1. Case #2 An Awesome Presentation Presented to You by the Best Presenters in the Whole Presentation World... ...Robert and Lauren!

2. Patient Information Female, 55 years old No history of health problems Marriage problems Recently won the lottery 3. Symptoms Fatigue Headaches Excessive salivation Nausea / Vomiting Diarrhea Vertigo Abdominal pain Weight loss 4. Physical Examination Swelling of eyelids Partial limb paralysis Hyperkeratosis of skin on palms & soles White banding on fingernails Muscle weakness 5. Lab Results Low levels of ATP production Unusually high levels of arsenic Abnormal levels of cell death Due to lack of energy 6. Our Theory Arsenic Poisoning! 7. Patient's Symptoms vs. Arsenic Poisoning Symptoms High levels of arsenic headache dizziness Falling body temperature White banding on fingernails diarrhea vomiting Abdominal pain Muscle weakness fatigue vertigo Excessive salivation Hyperkeratosis of skin on palms & soles Eyelid swelling Limb paralysis Weight loss Low levels of atp production Abnormal amount of cell death Garlic odor on breath Kidney failure Progressive blindness dementia 8. Arsenic Poisoning Organelle affected: mitochondria Inhibits pyruvate dehydrogenase Conversion of pyruvate to acetyl CoA decreased Citric acid cycle activity decreased Production of ATP decreased Inhibits cellular glucose uptake and fatty acid oxidation 9. How (we're guessing) It Happened Husband hated her as it was She won the lottery He wanted her money He poisoned her. ALL MEN ARE EVIL 10. How (we're guessing) It Happened Husband hated her as it was She won the lottery He wanted her money He poisoned her. ALL MEN ARE EVIL