analysis group, inc. · analysis group, inc. health ... hta/reimbursement submission: cea, bia,...
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BOSTON CHICAGO DALLAS DENVER LOS ANGELES MENLO PARK MONTREAL NEW YORK SAN FRANCISCO WASHINGTON
Analysis Group, Inc. Health Economics, Outcomes Research, and Epidemiology Practice Areas
September 13, 2012
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Analysis Group is the largest privately held economic consulting firm in North America
Our clients include major law firms, Fortune 100 companies, and government agencies
We have been growing steadily since our launch over 30 years ago and now have 10 offices in the U.S. and Canada
Our firm has over 500 professionals, many with graduate degrees in economics, finance, accounting, management, or law
We have been ranked as one of the top ten consulting firms by Vault for the past three years
We have been named one of the ‘Top Places to Work’ in Massachusetts by The Boston Globe for the past four years
A Snapshot of Our Firm
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Interdisciplinary team with expertise in: Health economics General economics Econometrics Biostatistics Epidemiology Pharmacy Medicine Finance Business Administration Accounting
Our Professional Team
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Over 120 health care specialists with advanced degrees: PhD, PharmD, MD, and ScD
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Pharmaceutical manufacturers
Medical device manufacturers
Drug delivery companies
Biotechnology companies
Payers (insurers, employers)
General and specialty hospitals, integrated delivery networks, joint ventures, and physician practices
Equipment and medical product companies
State and federal government
Our Clients
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Our Integrated Approach to Health Care
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COMMERCIAL RESULTS
Brand strategy and positioning
Market analysis and segmentation
Global pricing and reimbursement
Managed care contracting Competitive assessment Lifecycle and patent expiry
management strategy
SCIENTIFIC OUTCOMES
R&D health care economics Health outcomes and cost-
effectiveness Econometrics Public/regulatory hearings Epidemiology and
biostatistics Clinical trials optimization
BUSINESS DIRECTION
Therapeutic area selection and strategy
Product portfolio optimization Partnering, licensing,
outsourcing, acquisitions Organizational structuring to
achieve growth Technology and
commercialization assessment
LITIGATION Intellectual property Antitrust Product fraud Off-label investigations General commercial
business litigation Contract disputes
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Selected AG Health Care Studies in the News Votrient February 22, 2011 AG epidemiologists and Harvard affiliates used novel statistical methods to assess survival data for economic models demonstrating Votrient’s cost-effectiveness. NICE issued a positive Final Appraisal Determination for Votrient as a first-line treatment for advanced or metastatic renal cell carcinoma.
May 2, 2007 When the maker of the blockbuster antidepressant Celexa was threatened with safety concerns and additional black box warnings by the U.S. FDA, AG epidemiologists helped demonstrate that the drug was no less safe than class competitors and averted differential labeling.
Humira June 2008 AG pharmacoeconomists provided the maker of Humira with pivotal support in modeling and developing health economic submission packages for commercial and national payers. NICE has recommended Humira and not competing TNFs in certain indications.
Celexa
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Our Research Generates Timely and Impactful Scientific Evidence
Gaps in Scientific Research
Decision Maker Needs
Client Needs
Innovative research
Cutting-edge health data
World-class analytics
Academic thought leaders
Publications
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Analysis Group Assists Health Care Clients with HEOR Challenges Over the Product Life Cycle
Early stage modeling and GAP analysis
Personalized medicine analysis to help refocus clinical trial
Increase awareness of diseases (e.g., prevalence, burden of illness)
Identify, design, and validate appropriate PRO instrument
Treatment patterns of conventional therapy (adherence, dose escalation)
Drug safety
Limitations of standard care and competitors (unmet needs)
Demonstrate product value relative to conventional therapy
Cost of illness studies
HTA/reimbursement submission: CEA, BIA, Dossier
Treatment pattern and adherence
Support market expansion (burden of under-treatment, delayed treatment and delayed diagnosis)
Identify the patient subgroup populations who most likely to benefit from a given treatment
Discovery and Development
Product Approval and
Launch
Post-Launch Optimization
Patent Expiry and Late Life
Cycle
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Examples of Our Work:
Matching-Adjusted Indirect Comparisons
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Health care decision makers face choices among a growing number of alternative treatments
Policy makers recognize the importance of strengthening the evidence base for medical decisions (e.g., renewed U.S. public investment in CER)
Comparative evidence is valuable, but difficult to obtain
Head-to-head randomized trials provide the gold standard, but are not always available, especially for new drugs
A costly gap can result if treatment decisions and product strategies are developed without accounting for true product superiorities
Indirect Comparisons in Comparative Effectiveness Research
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Indirect comparisons help to fill such gaps
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Make a fair and credible comparison Need to adjust for differences between trials
Provide timely results Need to inform decisions as they are made; can’t wait for more
data
Draw robust conclusions Use all available clinical trial data Appreciated by payers
Goals of Indirect Comparison
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Inclusion/exclusion criteria for comparator trial need to be equivalent to or nested within the inclusion criteria for the IPD trial
Step 1: Study and Sample Selection
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A vs. placebo (IPD available) B vs. placebo (published trial)
Increasing Disease Severity Increasing Disease Severity
Incr
easi
ng A
ge
Incr
easi
ng A
ge
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Inclusion/exclusion criteria for the published comparator trial can then be imposed on the IPD to create comparable populations
Step 1: Study and Sample Selection
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A vs. placebo (IPD available) B vs. placebo (published trial)
Increasing Disease Severity Increasing Disease Severity
Incr
easi
ng A
ge
Incr
easi
ng A
ge
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Using robust statistical methodology, patients in Trial A can be re-weighted to match the baseline characteristics of those in Trial B
Step 2: Reweighting Patients
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0
10
20
30
40
50
60
Males Females
%
010203040506070
Males Females
%
010203040506070
Males Females
%
Increase weight for females relative to males
Trial of A vs. placebo Trial of B vs. placebo Re-weighted Trial of A vs. placebo
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Results: Comparison of Outcomes between Matched Trials
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Our drug’s efficacy after matching
Competitor drug’s published efficacy
Balanced placebo-arm efficacy from our trial (after matching) and the competitor’s trial (as published)
P < 0.001
Mea
n Im
prov
emen
t in
Sym
ptom
s
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Examples of Our Work:
Personalized Medicine
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Comparative Effectiveness Research (CER): “What treatment works best for which patient population?”
Traditional CER: Given a patient population, find the treatment that works best Individualized CER: Given a treatment, find the patient population for whom it works best
Personalized Medicine
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Any subpopulation involves a tradeoff between two goals Payers do not systematically consider this tradeoff when designing access
restrictions The optimal subpopulation is the largest subpopulation in which the value
proposition is acceptable to payers
Identification of Optimal Patient Subpopulations
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Maximize value proposition Payers want to get the most value while limiting costs
Maximize market size We want to access the largest market consistent with labeling
How can we identify this optimal subpopulation?
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In the full trial population, 21% more patients achieve response with active drug vs. placebo
Identification of Optimal Patient Subpopulations
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0 10 20 30 40 50 60 70 80 90
100
20 40 60 80 100
E
ffica
cy
Subpopulation Size
All Patients
Hypothetical data
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Subpopulations defined by specific patient characteristics may show greater efficacy but may have limited market potential
Identification of Optimal Patient Subpopulations
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0 10 20 30 40 50 60 70 80 90
100
20 40 60 80 100
E
ffica
cy
Subpopulation Size
All Patients
≥ 2 prior therapies Age < 50
Weight < 100 kg
Hypothetical data
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By combining multiple patient characteristics, the personalized medicine approach identifies the largest market size at any level of efficiency (the efficiency frontier)
Identification of Optimal Patient Subpopulations
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0 10 20 30 40 50 60 70 80 90
100
20 40 60 80 100
Ef
ficac
y
Subpopulation Size
All Patients
≥ 2 prior therapies Age < 50
Weight < 100 kg
Efficiency Frontier
Hypothetical data
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Examples of Our Work:
Drug Adherence
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Impact of Non-Adherence to Anti-Epileptic Drugs on Health Care Utilization Resources and Mortality
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Source: Duh MS, et al., ISPOR 2008; Duh MS, et al., ISPE 2008.
1.39
1.76
1.19
3.32
0.93
0
0.5
1
1.5
2
2.5
3
3.5
Hospitalizations Inpatient Days EmergencyRoom Visits
Outpatient Visits Mortality
Inci
denc
e Ra
te R
atio
Haza
rd R
atio
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Examples of Our Work:
Cost of Illness Studies
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Annual Costs per ADHD Patient and Non-ADHD Family Member
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$0
$1,000
$2,000
$3,000
Control Patients ADHD Patients Family Members inControl Family
Sample
Non-ADHD FamilyMembers in ADHD
Family Sample
Cos
t per
Yea
r
Hospital Outpatient Prescription Drug Hospital Inpatient Provider's Office Work Loss Other
$541
$1,574 $1,289
$2,495
ADHD Patients Non-ADHD Family Members
Source: Swensen A, Birnbaum H, et al., J Am Acad Child Adoles Psychiatry 2003; 42(12) 1415-1423.
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Your Career at Analysis Group
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Career advancement is based on individual contributions in distinct areas:
Career progression reflects:
Casework
Project Management
Business Development
Teamwork
Overall contribution to the firm
Your Career Path - Positions
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Analyst Senior Analyst Associate Manager Vice
President Managing Principal
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Ability to work across practice areas
Exposure to different industries and areas of expertise
A supportive environment where you will grow professionally:
Advisors and peer-mentors
Flexible case assignments
Collaborative/open-door policy
Lack of hierarchy
Highly motivated, highly skilled colleagues
Work closely with managing principals and academic affiliates; interact directly with clients
What Can You Expect as an Associate at Analysis Group?
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Advanced degree in quantitative sciences, such as health economics, biostatistics, econometrics, statistics, epidemiology, psychometrics
Outstanding track record of applying quantitative methods to real-world research problems, preferably in health care research
Proficiency in at least one statistical programming language (e.g., SAS, R, S-PLUS)
Excellent organizational and communication skills
Comfortable interacting with clients and key opinion leaders
Ability to work independently and with a team
An Ideal Candidate
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Interest in health economics, outcomes research, and epidemiology
Your academic experience and career goals
Industry experience or specialized expertise
Data-driven papers or projects you’ve worked on
Analytical and technical skills; conceptual capabilities
Communication skills and teamwork experiences
Displays of leadership
Your Interview: What We Want to Know About You
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Analysis Group, Inc. is currently conducting a resume drop for Johns Hopkins Bloomberg School of Public Health students. Resume Submission Deadline: Monday, October 15, 2012
Please submit your resume, unofficial transcript and a cover letter indicating geographic preference(s) through the Career Services office and the Analysis Group, Inc. website: www.analysisgroup.com/open_positions. In order to be considered, you MUST list Career Services/Job Posting in the source field. For more information about Analysis Group, please visit our website at www.analysisgroup.com
Application Information
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