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Power of the Mindin Health and Healing
Keith R. Holden, M.D.Accordo Health Institute 2014 Spring Symposium
www.Dr-Holden.com
Mindfulness Meditation
Mindfulness Meditation
• Attention in the present moment without judgment
Mindfulness Meditation
• Attention in the present moment without judgment
• Watch, Witness, and Allow
Relaxation & Epigenetics
• Controls oxidative stress
• Improves mitochondrial energy production
• Improves insulin production
• Reduces inflammation
• Improves telomere stability
Mindfulness Meditation -Anti-Inflammatory
• An intensive day of MM acts as an anti-inflammatory in EM
• Mechanism similar to NSAID
• Subset had faster cortisol recovery after social stress test
Mindfulness Meditation- Anti-Inflammatory
• Dusek et al., 2008
• Bhasin et al., 2013
• Creswell et al., 2012
• Black et al., 2013
Mindfulness meditation turns off NFKB
What is the Placebo Effect?
Placebo Effect
• Psychobiological phenomenon
• Starts in the brain
• Results in clinical improvement
• Ritual of therapeutic act
Ritual of Therapeutic Act
Benedetti, F. (2012) Physiological Reviews, 93: 1207-46
Benedetti et al (2011) Neuropsychopharmacology Reviews, 36: 339-354
Placebo Neurotransmitters
• Opiods
• Cholesytokinin
• Cannabinoids
• Dopamine
Placebo Pain Relief
• Dorsolateral prefrontal cortex
• Anterior cingulate cortex
• Hypothalamus
• Amygdala
• Periaqueductal grey
• Thalamus
• Insula
Placebo Immune Response
• Placebo conditioning of immune response
• Flavored drink assoc. with cyclosporin A
• Flavored drink suppressed immune function
Goebel at al. (2002) FASEB Journal, 16(14): 1869-73
Parkinson’s Disease
de la Fuente-Fernandez et al. (2001) Science 293: 1164-6
Placebo Mirrors Drugs
• Analgesics morphine and ketorolac
• Immunosuppresant cyclosporin A
• DA agonist apomorphine
• BZD receptor agonist midazolam
• BZD receptor antagonist flumazenil
Placebo Effect Quantified
• 66 participants - 6 migraine attacks
• Received either placebo or Maxalt 10mg
• Label: placebo, Maxalt or placebo, Maxalt
• Progressive boost w/ labeling
Mind-Body Connection
• Mindfulness
• Meditation
• Relaxation Response
• Placebo Effect - Power of Belief
The Future
• Placebo research will prove belief is a powerful epigenetic influencer .
• Healthcare will adopt placebo therapy.
• Mind-body programs will become the standard of care.
• Will become apparent the entire body is conscious down to our DNA.
Power of the Mindin Health and Healing
Keith R. Holden, M.D.Accordo Health Institute 2014 Spring Symposium
www.Dr-Holden.com
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