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THE RICH AXIS For universal immunisation, the world would need 2 doses of vaccines for 7.8 billion people. But the rich countries have already ordered a bulk of the vaccines to be manufactured in 2021 Seven vaccines are in various stages of clinical trials on humans in India. The vaccine industry is working on both international and domestic vaccine candidates Cambridge. UK Cambridge. UK Astrazeneca/Oxford Astrazeneca/Oxford Canada Canada Mexico Mexico Brazil Brazil Latin America Latin America Bloc** Bloc** Egypt Egypt EU* EU* Uzbekistan Uzbekistan India India Nepal Nepal China China Indonesia Indonesia Australia Australia Japan Japan S Korea S Korea Maryland, USA Maryland, USA Novavax Novavax New York, USA New York, USA Pfizer/ BioNTech Pfizer/ BioNTech Massachucetts, US Massachucetts, US Moderna Moderna Moscow, Russia Moscow, Russia Gamaleya Gamaleya Paris, France Paris, France Sanofi/GSK Sanofi/GSK Countries with ongoing phase 3 clinical trials Top 6 vaccine manufacturers and destination of their product 7.8 billion total people to be vaccinated 4.7 billion People to be vaccinated for herd immunity*** 2.2 billion Adults at severe risk of infection 2.3 million Total vaccine doses administered**** 3.7 billion People are willing to take the vaccine 2 billion doses COVAX will be provided in 2021 162 vaccine candidates in pre-clinical trials 52 vaccine candidates in clinical trials 13 vaccine candidates in phase 3 Advance market commitments (as of December 18, 2020 data) • Total worldwide confirmed purchases of COVID-19 vaccines: 7.7 billion doses • Total confirmed doses purchased by high-income countries: 4 billion • Total confirmed doses purchased by upper-middle-income countries 1.1 billion • Total confirmed doses purchased by lower-middle-income countries: 1.8 billion • Purchases by low-income countries: 0 • Total purchased by COVAX: 870 million Top 5 hoarders of COVID 19 vaccines USA COVAX EU India UK Explanation: *EU: 27 countries of the European Union; **Latin America bloc: all countries in the region, except Brazil;***at least 60% population needs to be vaccinated for herd immunity. The companies are providing to their home countries too. ****as of December 22, 2020; Covax is a global body which would supply to most countries in the world Source: London School of Hygiene & Tropical Medicine Vaccine Centre, Duke Global Health Innovation Center, www.bloomberg.com, www.ourworldindata.org, www.who.int; www.pib.nic.in; https://www.bmj.com/content/371/bmj.m4704 THE INDIAN VACCINE BAZAAR Covishield (chimpanzee adenovirus platform) SII + AstraZeneca Phase 2/3 Applied for EUA Covaxin (inactivated virus) Bharat biotech + ICMR Phase 3 Applied for EUA ZyCoV-D (DNA vaccine) Cadilla healthcare + dept of biotechnology Phase 2 Sputnik V (human adenovirus vaccine) Dr. Reddy’s Lab + Gamaleya National Centre phase 3 about to begin NVX-CoV2373 (protein subunit) SII + Novavax phase 3 under consideration COVID-19 vaccine (recombinant protein antigen based vaccine) Biological E Phase 1 and 2 HGCO 19 (mRNA based vaccine) Gennova + HDT USA phase 1 and 2 human trials approved 0M 200M 400M 600M 800M 1000M 1200M 1400M 1600M 1800M 2000M 2200M 2400M 2600M Potential dose purchases Confirmed dose purchases COVER STORY / VACCINE 26 DOWN TO EARTH 1-15 JANUARY 2021 DOWNTOEARTH.ORG.IN

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Page 1: ZyCoV-D THE Egypt Cadilla healthcare + Dr. Reddy’s Lab · 2021. 1. 4. · Dr. Reddy’s Lab + Gamaleya National Centre phase 3 about to begin NVX-CoV2373 (protein subunit) SII +

THE RICH AXISFor universal immunisation, the world would need 2 doses of vaccines for 7.8 billion people. But the rich countries have already ordered a bulk of the vaccines to be manufactured in 2021

Seven vaccines are in various stages of clinical trials on humans in India. The vaccine industry is working on both international and domestic vaccine candidates

Cambridge. UKCambridge. UKAstrazeneca/Oxford Astrazeneca/Oxford

CanadaCanada

MexicoMexico

BrazilBrazil

Latin America Latin America Bloc**Bloc**

EgyptEgypt

EU*EU*

UzbekistanUzbekistan

IndiaIndia

NepalNepal

ChinaChina

IndonesiaIndonesia

AustraliaAustralia

JapanJapanS KoreaS Korea

Maryland, USAMaryland, USANovavaxNovavax

New York, USANew York, USAPfizer/ BioNTechPfizer/ BioNTech

Massachucetts, USMassachucetts, USModernaModerna

Moscow, RussiaMoscow, RussiaGamaleyaGamaleya

Paris, FranceParis, FranceSanofi/GSKSanofi/GSK

Countries with ongoing phase 3 clinical trials

Top 6 vaccine manufacturers and destination of their product

7.8 billiontotal people to be vaccinated

4.7 billionPeople to be vaccinated for herd immunity***

2.2 billionAdults at severe risk of infection

2.3 millionTotal vaccine doses administered****

3.7 billionPeople are willing to take the vaccine

2 billiondoses COVAX will be provided in 2021

162vaccine candidates in pre-clinical trials

52 vaccine candidates in clinical trials

13 vaccine candidates in phase 3

Advance market commitments (as of December 18, 2020 data)• Total worldwide confirmed purchases of covid-19 vaccines: 7.7 billion doses • Total confirmed doses purchased by high-income countries: 4 billion• Total confirmed doses purchased by upper-middle-income countries 1.1 billion• Total confirmed doses purchased by lower-middle-income countries: 1.8 billion• Purchases by low-income countries: 0 • Total purchased by covax: 870 million

Top 5 hoarders of COVID 19 vaccines

USACOVAX

EUIndia

UK

Explanation: *EU: 27 countries of the European Union; **Latin America bloc: all countries in the region, except Brazil;***at least 60% population needs to be vaccinated for herd immunity. The companies are providing to their home countries too. ****as of December 22, 2020; Covax is a global body which would supply to most countries in the world

Source: London School of Hygiene & Tropical Medicine Vaccine Centre, Duke Global Health Innovation Center, www.bloomberg.com, www.ourworldindata.org, www.who.int; www.pib.nic.in; https://www.bmj.com/content/371/bmj.m4704

THE INDIAN VACCINE BAZAAR

Covishield (chimpanzee adenovirus platform) SII + AstraZeneca Phase 2/3

Applied for EUA

Covaxin (inactivated virus) Bharat biotech + ICMR Phase 3

Applied for EUA

ZyCoV-D (DNA vaccine) Cadilla healthcare + dept of biotechnology Phase 2

Sputnik V (human adenovirus vaccine) Dr. Reddy’s Lab + Gamaleya National Centre phase 3 about to begin

NVX-CoV2373 (protein subunit) SII + Novavax phase 3 under consideration

COVID-19 vaccine (recombinant protein antigen based vaccine) Biological E Phase 1 and 2

HGCO 19 (mRNA based vaccine) Gennova + HDT USA phase 1 and 2 human trials approved

0M 200M 400M 600M 800M 1000M 1200M 1400M 1600M 1800M 2000M 2200M 2400M 2600M

Potential dose purchases Confirmed dose purchases

COVER STORY/VACCINE

26 DOWN TO EARTH 1-15 JANUARY 2021 DOWNTOEARTH.ORG.IN

22-35Yearbeginner_Vaccine.indd 26-2722-35Yearbeginner_Vaccine.indd 26-27 29/12/20 10:23 AM29/12/20 10:23 AM

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