big data visualizationbigdata.citytech.cuny.edu/bd_media/2018/06/bbd-week-2018...biomedical big data...

Alexandros Sigaras | @AlexSigarasResearch Associate in Computational BiomedicineWeill Cornell Medicine

Sophia Roshal | @RoshalSophiaSoftware Engineer InternWeill Cornell Medicine

Biomedical Big Data Week We’ll Cornell Medicine

6.20.2018

Big Data VisualizationMixed Reality, Virtual Reality & Augmented Reality

Source: EMC & IDC“The Digital Universe. Driving Data Growth in Healthcare”

https://www.emc.com/analyst-report/digital-universe-healthcare-vertical-report-ar.pdf

Healthcare & Big DataToday

Healthcare & Big Data2025 Predictions

Astronomy Twitter Youtube Genomics

Acquisition 25zetta-bytes/year

0.5–15billion

tweets/year

500–900 million

hours/year

1zetta-

bases/year

Storage 1EB/year

1–17PB/year

1–2EB/year

2–40EB/year

Source: NIH“Big Data: Astronomical or Genomical Zachary Stephens et al.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494865/

Source: NIHhttps://www.genome.gov/sequencingcosts/

Cost per Genome

“My hope is that this becomes the foundation,the architecture,

whereby in 10 years fromnow we can look back

and say that we haverevolutionized

medicine.”

Precision Medicine InitiativeBudget

$130MF Y 1 6 E N A C T E D F Y 1 7 P R E S I D E N T ’ S

R E Q U E S T

$230M

Precision Medicine InitiativeRegional Medical Centers across USA

• Able to enroll diverse patient populations

• Strong electronic health record capacity

• Geographic spread

• Capacity to enroll 35,000 a year

Northwestern UniversityInstitute for Public Health and MedicineEvanston, IL

Universityof PittsburghClinical and Translational

Science Institute

Pittsburgh, PA

Universityof ArizonaCollege of Medicine

& Public Health

Tucson, AZ

Columbia/Cornell/NYP/Harlem HospitalInstitute for Genomic

Medicine

New York, NY

Universityof CaliforniaSan DiegoDepartment of Biomedical InformaticsLa Jolla, CA

Massachusetts General HospitalGenetics & Genomics Unit

Boston, MA

Henry FordHealth SystemPublic Health Sciences

Detroit, MI

GeisingerHealth SystemGenomic Medicine Institute

Danville, PA

Precision Medicine InitiativeNYC

Cancer MoonshotState of the Union | January 2016

21st Century Cures Act SignedDecember 13th 2016

https://www.whitehouse.gov/CancerMoonshot

Mission

Weill Cornell MedicineMission

Care

TeachDiscover

The New style of tailored treatment

http://meyercancer.weill.cornell.edu/news/2015-01-22/new-style-tailored-treatment

Irene Price | 76y Female

• 2009 | Diagnosed with Bladder Cancer; initially followed traditional treatment showing signs of success

• Relapse | High-grade urothelial carcinoma in bladder and several lymph nodes

• Cystectomy (Bladder removal), sample sent for Genetic Analysis (WES)

• Underwent Radiation Therapy, Genetic Analysis Results showed HER2 Amplification (mutation common in breast cancer)

• Relapse | Signs of metastasis to the liver• Chemotherapy targeted treatment | 8 cycles with

Taxol and Herceptin• Disease free since Nov 2014

Medical History

NGS Test Workflow

15

Orders Test Receives Report

Patient

Referring Physician

2000 Cores2PB Storage

Institute for Computational Biomedicine

Today

*source: ipm-cbio.med.cornell.edu

https://youtu.be/_Fly4U9eFRY

*credits: Lucas Films

Star WarsEpisode V – The Empire Strikes Back (1980)

*credits: Microsoft Researchhttps://www.microsoft.com/en-us/research/project/holoportation-3/

Video: https://youtu.be/7d59O6cfaM0

Microsoft HololensHoloportation

*credits: Case Western Reserve University

Microsoft HololensHealthcare

*credits: Case Western Reserve University

Microsoft HololensHealthcare

Reality-VirtualityContinuum

Milgram, Paul; H. Takemura; A. Utsumi; F. Kishino (1994). "Augmented Reality: A class of displays on the reality-virtuality continuum"

PhysicalReality (PR)

VirtualReality (VR)

AugmentedReality (AR)

AugmentedVirtuality (AV)

Mixed Reality (MR)

Gaze VoiceGesture

Ways to Interact

Visualizing Protein Structures

Visualizing Networks

Source: http://www.creativeapplications.net/linux/gephi-mac-windows-linux/

Visualizing Cancer Drug Networks

Data: Kaitlyn Gayvert

Bringing Networksinto Reality

https://youtu.be/Yu3Vxy6lQwg

Tumor BoardUsing Hololens across the world

https://youtu.be/O99CMi2ahD0

Demos

Minority Report

Release Date: June 21 2002

John Underkoffler

https://www.ted.com/talks/john_underkoffler_drive_3d_data_with_a_gesture

HealthcareLooking into the future

https://youtu.be/ZhAzqaV-lQk

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