bme 482 kevin sylvestre. seizures which are difficult to control, despite treatment often must...
DESCRIPTION
If SE is interrupted and eliminated, this constitutes cure One method: transcutaneous electrical stimulation (TcES) Utilizes tripolar concentric ring electrodes, developed by Dr. Walter Besio (currently of URI BME)TRANSCRIPT
BME 482Kevin Sylvestre
Seizures which are difficult to control, despite treatment
Often must resort to invasive brain surgery to treat
Very dangerous, can lead to status epilepticus (SE) Persistent seizure, 20% mortality rate, often
result in permanent damage
If SE is interrupted and eliminated, this constitutes cure
One method: transcutaneous electrical stimulation (TcES)
Utilizes tripolar concentric ring electrodes, developed by Dr. Walter Besio (currently of URI BME)
High spatial resolution thanks to unique configuration
Desirable in epileptic diagnosis
Potentially useful for epileptic treatment
Experiment in 2007: 16 rats (8 control, 8 experimental) All have pilocarpine-induced seizures with SE Experimental given TcES Result:
▪ Experimental group returned to baseline activity after 1-3 applications of TcES, most survived
▪ Control group expired after average of 15 hours
No tonic contractions, aversion responses or escape behavior elicited by rats Rats went about business normally, even
during TcES Most likely indicates painlessness
TES often induces negative reactions Leaves rats gasping and incapacitated
Besio W., Koka K., Cole A., “Feasibility of Non-invasive Transcutaneous Electrical Stimulation for Modulating Pilocarpine-induced Status Epilepticus Seizures in Rats,” Accepted by Epilepsia, 4/18/2007. IF 3.55
Besio W., Koka K., Aakula R., Dai W., “Tri-polar Concentric Ring Electrode Development for Laplacian Electroencephalography,” IEEE Trans BME, Vol. 53, No. 5, pp. 926-933, 2006. IF 1.6
Status epilepticus. (2010, March 13). In Wikipedia, The Free Encyclopedia. Retrieved 18:09, April 4, 2010, from http://en.wikipedia.org/w/index.php?title=Status_epilepticus&oldid=349535889