alzheimers
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About A.D.
Chronic dysfunction of cortical and sub-cortical areas in
the brain
A.D. – Fourth leading cause of death in developed countries
A.D. affects > 12 million worldwide
> 4 million in U.S.
Expenses – health care costs > 80 billion / year
PPRC/INDIA 05
A.D. ResearchDevelopment of promising Drugs
From natural source:
1. Terrestrial plants
2. Marine organisms
3. Micro organisms
4. Animal venoms
PPRC/INDIA 09
Lycopodium serratum Thunb. “Qin Ta”
Chemical: huperzine A, α-onocerin
Family: Lycopodiaceae
PPRC/INDIA 14
Caragana chamlague
Chemical: stilbene oligoneers,(+)-α-viniferin,
kobophenol
Family: Fabaceae
PPRC/INDIA 35
Centella asiatica
Chemical: bornyl acetate, α-pinene,
β-pinene,γ- terpinene
Family: Apiaceae
PPRC/INDIA 38
Marine sponge - Reniera sarai
Chemical: 3-alkyl pyridinium polymer type
compounds, parazoanthoxanthin A
PPRC/INDIA 42
Monomorium minumum (Ant)
Chemical: 2,5-dialkylpyrrolidines
– alkaloidal tyoe of compound
PPRC/INDIA 61