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A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

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Page 1: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

AKnowledge Based Economy

(KBE)

* Money, Time and Talent !

History | KBE | Biomed | S&E | Talent | Enterprise

Building

Page 2: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Map of Singapore: Location of one-north

ChangiAirportChangiAirport

National University of S’poreNational University HospitalNational University of S’poreNational University HospitalTuas

Biomedical ParkTuasBiomedical Park City CentreCity Centre

Seaport & Container Terminals

Seaport & Container Terminals

one-northone-north

SGHSGH

Nanyang Technological UniversityNanyang Technological University

Jurong IslandJurong Island

BiopolisBiopolisFusionopolisFusionopolis

Page 3: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Labour-intensive

Skills-intensive

Capital-intensive

Technology-intensive

Innovator of new products

& services

Knowledge-Intensive

Singapore’s Economic Progress

Keep moving up !

History | KBE | Biomed | S&E | Talent | Enterprise

Page 4: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

History | KBE | Biomed | S&E | Talent | Enterprise

0

5,000

10,000

15,000

20,000

25,000

1965 1970 1975 1980 1985 1990

The Turning Point

1985: Economy shrank 1.5%1985: 4% unemployment1986: 7% unemployment

1985/6Recession

1987Recovery

Independence1965

S$ 1,567(1965)

S$14,345(1986)

GD

P P

er c

apit

a (S

$)

Page 5: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

The UpTurn

History | KBE | Biomed | S&E | Talent | Enterprise

GD

P P

er c

apit

a (S

$)

1986: Economy grew 2%1987: Economy grew 9%1988: 20,000 new jobs created

S$14,345(1986)S$ 1,567

(1965)

Independence1965

S$46,832(2006)

0

5,000

10,000

15,000

20,000

25,000

30,000

35,000

40,000

45,000

50,000

1965 1970 1975 1980 1985 1990 1995 2000 2005

Page 6: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

0

5,000

10,000

15,000

20,000

25,000

1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006

S$ Mil

Building the Data Storage Industry ClusterCumulative Output (1986-2000): S$170 billion

S$11 billion(2006)

S$20 billion(1997)

S$2.4 billion(1986)

Page 7: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Building the Semiconductor Industry Cluster

S$36 billion(2006)

Cumulative Output (1986-2000): S$122 billion

S$11 billion(1998)

S$2.3 billion(1986)

0

10,000

20,000

30,000

40,0001

98

0

19

82

19

84

19

86

19

88

19

90

19

92

19

94

19

96

19

98

20

00

20

02

20

04

20

06

Page 8: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Building The Chemicals Industry Cluster

10,000

20,000

30,000

40,000

50,000

60,000

1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006

S$ Million

Cumulative Output (1986 – 2000) - S$266 billionS$76 billion

(2006)

Off

icia

l O

pe

nin

g

of

Ju

ron

g I

slan

d

199

5 C

on

stru

ctio

nst

arte

d o

n J

uro

ng

Isl

and

History | KBE | Biomed | S&E | Talent | Enterprise(S

$32

bil

lio

n)

(S$1

7 b

illi

on

)

Page 9: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

The Jurong Island Story

These seven tiny islands (800 ha in all) then became …..

… a 3,400 ha single island

1991 present

History | KBE | Biomed | S&E | Talent | Enterprise

Page 10: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Jurong Island TodayJurong Chemical Island ….Today

… a 3,400 ha single island

Page 11: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

2006 GDP Pie (S$210 billion)

27.7%(Manufacturing)

3.6%(Construction)

15.2%(Wholesale &Retail Trade)9.6%

(Transport &Storage)

1.9%(Hotels &

Restaurants)

3.8%(Info & Comms)

11.2%(Financial Svcs)

11.5%(Business Svcs)

10.2%(Other Services)

5.2%(Others)

Manufacturing

Construction

Wholesale & Retail Trade

Transport & Storage

Hotels and Restaurants

Information & Communications

Financial Services

Business Services

Other Services

Others

History | KBE | Biomed | S&E | Talent | Enterprise

MANUFACTURING

Page 12: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Manufacturing

S$ Million

Biomedical Sciences

Electronics

Chemicals

0

20,000

40,000

60,000

80,000

100,000

1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006p

Electronics (incl Data Storage and Semiconductors) Chemicals BMS Precision Engrg

Precision Engrg

History | KBE | Biomed | S&E | Talent | Enterprise

Total Manufacturing Output of 4 key clusters : $235 billion (2006)

Page 13: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Manufacturing

0

1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006p

Electronics Chemicals BMS Precision Engrg

20000

40000

60000

80000

100000

120000

140000

Person

Electronics

PrecisionEngrg

Chemicals

BiomedicalSciences

History | KBE | Biomed | S&E | Talent | Enterprise

Total Employment in 4 clusters : 223, 277 (2006)

Page 14: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Singapore has promoted and attracted 4 waves of investments: -

* Data storage (1986-1990)

* Semiconductors (1991-1995)

* Chemicals (1996 to 2000)

* Biomedical industries (2001 to 2006)

Creation of 4 clusters of growth

Page 15: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Four Industry Waves (1986 to 2006)

Data Storage S$170 b

Semiconductors S$122 b

Chemicals S$266 b

Biomedical Sciences S$125 b

History | KBE | Biomed | S&E | Talent | Enterprise

Page 16: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Stagnation

Labour Intensive

Skills Intensive

Capital Intensive

Technology Intensive

GD

P P

er c

apit

a (S

$)Where do we go from here?

High Growth

Decline

History | KBE | Biomed | S&E | Talent | Enterprise

Page 17: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

1965 – 1978: Export Oriented Industrialisation

1986 – 2000:Capability Building and

Economic Diversification

Moving forward to a Knowledge Based Economy model

1979 – 1985: Industrial Restructuring

2001 onwards:Transforming to Knowledge-

Based Economy

History | KBE | Biomed | S&E | Talent | Enterprise

Page 18: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

From Manufacturing to Knowledge-Based Economy

• An Economy based on cost efficiency is not sustainable in the long term

• Move up the Value chain with focus on high value-added activities

• Graduate Education is a necessity for high value-added R&D-oriented industries

• Research Development Production Marketing Distribution Servicing

History | KBE | Biomed | S&E | Talent | Enterprise

Page 19: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

What is a Knowledge-Based Economy?

How do we create knowledge and useful ideas? R&D and innovation.

Where? New high growth areas like biomedical sciences, nanotechnology, energy.

Why? R&D generates intellectual property (IP) and this is the “real value-added” R&D complements our manufacturing core. Coupling the two will create clusters of high value-added activity.

Create, Own + Exploit (COE) Knowledge

History | KBE | Biomed | S&E | Talent | Enterprise

Page 20: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Science and Engineering

Research Council

Biomedical Research Council

Exploit Technologies

Corporate Planning and

Administration

A*STAR Graduate Academy

Building up the R&D foundation (2001)

History | KBE | Biomed | S&E | Talent | Enterprise

Page 21: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

A*STAR’s Foundations

Researchgovernance framework

Research Infrastructure

Talent- DevelopmentCommercialisation

InternationalPartnerships

Research governance framework

* Established Research Councils and RI Scientific Advisory Boards

Research Infrastructure

* Completed Biopolis Phase 1 & Phase 2

Focus on Talent

* Attracted international scientific leaders and scientists

* Set up A*STAR Graduate Academy to groom Singaporean PhD talent

Encourage Commercialisation

* Streamlined Intellectual Property policies* Established Commercialisation of Technology

Fund

International Partnerships

* Partnerships for research collaboration and graduate education/training

History | KBE | Biomed | S&E | Talent | Enterprise

Page 22: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

A snapshot of Singapore’s current R&D scene

History | KBE | Biomed | S&E | Talent | Enterprise

Page 23: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

International Comparison of R&D IntensityInternational Comparison of R&D Intensity

Source: National Survey of R&D in Singapore 2005 and OECD MSTI 2006_1

Finland

Ireland

Japan

Korea

Total OECDSingapore2.36% (2005)

United StatesTaiwan

1

1.5

2

2.5

3

3.5

4

2000 2001 2002 2003 2004 2005

Year

R&

D /

GD

P %

History | KBE | Biomed | S&E | Talent | Enterprise

Singapore’s Goal: 3.0% by 2010Singapore’s Goal: 3.0% by 2010Limit: TALENTLimit: TALENT

Singapore1.88%(2000)

Page 24: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Building up R&D Human Capital

2000 - 2006R

esea

rch

Sci

entis

ts a

nd E

ngin

eers

(R

SE

)

RS

E p

er 1

0,00

0

History | KBE | Biomed | S&E | Talent | Enterprise

10000

12000

14000

16000

18000

20000

22000

24000

26000

28000

2000 2001 2002 2003 2004 2005 2006

10

30

50

70

90

110

130

No. of research manpower

No. of research manpower per 10,000 labour force

Page 25: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

No. of Patents Applied / Awarded

History | KBE | Biomed | S&E | Talent | Enterprise

0200400600800

1000120014001600180020002200

2000 2001 2002 2003 2004 2005 2006Patents applied

Patents awarded

Goal

Page 26: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Building up Biomedical Sciences

A*STAR2001

History | KBE | Biomed | S&E | Talent | Enterprise

Page 27: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Vision

Singapore – The Biopolis of AsiaSingapore – The Biopolis of Asia

Basic, Translational

& Clinical Research

Product & Process

Development

Pilot & Commercial

Manufacturing

Regional HQ & Shared Services

Healthcare Delivery

An International Biomedical Sciences Cluster Advancing Human Health

Through the Pursuit of Excellence in Research & Development, Manufacturing, and Healthcare Delivery

History | KBE | Biomed | S&E | Talent | Enterprise

Page 28: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

S*BIOResearch Development Manufacturing Healthcare

Services

Human Capital Development

Intellectual Capital

Development

Industrial Capital Development

Biomedical Sciences Value Chain

History | KBE | Biomed | S&E | Talent | Enterprise

Page 29: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

How It All Started….

A/Prof. Kong Hwai LoongProf. John Wong

Prof. Tan Chorh Chuan26thJune 2000

Page 30: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Sir Richard Sykes (Chairman)Imperial College (UK)

Dr John Mendelssohn (Co-Chairman)MD Anderson (USA)

Dr David Baltimore (Emeritus)California Institute of Technology(USA)

Dr Leland HartwellFred Hutchinson CancerResearch Center (USA)

Dr Colin BlakemoreMedical Research Council(UK)

Dr Richard Lerner (Emeritus)Scripps Research Institute(USA)

Dr John Reed (Emeritus)Burnham Institute(USA)

Dr John BellUniversity of Oxford(UK)

Dr Sydney BrennerThe Salk Institute(USA)

Sir George Radda (Emeritus)University of Oxford(UK)

Dr Harriet Wallberg-HenrikssonKarolinska Institutet(Sweden)

Dr Peter GrussMax Planck Society(Germany)

Dr Philippe Kourilsky (Emeritus)College de France(France)Dr Alan Bernstein (Emeritus)Canadian Institutes of Health Research (Canada)

Dr Suzanne CoryWEHI (Australia)

Dr Samuel Barondes (Emeritus)University of California, SanFrancisco (USA)

Dr David I. Hirsh (Emeritus)Columbia University(USA)

Dr Paul A. Marks (Emeritus)Memorial Sloan-Kettering CancerCenter (USA)

Dr Alan Munro (Emeritus)University of Cambridge(UK)

Sir Keith Peters (Emeritus)GlaxoSmithKline(UK)

Dr Hans Wigzell (Emeritus)Karolinska Institutet(Sweden)

Dr Axel Ullrich (Emeritus)Max-Planck Institute of Biochemistry (Germany)

Dr John Shine (Emeritus)Garvan Institute of Medical Research (Australia)

Dr Susan Lindquist (Emeritus)Whitehead Institute of Biomedical Research (USA)

Dr Stanley N. Cohen (Emeritus)Stanford University(USA)

Dr Helen HobbsUT Southwestern (USA)

Dr Tadataka YamadaGates Foundation (USA)

Dr Rolf ZinkernagelUniversity of Zurich (Switzerland)

Dr William EvansSt Jude (USA)

Sir Philip CohenUniversity of Dundee (UK)

Dr Anthony PawsonSamuel Lunenfeld Research Institute (Canada)

BMS International Advisory Council

Page 31: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Breaking New Ground in 2001 …Biopolis

History | KBE | Biomed | S&E | Talent | Enterprise

Page 32: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Biopolis

Biopolis Phase 1

All 5 BMRC Research Institutes S&T offices (British High Com and RIKEN) Corporate labs (NITD, GSK) 185,000 square metres Officially opened on October 2003

Biopolis Phase 2

BMRC Research Institutes Corporate labs Additional 37,000 square metres Officially opened on 30 October 2006

Biopolis 1

Biopolis 2

Page 33: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

BMRC Research Institutes

Genome Institute of Singapore (GIS)

Institute of Bioengineering & Nanotechnology (IBN)

BioinformaticsInstitute (BII)

Institute of Medical Biology (IMB)

Singapore Institute for Clinical Sciences (SICS)

BioprocessingTechnologyInstitute (BTI)

Institute ofMolecular andCell Biology(IMCB)

History | KBE | Biomed | S&E | Talent | Enterprise

Page 34: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Phase 1 185,000 sqm S$500 million invested Public & corporate R&D labs > 95% of space committed

Phase 4

Phase 3

Shared Facilities Shared R&D equipment Shared animal facility

Phase 2 37,000 sqm Opened on 30 October 2006

Biopolis Tuas Biomedical Park

Tuas Biomedical Park I & II 360 Ha of prepared industrial land Ready infrastructure provided - Stable water, Electricity, Telecommunications, Sewerage discharge

Integrated Infrastructure: Tuas Biomedical Park

History | KBE | Biomed | S&E | Talent | Enterprise

Page 35: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Biomedical Sciences (BMS) Manufacturing Performance

1986-2006

History | KBE | Biomed | S&E | Talent | Enterprise

Out

put

$ ‘000S$23 billion

(2006)

0

5,000

10,000

15,000

20,000

25,00019

86

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

Manufacturing Output Value-Added

S$6 billion(2000)

Cumulative Output (1986 – 2006) - S$125 billion

Page 36: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

0

2000

4000

6000

8000

10000

12000

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

Biomedical Sciences (BMS) Actual Employment 1986 - 2006

5,880(2000)

10,572(2006)

Em

ploy

men

t

History | KBE | Biomed | S&E | Talent | Enterprise

Page 37: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Genomics & Proteomics

Bioprocessing

Chemical Synthesis

BIOTECHNOLOGYHEALTHCARESERVICES &

DELIVERY

Molecular & Cell Biology

Bioengineering &Nanotechnology

Computational Biology

Industry Sectors

Industry Sectors

Bioimaging

Cohort Studies

Biomarkers

Stem

cel

ls

Drug D

isco

very

CLINICAL RESEARCH

TRANSLATIONAL RESEARCH

PHARMACEUTICALS MEDICAL TECHNOLOGY

Biomedical Cluster Map

History | KBE | Biomed | S&E | Talent | Enterprise

Page 38: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

MEaT = Medical Enginering and TechnologyIMCB = Institute of Molecular & Cell BiologyGIS = Genome Institute of SingaporeBTI = Bioprocessing Technical InstituteIBN = Institute of Bioengineering and NanotechnologyBII = Bioinformatics InstituteCMM = Centre for Molecular MedicineSICS = Singapore Institute for Clinical SciencesSBIC = Singapore Bioimaging Consortium

SIgN = Singapore Immunology NetworkSSCC = Singapore Stem Cell Consortium STN = Singapore Tissue NetworkSCS = Singapore Cancer SyndicateSCCS = Singapore Consortium of Cohort StudiesDPF = Data Privacy FrameworkBMS IF = Biomedical International FellowshipCSI = Clincian Scientist InvestigatorshipIRBs = Institutional Review Boards

Mission-oriented BENCH

INDUSTRY

Co-investment, VC funding

RISC grants, infrastructure, tax breaks

Pharma MEaT Biotech

Biologics (c

ells / v

accines)

Med tech

/ devic

es

Drug discove

ry & devt

Singapore Clinical Trials

• IMCB, GIS, BTI• IBN, BII, • CMM, SICS

Research Institutes

• SBIC• SSCC

• SIgN• Biomarkers

Research Consortia

Set up by A*STAR / BMRC

BEDSIDE

Clinical Research Programmes• Focus, strategy

Human Capital• Development, recruitment

Infrastructure• For Clinical Trials

Regulatory Framework• IRBs

DPF Office

MBBS PhD / BMS IF / CSI awards

Translational / Investigational

Medicine NMRC / HSA

Clinical Trials Overseas Clinical Trials

STN

SCS

SCCS

Academic BENCH

NUS, NTU

Page 39: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Clinical

BIOMEDICAL RESEARCH

TranslationalBasic

Singapore Health Services• Singapore General Hospital• National Cancer Centre• National Heart Centre• Singapore National Eye Centre• KK Women and Children’s Hospital• National Neuroscience Institute

National Healthcare Group• National University Hospital• The Cancer Institute• Tan Tock Seng Hospital• Communicable Disease Centre• National Skin Centre

Extramural Grants

− Singapore Cancer Syndicate− Singapore Bioimaging

Consortium − Singapore Stem Cell

Consortium− Singapore Immunology

Network− Member of Intl Cancer

Biomarker Consortium

Singapore Institute for Clinical Sciences (SICS)

• Develop programmes in Translational Clinical Medicine

• Develop critical resources:- Singapore Tissue Network- Singapore Consortium of Cohort Studies

• Develop Clinician Scientists:- Clinician Scientist Investigatorship (CSI) Awards- PhD training for medical doctors- Biomedical International Fellowships

MOH HQ- Ethical regulations/framework for

clinical research e.g. IRBs

NMRC- Clinical research strategy- Grant management- Manpower development

- HSA- Evaluation capabilities for new

technologies

Research Institutes

• Institute of Molecular & Cell Biology

• Genome Institute of Singapore

• Institute of Bioengineering & Nanotechnology

• Bioprocessing Technology Institute

• Bioinformatics Institute

UNIVERSITIES

Institute of Medicinal Biology (IMB)

CMM @ Biopolis(2006 -2008)− Singapore Oncogenome Group− Regenerative Medicine− Epithelial Biology

Consortia

SICS @ Kent Ridge- Genetic Medicine- Virology/Infectious Diseases

SICS @ Outram(2008-2010)− Cardiovascular Diseases− Eye Diseases

A*STAR Biomedical Research Ministry Of Health

Page 40: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Hub for Clinical Trials & Regional Management

14 emp Phase 1-4 Trials

10 emp Phase 3-4 Trials

8 emp Phase 3 Trials Results Used in

NDA Submission

10 emp Phase 2-4 Trials

GSK and GSK Biologicals

42 emp Phase 2-4 Trials

20 emp 28 Bed Phase 1

Unit Phase 3-4 Trials

12 emp Phase 2-3 Trials Centralized Data

32 emp Phase 2-4 Trials

65 emp 31 bed Phase 1

Unit Japan Bridging

Studies

6 emp Phase 2-3 Trials Results Used in

NDA Submission

4 emp Phase 2-4 Trials Data Management

22 emp Phase 2-4 Trials Data Management

LILLY

Bristol-Myers Squibb Company

Local: Early Phase and Complex TrialsLocal: Early Phase and Complex Trials

History | KBE | Biomed | S&E | Talent | Enterprise

Page 41: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Fusion of Science and Engineering

History | KBE | Biomed | S&E | Talent | Enterprise

Page 42: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Science & Engineering Industry Clusters

ELECTRONICS INFOCOMM

ENGINEERINGCHEMICALS

Semiconductors

Storage & PeripheralsDevices

Digital Content & Media

Software & Computing

Communications

Petroleum/Petrochemicals

Performance Materials

Bio & Consumer Chemistry

Specialty Chemicals

Process Engineering *

Advanced Display

Electronic Components

Electronic Modules

Microelectronics

Computational Science

DataStorage

Infocomm Research

Chemical Sciences

Material Science & Engineering

Manufacturing Technology

I2RIME

DSI

IMRE

ICES

SIMTech

IHPC

Machinery & Systems

Precision Modules

Aerospace

Precision Components

Marine & Offshore

Automotive

Alignment of SERC RIs to meet Industry Needs

Science and Engineering Cluster Map

History | KBE | Biomed | S&E | Talent | Enterprise

Page 43: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

ELECTRONICS INFOCOMM

ENGINEERINGCHEMICALS

Machinery & Systems

Precision Modules

Aerospace

Precision Components

Offshore Engrg

Petroleum/Petrochemicals

Performance Materials

Bio & Consumer Chemistry

Specialty Chemicals

Process Engineering

MicroElectronics

DataStorage

Info-Comm Sciences

Chemical Sciences

Materials Sciences

Manufacturing Technology

Devices

Digital Content & Media

Software & Computing

Communications

Semiconductors

Storage & Peripherals

Advanced Display

Electronic Components

Electronic Modules

Home 2015

Ultra wide BandPolymer Elec.

Photonics

Nano-elect.

Sensors

Mfg Systems

Imaging

Human-factor Engineering

Energy

SyntheticChemistry

Nanotechnology

Human-machine interface

Arrayed sensor networks

Developing New Competencies

History | KBE | Biomed | S&E | Talent | Enterprise

Page 44: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

SERC Research Institutes

Data Storage Institute (DSI)

Institute for Chemical & Engineering

Sciences (ICES)

Institute for Infocomm Research (I2R)

Institute of Micro-

electronics (IME)

Institute of Materials Research & Engineering (IMRE)

Institute of High Performance Computing (IHPC)

Singapore Institute of Manufacturing Technology (SIMTech)

History | KBE | Biomed | S&E | Talent | Enterprise

Page 45: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

SERC RIs initiated

838 Industry R&D projects from FY01-FY06*

* As of 31st December 2006

Attracting and Anchoring Corporate R&D activities

History | KBE | Biomed | S&E | Talent | Enterprise

Page 46: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Fusionopolis – Home for Integration of Technologies and Capabilities

Devices

(IME, DSI)

Materials (IMRE)

ComputerModeling (IHPC)

Platform (SIMTech / IME)Technologies

Systems / Applications (I2R)

Sy

ste

m In

teg

rati

on

(SIM

Te

ch)

Central Facilities

Chemistry (ICES)

History | KBE | Biomed | S&E | Talent | Enterprise

Page 47: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

SERC, CPAD, ETPL, I2R, IHPC, DSI (network storage), SIMTech (Industrial

Informatics) located at Fusionopolis Phase 1

Fusionopolis Phase 1 Facilities

History | KBE | Biomed | S&E | Talent | Enterprise

Page 48: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Singapore’s most powerful Computers- driving innovations

S'pore's largest R&D cleanroom at your service

State-of-the-art cleanroom

Small Matters!produce high-resolution,

3D images down

to an atomic level

Science meets businessPartnering industry in joint

development of next

generation technologies

Integration of SERC RI Capabilities

Bringing TechnologyFrom the labs to

Your Daily Experienceexperimental place to innovate

and create ideas

for R&D and new applications

A Magnet for the Best and Brightest

Outstanding researchers with diverse cultures to create highly inventive environment

Area of Phase 1 : 120,000m2Area of Phase 2 : 103,688m2No. of Researchers : > 1600

Realising Fusionopolis

Page 49: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

One-North

Page 50: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

FUSIONpolis – Aerial view

Circle line MRT

Co-location of Fusionopolis and Biopolis

History | KBE | Biomed | S&E | Talent | Enterprise

Page 51: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

HUMAN CAPITAL

make up a Knowledge-Based Economy (KBE)

History | KBE | Biomed | S&E | Talent | Enterprise

Page 52: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Human Capital - Whales

History | KBE | Biomed | S&E | Talent | Enterprise

Page 53: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

2001

Dr Edison Liu Executive Director,

GIS

2002

Dr Yoshiaki Ito PI, IMCB

2003 2004 2005 2006

Sir David Lane Executive Director, IMCB & Executive

Dy Chmn (BSTG), BMRC

Dr Birgitte Lane Executive

Director, IMB

Dr Neal Copeland & Dr Nancy Jenkins

PIs, IMCB

Dr Phil InghamPI, IMCB

Dr Jean Paul Thiery

PI, IMCB

Dr Edward HolmesExecutive Dy Chmn (TCSG), BMRC &

Chmn, NMRC

Dr Judith Swain

Executive Director, SICS

Dr Philippe Kourilsky Chairman, SIgN

Dr Axel Ullrich Director, SOG Lab

Sir George Radda Chairman, SBIC

Dr Jackie YingExecutive

Director, IBN

When physician-scientists Judith Swain and Ed Holmes take up their posts in Singapore…, they will join a star-studded community at one of the world’s most rapidly developing biomedical research centres. …they are the latest of many Western scientists who have headed for the impressive facilities of the tiny city-state.

Naturejobs, 5 Jul 06

Attracting International Talent (Whales)

History | KBE | Biomed | S&E | Talent | Enterprise

Page 54: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Human Capital - Guppies

History | KBE | Biomed | S&E | Talent | Enterprise

Page 55: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

YouthScience

YRAP & JC Awards

NSS(BS)NSS(PhD)

AGSIF(MD)

10-14 yrs < 35 yrs

Nurturing & Developing Human Capital (Guppies)

15-18 yrs 19-23 yrs 24-30 yrs

Talent Pipeline

History | KBE | Biomed | S&E | Talent | Enterprise

Gu

pp

ies

Sen

ior

Gu

pp

ies

Yo

un

gW

hal

es

Page 56: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

A*STAR SCHOLARSHIPS

BS

International Fellowship (IF) for Medical Doctors

PhD

National Science Scholarships

(NSS)

A*STAR Graduate Scholarships

(AGS)

Imperial College London, UK

National University of Singapore

University of Illinois, Urbana-Champaign, USA

Karolinska Institutet, Sweden

University of Dundee, UK

Nanyang Technological University

Carnegie Mellon University, USA

Nurturing & Developing Human Capital

University of Cambridge, UK

MBBS-PhD

History | KBE | Biomed | S&E | Talent | Enterprise

(3 years)

(3-5 years)

(8 years)

(1-2 years)

Page 57: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

MITPhysics

(Malaysia)

Human Capital: International Guppies

StanfordChemical Engineering

(Shanghai)

MITBio Engineering

(Hong Kong)

MITChemical Engineering

(Germany)

StanfordComputer Science

(India)

MITChemical Engineering

(Vietnam)

Page 58: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

RockefellerBacteriology

Human Capital: Singapore Guppies

StanfordBiochemistry

StanfordBiochemistry

Medicine/PhDDuke

Medicine/PhDCamrbidge, London

Computer ScienceCarnegie-Mellon

Page 59: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

International Linkages

History | KBE | Biomed | S&E | Talent | Enterprise

Page 60: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

A*STAR Partners in PhD TrainingA*STAR Partners in PhD Training

• PhD studies in Biomedical Sciences, Physical Sciences and Engineering

• Scholars are supervised throughout their course of study• Upon completion, Scholar is awarded PhD degree from the

respective university• Promotes collaborations between A*STAR Research Institutes &

Universities

LOCAL

OVERSEAS

History | KBE | Biomed | S&E | Talent | Enterprise

Page 61: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

NSS(BS) - 3 yrs

232*AGS - 4 yrs

217 at partner universities

NSS(PhD) - 4-5 yrs

200overseas

46 Completed PhDs

Nurturing & Developing Human Capital695 Potential and Completed PhDs

IF

Correct as at 25 July 2007•Of which, 70 BS and 1 MBBS are NSFs.

755

Completed

History | KBE | Biomed | S&E | Talent | Enterprise

Page 62: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Ng San San,

Susanne

Yar Kar Peo

KeefeChng

Ho Ying Swan

WongEeTsin

Yeo Yong Kee

Zhang Rui

Completed PhDsCompleted PhDs

ChowKeat

Theng

Andrea Pillai

Amanda Chan

CleoChoong

Chit Fang

Cheok

AnweshaDey

AndrewWan

Loo Li

Shen

Ang Hwee Ching

Andrew Ang

Gary Ng

Sum Huan

Leong Li

Ming

Yeo Sze Ling

Leong Siang Huei

Ng Kee Woei

Yuen Chau

Tng Hui Ching, Emilia

Foo Yong Lim

Ho HanKiat

Koh Kian Peng

LimChinYan

Low Yen Ling

Ng Sean Pin

Ng Ching Ging

Chua YangChoo

ChanKok

Ping

Teo Hsiang

Ling

TracyHo

Max Fun

Quek Su Ying

Wee Boon Yu

BiomedicalSciences

(30)

Science &Engineering

(16)

As of July 07

ChawKwanChun

Page 63: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Even More to Return with PhDsEven More to Return with PhDs

• 33 Completed PhDs returned in 2005-06.• 59 projected to return in 2007, of which 13 have already been deployed.• 80 projected to return annually on average from 2011.

Correct as at 1 August 2007Based on reaching annual scholarship targets up to 2010, and 10% attrition rate of NSS(BS) moving onto to PhD

Projected No. of Returning PhD Scholars

11

22

5965

3542

89

107

125120

135

82

55 54 54

27 27

0

20

40

60

80

100

120

140

160

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021

Page 64: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

LOCAL ENTERPRISE

DEVELOPMENT

R&D

Intellectual Property

Sustainable Vibrant

EconomyHistory | KBE | Biomed | S&E | Talent | Enterprise

Page 65: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Small & Medium Enterprises (SMEs) • 46% of GDP and 63% of employment

• Local SMEs: 25% of GDP and 51% of employment

• Small is NOT Beautiful. Few small enterprises survive in the long term

• Elephants can Dance

• Challenges:

How to sustain broad-based economic growth? How to encourage Innovation and Creativity?

History | KBE | Biomed | S&E | Talent | Enterprise

Page 66: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Contribution of Local SMEs (2005)

5

3.8

8.9

0

2

4

6

8

10

Manufacturing (Local SMEs)

percent

Note: SMEs are defined as enterprises with 30% or more local equity ownership, with net fixed assets investment of $15mil or less for manufacturing industries, and enterprises with 200 or less employees for service industries.

• Share of Enterprises • Contribution to GDP • Contribution to Employment

Local SMEs

90.8%

25.4%

51.0%

Foreign SMEs

8.6%

20.5%

11.5%

All SMEs

99.4%

45.9%

62.5%

Enterprises

Value Added

Employment75.1

19

34.8

0

20

40

60

80

Services (Local SMEs)

percent percent10.7

2.6

7.3

0

2

4

6

8

10

12

Others (Local SMEs)

History | KBE | Biomed | S&E | Talent | Enterprise

Page 67: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Number of Local Enterprises in Manufacturing & Services Sectors

Industry-led:

LEAD Prog

with industry associations

Source: EDB & DOS; excluded NPOs

Notes: ^ Figures are SPRING’s estimates

+ This group of enterprises meet the SMEs’ definitions and are eligible for SME incentives

* Excludes local SMEs in Construction, Utilities, Agriculture and Fishing (approx. 15,600 in 2005)

48,526

91^

48,435

163^

412^

575

824^

5,125^

5,949

41,911

SPRING’s Verticals

119,70141,289112,5177,1467,184Sub-total (<$50m):

55279^4648488 $25m - <$50m

1,562143^1,281269281 $10m - <$25m

46826^4006568 $50m & aboveLarge+

2,1142221,745353369$10m - <$50m

Medium

41,315

392^

3,346^

3,738

37,329

SPRING’s Verticals

112,917

2,001

12,765

14,766

96,006

All Ind.

Local Services SMEs (2004)

120,169

2,438

14,554

16,992

100,595

All Ind*.

TotalLocal Manufacturing SMEs (2005)

Sales RevenueSize of

Enterprises

7,252

437

1,789

2,226

4,589

All Ind.

2,211 $1m - <$10m

7,211Total: 

432 $5m - <$10m

1,779 $1m - <$5mSmall

4,582 < $1mMicro

SPRING’s Verticals

Broad-based:

EnterpriseOne

with chambers

& major associations

Focused Support for

Growth Enterprises

~ 100,000 micro-sized enterprises; 20,000 Small & Medium-Sized Enterprises

Page 68: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

“EVERY GREAT OAK TREE STARTED AS A DETERMINED ACORN”

Oak Trees

Acorn

TO HAVE A FOREST OF OAK TREES, WE

NEED TO SEED MANY (SURVIVING) ACORNS!

History | KBE | Biomed | S&E | Talent | Enterprise

Page 69: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Young ACORNs – “New Enterprises,

Start-ups”

Nurturing, Grooming –

“Work of economic agencies”

Oak Trees – “Future economic prosperity”

“Economic Decline”

History | KBE | Biomed | S&E | Talent | Enterprise

LIFE

DEATH

BIRTH

An acorn that does not grow up is a dead acorn !

Page 70: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

The Economy is a dynamic Pyramid

Global Enterprises

Large Enterprises(output > $50 million)

Medium Enterprises (output < $50 million)

Small Enterprises (includes young start-ups)

History | KBE | Biomed | S&E | Talent | Enterprise

Page 71: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

What Small and Medium Enterprises (SMEs) need ?

Know How/What

Management

Global Enterprises

Large Enterprises(output > $50 million)

Medium Enterprises (output < $50 million)

Small Enterprises (includes young start-ups)

Money

Markets

History | KBE | Biomed | S&E | Talent | Enterprise

Page 72: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Management

Partner MAS and Financial Institutions

to enhance SMEs’ access to financing

Money

Partner IE and EDB to increase

overseas market access

Markets

Know-how / Know-what

Partner Universities to upgrade management competence

Partner A*STAR, Universities and Polytechnics to help companies acquire & adopt technologies to

innovate and grow

The 3MK Strategy

History | KBE | Biomed | S&E | Talent | Enterprise

Page 73: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Guiding principles1) Private sector is primary source of funds2) Government plays catalytic role where there are gaps3) Involve private sector partners

Enhance SME Financing

Review Regulations

Educate and

Raise Awareness

Provide Complementary

Sources of Financing

$ $ $ for SMEs

Page 74: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Improve Access to Overseas Markets

Facilitate access to Global marketsFacilitate access to Global markets

Link SMEs to MNCs and foreign SMEsLink SMEs to MNCs and foreign SMEs

Provide Export Technical Assistance Provide Export Technical Assistance History | KBE | Biomed | S&E | Talent | Enterprise

Page 75: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Enhancing Know-how / Know-what

• Research Institutes• Universities• Polytechnics• Technology service providers

SMEs

• Catalyze projects• Promote awareness• Partial funding

SPRING

•IES•EDB

Technology Innovation Programme (August 2007) $150m over 5 years to help local SMEs compete on technology, not just cost.

SMEs can tap on knowledge centres to innovate

• Individual companies• Consortia• Industry

Knowledge Centres

History | KBE | Biomed | S&E | Talent | Enterprise

A*STAR

Page 76: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Upgrade Management Skills

• Co-fund and train 1,000 SME CEOs and Managers over 5 years

• Funded local Universities to develop curriculum for

SMEs

• EMBA and Executive Development courses

History | KBE | Biomed | S&E | Talent | Enterprise

Management Development Programme (April 2007)

Page 77: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

3G – Grow, Glow and Globalise

Global Enterprises

Large Enterprises(output > $50 million)

Medium Enterprises (output < $50 million)

Small Enterprises (includes young start-ups)

SPRING

- Enterprise development

A*STAR

- Generating Know How

- Attracting Whales (Talent)

EDB

- Attracting Overseas Investments

IE Singapore

- Oversee Markets Access

History | KBE | Biomed | S&E | Talent | Enterprise

Page 78: A Knowledge Based Economy (KBE) * Money, Time and Talent ! History | KBE | Biomed | S&E | Talent | Enterprise Building

Key Challenges for Singapore

• Face Global Competition

History | KBE | Biomed | S&E | Talent | Enterprise

• Transit from Manufacturing to “know-how”, a Knowledge Based Economy (KBE)

• Nurture an Enterprise culture: - Passion (risk taking)- Determination (hard work)- Vision (Global)- Focus (Operational)