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    CANCER TREATMENT

    TYPES

    P. Sahithi

    09C21A04A2

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    CONTENTS

    What is Cancer ?

    Types of Cancer

    Causes of Cancer

    Lung Cancer

    Blood Cancer

    Skin Cancer

    Modalities of treatment

    Surgery

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    Radiation Therapy

    Nuclear Medicine

    Chemotherapy

    Endocrine Therapy

    Biologic Therapy

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    WHAT IS CANCER EXACTLY

    Cancer is an uncontrolled growth of the

    cells in the body. It may occur in any part of

    the body.

    The growth of cells may be dangerous if it

    breaks away from the place of initialdevelopment and travels through the blood

    stream to strike on organ and continue with

    its unwarranted and uncontrollable growth.

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    TYPES OF CANCER

    There are more then 200 types of cancer the

    most common ones are lung cancer, blood

    cancer and skin cancer. These major typesdivided into further sub categories

    Benign cancer and Malignant cancer.

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    Benign cancer are harmless unlike

    malignant cancer.

    It is difficult to control the malignant

    cancerous cells and it needs an

    immediate medical attention and

    treatment

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    CAUSES OF CANCER

    There are various causes of uncontrolled

    growth of cells in the body.

    Genetics may be one of such causes,though to a small percentage.

    Certain life styles like use of tobacco

    exposure to radiation, obesity or someinfections may lead to cancer.

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    Cancer may be sound like incurable

    disease but it can be cured if it is detected

    at the early stage.

    By capturing early symptoms cancer can

    be curable.

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    CANCER SPREAD STEP BY STEP

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    LUNG CANCER

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    Lung cancer is the most common type of

    cancer and is the major cause of the overall

    cancer-related deaths worldwide. Thedisease can be cured only if detected in the

    early phase.

    Unfortunately, in most of the cases, thecancer is detected at a late stage and thus,

    the chances of survival decrease

    considerably. Cancer of the lungs can be either primary or

    secondary in nature.

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    The primary cancer of the lungs develops

    mainly in the lungs and spreads to other

    parts of the body later.

    Secondary cancer of the lungs is the one in

    which the origin of cancer is located in

    areas other than the lungs and reaches thelungs at a later stage.

    Cancer of the lungs can be primarily of two

    distinct types as the small-cell lung cancer(SCLC) and non-small-cell lung cancer

    (NSCLC).

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    Apart from NSCLC and SCLC, there is

    another type of cancer known as bronchial

    characinoid. This is the only type of cancer

    occurring in lungs, which is not directly

    related to smoking.

    The main cause of lung cancer is addiction

    of smoking.

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    BLOOD CANCER

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    Blood cancer is one of the most common

    forms of cancer and is detected mainly in

    the adults. The cancerous cells develop primarily in the

    bone marrow or the bloodstream. Abnormal

    growth of the WBC is the main cause ofthe disease.

    The cancer is of three main types; multiple

    myeloma, lymphoma and leukemia. These cancer cells damage the adjacent

    tissues and disturb the overall cell-growth

    mechanism.

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    The cells are also known as the tumor cells or the

    malignant cells.

    The Chronic leukemia further classified into

    Chronic myeloid- Mainly detected in adults and affects the

    myeloid cells.

    Chronic lymphocytic- Occurring mostly in the adultsabove 55 years and very rarely detected in children.

    Acute myeloid- Detected in both children and adults.

    Acute lymphocytic- Most common leukemia detected in

    children.

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    SKIN CANCER

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    The cancer is also known as skin neoplasia.

    The cancer is of three main types as

    melanoma, basal cell carcinoma andsquamous cell carcinoma.

    Basal cell carcinoma and squamous cell

    carcinoma are also known as non-melanomacancers of the skin.

    Melanoma is the deadliest of the three

    types of cancers and causes maximumnumber of deaths due to cancer of the skin.

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    Surgery:

    Surgery can be used to

    diagnose, treat, or even

    prevent cancer in some cases.

    Most people with cancer willhave some type of surgery.

    Having surgery for cancer is

    different for every patient,

    depending on the type ofsurgery, the type of cancer,

    and the patients health.

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    Types of surgery:- Diagnostic surgery:

    This helps to determine whether cells are

    cancerous or not, identify the type of cancer and to

    determine the stage of the cancer.

    Curative surgery:

    It removes the cancerous tumor or growth

    from the body. This type of treatment is often considered

    the primary treatment.

    Debunking surgery:

    Debunking surgery removes a portion,

    though not all, of a cancer tumor. It is used in certain

    situations when removing an entire tumor may cause

    damage to an organ or the body.

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    There are several specialized surgeries used during cancer

    treatment.

    Cryosurgery :

    this surgery technique uses extremely cold

    temperatures to kill cancer cells. It is used most often withskin cancer.

    Laser surgery:

    this technique uses beams of light energy insteadof instruments to remove very small cancers, to destroy

    tumors, or to activate drugs to kill cancer cells.

    Electro surgery:

    skin and oral cancer are some times treated withelectro surgery. This technique uses electrical current to

    kill cancer cells.

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    Radiation therapy

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    Radiation therapy:

    The use of high energyradiation from x-rays,

    gamma rays, neutrons,and other sources tokill cancer cells andshrink tumors.

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    Rational for radiotherapy:-

    Purpose: To eradicate tumors at primary

    stage and in some cases regional lymph

    nodes. Principle advantage: spares normal tissue

    function.

    For example, preservation ofnatural voice in advance laryngeal cancer.

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    How radiotherapy works ??

    Radiation causes damage to DNA in both normal

    and malignant cells.

    Cells unable to repair this damage by time of next

    division, then they die in MITOSIS.

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    Nuclear medicine

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    Radio nuclides:

    For decades have been used systemically to treatmalignant disorders.

    They are administer by specialists in nuclearmedicine or radiation oncologist.

    Radioactive iodine in the from of131I is effectivetherapy for well differentiated thyroid ca

    Strontium-89. Is used for the treatment of bodymetastasis. It is an alkaline earth element in thesame family as calcium

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    Chemotherapy

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    Chemotherapy:

    Chemotherapy is the use of chemicals

    (medication) to treat disease - more

    specifically, it usually refers to thedestruction of cancer cells. However,

    chemotherapy may also includes the use of

    antibiotics or other medications to treat anyillness or infection

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    How does chemotherapy work ? When our body cells are

    damaged or die we producenew ones to replace them.This is done in an orderlyway, in a balanced way.

    Cancer cells do not havethat orderly capacity - theirreproduction (division andgrowth) is out of control -more and more of them are

    produced and they start tooccupy more and morespace, until eventually they

    push out space occupied byuseful cells.

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    Chemotherapy (chemo)

    drugs interfere with a

    cancer cell's ability todivide and reproduce.

    Chemo drugs may be

    applied into thebloodstream to attack

    cancer cells throughout

    the body, or they can be

    delivered directly to

    specific cancer sites.

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    Goals of chemotherapy:-

    Total remission - to cure the patient completely. In some

    cases chemotherapy alone can get rid of the cancer

    completely.

    Prevent recurrence - chemotherapy, when used to prevent

    the return of a cancer, is most often used after a tumor isremoved surgically

    Slow down cancer progression - used mainly when the

    cancer is in its advanced stages and a cure is unlikely.

    Chemotherapy can slow down the advancement of thecancer.

    To relieve symptoms - also more frequently used for

    patients with advanced cancer.

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    What are the chemotherapeuticagent.?

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    Complication of Chemotherapy:

    Every chemotherapeutic will have some

    deleterious side effect on normal tissue .

    E.G; Myelo suppression, nausea& vomiting,

    Stomatitis, and alopecia are the most

    frequently observed side effects.

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    Criteria used to describe response

    are:

    Complete response (complete remission)is thedisappearance of all detectable malignant disease.

    Partial response: is decrease by more than 50% inthe sum of the products of the perpendiculardiameters of all measurable lesions.

    Stable disease: no increase in size of any lesionnor the appearance of any new lesions.

    Progressive disease: means an increase by at least25% in the sum of the products of the

    perpendicular diameters of measurable lesion orthe appearance of new lesions.

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    Endocrine therapy:

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    Endocrine therapy:

    Many hormonal antitumor agents are functional agonist orantagonist of the steroid hormone family.

    Adrenocorticoids:

    Ant androgen:

    Estrogen:

    Ant estrogen:

    Progestin's

    Aromatize :

    Gonadotropin-releasing hormone agonists:

    Somatostatiinhibitorn analogues:

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    Adrenocorticosteroid:

    Are frequently used in combination regimen for

    the treatment of lymphocytic leukemia and

    lymphoma.

    They function by binding to glucocorticoid-

    specific receptors present in lymphoid cells and

    initiate programmed cell death

    They most commonly used agent are prednisone,methyl prednisone , dexamethosone.

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    Ant androgens:

    Flu amide

    Effectively blocks the binding of androgen

    to its receptor in the peripheral tissue .

    It is used in the treatment of disseminated

    prostate ca

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    CONCLUSION

    Increase your life span by preventing this

    dreadful disease.

    Maintain a healthy diet.

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