Author:ELENA DANCIUAuthor:ELENA DANCIUCoordinators:Assistant Professor Coordinators:Assistant Professor Dr.Marius Dr.Marius MateMateii

Prof.Dr. Horatiu SuciuProf.Dr. Horatiu Suciu

Patent Ductus Patent Ductus ArteriosusArteriosus  Definition: PDA represent postpartum persistencepersistence of the

embryological communicationcommunication between distal area of Aortic Isthmus and left Pulmonary Artery.

Simptoms: vary with the size of the defect and whether the baby is full-term or premature.fatiguefatigue while eatingmalnutritiongrowth deficiencytachypneatachypneatachycardiatachycardiaSweatingSweating during crying or eatingComplications:•  congestive heart failure• bronchopulmonary dysplasia• necrotizing enterocolitis• intracranial hemorrhage• renal insuficiency

RISK FACTORS/TREATMENT

OBJECTIVESOBJECTIVES The aim of my study is to evaluate by a descriptive survey the PDA records of Cardiovascular Diseases and Transplant Institute-Tg.Mures and to state some conclusions  related to clinical and therapeutic approach of this pathology.

  Points of interest:

Mean age of the patients at the surgical intervention time Gender distribution Prevalence association of PDA with other Congenital Heart DefectsPrevalence association of PDA with other Congenital Heart Defects depending on gender Mean weight /height at the time of surgery timeAssociation between Down Sindrom and PDA+other malformations;The frequency of different Congenital Heart Defects that require maintaining Patency of the ductus.

Material and Material and MethodMethod

Type of study: descriptive and analytical study, retrospective Location: Cardiovascular Disease and Transplant Institute in Targu Mures343 medical records: 188females~55% and 155 males~45%Time period of study: from January 5th 2011 to December 23th 2014.Data collected: age, sex, weight, length, type of CHD associated with PDA, type of therapeutic intervention;

The datas were analyzed by SPSS software and Chi-Square test was used to compare variables between groups.

The datas were analyzed by SPSS software and Chi-Square test was used to compare variables between groups.

RESULTSMean age of the patients at Mean age of the patients at

the time of surgerythe time of surgery

WEIGHT(kg) HEIGHT(cm)

Number of values 343 343

Minimum 1,100 37,00

Median 5,300 63,00

Maximum 53,00 161,0

Mean 8,448 71,73

Std. Deviation 7,780 23,74

The Mean Weight and The Mean Weight and Height at the time of Height at the time of

surgery surgery

Prevalence and association of Prevalence and association of PDA with other Congenital Heart PDA with other Congenital Heart

DefectsDefects

ISOLATED PDA/GENDERISOLATED PDA/GENDER p=0,000

Fallot Tetralogy/Gender p=0,015

AORTIC COARCTATION/GENDERAORTIC COARCTATION/GENDER

p=0,007p=0,007

Fallot Tetralogy/Ductal Fallot Tetralogy/Ductal dependent dependent circulationcirculation p=0,028p=0,028

Aortic Aortic Coarctation/Ductus Coarctation/Ductus dependent circulation dependent circulation p=0,000p=0,000

RESULTS

Pulmonary Valve/Branch Pulmonary Valve/Branch Atresia//Ductus dependent Atresia//Ductus dependent

circulationcirculation p=0,000p=0,000

RESULTS

DISCUSSION

CONCLUSIONSCONCLUSIONS

1.Gender equality regarding the incidence of PDA;

2.The association between PDA+FT,PDA+Aortic Coarctation and PDA+TGA have a higher frequency in males than in females

3.Isolated PDA is more frequent in females than in male;

4.The most frequent CHD associated with PDA are :PDA+ASD,PDA+VSD,PDA+TGAand PDA+AoCo.;

5.Some of the CHD that are less associated with PDA are:Hypoplasia of Aortic Arch,Tricuspid Insufficiency,Tricuspid/Mitral Stenosis;

6.Down Sindrome has a statistical singnificance for association with PDA+Pulmonary Hipertension and PDA+ Atrioventricular comun ductus;7.The association between Ductal Dependent Circulation and: Fallot Tetralogy,Aortic Coarctation and Pulmonary Valve/Branch Atresia has an important statistical significance

Yuk Law, Jeff Smallhorn and Ian Adatia: Echocardiographic delineation of anomalous origin of the right subclavian artery from the right pulmonary artery, Cardiology in the Young / Volume 7 / Issue 03 / July 1997, pp 328 - 330Shanmugasundaram Sivakumar, Lleona Lee, Angela Tillett, Francis Wells, Jon Dunning and A Wilf Kelsall: Outcome of ligation of the persistently patent arterial duct in neonates as performed by an outreach surgical team, Cardiology in the Young /Volume 17 / Issue 05 / October 2007, pp 541 - 544Austine K. Siomos, Max B. Mitchell and Brian M. Fonseca: Successful surgical repair of a massive window duct in a 1-month old with aniridia and pulmonary interstitial glycogenosis, Cardiology in the Young / Volume 25 / Issue 03 / March 2015, pp 594 - 596Michele D’Alto, Giuseppe Santoro, Maria T. Palladino, Francesco Parisi and Maria G. Russo: Patent ductus arteriosus stenting for palliation of severe pulmonary arterial hypertension in childhood, Cardiology in the Young / Volume 25 / Issue 02 / February 2015, pp 350 - 354Ravikumar Parikh, Robert J. S. Negrine, Ashish Chikermane, Shree Vishna Rasiah and Andrew K. Ewer: Assessment of myocardial function in preterm infants with patent ductus arteriosus using tissue Doppler imaging, Cardiology in the Young /Volume 25 / Issue 01 

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