-MO-03FROM STRUCTURE TO MECHANISMS OF ZIKA VIRUS INDUCED NEURODEVELOPMENTAL DISEASEDiego Ferrero1, Victor Ruiz-Arroyo1, Murielle Saade1, José Manuel Blanco1, Alba Guarné2, Elisa Martí1, Nuria Verdaguer1.1IBMB-CSIC, Barcelona, Spain; 2McGill University, Montreal, Canada.

O-MO-04BIRNAVIRUS REPLICATION STRATEGYDaniel Fuentes-Martínez1, Sylvia Gutierrez2, M. Teresa Rejas3, Ana Oña2, Milagros Guerra3, Dolores Rodríguez1, José F. Rodríguez1.1Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología CSIC, Madrid, Spain; 2Advanced Light Microscopy Facility, Centro Nacional de Biotecnología CSIC, Madrid, Spain; 3Electron Microscopy Facility, Centro de Biología Molecular Severo Ochoa CSIC, Madrid, Spain. 10:30-11:00 Coffe break

11:00-12:00 PLENARY LECTURE: Viral discoveryAuditori – Plenary RoomChair: Rosa Pinto, Universitat de Barcelona, Spain

Viral evolution and emerging viruses. Marco Vignuzzi, Institut Pasteur, France – GVN Center

12:00-13:00 YOUNG VIROLOGIST LECTURE (SEV Award)Auditori – Plenary RoomChair: Rosa Pinto, Universitat de Barcelona, Spain

Host-virus interactions: a journey from hepatitis C to hepatitis B virus infection. Urtzi Garaigorta, Centro Nacional de Biotecnologia, CSIC, Spain 13:00-13:30 Concluding remarks, closing ceremony and presentation the following SEV congress

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ANTI-VIRALS

P-AV-01IMAGING AS A POWERFUL TOOL TO STUDY THE MECHANISM OF ACTION OF ANTIVIRALSMoisés García Serradilla, Cristina Risco.Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.

P-AV-02SELECTION AND EXPRESSION OF HIGHLY EFFICIENT ANTIVIRAL SMALL RNAS IN PLANTSAlberto Carbonell1, Purificación Lisón1, Carmelo López2, José-Antonio Daròs1.1IBMCP (CSIC-Universitat Politècnica de València), Valencia, Spain; 2COMAV (Universitat Politècnica de València), Valencia, Spain.

P-AV-03ANTIVIRAL ACTIVITY IN VITRO OF THE ESSENTIAL OIL EXTRACT OF LIPPIA ALBA AGAINST ZIKA VIRUSBernardo Esteban Quispe Bravo, Juan Samuel Sulca Herencia, Harumy Rojas Chuchón, Sandra Liliana Landazabal Castillo, Joe Hermosilla Jara, Enrique Walter Mamani Zapana, Egma Marcelina Mayta Huatuco.UNMSM, Lima, Peru.

P-AV-04RESISTANCE OF HIGH FITNESS HEPATITIS C VIRUS TO LETHAL MUTAGENESISIsabel Gallego1, Josep Gregori2, María Eugenia Soria3, Carlos García-Crespo4, Mónica García-Álvarez4, Alfonso Gómez-González4, Rosalie Valiergue4, Jordi Gómez5, Juan Ignacio Esteban6, Josep Quer6, Esteban Domingo1, Celia Perales7.1CBM Severo Ochoa (CSIC-UAM) and CIBER de Enfermedades Hepáticas y Digestivas (ISCIII), Madrid, Spain; 2CIBER de Enfermedades Hepáticas y Digestivas (ISCIII) and Liver Unit, Internal Medicine HUVH (VHIR) and Roche Diagnostics, S.L., Barcelona, Spain; 3CBM Severo Ochoa (CSIC-UAM) and Liver Unit, Internal Medicine HUVH (VHIR), Madrid, Spain; 4CBM Severo Ochoa (CSIC-UAM), Madrid, Spain; 5CIBER de Enfermedades Hepáticas y Digestivas (ISCIII) and Instituto de Parasitología y Biomedicina López-Neyra (CSIC), Granada, Spain; 6CIBER de Enfermedades Hepáticas y Digestivas (ISCIII) and Liver Unit, Internal Medicine HUVH (VHIR) and Universitat Autónoma de Barcelona, Barcelona, Spain; 7CBM Severo Ochoa (CSIC-UAM) and CIBER de Enfermedades Hepáticas y Digestivas (ISCIII) and Liver Unit, Internal Medicine HUVH (VHIR), Madrid, Spain.

P-AV-05PHARMACOLOGICAL INHIBITION OF CDK4/6 ENHANCES ANTIVIRAL AND CYTOTOXIC ACTIVITY OF ANTIMETABOLITESEva Riveira Muñoz1, Eudald Felip1, Maria Pujantell1, Edurne García Vidal1, Bonaventura Clotet1, Roger Badia1, Mireia Margalí2, José Esté1, Ester Ballana1.1IrsiCaixa AIDS Research Institute, Badalona, Spain; 2Instituto Catalán de Oncología, Badalona, Spain.

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P-AV-06INTERFERON ALPHA TREATMENT: EVIDENCES OF ITS ANTIVIRAL EFFECT IN FELV AND FIV INFECTED CATSEsperanza Gómez-Lucía1, Victorio M. Collado1, Sonsoles Martín2, Guadalupe Miró1, Ana Doménech1.1Department of Animal Health, Faculty of Veterinary Medicine. Complutense University of Madrid,, Madrid, Spain; 2Department of Animal Medicine and Surgery- Faculty of Veterinary Medicine. Complutense University of Madrid, Madrid, Spain.

P-AV-07HOW TO DESIGN A ROBUST ULTRA-DEEP SEQUENCING PROCEDURE TO ANALYZE HIGHLY VARIABLE RNA VIRUS MUTANT SPECTRAMaría Eugenia Soria1, Josep Gregori2, Qian Chen3, Damir García-Cehic4, Meritxell Llorens3, Ana I de Ávila5, Nathan M Beach5, Esteban Domingo6, Francisco Rodríguez-Frías7, María Buti8, Rafael Esteban8, Juan Ignacio Esteban8, Josep Quer8, Celia Perales9.1CBM Severo Ochoa (CSIC-UAM) and Liver Unit, Internal Medicine HUVH (VHIR), Madrid, Spain; 2CIBER de Enfermedades Hepáticas y Digestivas (ISCIII) and Liver Unit, Internal Medicine HUVH (VHIR) and Roche Diagnostics, S.L., Barcelona, Spain; 3Liver Unit, Internal Medicine HUVH (VHIR), Barcelona, Spain; 4CIBER de Enfermedades Hepáticas y Digestivas (ISCIII) and Liver Unit, Internal Medicine HUVH (VHIR), Barcelona, Spain; 5CBM Severo Ochoa (CSIC-UAM), Madrid, Spain; 6CBM Severo Ochoa (CSIC-UAM) and CIBER de Enfermedades Hepáticas y Digestivas (ISCIII), Madrid, Spain; 7CIBER de Enfermedades Hepáticas y Digestivas (ISCIII), Liver Unit, Department of Biochemistry and Microbiology HUVH and Universitat Autónoma de Barcelona, Barcelona, Spain; 8CIBER de Enfermedades Hepáticas y Digestivas (ISCIII) and Liver Unit, Internal Medicine HUVH (VHIR) and Universitat Autónoma de Barcelona, Barcelona, Spain; 9CBM Severo Ochoa (CSIC-UAM) and CIBER de Enfermedades Hepáticas y Digestivas (ISCIII) and Liver Unit, Internal Medicine HUVH (VHIR), Madrid, Spain.

P-AV-08A CELL-TARGETED DRUG, LAURYL GALLATE, INHIBITS FOOT-AND-MOUSE DISEASE VIRUS INFECTION IN CULTURED CELLS AND IN A MOUSE MODELPatricia de Leon, María José Bustos, Elisa Torres, Rodrigo Cañas-Arranz, Angel L. Carrascosa, Francisco Sobrino.CBMSO-CSIC, Madrid, Spain.

P-AV-09DENDRIMER NANOTECHNOLOGY USED NOVEL APPROACH FOR TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS Rafael Ceña Diez1, Ignacio Rodriguez-Izquierdo1, Maria Jesús Serramia Lobera1, Rosa Rodriguez-Fernández2, Isidoro Martínez3, Maria Angeles Muñoz-Fernández1.1Gregorio Marañón University General Hospital. Gregorio Marañón HealthResearchInstitute (IiSGM). Spanish HIV HGM BioBank.C/Dr. Esquerdo 46, 28007, Madrid, Spain; 2Hospitalización de Pediatría. Gregorio Marañón University General Hospital. Gregorio Marañón HealthResearchInstitute (IiSGM). C/Dr. Esquerdo 46, 28007, Madrid, Spain; 3Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

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P-AV-10ANTIVIRAL ACTIVITY AND MECHANISM OF ACTION OF GUANOSINE AGAINST HCVRosario Sabariegos1, Ana Ortega-Prieto2, Luis Díaz-Martínez3, Ana Grande-Pérez3, Isabel Gallego4, Ana Isabel de Ávila2, Esteban Domingo4, Antonio Mas1, Celia Perales4.1Laboratorio de Virología Molecular, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla-La Mancha, Albacete, Spain; 2Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Cantoblanco, Madrid, Spain; 3Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora," Consejo Superior de Investigaciones Científicas-Universidad de Málaga, Área de Genética, Facultad de Ciencias, Málaga, Spain; 4Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Cantoblanco and CIBERehd, Instituto de Salud Carlos III, Madrid, Spain.

P-AV-11DEVELOPMENT OF AND ELISA TO STUDY SPECIFIC INHIBITORS OF FILOVIRUS INFECTION DIRECTED TO THE ENDOSOMAL RECEPTOR PROTEIN NPC1.Fatima Lasala, Lucia Garcia, Nuria Labiod, Rafael Delgado.Instituto de Investigación Hospital Universitario 12 de Octubre, Madrid, Spain.

P-AV-12DUAL EFFECT OF THE BROAD SPECTRUM KINASE INHIBITOR MIDOSTAURIN IN ACUTE AND LATENT HIV-1 INFECTIONEdurne Garcia-Vidal, Maria Pujantell, Roger Badia, Marc Castellví, Bonaventura Clotet, Eva Riveira-Muñoz, Ester Ballana, José A. Esté.IrsiCaixa AIDS Research Institute, Badalona, Spain.

P-AV-13NICLOSAMIDE NEW ANALOGS AS POTENT ANTIVIRAL AGENTS AGAINST HUMAN ADENOVIRUSJavier Sánchez Céspedes1, Judith Berastegui Cabrera1, Jimin Xu2, Jia Zhou2, José Antonio Marrugal-Lorenzo1, Ana Serna Gallego1, Haiying Chen2, María Del Mar Rigual-Abolafio1, Jerónimo Pachón1.1Institute of Biomedicine of Seville (IBiS), Seville, Spain; 2University of Texas Medical Branch, Texas, United States.

VIRUSES AS BIOTECHNOLOGICAL TOOLS

P-BT-01MOLECULAR CHARACTERIZATION OF AN ISOLATE OF THE B1 GENOGROUP OF SMALL RUMINANT LENTIVIRUS THAT CIRCULATES NATURALLY IN A GOAT POPULATION IN MEXICOJazmín de la Luz-Armendáriz1, Andrés Ducoing-Watty1, Humberto Ramírez-Mendoza1, Eduardo Cabrera-Domínguez1, Alicia Soberón-Mobarak1, Luis Gómez-Núñez2, José Francisco Rivera-Benítez2.1Facultad de Medicina Veterinaria y Zootecnia UNAM, Ciudad de México, Mexico; 2CENID-MA, INIFAP, Ciudad de México, Mexico.

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P-BT-02EXPERIMENTAL EVOLUTION OF A MYCOBACTERIOPHAGEPilar Domingo-Calap, María Concepción Cebriá-Mendoza, Rafael Sanjuán.Institute for Integrative Systems Biology, Universitat de Valencia, Paterna, Spain.

P-BT-03SPANISH NETWORK OF BACTERIOPHAGES AND TRANSDUCTER ELEMENTS (FAGOMA)Pilar García.IPLA-CSIC, Villaviciosa. Asturias, Spain.

EMERGING AND RE-EMERGING VIRUSES

P-EM-01FOLLOW-UP OF AN ENZOOTIC FOCUS OF CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS IN SPAIN (2011-2015)Ana Negredo1, Miguel Ángel Habela2, Eva Ramírez de Arellano1, Francisco Diez1, Fátima Lasala1, Pablo López1, Ana Sarriá3, Nuria Labiod1, Rafael Calero-Bernal2, Miguel Arenas4, Antonio Tenorio1, Agustín Estrada5, Mª Paz Sánchez-Seco1.1Centro Nacional de Microbiología, Madrid, Spain; 2Universidad de Extremadura, Extremadura, Spain; 3Hospital Universitario La Paz-Carlos III, Madrid, Spain; 4Universidad de Vigo, Vigo, Spain; 5Universidad de Zaragoza, Zaragoza, Spain.

P-EM-02EXPERIMENTAL STUDY OF ZIKA VIRUS TRANSMISSION BY AEDES ALBOPICTUS AND CULEX PIPIENS MOSQUITOES FROM CATALONIA Ana Isabel Núñez1, Raquel Rivas1, Lotty Birnberg1, Carles Aranda2, Núria Pujol1, Marta Verdún1, Sandra Talavera1, Núria Busquets1.1IRTA-CReSA, Bellaterra, Campus UAB, Spain; 2Servei de Control de Mosquits, El Prat de Llobregat, Spain.

P-EM-03DIVERSITY OF VIRAL PATHOGENS IN IRRIGATION WATERMarta Rusiñol1, Sandra Martínez-Puchol1, Xavier Fernández-Cassi1, Natalia Timoneda2, Josep F Abril3, Ayalkibet Hundesa1, Sílvia Bofill-Mas1, Rosina Girones1.1Laboratory of Viruses Contaminants of Water and Food, Department of Genetics, Statistics and Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain; 2Laboratory of Viruses Contaminants of Water and Food and Computational Genomics Lab, Department of Genetics, Statistics and Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain; 3Computational Genomics Lab, Department of Genetics, Statistics and Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain.

P-EM-04AN ATTENUATED VARIANT OF RIFT VALLEY FEVER VIRUS GENERATED BY A MUTAGENIC DRUG (FAVIPIRAVIR) UNVEILS POTENTIAL VIRULENCE MARKERS Belén Borrego, Sandra Moreno, Alejandro Brun.INIA-CISA, Valdeolmos, Madrid, Spain.

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P-EM-05FATAL INFECTION BY CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS IN SPAIN (2018). IDENTIFICATION OF A NEW VIRUSAnabel Negredo1, Rafael Sánchez-Arroyo2, Fernando de Ory1, Marco Antonio Budiño2, Ana Vázquez1, Mª Angeles Garcinuño2, Lourdes Hernández1, César de la Hoz González2, Francisca Molero1, Carmen Grande2, Mª Paz Sánchez-Seco1.1Centro Nacional de Microbiología, Madrid, Spain; 2Hospital Nuestra s

xv congreso nacional de virologÍa la de sev...4 queridos amigos y amigas, es un gran placer daros...

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