African Union - Pan African Veterinary Vaccine Centre

(AU-PANVAC)

Brief Presentation of AU-PANVAC

Established since 1986 to support Pan African Rinderpest Campaign (PARC): FAO project for Quality Control of Rinderpest

Vaccine (TCP/RAF/6767 and 6766) Two Centers Regional Center: Dakar (Senegal) and

Debre-Zeit (Ethiopia) 1993: The 2 Centres were merged to create

PANVAC Status: In 2004 PANVAC became Specialized Technical

Office of African Union Commission (AUC) AU-PANVAC dealing with :

All veterinarian vaccines Diagnostic Reagents Production & Supply to

Labs

Mandates International Independent Quality Control of

Veterinary Vaccines produced in Africa and imported into Africa.

Produce and distribute essential biological reagents for animal disease diagnosis and surveillance

Facilitate the standardization of veterinary vaccines production and harmonization of their quality control techniques in Africa

Promote the transfer of vaccine production technologies in Africa;

Provide training and technical support services to veterinary laboratories.

Vaccines Quality Control Activities

African Union – Pan African Veterinary Vaccine Centre (AU-PANVAC)

Bacteria vaccines: Contagious Bovine Pleuropneumonia vaccine (CBPP) Haemorrhagic septicaemia vaccine (HS) Contagious Caprine Pleuropneumonia vaccine (CCPP) Anthrax vaccine (AS) Black leg vaccine (BL)

Viral vaccines: Peste des Petits Ruminants (PPR) NewCastle Disease (NCD) Capripoxviruses (LSD, Sheep pox & Goat pox) Infectious Bursal Disease (IBD) Rift Valley Fever (RVF) Rabies Infectious Bronchitis (IB)

Vaccines Received for Quality Control

Vaccines Quality Control Tests Vaccine QC: Tests realized (OIE

Manual)

1.Identity testi. Nucleic acid recognition (PCR)ii. Serological tests

2.Purity Test: Contaminationi. Bacteria/mycoplasmaii. Fungiiii. Extraneous viruses

3.Safety Testi. Laboratory animalsii. Host animals

4. Potency Testi. In-vitro tests – Viable Counts/Titrations Live

vaccinesii. Host Challenge studiesiii. Serological tests

5. Stability Test: Shelf-Lifei. Vacuum testii. Residual Moisture Estimationiii. Accelerated Stability Studies

6. Other Testsi. Residual In-activant (Formaldehyde %)

KILLED VACCINES

Vaccines Quality Control Tests…

Harmonize Vaccines Production & Quality Control Techniques in Africa

Repository of Biological materials at AU-PANVAC:

Vaccine seeds Cells

To enhance reliability of vaccines quality To contribute to ensure harmonization of vaccine

quality

Develop and distribute SOPs for Vaccines Quality Control

International Recognition in Vaccine QC

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Training for technicians in Quality Assurance and vaccine QC: Every year two module of training were conducted

Training course in collaboration with WRL of CBPP, CIRAD: 8 countries (BVI Botswana, LANAVET Cameroon, KEVEVAPI Kenya, LCV Mali, NVI Ethiopia, NVRI Nigeria, Central Vet. Lab. Tanzania)

Training and Technical Assistance Activities

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Training and Technical Assistance Activities…

Safe storage of Rinderpest Materials 8th Conference of Ministers responsible for

livestock held in Entebbe, Uganda (May 2010) recommended:

That AU Member States speed up the process of Rinderpest virus sequestration, by completing the FAO/OIE questionnaire regarding the inventory of the virus (samples, vaccines), without any further delay; That all Rinderpest virus strains held in Africa be destroyed and what is deemed necessary handed over to AU-PANVAC for safe storage;

The Executive Council decision [EX.CL/Dec.617 (XVIII)] endorsed those resolutions during the African Union summit in January 2011

Safe storage of Rinderpest Materials… Acquirement of Bio-Safety Level 3 (BSL 3)

Laboratory Launching AU/PANVAC Bio-Safety Level 3 (BSL 3)

Laboratory 14th of October, 2011 in presence of: In presence of the Deputy Chairperson of African

Union Commission & the Commissioner for Rural Economy and Agriculture

AU-PANVAC BSL3 Laboratory

Prefabricated BSL3 supplied by LABOVER (France)

AU-PANVAC BSL3 Laboratory

Safe storage of Rinderpest Materials… IAEA/FAO/PANVAC Workshop on “Bio-safety,

sequestration and risk analysis for laboratories holding Rinderpest virus” Debre-Zeit 4-7 July 2011 The Objective: To provide the necessary guidelines

to support the activities of Rinderpest virus holding laboratories in maintaining the world free from Rinderpest.

The workshop was attended by representatives from: Countries: China, India, Kazakshtan, Kenya,

Nigeria, Senegal, Mongolia, Cameroon, Botswana, Russia, Mali.

Invited experts from: Italy, Netherlands Japan, UK, France, Germany

Safe storage of Rinderpest Material… Participants of the Workshop on “Bio-safety,

sequestration and risk analysis for laboratories holding Rinderpest virus

Safe storage of Rinderpest Material…

African Union – Pan African Veterinary Vaccine Centre (AU-PANVAC)

Development of protocols with FAO Support initiated in 2011 Development of protocols for the transfer of

RP materials to AU-PANVAC and management of biosecurity material at AU-PANVAC With the support of Dr David Ulaeto:

Scientific Advisor OIE ad hoc Group on RP and Members of WHO Advisory Committee on Variola Virus Research):

Development of protocols for the ownership to transfer RP materials to AU-PANVAC With the support of Dr. David Lavanchy:

Advisor to World Health Organisation

Safe storage of Rinderpest Material…

Transfer of RP Containing Materials (RPCM) to AU-PANVAC facilities

Botswana: Two shipments of RPCM (vaccine seed)

August 2015 November 2015

Sudan

Process for shipment: On going

Africa RP Vaccine Strategic Reserves Africa’s strategic reserves stored at AU-PANVAC

RP Vaccine procured in 2011 with FAO Support: 1.5 million doses for emergency preparedness Countries have requested to increase the

emergency stock during the Sharm Al Sheikh meeting

Shipment of vaccines in case of an outbreak: ETHIOPIAN AIRLINE: Direct connection to

most African Countries 300 vials of vaccine seed stock for vaccine

production

THANKS FOR

YOUR ATTENTION