biolaurus€¦ · drug development research. from discovery stage efficacy studies to follow-on...
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BIOLAURUSPRECLINICAL MOLECULAR IMAGING
EXPERTSCAPABILITIES 2018
BIOLAURUSCAPABILITIES 2018
We are In Vivo Preclinical Molecular Imaging Contract Research Specialists. We are focused on working collaboratively with you to provide solutions to the complex research challenges you face in drug discovery and drug development research.
From discovery stage efficacy studies to follow-on safety/toxicology studies for clinical stage drugs we have a demonstrated ability to develop innovative studies and in vivo assays harnessing the power of in vivo quantitative imaging.
We combine the research depth of a preclinical CRO with a deep understanding of the latest imaging technologies and quantitative in vivo analytics.
Study Design
• Efficacy• Multi- compartment PK/PD• Assay Development• Safety Toxicology• Gene Expression
• PET/SPECT/CT• µCT• Ultrasound• Optical• MRI
Multi-modality Imaging
• 4D visualization• Real Time• Quantitative• Kinetics• Multi-compartment• Dosimetry
AnalyticsReport
• Digital Replica• Re-interrogate
Image Informatics
• Drug and biomarker labeling chemistry (FLI and BLI)
• Radiochemistry (C-11, F18, Tc-99m, In-111, Zr-89….)
• Contrast tracers PET/SPECT/CT• Cell Tracking (cell labeling and
gene expression)• PET/SPECT/FLI/BLI
Drug and Function
Biomarkers
Study Management
• Detailed Protocol • In-Life Study Management• Data Management
Bringing you solutions....
PRECLINICALMOLECULAR IMAGING
EXPERTS
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BIOLAURUS CAPABILITIES
Therapeutic IndicationsOncology
Central Nervous SystemImmune Therapeutics
Stem Cell TherapeuticsPlatelet Activation/Survival
CardiovascularPulmonary
Bone RegenerationGastro-intestinal
Bioluminescence – liver in vivo labeled with Luciferase
plasmid via HDTV
CT cross-section of lumbar spine implanted with spinal fusion material. New bone
surrounds remnants of material (green)
Ultrasound imaging of VEGFR in renal carcinoma with VEGF-
microbubble
Services & SolutionsStudy Design
Imaging Assay DevelopmentGene Expression
Safety PharmacologyImaging Toxicology (iTox™)
In Vivo EfficacyMechanism of Action
Disease StagingPK/PD
BiodistributionFluorescence chemistry
NASH Model Radiochemistry
(from Tc-99m to Zr-89)• C-11, F-18 (cyclotron)• C-14 and H-3 labeling
Quantitative Image Analysis• Receptor Binding Kinetics (PKin)
• PD analytics• Cell tracking/persistence• Bone morphometry
Bringing your research to light....
Imaging ModalitiesSPECT
PETCT
Micro-CTMRI
Ultrasound Optical Imaging
BLIFLI
FLIM
Need a GLP Study?Contact us!
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BIOLAURUSABOUT
At BioLaurus, we take pride in our expertise and specialization in the niche field of preclinical molecular imaging. And your needs are important to us – not just as a study, but as a scientific partner as well. We strive for excellence across all performance platforms – scientific, relational and budgetary. And we deliver.
2305 Historic Decatur Road, Suite 100 San Diego, Ca 92106
619.732.6580
Kimberly Brue, Scientific Business [email protected]
www.biolaurus.com
BIOLAURUS CAPABILITIESCOPYRIGHT 2018
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