antinfek 10h

Total Renewable, Sustainable Organic Solutions to the Global Energy, Water & Environment 03/08/2009 WWW.DOVEBIOTECH.COM Page 1 of 18

LEADER IN ORGANIC BIOTECHNOLOGY

ANTINFEK™ 10H ORGANIC WATER TREATMENT & DISINFECTANT

TABLE OF CONTENTS

Section Description Page

1.0 PRODUCT DESCRIPTION…...……………………………………….... 2

2.0 PRODUCT ADVANTAGES…...……………………………………….... 3

3.0 SUGGESTED APPLICATION & DOSAGE OF ANTINFEK™ 10H .. 5

4.0 MEASURING THE ANTINFEK™ 10H CONCENTRATION IN THE WATER ………………………………………………………....

6

5.0 HOW ANTINFEK™ 10H DESTROYS BACTERIA..……………….... 6

6.0 EXAMPLES AND DESCRIPTIONS OF WATER BORNE

DISEASES THAT ANTINFEK™ 10H DESTROYS …………………

9

7.0 EXAMPLE OF GRAM + VE BACTERIA, WHICH ANTINFEK™ 10H DESTROYS ………………………….......

10

8.0 EXAMPLE OF GRAM - VE BACTERIA,

WHICH ANTINFEK™ 10H DESTROYS ………………………….......

11

9.0 EXAMPLES OF FUNGI, WHICH ANTINFEK™ 10H DESTROYS ………………………….......

11

10.0 MATERIAL SAFETY DATA SHEET (MSDS)

OF ANTINFEK™ 10H ……………………………………………...........

12

11.0 GLOSSARY …………………………………..………………………….. 16




** A BREAKTHROUGH IN WATER TREATMENT AND DISINFECTANTS ** 1.0 PRODUCT DESCRIPTION ANTINFEK™ 10H is a powerful Organic Bio-Polymer based solution, with no side effects to humans, animals, and the environment. ANTNFEK™ 10H is the most efficient and effective disinfecton for the treatment and decontamination of water and complete destruction of waterborne diseases, bacteria, fungi, mold, mildew, algae and dust-mites on contact.

A) Waterborne diseases such as Cholera, Hepatitis, Typhoid, Dysentery, Glardia, etc. B) Bacteria (GRAM + VE) and (GRAM – VE) such as Lactobacillus Brevis, Bacillus

Subtillis, MRSA, Streptococcus Faecium, Streptococcus Lactis, Staphylococcus Aureus, Staphylococcus Albus, Staphylococcus Epidermidis, Enterobacter Cloacae, Escherichia Coli, Pseudomonas Aeruginosa, Klebsiella Pneumoniae, Salmonella Typhimurium, Proteus Vulgaris, Pseudomonas Aeruginosa, Pseudomonas Putida, Serratia Marcescens, Antrax etc.

C) Fungi such as Aureobasidium Pullulans, Aspergillus Niger, Trichophyton Mentagrophytes,

Rhizopus Stolonifer, Chaetomium Globosum, Saccharomyces Serevisiae, Candida Albicans, Mycrosporum Ferrugineum, Trichophyton Crateriform, Trichoderma Virige, Epidermaphiton Rubrum, Mold Fungi, etc.

ANTINFEK™ 10H with a simple application and instant results is added to the drinking and natural, city water, swimming pools, spas, hot tubs, river water, underground water, industrial sewage water after treatment of heavy solids, equipment cooling systems, open-ended heat-supply system hot water and pipeline, as well as medical decontamination and disinfection of potable water, household cleaning and washing, child care, public catering, and food industry facilities. ANTINFEK™ 10H meets the strictest environmental, safety and durability requirements without changing decontamination technology or existing equipment, and is also capable of replacing the existing chemical reagents such as Chlorines, Industrial Antiseptics, Bleaches and Hydrochlorides in any environment. The basis of ANTINFEK™ 10H compound is organic polymers – well water-soluble bactericidal Polyelectrolyte based on Guanidine compounds which kills both gram-positive and gram-negative bacteria, and broad spectrum virucide. ANTINFEK™ 10H active components consist of Polyhexamethylene Biguanidine Hydrochloride 14% and 85% of distilled water. ANTINFEK™ 10H is the only organic product, develop exclusively by DOVE BIOTECH CO., LTD. which is FDA approved (THAI. FDA license no. A40288282) and THAI. FDA registration no. 810/2547) with total protection from waterborne diseases, pathogenic bacteria, Gram + VE and Gram – VE and Fungi. ANTINFEK™ 10H active biocide is non-toxic in diluted form and it is extremely environment friendly, containing no arsenics, heavy metals, halogens, phenolics, formaldehydes, and insecticides. Significant characteristics of ANTINFEK™ 10H compounds are increased levels of Log Kill (~3) and large surface area (particle size in microns), which enhances its effectiveness against a myriad of harmful microorganisms, mold and mildew.




2.0 PRODUCT ADVANTAGES

A) Chlorine based disinfectants are highly toxic. Chlorine is used in human contact environments in very small dosages due to its high toxicity, however even in small dosages it can still have a cumulative effect and result in side effects on human health after extended exposure. Every year overdose of chlorine results in thousands of deaths around the world. ANTINFEK™ 10H in diluted form has no side effects on human, aquatic organism and the environment.

B) Chlorine is only effective against a few waterborne diseases, whereas ANTINFEK™ 10H

destroys all waterborne diseases, bacteria, and fungi instantly and on contact, with 100% decontamination results.

C) ANTINFEK™ 10H’s cost is only a fraction of the cost of Chlorine, which makes

ANTINFEK™ 10H the most economical decontamination agent in the market. D) Chlorine treated water contains a heavy smell, while ANTINFEK™ 10H treated water has

no smell. E) Chlorine treated pool water affects eyes, skin, hair, and creates irritation; while water treated

with ANTINFEK™ 10H has no side effects, creates no discomfort to the eyes neither skin irritation.

F) ANTINFEK™ 10H prevents the growth of Algae in water. It is extremely effective against

green, black, and mustard Algae. G) Chlorine evaporates rapidly from water and therefore the protection level in the water varies

throughout the day and requires continuous daily addition of Chlorine. Even with these daily additions, bacteria levels fluctuate greatly, while ANTINFEK™ 10H offers consistent and long lasting protection. With just one application of ANTINFEK™ 10H, the bacteria levels are controlled for as long as 15 - 20 days.

H) In addition to its lower costs, ANTINFEK™ 10H also requires much lower dosage than

Chlorine and other chemical agents, Compared with Chlorine, the require dosage of ANTINFEK™ 10H is about 12 times lower.

I) While Chlorine is very oxidizing and creates corrosion of pipes and equipment,

ANTINFEK™ 10H is NOT-CORROSIVE. Therefore the use of ANTINFEK™ 10H leads to extensive savings and maintenance costs. Further more the shipping, storing and handling of ANTINFEK™ 10H does not require any precautions due to its lack of toxicity and explosion risk.




EFFECTIVE DOSAGING SCHEDULES OF ANTINFEK™ VS CHLORINE

DISINIFICANT AGENT

DOSING RATE

(STAGE#1)

DOSING RATE

(STAGE#2)

EFFECTIVE LIFE OF AGENT

PATHOGENIC EFFICIENCY

CREATES THM

ANTINFEK™ 10H 0.4 mg/Liter NIL 20 Days 100% None

CHLORINE 4.5 mg/Liter 1.5 mg/Liter 8 – 24 Hours 90% Yes

J) The active ingredient of ANTINFEK™ 10H can be processed in temperatures of up to 200º C (392 Fahrenheit) without losing its effectiveness and with no harm to human beings, while Chlorine in hot showers and hot baths evaporates rapidly and creates toxic Chloroform Gas. It also can spread through the house and be inhaled by others. According to research conducted in the United States and presented to the American Chemical Association as well as numerous research projects conducted by other scientists, it was determined that house-holds can receive 6 to 100 times more of the chemical (Chlorine, etc.), by simply breathing the air around showers and hot baths than if they would drink the water.

K) ANTINFEK™ 10H bactericidal efficiency was tested against chlorine and sodium

hydrochloride in compliance with International Sanitary Regulations. The effect of river water decontamination was observed at the compound dose of 0.4 mg/l, and the virtually complete 100% inactivation of such microorganisms as HPC, GCB (General Coliform Bacteria), TCB (Thermo Tolerant Coliform Bacteria), Staphylococcus, Salmonella, Cali Protobes, Pseudomonas Aeruginosage, Sulfite reducing Clostridial Bacteria occurred at the compound dose of 0.4 mg/l, wherein the required decontamination level with the use of chlorine is attained at 4.5 mg/l and with the use of sodium hydrochloride is observed at 2 – 2.5 mg/l.

L) Disinfection by-products are created when chlorine reacts with natural substances in water. Some disinfection by-products are suspected of harming human health by causing cancer or adverse reproductive effects. Scientists are studying this suspected link. While they conduct their research, water treatment agencies are continuing to reduce disinfection by-products in our water to the lowest level possible and looking at organic alternatives such as ANTINFEK™ 10H.

Since the discovery of Trihalomethanes (THMs) in 1974, drinking-water professionals have recognized the need to modify traditional chlorine disinfection practices in response to new knowledge about the formation of these chemicals. THM (four closely related chemical compounds) are formed when chlorine is added to water from reservoirs containing naturally occurring matter, such as leaf and plant debris. In 1979 an international standard was adopted requiring that THMs in tap water be less than 0.100 ppm, based on a running annual average. In November 1998, US and European governments proposed new regulations that will the running annual average standard to 0.080 ppm, and today it is lowered even further, a strategy has also been endorsed by the World Health Organization.




In changing the THM standard, the WHO has recognized the need to weigh the lifetime risk of cancer caused by disinfection by-products against the risk of disease caused by waterborne microbes. One way to reduce exposure to disinfection by-products would be to lower the amount of chlorine used for disinfection, but that is likely to increase the potential for waterborne disease. Therefore international health agencies are working at finding the right level of disinfection, in order to control waterborne pathogens, while minimizing the lifetime risk of cancer caused by the use of an organic agent such as ANTINFEK™ 10H.

3.0 SUGGESTED APPLICATION & DOSAGE OF ANTINFEK™ 10H ANTINFEK™ 10H can be simply substituted for Chlorine, industrial antiseptics and bleaches in any environment. No special equipment or system modifications need to be made, where the dosage is issued in liquid form. ANTINFEK™ 10H has no smell, and is non-toxic.

A) In the case of potable water, where the possibility of waterborne-diseases exists, mix 0.2 mg of ANTINFEK™ 10H per 1 liter of raw water to be purified. The dosage rate of 1 liter (0.264 GAL) of ANTINFEK™ 10H can treat 5,000,000 Liters (1,321,004 GAL) of water.

B) In the case of waste water or water that has passed through a solid filtration, mix 0.4 mg of

ANTINFEK™ 10H per 1 liter of raw water to be purified. The dosage rate of 1 liter (0.264 GAL) of ANTINFEK™ 10H can treat 2,500,000 liters (660,520 GAL) of water.

ANTINFEKTM 10H Dosing

Contaminated Source Water

Equalization Tank Purified Water Out

Both Tank Dimensions: Width = 2.5m Height = 2.8m Length = 2.5m

DOVE BIOTECH ORGANIC FILTER

Static Filter Screens

PH

PH

Mixer




4.0 MEASURING THE ANTINFEK™ 10H CONCENTRATION IN THE WATER To measure the remaining concentration of ANTINFEK™ 10H in the treated water, DOVE BIOTECH CO., LTD. provides a battery operated pocket photometer with suitable reagents. To determine the exact residual, a sample of 2ml of treated water is poured into a bottle with the reagent. After three minutes the bottle can be placed into the compartment of the photometer, and after a few seconds the photometer indicates the exact concentration of ANTINFEK™ 10H of the sample in mg/liter. The photometer is calibrated for a concentrations of 0 – 1.0 mg/l.

5.0 HOW ANTINFEK™ 10H DESTROYS BACTERIA Cell-walls of bacteria are primarily used for protection against hostile environments, and in the case of pathogenic bacteria against the immune system of the host. They contain Peptidoglycan, which can be made visible in Gram-positive bacteria by staining. The cell wall of Gram-positive bacteria consists of many polymer layers of Peptidoglycan, which is connected by Amino acid, like a grid. On the other hand the cell wall of Gram-negative bacteria is much thinner, being comprised of only 20% Peptidoglycan, and also has two unique regions which surround the outer plasma membrane (Periplasmic Space & Lipopolysaccharide Layer). ANTINFEK™ 10H active ingredient is a positively charged (Cationic) polymer, which binds to bacteria and results in degrading and disrupting the cell membrane wall, by eliminating important gradient or gradients. The degrading enzymes leave tiny holes on the cell wall, which causes the cell to leak. The ANTINFEK™ 10H molecules then enter the bacterium plasma membrane, and through the cell wall enter the cytoplasm (protoplast) through the holes and completely destroy the Nucleoid.




Gram-Negative Bacteria Cell Wall Diagram Simplified

Pictures of Gram Positive and Gram Negative Bacteria Cell

ANTINFEKTM 10H PASSES THROUGH THE CELL WALLS AND DESTROYS THE GRAM-NEGATIVE BACTERIA FROM THE INSIDE

EXTERNAL PLASMA MEMBRANE (LIPOPOLYSACCHARIDES COMPLEX CARBOHYDRATES)

CELL WALL (PEPTIDOGLYCAN / PROTEIN-SUGAR / POLYSACCHARINE MOLECULE)

CYTOPLASMIC MEMBRANE

CYTOPLASM (PROTOPLASM)

NUCLEOID




Note: Gram-Positive Bacteria Cell Wall lacks the Outer Membrane.




6.0 EXAMPLES AND DESCRIPTIONS OF WATER BORN DISEASES THAT ANTINFEKTM 10H DESTROYS

HEPATITIS-A HEPATITIS-A is an inflammation (irritation and swelling) of the liver caused by the Hepatitis A, which can eventually cause death.

TYPHOID FEVER TYPHOID FEVER is a bacteria infection characterized by diarrhea, systemic disease, and a rash – most commonly caused by the bacteria Salmonella Typhi, which can cause death.

CHOLERA CHOLERA is an infection of the small intestine caused by the bacterium Vibrio-Cholerae, resulting in profuse watery diarrhea and death.

DYSENTERY DYSENTERY is an infection of the intestine (bowel) caused by the parasite Entamoeba Histolytica.




GIARDIA

GIARDIA is an infection of the small intestine caused by a protozoa, Giardia Lamblia.

7.0 EXAMPLES OF GRAM + VE BACTERIA, WHICH ANTINFEKTM 10H DESTROYS

Lactobacillus Brevis Bacillus Subtillis

MRSA Streptococcus Faecalis

Staphylococcus Aureus (a.k.a. Staph.)




8.0 EXAMPLES OF GRAM - VE BACTERIA, WHICH ANTINFEKTM 10H DESTROYS

Escherichia Coli (a.k.a. e-Coli) Pseudomonas Aeruginosa

Klebsiella Pneumoniae Salmonella Typhimurium

9.0 EXAMPLES OF FUNGI, WHICH ANTINFEKTM 10H DESTROYS

Aureobasidium Pullulans Aspergillus Niger

Stolonifer Chaetomium Globosum

Saccharomyces Cerevisiae Candida Albicans




10.0 MATERIAL SAFETY DATA SHEET OF ANTINFEK™ 10H

2. COMPOSITION, INFORMATION ON INGREDIENTS

Major Components 1. Polyhexamethylene Biguanidine Hydrochloride 14% 2. Distilled Water 85%

Minor Components 1. Citric acid 0.8% 2. Silver Ion 0.01 mg/m3

Hazardous Ingredients None

3. HAZARDS IDENTIFICATION HUMAN HEALTH HAZARDS AGENTS

Inhalation Non-toxic

Skin Contact Non-toxic

Eye Contact Non-toxic

Ingestion Non-toxic

Human Health Chronic Hazards

Non-toxic

Environmental Hazards The preparation has no nitrates, nor other toxic components of nitrogen or phosphorus.

1. IDENTIFICATION OF THE PREPARATION AND COMPANY

Product Name ANTINFEK™ 10H

Product Use General Disinfectant

Manufacturer DOVE BIOTECH CO., LTD. 75/9 Moo 11, Paholyothin Rd., Klongueng, Klongluang, Pathumthani 10220, THAILAND Tel : (+66) 2 5295729, 5295514

Information DOVE BIOTECH CO., LTD. 919/363 29th Floor, Jewel Trade Center Bldg., Silom Road, Bangrak, Bangkok 10500, THAILAND Tel : (+66) 2 6301750-3 DOVE BIOTECH SDN. BHD. Level 7 & Level 8, S-7-G, S-8-G, Menara Northam 55, Jalan Sultan Ahmad Shah 10050 Penang, MALAYSIA Tel : (+604) 2102828 http://www.dovebiotech.com/




4. FIRST-AID MEASURES

Inhalation Non-toxic

Skin Contact Non-toxic

Eye Contact Washing by water

Ingestion Non-toxic

6. ACCIDENTAL RELEASE MEASURES

Personal Precaution None

Environmental Precaution None

Methods for Cleaning Up Simple mechanical equipment.

7. HANDLING AND STORAGE

Handling Simple handling procedures.

Storage Conditions Both indoor and dry storage is allowed, Temperature 0 to 50º C.

8. EXPOSURE CONTROL/PERSONAL PROTECTION

Engineering Measures Simple measures for work with organic water disinfectants.

Respiration Protection Simple respirators.

Hand Protection Simple gloves.

Eye Protection Spectacles (goggles).

Hygiene Recommendations Simple hygiene procedures for work with organic disinfectant materials.

9. STABILITY AND REACTIVITY

Stability 3-5 Years

Conditions to avoid None

Materials to avoid None

Hazardous Decomposition Product

None

5. FIRE-FIGHTING MEASURES

Fire and Explosion Hazard The product is non flammable.




10. PHYSICAL AND CHEMICAL PROPERTIES

Form Liquid

Color Transparent

Boiling Point 100º C

Auto-flammability None

Explosion Limits None

Vapor Pressure Non-vaporous product

Relative Density 998-1,030 (at 20º C)

Solubility in Water 100%

pH 7.0

Octane/water coefficient None

Viscosity None

Volume Weight 998-1,030 kg/m³

Freezing Point 0º C

Pour Point 0º C

Floatation Capacity 0 %

Decrease of Inter-phase Tension Water/oil

None

11. TOXICOLOGICAL INFORMATION

Acute Toxicity Data The preparation and its separate components are non toxic for humans, animals and plants in accordance with (THAI. FDA license no. A4 0288282), and Thai FDA registration no. 810/2547.

Acute Lethality Values No lethal effects.

Primary (Draize Test) Skin/eye Sensitivity No effects were identified.

Chronic Toxicity Data No allergic reaction identified.

12. ECOLOGICAL INFORMATION

Persistency and Degradation Eco-toxicological Effects

ANTINFEK™ 10H has no adverse effect or degradation on the ecology since the substance is non-toxic.




13. DISPOSAL CONSIDERATIONS

Mobility and Accumulation Potential

ANTINFEK™ 10H will not accumulate in the environment as the product affects gram negative and gram positive bacteria found in the physical environment.

14. TRANSPORT INFORMATION

Packaging 200 liter plastic drums 20 and 1 liter plastic pails (EC Standard).

Class Non hazardous.

15. REGULATORY INFORMATION Non hazardous according to Directive 67/ 548/ EEC

16. OTHER INFORMATION To the best of our knowledge, the information contained herein is accurate. However, this information is intended to be used only as a guide and does not purport to be complete. Individuals receiving this information and the user of these products have the sole responsibility to exercise their own judgment to determine the suitability of the materials for any use and the results of its use.




11.0 GLOSSARY Aerobic An organism that requires oxygen to generate energy. Algae A very simple plant without stems or leaves that grows in or near

water. Antiseptics Antimicrobial substances that are applied to living tissue/skin to

reduce the possibility of infection, sepsis, or putrefaction capable of destroying microbes (bacteriocidal).

Bleaches A chemical that removes colors or whitens, often via oxidation having strong bactericidal properties, and are used for disinfecting and sterilizing. Most bleaches are hazardous if ingested or inhaled, and should be used with care.

Bio - polymer A chemical compound that has a simple structure of large molecules

which relating to or using living things. Bacteria Very small living things, some of which cause illness or disease. Cytoplasm The part of a cell that is enclosed within the plasma membrane. Chlorination Treatment with chlorine or bleaching powder for the purpose of

disinfection, the retardation of decomposition, or the oxidation of organic matter.

Clarifier The final setting basin, which allows for separation of solids from

the flow stream. This equipment also allows for the return of solids to the aeration basins.

Disinfection The partial destruction, ordinarily by the use of some chemical, of the

Domestic sewage Sewage derived principally from dwelling, Business Buildings, Institution and the like (it may contain ground water, surface water or storm water. It may also contain a small amount of industrial wasted liquid.

Dust-mite Microscope bugs that primarily live on dead skin cells regularly

shed from humans and their animal pets cause allergic reactions in asthmatics and others who are allergic to their feces.

Decontamination To remove a dangerous substance from somewhere. Distilled Water Water which made it more pure.




Degrading Enzyme Known alternatively as insulysin or insulin protease, Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence.

Domestic sewage Sewage derived principally from dwelling, Business Buildings,

Institution and the like (it may contain ground water, surface water or storm water. It may also contain a small amount of industrial wasted liquid.

Effluent Sewage, party or completely treated, flowing out of any sewage treatment device.

Fungi A simple type of plant that has no leaves or flowers and that grows on plants or other surfaces.

FDA Food and Drug Administration, responsible for the protection of

consumer rights in the administration of the Pure Food and Drug. Gram+VE Bacteria are divided into Gram-positive bacteria, which take the blue

color after staining with Gram-staining method. Gram-VE Bacteria are divided into Gram-negative bacteria, which take the red

color after staining with Gram-staining method. Gray water Non – industrial wastewater generated from domestic process such

as washing dishes. Laundry and bathing. Gray water gets its name from its cloudy appearance and from its status as being neither fresh (white water from groundwater or portable) or heavily polluted (black water)

HPC The Health Professions Council is a UK health regulator. It was

created by the Health Professions Order 2001 to protect the public by setting and maintaining standards for the professions it regulates.

Hydrochlorides are salts resulting, or regarded as resulting, from the reaction of

hydrochloric acid with an organic base (mostly amines). Immune System The system by which your body protects itself against disease. Influent Sewage, raw or party treated, flowing into any sewage treatment

device. Microbiocidal

Antimicrobial agents that are applied to non – living objects to destroy microorganisms.

Multiparameter A water quality monitoring hardware and software.




Mold A soft green, grey, or black substance that grows on food which has been kept too long, and on objects that are in warm, wet air.

Mildew A white or grey substance that grows on walls or other surfaces in wet, slightly warm conditions.

Necleiod An irregularly-shaped region within the cell of prokaryotes which

has nuclear material without a nuclear membrane and where the genetic material is localized. The genome of prokaryotic organisms generally is a circular, double-stranded piece of DNA, of which multiple copies may exist at any time.

Organic Living or produced by or from living things. Polyelectrolyte Polymers whose repeating units bear an electrolyte group. Polyhexamethylene Biguanide Hydrochloride

Used as broad-spectrum antibacterial fungicide, take effective for kill gram-positive bacteria,gram-negative bacteria,fungus and yeast.

Pathogenic Bacteria Bacteria that cause infectious diseases. Peptidoglycan Polymer consisting of sugars and amino acids that forms a mesh-

like layer outside the plasma membrane of bacteria, forming the cell wall.

Reagent A substance that shows that another substance in a compound exists,

by causing a chemical reaction. Stable Solids Suspended solids which will sink or settle in still water sewage in a

reasonable period (approximately 2hrs.) Waterborne To spread or carried by water.

antinfek 10h

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