bioit 2015 data lake talk

Citeline © 2015 All rights reserved. ©2015 Cambridge Semantics Inc. All rights reserved.

A Data Lake for Competitive and Clinical Trial Intelligence

Ben Szekely - Cambridge SemanticsFounding EngineerVP of [email protected]

Christine Blazynski - Informa - CitelineChief Science OfficerSr. VP New Product [email protected]


Cambridge Semantics

Cambridge Semantics provides the Anzo Smart Data Platform - based on Semantic Web technology - for Smart Data management, analytics and advanced Search. The Anzo Pharma SmartBench delivers custom Pharma solutions in Competitive Intelligence, Scientific Affairs, Clinical Metadata Management and more… • Founded in 2007 by senior members of IBM’s Advanced Internet Technology Group• The Anzo Software Suite is built on World Wide Web Consortium (W3C) open data standards and 12+ years of

R&D

The Data Lake

Limitless data repository capable of integrating information of all sources and formats


The Semantic Data Lake Design Goals

• Data Representation– Flexible, standards-based graph

model, accessible by informaticians and business users – RDF & OWL

• Data Ingestion– User configurable tools to map,

ingest and link data from any source

– Unstructured data processing, NLP, Text Analytics

• Data Consumption– Semantic search, dashboards,

network views


Flexible Search, Analytics and Visualization


Semantic Data Lakes in Pharma

• Competitive Intelligence & Business Development

• Clinical Trial Intelligence• Clinical Data Integration• R&D Compound Screening• PV & Safety• Medical/Scientific Affairs


The Informa Anzo Data Lake

• Contextualize & Integrate Incoming Data using Ontologies

Anzo Volume

• Multi-node scalable architecture, distributed in-memory analytic query engine

• Real-time dynamic analytics, search and visualization


Citeline/Informa Semantic Model

Compound Indications Target Company

BYL-719 NSCLC PI3 kinase alpha inhibitor

Novartis

Pharmaprojects, Biomedtracker

Phase Intervention Sponsor Results…

I BYL-719 Novartis ….

Trialtrove, SitetroveDrug

Trial

Company

Disease

Indication

Developer

Sponsor

Condition

BYL-719

TargetPI3 kinase alpha inhibitor

Non-small cell lung cancer

NSCLCI

Novartis

Target

Name

Synonym

Treatment

Phase

InvestigatorSite


Informa/Citeline

• Robust, Robust, Reliable, Relevant R&D intelligence


The Business Question

Which molecular targets are the “hottest” across the top 5 cancers?

Source: Pharmaprojects


Disease-Target-Compound Heat Map


The Business Question

Which molecular targets are being investigated in clinical trials in the top 5 cancers?

Sources: Pharmaprojects and Trialtrove


Disease-Target-Trial Heat Map


Business Question

Who are the key opinion leaders in Argentina with the experience to help with my Phase II through III trials in type 2 diabetes, HIV, osteoporosis and stroke prevention?

Source: Sitetrove


Sitetrove KOL by Country


Business Question

Across oncology, please help me to understand where and how companion diagnostics are being investigated.

Sources: Pharmaprojects and Trialtrove


Companion Diagnostics - Oncology


Business Question

Sources: BiomedTracker/CatalystTracker and Trialtrove

During the past year, how many clinical trials reported top line results? Can I see this by month?


BioMedtracker - Trialtrove


Where to find us?

• Want a closer look?– Visit us at booth 336

• Contact us at– www.cambridgesemantics.com– www.citeline.com– www.biomedtracker.com

http://www.citeline.com/

bioit 2015 data lake talk

Documents