catalogo spring bioscience

Research Catalog

Primary Antibodies

Detection Systems

Antibody Microarrays

Recombinant Proteins

Other Complementary Reagents

TARGETED PRODUCTS FOR CANCER RESEARCH 2012

Recombinant Antibodies

Mutation-Specific Antibodies

Rabbit And Other Species Monoclonals

TECHNICAL CAPABILITIES

Delivering Best-in-Class

Rabbit Monoclonals since 2001.

Ki-67 (SP6)

Rabbit Monoclonal

Human Tonsil

iNOS (SP126)

Rabbit Monoclonal

Human Lung

Actin-beta (SP124)

Rabbit Monoclonal

Human Placenta

F4/80 (SP115)

Rabbit Monoclonal

Mouse Liver

IKAROS (SP108)

Rabbit Monoclonal

Human Tonsil

CD278/ICOS (SP98)

Rabbit Monoclonal

Human Reactive

Lymph Node

FOXA1 (SP88)

Rabbit Monoclonal

Human Prostate

FEATURING SP CLONES

M E S S A G E F R O M S P R I N G B I O S C I E N C E

Community of Cancer Researchers,

Thank you for using our 2012 product catalog. Spring Bioscience is driven to build essential tools for cancer researchers so that tomorrows patients may benefit from todays innovations. As a part of the Roche Diagnostics team and members of a society afflicted by cancer, we put tomorrows cancer patients at the center of our mission and are impassioned to enable researchers with high-quality tools for the analysis of cancer tissue.

Spring was founded in 2001 by a team of scientists and achieved early success with their line of SP Clone rabbit monoclonal antibodies for clinical immunohistochemistry. This momentum was quickly noticed by Ventana Medical Systems who acquired the company in 2007 for its antibody development capabilities. Ventana Medical Systems was shortly thereafter acquired by Roche. Today, Spring serves an important role as an antibody center of excellence in Roches mission to deliver companion diagnostics. This is accomplished through not only developing antibodies destined for clinical assays through Ventana and other Roche affiliates but using our collective medical/market intelligence to serve the cancer research community.

Our 2012 catalog highlights the dozens of new products we launched during 2011 and various other product updates including improved product utility and application images.

By the time you are reading this catalog we will have also launched a new website at www.springbio.com which will contain a host of other product resources not available in the catalog. For example, hundreds of additional product images, customer feedback section, and much more.

Thank you for the opportunity to assist you in your important and purposed work and if there is anything we can do to better serve you please let us know.

Sincerely,

Steve Reichling, General Manager, Spring Bioscience

TA B L E O F C O N T E N T S

Table of Contents

Primary Antibody Products 11

Detection and Ancillary Products 109

Antibody Microarray Products 113

Recombinant Protein Products 115

Product Index 117

6Root Cat# Product Name Clone Bre

ast

Card

iovas

cular

Cerv

ix

Color

ectu

m

Endo

crine

Hem

atop

oietic

Cells

Kidne

y

Liver

Lung

Nerv

ous T

issue

Osse

ous T

issue

Ovar

y

Panc

reas

Place

nta

Pleur

a

Pros

tate

Skin

SM In

testi

ne

Soft

Tissu

e

Stom

ach

Testi

s

Thyro

id

Urina

ry Bl

adde

r

M424 Actin-beta SP124

M308 ALK/p80 SP8

M407 Androgen Receptor (AR) SP107

M347 BAX SP47

M366 BCL-2 alpha SP66

M392 BOB-1 SP92

M391 C4d SP91 EC DC

M364 Cadherin-E/E-Cadherin SP64

M390 Cadherin-N/N-Cadherin SP90

M317 Calcitonin SP17

M381 Calpain SP81

M382 Calpastatin SP82

M313 Calretinin SP13

M406 Carbonic Anhydrase 9 (CA-9)

SP106

M343 Caveolin-1 SP43

M307 CD3 SP7 TC

M335 CD4 SP35 TC

M319 CD5 SP19 TC

M394 CD7 SP94 TC

M316 CD8 SP16 TC

M367 CD10 SP67

M410 CD19 SP110 BC

M332 CD20 SP32 BC

M404 CD22 SP104 BC

M323 CD23 SP23 BC

M338 CD31 SP38 EC EC EC EC EC EC EC EC EC EC EC EC EC EC EC EC EC EC EC EC EC EC EC

M355 CD43 SP55 TC

M337 CD44 Std SP37

M318 CD79a SP18 BC

M419 CD99 SP119

M326 CD117/c-kit SP26

M396 CD163 SP96

M398 CD278/ICOS SP98 TC

M380 CDK2 SP80

M354 CDX2 SP54

M303 c-erbB-2/HER-2 SP3


M312 Chromogranin A SP12 NE NE NE NE NE NE NE NE NE

M344 c-Met SP44

M359 c-Met (Paired 1003) SP59

M358 c-Met (Phospho T1003) SP58

M321 COX-2 SP21

M383 c-TEN SP83

M304 Cyclin D1 SP4 PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC

M331 DOG-1 SP31

M309 Epidermal Growth Factor Receptor (EGFR)

SP9


SP84

M368 ERCC1 SP68

M301 Estrogen Receptor (ER) SP1

M415 F4/80 SP115 M M K M M M M

M423 FLK-1 (mouse) SP123

M388 FOXA1 SP88

Rabbit Monoclonal Antibodies by Tissue Focus

7Root Cat# Product Name Clone Bre

ast

Card

iovas

cular

Cerv

ix

Color

ectu

m

Endo

crine

Hem

atop

oietic

Cells

Kidne

y

Liver

Lung

Nerv

ous T

issue

Osse

ous T

issue

Ovar

y

Panc

reas

Place

nta

Pleur

a

Pros

tate

Skin

SM In

testi

ne

Soft

Tissu

e

Stom

ach

Testi

s

Thyro

id

Urina

ry Bl

adde

r

M397 FOXP3 SP97

M378 Glial Fibrillary Acidic Protein (GFAP)

SP78

M386 Glypican-3 SP86

M420 hENT1 SP120

M408 IKAROS SP108

M405 J-chain SP105 PC

M327 Keratin 5 SP27

M387 Keratin 6 SP87

M352 Keratin 7 SP52

M402 Keratin 8 SP102






M306 Ki-67 SP6 PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC PLC

M351 LMO2 SP51

M385 MCM2 SP85

M374 Mesothelin SP74

M346 MSH2 SP46

M393 MSH6 SP93

M414 MUM1/IRF4 SP114

M372 Myeloperoxidase (MPO) SP72

M403 Nestin SP103 ST ST ST

M426 Nitric Oxide Synthase-Inducible (iNOS)

SP126 M M M M M M

M363 p120 (catenin delta 1) SP63

M305 p53 SP5

M418 p57 SP118

M334 PAX-5 SP34

M362 PI3K p85 SP62

M315 PLAP SP15

M302 Progesterone Receptor (PR) SP2


M329 PSMA SP29

M350 S6 Ribosomal (Phospho S235/236)

SP50

M345 S6 Ribosomal (Phospho S240/244)

SP45

M422 SLIT2 SP122

M376 SOX-2 SP76 ST ST ST ST ST ST ST ST ST ST

M349 Stathmin SP49

M379 Survivin SP79

M311 Synaptophysin SP11 NE NE NE NE NE NE NE NE

M336 Syntaxin 1A SP36

M370 Tau (Neuronal Marker) SP70

M412 Thymidylate Synthase (TS) SP112

M373 Uroplakin III SP73

M328 Vascular Endothelial Growth Factor (VEGF)

SP28

M320 Vimentin SP20

M417 Vinculin SP117 MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

MC, EC

Indicates the organs or tumors derived from these organs express these markers using the information available in the public domain. Abbreviation: TC = T lymphocyte, BC = B lymphocyte, DC=dendritic cell, EC =endothelial cell, PC= plasma cell, NE = neuroendocrine cell, PLC =proliferating cell, ST=stem cell, M=macrophages, K=Kupffer cells, MC=Cardiac, skeletal, and smooth cells.

8Root Cat# Product Name Clone AK

T/PK

B Sign

aling

Angio

gene

sis

Apop

tosis

B Cell

Mar

kers

Canc

er M

arke

rs

Cell A

dhes

ion

Cell C

ycle

Cell J

uncti

ons

Com

plem

ent

Cyto

skele

tal P

rote

ins

DNA R

eplic

ation

and R

epair

DNA S

ynth

esis

EGFR

Fam

ily

Enzy

mes

Hem

atop

oiesis

Hom

eodo

main

Prot

eins

Horm

ones

Imm

unog

lobuli

n

Lym

phoc

yte S

ignali

ng

Neur

oscie

nce

Nitro

gen M

etab

olism

Onco

gene

sis

Signa

l Tra

nsdu

ction

Stem

Cell

Ster

oid Re

cept

ors

Synt

hesis

and D

egra

datio

n

Trans

cript

ional

Regu

lator

s

Trans

lation

al Co

ntro

l

M424 Actin-beta SP124

M308 ALK/p80 SP8

M407 Androgen Receptor (AR) SP107

M347 BAX SP47

M366 BCL-2 alpha SP66

M392 BOB-1 SP92

M391 C4d SP91

M364 Cadherin-E/E-Cadherin SP64

M390 Cadherin-N/N-Cadherin SP90

M317 Calcitonin SP17

M381 Calpain SP81

M382 Calpastatin SP82

M313 Calretinin SP13

M406 Carbonic Anhydrase 9 (CA-9)

SP106

M343 Caveolin-1 SP43

M307 CD3 SP7

M335 CD4 SP35

M319 CD5 SP19

M394 CD7 SP94

M316 CD8 SP16

M367 CD10 SP67

M410 CD19 SP110

M332 CD20 SP32

M404 CD22 SP104

M323 CD23 SP23

M338 CD31 SP38

M355 CD43 SP55

M337 CD44 Std SP37

M318 CD79a SP18

M419 CD99 SP119

M326 CD117/c-kit SP26

M396 CD163 SP96

M398 CD278/ICOS SP98

M380 CDK2 SP80

M354 CDX2 SP54



M312 Chromogranin A SP12

M344 c-Met SP44

M359 c-Met (Paired 1003) SP59

M358 c-Met (phospho T1003) SP58

M321 COX-2 SP21

M383 c-TEN SP83

M304 Cyclin D1 SP4

M331 DOG-1 SP31


SP9


SP84

M368 ERCC1 SP68

M301 Estrogen Receptor (ER) SP1

M415 F4/80 SP115

Rabbit Monoclonal Antibodies by Major Research Interest

9Root Cat# Product Name Clone AK

T/PK

B Sign

aling

Angio

gene

sis

Apop

tosis

B Cell

Mar

kers

Canc

er M

arke

rs

Cell A

dhes

ion

Cell C

ycle

Cell J

uncti

ons

Com

plem

ent

Cyto

skele

tal P

rote

ins

DNA R

eplic

ation

and R

epair

DNA S

ynth

esis

EGFR

Fam

ily

Enzy

mes

Hem

atop

oiesis

Hom

eodo

main

Prot

eins

Horm

ones

Imm

unog

lobuli

n

Lym

phoc

yte S

ignali

ng

Neur

oscie

nce

Nitro

gen M

etab

olism

Onco

gene

sis

Signa

l Tra

nsdu

ction

Stem

Cell

Ster

oid Re

cept

ors

Synt

hesis

and D

egra

datio

n

Trans

cript

ional

Regu

lator

s

Trans

lation

al Co

ntro

l

M423 FLK-1 (mouse) SP123

M388 FOXA1 SP88

M397 FOXP3 SP97

M378 Glial Fibrillary Acidic Protein (GFAP)

SP78

M386 Glypican-3 SP86

M420 hENT1 SP120

M408 IKAROS SP108

M405 J-chain SP105

M327 Keratin 5 SP27

M387 Keratin 6 SP87

M352 Keratin 7 SP52







M306 Ki-67 SP6

M351 LMO2 SP51

M385 MCM2 SP85

M374 Mesothelin SP74

M346 MSH2 SP46

M393 MSH6 SP93

M414 MUM1/IRF4 SP114

M372 Myeloperoxidase (MPO) SP72

M403 Nestin SP103

M426 Nitric Oxide Synthase-Inducible (iNOS)

SP126

M363 p120 (catenin delta 1) SP63

M305 p53 SP5

M418 p57 SP118

M334 PAX-5 SP34

M362 PI3k p85 SP62

M315 PLAP SP15



M329 PSMA SP29

M350 S6 Ribosomal (phospho S235/236)

SP50

M345 S6 Ribosomal (phospho S240/244)

SP45

M422 SLIT2 SP122

M376 SOX-2 SP76

M349 Stathmin SP49

M379 Survivin SP79

M311 Synaptophysin SP11

M336 Syntaxin 1A SP36

M370 Tau (Neuronal Marker) SP70

M412 Thymidylate Synthase (TS) SP112

M373 Uroplakin III SP73

M328 Vascular Endothelial Growth Factor (VEGF)

SP28

M320 Vimentin SP20

M417 Vinculin SP117

10

SP = Spring Bioscience Corporation

While you may not be familiar with Spring Bioscience Corporation, you are probably

quite familiar with rabbit monoclonal SP clones. All SP antibody clone products were

designed and manufactured by Spring Bioscience. It all started with SP1, the now gold

standard Estrogen Receptor marker. SP clones continue to emerge as best-in-class

immunohistochemistry markers for their high affinity, sensitivity, and specificity.

FEATURING SP CLONES

Delivering Best-in-Class

Rabbit Monoclonals since 2001.

CD19Rabbit Monoclonal







Terms and Conditions Spring Bioscience products are for research use only. They are not for use in diagnostic procedures. Spring Bioscience strives to provide complete and accurate information; however, Spring Bioscience and its business associates assume no liability for any reliance on any of the information provided. Furthermore, Spring Bioscience assumes no liability for any omissions. It is the sole responsibility of researchers to independently validate the information and proper use of any products. Spring Bioscience reserves the right to make any changes, additions, and/or deletions to its product information at anytime without notice.

11

P R I M A R Y A N T I B O D Y P R O D U C T S

Spring Bioscience develops and manufactures a wide range of products primarily specialized for IHC.

Primary Antibodies specifically characterized for use in IHC, featuring:

Clean and intense staining

Lower pre-treatment requirement

Robust performance for FFPE tissue

Improved reproducibility

Accepted by industry leaders

Available in 0.1ml, 0.5ml and 1.0ml concentrated sizes as well as a 7ml ready-to-use configuration.

Antibody product technologies include:

Rabbit Monoclonal (SP clones)

Mouse Monoclonal (SPM clones)

Rabbit Polyclonal

12 Applications Legend: IHC-P = Immunohistochemistry (Paraffin); WB = Western Blotting*Only tested species are listed. Based on sequence homology it is likely that this antibody will work in additional species. Please reference www.springbio.com for more details.**Product available to direct customers and Spring-appointed distributors only.

14-3-3 beta Rabbit Polyclonal Catalog No. Size Format

E2920 0.1ml Concentrate



E2921 7.0ml Ready-to-use

Clone: N/A

Immunogen: Synthetic peptide from N-terminus of human 14-3-3 beta.

Application: IHC-P, WB

Species Reactivity: Human*

Isotype: Rabbit IgG

Control Tissue: Brain, Prostate Carcinoma, Liver Carcinoma

Cellular Localization: Cytoplasm

Control Lysate: Jurkat

Molecular Weight: 30 kDa

Human Brain stained with anti-14-3-3 beta antibody E292

Product Description: At least 7 mammalian isoforms comprise the 14-3-3 family of signaling intermediates. 14-3-3 molecules are highly conserved, expressed in a broad range of tissues and cell types and were first discovered as a series of highly abundant proteins in brain tissue. There is increasing evidence that 14-3-3 proteins are critical to cell transformation and mitotic signaling.

14-3-3 zeta Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from internal region of human 14-3-3 zeta.



Isotype: Rabbit IgG

Control Tissue: Breast Carcinoma, Tonsil


Control Lysate: 293T


Human Breast Carcinoma stained with anti-14-3-3 zeta antibody E1260

Product Description: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation and activation/repression of enzyme activity.

Actin-beta Rabbit Monoclonal Catalog No. Size Format

M4240 0.1ml Concentrate



M4241 7.0ml Ready-to-use

Clone: SP124

Immunogen: Synthetic peptide near the N-terminus of human actin-beta protein.



Isotype: Rabbit IgG

Control Tissue: Placenta


Control Lysate: Raji


Human Placenta stained with anti-Actin-beta antibody M424

Product Description: Beta-actin is a nonmuscle cytoskeletal protein in all human cell types and is involved in cell motility, structure, and integrity. There are six different actin isoforms in human. Antibody to beta-actin provides a specific and useful tool in studying the intracellular distribution of beta-actin and the static and dynamic aspects of the cytoskeleton.

Actin-beta Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: N-terminus of human beta actin.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Leiomyoma, Skin

Cellular Localization: Cytoplasm, Membrane

Human Leiomyoma stained with anti-Actin-beta antibody E455

Product Description: The two major cytoskeletal proteins implicated in cell motility are actin and myosin. There are three -actins (skeletal, cardiac, and smooth muscle), one -actin (-nonmuscle), and two -actins (-smooth muscle and -nonmuscle). Antibody to -actin provides a specific and useful tool in studying the intracellular distribution of -actin and the static and dynamic aspects of the cytoskeleton.

Actin-Skeletal Muscle Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from N-terminus of human alpha skeletal muscle isoform of actin.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Skeletal Muscle


Human Skeletal Muscle stained with anti-Actin-Skeletal Muscle antibody E388

Product Description: This antibody reacts with sarcomeric actins of normal tissues and neoplasms derived from such tissues (i.e. rhabdomyosarcomas).

Actin-Skeletal Muscle Mouse Monoclonal Catalog No. Size Format





Clone: 5C5.F8.C7

Immunogen: N-terminus decapeptide of alpha skeletal muscle isoform of actin.

Application: IHC-P


Isotype: Mouse IgM

Control Tissue: Skeletal Muscle


Human Skeletal Muscle stained with anti-Actin-Skeletal Muscle antibody E1665

Product Description: This antibody reacts with sarcomeric actins of normal tissues and neoplasms derived from such tissues (i.e. rhabdomyosarcomas).

US ORdeRS Online: www.springbio.com email: [email protected] Tel: (925) 474-8440 Fax: (925) 474-8469 INTeRNATIONAL ORdeRS email: [email protected] 13

Primary Antibodies

Actin-Smooth Muscle Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from N-terminus of human alpha smooth muscle isoform of actin.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Leiomyoma, Smooth Muscle in Small Intestine


Human Smooth Muscle in Small Intestine stained with anti-Actin-Smooth Muscle antibody E246

Product Description: This antibody stains smooth muscle cells in vessel walls, gut wall, and myometrium. Myoepithelial cells in breast and salivary gland are also stained. It reacts with tumors arising from smooth muscles and myoepithelial cells. Actin from fibroblasts (beta- and gamma-cytoplasmic), striated muscle (alpha-sarcomeric), and myocardium (alpha-myocardial) are not stained.

Actin-Smooth Muscle Mouse Monoclonal Catalog No. Size Format





Clone: 1A4

Immunogen: Synthetic peptide from N-terminus of human alpha smooth muscle isoform of actin.

Application: IHC-P


Isotype: Mouse IgG1/k

Control Tissue: Leiomyoma, Smooth Muscle


Human Smooth Muscle stained with anti-Actin-Smooth Muscle antibody E1434

Product Description: This antibody stains smooth muscle cells in vessel walls, gut wall, and myometrium. Myoepithelial cells in breast and salivary gland are also stained. It reacts with tumors arising from smooth muscles and myoepithelial cells. Actin from fibroblasts (beta- and gamma-cytoplasmic), striated muscle (alpha-sarcomeric), and myocardium (alpha-myocardial) are not stained.

Adenomatous Polyposis Coli (APC) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from C-terminus of human APC protein.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Colon, Colon Carcinoma


Human Colon Carcinoma stained with anti-Adenomatous Polyposis Coli (APC) antibody E408

Product Description: APC is associated with structural components of intracellular junctions, including conductin, and it competes with E-cadherin for binding to specific internal regions of both - and -catenin. Like APC, APC2 contains SAMP domains, which are required for conductin binding. Both APC and APC2 regulate the formation of active -catenin-Tcf complexes.

Adrenocorticotrophic Hormone (ACTH) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from N-terminus of human ACTH.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Pituitary


Human Pituitary stained with anti-Adrenocorticotrophic Hormone (ACTH) antibody E349

Product Description: ACTH labels corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.

Adrenocorticotrophic Hormone (ACTH) Mouse Monoclonal Catalog No. Size Format





Clone: SPM501

Immunogen: ACTH synthetic peptide.

Application: IHC-P


Isotype: Mouse IgG1

Control Tissue: Pituitary


Human Pituitary stained with anti-Adrenocorticotrophic Hormone (ACTH) antibody E1645

Product Description: ACTH labels corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.

AKT-1/AKT-2 Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from N-terminus of human AKT-1.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Lung Carcinoma


Human Lung Carcinoma stained with anti-AKT-1/AKT-2 antibody E1084

Product Description: Two serine/threonine kinases, designated AKT-1 and AKT-2 (alternatively referred to as PKB or RacPK), exhibit sequence homology with the protein kinase A and C families and are encoded by the c-AKT proto-oncogene. AKT-1 and AKT-2 contain a Pleckstrin homology (PH) domain and are activated by PDGF stimulation. This activation is dependent on PDGFR-beta tyrosine residues 740 and 751, which bind the 85kDa subunit of the phosphatidylinositol 3-kinase (PI-3 kinase) complex.


AKT-1/PKB (Phospho S473) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from the region of human AKT-1 that contains phosphorylated site of serine 473.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Breast Carcinoma

Cellular Localization: Cytoplasm, Nucleus

Human Breast Carcinoma stained with anti-AKT-1/PKB (Phospho S473) antibody E1345

Product Description: The AKT-1 serine threonine protein kinase is catalytically inactive in serum starved primary and immortalized fibroblasts and activated by platelet derived growth factor. The activation is rapid and specific. Survival factors can suppress apoptosis in a transcription independent manner by activating AKT-1, which then phosphorylates and inactivates components of the apoptotic machinery. This antibody is specific to the phosphorylated form of AKT-1.

ALK/p80 Rabbit Monoclonal Catalog No. Size Format





Clone: SP8

Immunogen: Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Anaplastic Lymphoma


Human Anaplastic Lymphoma stained with anti-ALK/p80 antibody M308

Product Description: This antibody recognizes a human p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of large cell lymphomas. This antibody can be used to detect p80 in these lymphomas and may also be used to detect a subtype of large B cell lymphoma, which expresses the full-length ALK protein.

ALK/p80 Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C- terminus of the NPM-ALK transcript.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Anaplastic Lymphoma


Human Anaplastic Lymphoma stained with anti-ALK/p80 antibody E109

Product Description: This antibody recognizes a human p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of large cell lymphomas. This antibody can be used to detect p80 in these lymphomas and may also be used to detect a subtype of large B cell lymphoma, which expresses the full-length ALK protein.

alpha Fetoprotein (AFP) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Human alpha-fetoprotein purified from human cord serum.



Isotype: Rabbit IgG

Control Tissue: Human alpha-fetoprotein purified from human cord serum.


Control Lysate: HepG2


Human Fetal Liver stained with anti-alpha Fetoprotein (AFP) antibody E295

Product Description: AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been identified in hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.

alpha-1-Antichymotrypsin Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Purified human alpha-1-antichymotrypsin.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Tonsil


Human Tonsil stained with anti-alpha-1-Antichymotrypsin antibody E345

Product Description: Alpha-1-Antichymotrypsin (Alpha 1-ACT) is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1-ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimers disease (AD) and in normal aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation.

alpha-1-Antitrypsin Rabbit Polyclonal Catalog No. Size Format





Clone: 5C5.F8.C7

Immunogen: Purified human alpha-1-antitrypsin.

Application: IHC-P


Isotype: Rabbit IgG



Human Tonsil stained with anti-alpha-1-Antitrypsin antibody E344

Product Description: Alpha-1-antitrypsin (alpha-1-AT) exists in a number of genetic variants. MM variant is the most common. Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema).


Primary Antibodies

Amylin Peptide Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from N-terminus of human amylin protein.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Pancreas


Human Pancreas stained with anti-Amylin Peptide antibody E340

Product Description: Amylin is a pancreatic islet peptide with a role in the maintenance of glucose homoeostasis. It is predominantly found in the beta cells of the pancreas and to a lesser extent in the gastrointestinal tract and nervous system. This antibody may prove of value in studies to determine the level of staining for amylin in normal and diabetic pancreas and pancreatic carcinoma.

Amyloid Precursor Protein (APP) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide corresponding to N-terminus of human APP.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Alzheimers Brain

Cellular Localization: Cytoplasm, Extracellular Matrix

Human Alzheimers Brain stained with anti-Amyloid Precursor Protein (APP) antibody E265

Product Description: This antibody recognizes APP (-APP770), MW 110kDa. Predicted to recognize -APP695 and -APP751. Amyloid precursor protein (APP) and APP-like proteins are transmembrane glycoproteins with a similar modular domain structure.

Amyloid-beta/Amyloid A4 Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from N-terminus of human amyloid beta.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Alzheimers Brain

Cellular Localization: Transmembrane, Extracellular Matrix

Human Alzheimers Brain stained with anti-Amyloid-beta/Amyloid A4 antibody E353

Product Description: Amyloid beta-protein/amyloid A4 or amyloid beta-peptide is derived from the amyloid betaprecursor protein. Beta amyloid is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles in Alzheimers brain. Beta amyloid deposits are also detected in Lewy body dementia, Downs syndrome, amyloidosis (Dutch type) and in the Guam Parkinson-Dementia complex.

Androgen Receptor (AR) Rabbit Monoclonal Catalog No. Size Format





Clone: SP107

Immunogen: Synthetic peptide derived from near N-terminus of human AR.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Prostate Carcinoma

Cellular Localization: Nucleus

Human Prostate Carcinoma stained with anti-Androgen Receptor (AR) antibody M407

Product Description: The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. The expression of AR is reportedly inversely correlated with histologic grade, i.e., well differentiated prostate tumors show higher expression than the poorly differentiated tumors.

Androgen Receptor (AR) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from near N-terminus of human AR.



Isotype: Rabbit IgG

Control Tissue: Prostate Carcinoma


Control Lysate: LnCap


Human Prostate Carcinoma stained with anti-Androgen Receptor (AR) antibody E272

Product Description: The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. The expression of AR is reportedly inversely correlated with histologic grade, i.e., well differentiated prostate tumors show higher expression than the poorly differentiated tumors.

Annexin I Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide corresponding to N-terminus of human annexin I.

Application: IHC-P


Isotype: Rabbit IgG


Cellular Localization: Membrane

Human Placenta stained with anti-Annexin I antibody E1403

Product Description: Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis and cellular adhesion. Annexin A1, a gene related to phagocytosis, was found to be one of the most highly upregulated genes in hairy cell leukemia.


Annexin VI Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide corresponding to N-terminus of human Annexin VI.



Isotype: Rabbit IgG

Control Tissue: Liver, Tonsil




Human Liver stained with anti-Annexin VI antibody E1238

Product Description: Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis and cellular adhesion. Annexin VI is positively regulated by calcium. It contains 8 annexin repeats and it binds actin filament and lipids. Annexin VI has been localized to stress fibers, membrane ruffles, and microspikes.

Apoptosis Protease Activating Factor 1 (APAF-1) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from C-terminus of human APAF-1.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Testis


Human Testis stained with anti-Apoptosis Protease Activating Factor 1 (APAF-1) antibody E395

Product Description: APAF-1 is a cytosolic protein that rests in a latent state until bound by cytochrome c (APAF-2). The resulting APAF-1/cytochrome c complex associates with the zymogen form of caspase-9 (APAF-3) in the presence of dATP or ATP, promoting the autocatalytic activation of caspase-9. This antibody can be useful in studies of apoptotic cell death.

BAK Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from N-terminus of human BAK.

Application: IHC-P


Isotype: Rabbit IgG



Human Tonsil stained with anti-BAK antibody E332

Product Description: BAK or BCL-2-homologous antagonist is a member of the BCL-2 family of homologous proteins which function in the regulation of apoptosis. The BCL-2 related proteins interact with one another through the formation of homo- and heterodimers. BAK has been localized by immunohistochemistry to the cytosol of cells and stains in a punctate pattern characteristic of other BCL-2 family proteins, which have been localized to intracellular organelles.

BAX Rabbit Monoclonal Catalog No. Size Format





Clone: SP47

Immunogen: Synthetic peptide corresponding to internal region of human BAX protein.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Breast, Colon


Human Breast stained with anti-BAX antibody M347

Product Description: BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.

BAX Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from internal region of human BAX protein.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Breast, Colon


Human Breast stained with anti-BAX antibody E1799

Product Description: BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.

BCL-2 alpha** Rabbit Monoclonal Catalog No. Size Format





Clone: SP66

Immunogen: Synthetic peptide corresponding to N-terminus of human BCL-2 alpha protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Tonsil stained with anti-BCL-2 alpha antibody M366

Product Description: Expression of BCL-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative.


Primary Antibodies

BCL-2 alpha Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide corresponding to N-terminus of human BCL-2 alpha protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Tonsil stained with anti-BCL-2 alpha antibody E1798

Product Description: Expression of BCL-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative.

BCL-6 Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide corresponding to internal region of human BCL-6 protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Tonsil stained with anti-BCL-6 antibody E1409

Product Description: BCL-6 proto-oncogene product is mainly expressed in normal germinal center B cells and related lymphomas. BCL-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkins lymphomas and BCL-6 rearrangements have been detected in diffuse large B cell lymphomas. BCL-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt lymphomas and in nodular, lymphocyte predominant Hodgkins disease.






Clone: N/A

Immunogen: Synthetic peptide near the N-terminus of human BCL-10 protein.

Application: IHC-P


Isotype: Rabbit IgG




Product Description: BCL-10 is a cytoplasmic protein expressed at different levels in most normal human cells and translocates into the nucleus of MALT lymphoma, especially in those with translocation (1;14)(p22;q32). BCL-10 and MALT-1 protein form a complex in MALT lymphoma. They are thought to synergize in the activation of NF-kappaB, and may contribute to the same pathogenic process that leads to malignancy. Mutations in BCL-10 are observed in some B and T cell lymphomas.






Clone: N/A

Immunogen: Synthetic peptide corresponding to internal region of human BCL-10.

Application: IHC-P


Isotype: Rabbit IgG




Product Description: BCL-10/CIPER/CLAP/mE10 is expressed in many human and murine tissues. It contains a CARD (caspase recruiting domain) domain and is involved in activation of caspase 9 to induce apoptosis. It is a cellular homolog of equine herpesvirus 2 E-10. It is known to induce activation of JNK, p38 and NF-kappaB. Mutations in BCL-10 are observed in many B and T cell lymphomas implicating its role in pathogenesis of human cancer.

BCL-10 Mouse Monoclonal Catalog No. Size Format





Clone: SPM520

Immunogen: Recombinant BCL-10 protein.

Application: IHC-P


Isotype: Mouse IgG1




Product Description: BCL-10/CIPER/CLAP/mE10 is expressed in many human and murine tissues. It contains a CARD (caspase recruiting domain) domain and is involved in activation of caspase 9 to induce apoptosis. It is a cellular homolog of equine herpesvirus 2 E-10. It is known to induce activation of JNK, p38 and NF-kappaB. Mutations in BCL-10 are observed in many B and T cell lymphomas implicating its role in pathogenesis of human cancer.

BCL-X Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic protein derived from near N-terminus of the human BCL-X protein.



Isotype: Rabbit IgG

Control Tissue: Hodgkins Lymphoma

Cellular Localization: Cytoplasm, Membrane, Nucleus



Human Hodgkins Lymphoma stained with anti-BCL-X antibody E337

Product Description: BCL-X is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. BCL-X has two isoforms, BCL-XL (long) a 241 amino acid protein and BCL-XS (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the BCL-2 family.


BCL-XL Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from N-terminus of human BCL-X protein.



Isotype: Rabbit IgG

Control Tissue: Colon Carcinoma, Hodgkins Lymphoma




Human Colon Carcinoma stained with anti-BCL-XL antibody E420


BCL-XL Mouse Monoclonal Catalog No. Size Format





Clone: 7D9

Immunogen: Synthetic peptide corresponding to N-terminus of mouse BCL-XL protein.

Application: IHC-P


Isotype: Mouse IgG2a

Control Tissue: Hodgkins Lymphoma


Human Hodgkins Lymphoma stained with anti-BCL-XL antibody E1666


BIM/BOd Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from N-terminus of human BIM.

Application: IHC-P


Isotype: Rabbit IgG



Human Placenta stained with anti-BIM/BOd antibody E436

Product Description: BIM/BOD (BCL-2-related Ovarian Death Gene) belongs to BCL-2 family of proteins containing BCL-2 homology domain3 (BH3). It is proapoptotic and exerts its effects by interacting with prosurvival members of the BCL-2 family like BCL-2, BCL-XL and BCL-W. It exhibits three splice variants; BIML, BIMS and BIMEL. They all share homology in their C-terminus BH3 domain and are ubiquitously expressed. BIMS is the strongest of them with respect to the proapoptotic capacity.

Bnip3L Rabbit Monoclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide corresponding to internal region of human BNIP3L protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Breast Carcinoma stained with anti-Bnip3L antibody E1684

Product Description: BCL2/adenovirus E1B 19kDa protein-interacting protein 3-like (Bnip3L) is a protein encoded by the BNIP3L gene in humans. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes suppression by BCL-2 and BCL-XL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues. Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.

BOB-1 Rabbit Monoclonal Catalog No. Size Format





Clone: SP92

Immunogen: Synthetic peptide corresponding to C-terminus of human BOB-1 protein.



Isotype: Rabbit IgG



Control Lysate: Ramos


Human Tonsil stained with anti-BOB-1 antibody M392

Product Description: B cell Oct binding protein 1 (BOB-1), is a transcription factor that is required for germinal center formation and immunoglobulin production. BOB-1 is expressed at high levels in spleen and peripheral blood leukocytes and represents an OCT co-factor capable of conferring cell specific activation of OCT-1 and OCT-2.

BOB-1 Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from C-terminus of human BOB-1.



Isotype: Rabbit IgG





Human Tonsil stained with anti-BOB-1 antibody E1667

Product Description: B cell Oct binding protein 1 (BOB-1), is a transcription factor that is required for germinal center formation and immunoglobulin production. BOB-1 is expressed at high levels in spleen and peripheral blood leukocytes and represents an OCT co-factor capable of conferring cell specific activation of OCT-1 and OCT-2.


Primary Antibodies

Bone Morphogenetic Protein 4 (BMP-4) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Recombinant human BMP-4 protein.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Bone Marrow


Human Bone Marrow stained with anti-Bone Morphogenetic Protein 4 (BMP-4) antibody E1251

Product Description: Bone morphogenetic protein 4 (BMP4) is one of nine structurally related BMPs belonging to the transforming growth factor beta superfamily of secreted proteins. BMP4 has important roles as a signaling molecule in the developing central and peripheral nervous system, musculature and skeleton. BMP also plays an important role in early tooth morphogenesis.

C4d** Rabbit Monoclonal Catalog No. Size Format





Clone: SP91

Immunogen: Synthetic peptide corresponding to C-terminus of human C4d protein.

Application: IHC-P


Isotype: Rabbit IgG


Cellular Localization: Secreted Protein

Human Tonsil stained with anti-C4d antibody M391

Product Description: C4 plays a central role in the activation of the classical pathway of the complement system. Prior to secretion, the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha, beta and gamma). During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.

C4d Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide of human C4d.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Kidney, Tonsil

Cellular Localization: Secreted Protein

Human Tonsil stained with anti-C4d antibody E1734

Product Description: C4 plays a central role in the activation of the classical pathway of the complement system. Prior to secretion, the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha, beta and gamma). During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.

c-Abl Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from the sequence adjacent to protein tyrosine kinase domain of human c-Abl.

Application: IHC-P


Isotype: Rabbit IgG



Human Placenta stained with anti-c-Abl antibody E400

Product Description: The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

Cadherin-e/e-Cadherin** Rabbit Monoclonal Catalog No. Size Format





Clone: SP64

Immunogen: Recombinant protein encoding aa 600-707 of human cadherin-E.



Isotype: Rabbit IgG

Control Tissue: Breast Carcinoma, Colon


Control Lysate: MCF7


Human Breast Carcinoma stained with anti-Cadherin-e/e-Cadherin antibody M364

Product Description: Cadherin-E/E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity.

Cadherin-e/e-Cadherin Mouse Monoclonal Catalog No. Size Format





Clone: SPM471


Application: IHC-P


Isotype: Mouse IgG2b/k

Control Tissue: Breast, Skin, Tonsil


Human Breast stained with anti-Cadherin-e/e-Cadherin antibody E864

Product Description: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity.


Cadherin-e/e-Cadherin Rabbit Polyclonal Catalog No. Size Format





Clone: N/A


Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Breast, Skin, Tonsil


Human Skin stained with anti-Cadherin-e/e-Cadherin antibody E346

Product Description: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity.

Cadherin-N/N-Cadherin Rabbit Monoclonal Catalog No. Size Format





Clone: SP90

Immunogen: Synthetic peptide corresponding to C-terminus of human cadherin-N protein.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Mesothelioma


Human Mesothelioma stained with anti-Cadherin-N/N-Cadherin antibody M390

Product Description: Cadherin-N/N-cadherin is a 140kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion. The function of N-cadherin is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminus region of N-cadherin and the cytoplasmic catenin proteins.

Cadherin-N/N-Cadherin Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide corresponding to C-terminus of human cadherin-N protein.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Adrenal Gland, Liver, Pancreas


Human Liver stained with anti-Cadherin-N/N-Cadherin antibody E1826

Product Description: Cadherin-N/N-cadherin is a 140kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion. The function of N-cadherin is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminus region of N-cadherin and the cytoplasmic catenin proteins.

Cadherin-pan Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from C-terminus of chicken cadherin-N protein.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Skin, Tonsil


Human Skin stained with anti-Cadherin-pan antibody E236

Product Description: Cadherins are calcium dependent cell adhesion molecules, which play important roles in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. In adhesion junctions, cadherins are bound to and catenins, which in turn bind to catenin, an actin-binding protein. Cadherins play important roles in tumor invasion and metastasis.

Calbindin d28 Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from C-terminus of human calbindin D28K protein.



Isotype: Rabbit IgG

Control Tissue: Cerebellum, Kidney


Control Lysate: Human Kidney


Human Cerebellum stained with anti-Calbindin d28 antibody E1034

Product Description: Calbindin-D-28K is a highly conserved calcium binding protein. It belongs to a family of low molecular weight calcium-binding proteins (CaBPs). Calbindin-D-28K is found predominantly in subpopulations of central and peripheral nervous system neurons, and in certain epithelial nervous system neurons, and in certain epithelial cells involved in Ca2+ transport such as distal tubular cells and cortical collecting tubules of the kidney, and in enteric neuroendocrine cells.

Calcitonin Rabbit Monoclonal Catalog No. Size Format





Clone: SP17

Immunogen: Synthetic human calcitonin 1-32 amino acid peptide.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Thyroid, Thyroid Medullary Carcinoma


Human Thyroid Medullary Carcinoma stained with anti-Calcitonin antibody M317

Product Description: Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Calcitonin is expressed in a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.


Primary Antibodies

Calcitonin Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic human calcitonin 1-32 amino acid peptide.



Isotype: Rabbit IgG

Control Tissue: Thyroid, Thyroid Medullary Carcinoma


Control Lysate: Human Thyroid


Human Thyroid stained with anti-Calcitonin antibody E115

Product Description: Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Calcitonin is expressed in a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.

Calcium Sensing Receptor (CaSR) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from N-terminus of rat calcium sensing receptor.

Application: IHC-P


Isotype: Rabbit IgG



Human Placenta stained with anti-Calcium Sensing Receptor (CaSR) antibody E1062

Product Description: The calcium sensing receptor (CaSR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).

Calpain Rabbit Monoclonal Catalog No. Size Format





Clone: SP81

Immunogen: Synthetic peptide derived from internal region of human calpain protein.


Species Reactivity: Human*, Mouse*

Isotype: Rabbit IgG





Human Breast Carcinoma stained with anti-Calpain antibody M381

Product Description: Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes due to calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. Calpain S1 is a small subunit common to both Calpain I and II and is associated with myotonic dystrophy.

Calpain Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from internal region of human calpain protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Breast Carcinoma stained with anti-Calpain antibody E1878

Product Description: Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes due to calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. Calpain S1 is a small subunit common to both Calpain I and II and is associated with myotonic dystrophy.

Calpastatin Rabbit Monoclonal Catalog No. Size Format





Clone: SP82

Immunogen: Synthetic peptide derived from near C-terminus of human calpastatin protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Breast Carcinoma stained with anti-Calpastatin antibody M382

Product Description: Calpastatin is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. Calpastatin, a specific endogenous inhibitor of calpain, functions by binding to calpain. It contains mutliple inhibitory fragments for calpain activity.

Calpastatin Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from near C-terminus of human calpastatin protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Breast Carcinoma stained with anti-Calpastatin antibody E1879

Product Description: Calpastatin is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. Calpastatin, a specific endogenous inhibitor of calpain, functions by binding to calpain. It contains mutliple inhibitory fragments for calpain activity.


Calretinin Rabbit Monoclonal Catalog No. Size Format





Clone: SP13

Immunogen: Recombinant full length mouse calretinin protein.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Colon, Mesothelioma


Human Mesothelioma stained with anti-Calretinin antibody M313

Product Description: Calretinin is an intracellular calcium-binding protein belonging to the troponin C superfamily. The immunohistochemical detection of calretinin in developing cerebellum is restricted to the later stages indicated by weak staining from week 21 of gestation in Purkinje and basket cells and in neurons of the dentate nucleus. In tumors, calretinin has been detected in mesotheliomas and some pulmonary adenocarcinomas.

Calretinin Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Recombinant full length mouse calretinin protein.



Isotype: Rabbit IgG

Control Tissue: Colon, Mesothelioma


Control Lysate: Human Brain


Human Mesothelioma stained with anti-Calretinin antibody E117

Product Description: Calretinin is an intracellular calcium-binding protein belonging to the troponin C superfamily. The immunohistochemical detection of calretinin in developing cerebellum is restricted to the later stages indicated by weak staining from week 21 of gestation in Purkinje and basket cells and in neurons of the dentate nucleus. In tumors, calretinin has been detected in mesotheliomas and some pulmonary adenocarcinomas.

CaM Kinase IV Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from C-terminus of rat CaM kinase IV.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Brain


Human Brain stained with anti-CaM Kinase IV antibody E1060

Product Description: Calmodulin dependent protein kinases (CaM kinases) consist of a family of Ser/Thr protein kinases including CaMKI, CaMKII and CaMKIV. CaMKs play a central role in many cellular functions in response to Ca2+ signaling, including synthesis and secretion of neurotransmitters, axonal transport, long term potentiation etc. CaM kinase IV is abundantly expressed in the brain and in the thymus and is localized to the cytoplasm and nucleus.

CaM Kinase Kinase alpha Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide corresponding to C-terminus of human CaM kinase kinase alpha.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Brain


Human Brain stained with anti-CaM Kinase Kinase alpha antibody E1385

Product Description: Ca2+/Calmodulin dependent protein kinases (CaM Kinase I, II and IV) are considered to play a central role in many cellular functions in response to Ca2+ signaling, including synthesis and secretion of neurotransmitters, axonal transport, long term potentiation (LTP), receptor function, modification of the cytoskeleton and regulation of gene expression.

Carbonic Anhydrase 9 (CA-9) Rabbit Monoclonal Catalog No. Size Format





Clone: SP106

Immunogen: Synthetic peptide derived from human CA-9.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Stomach

Cellular Localization: Membrane, Nucleus

Human Stomach stained with anti-Carbonic Anhydrase 9 (CA-9) antibody M406

Product Description: Carbonic anhydrase (CA) is an enzyme that assists rapid inter-conversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. CA-9 is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. CA-9 is a reliable histochemical marker of hypoxia.

Carbonic Anhydrase 9 (CA-9) Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from human CA-9.



Isotype: Rabbit IgG


Cellular Localization: Membrane, Nucleus



Human Stomach stained with anti-Carbonic Anhydrase 9 (CA-9) antibody E1842

Product Description: Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux and it can be used as a histochemical marker of hypoxia.


Primary Antibodies

CAS Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from N-terminus of human CAS.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Liver Carcinoma


Human Liver Carcinoma stained with anti-CAS antibody E1081

Product Description: CAS (Cellular Apoptosis Susceptibility) contains 971 amino acids with 59% overall sequence homology as compared to yeast chromosome segregation homolog, CSE1. CAS is highly expressed in testis and fetal liver. CAS expression in human fibroblasts increases as cells are induced to proliferate and decreases in growth arrested cells.

Caspase-1 Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from internal region of human caspase-1 protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Placenta stained with anti-Caspase-1 antibody E391

Product Description: Caspase-1/ICE (Interleukin-1 Beta Converting Enzyme) is expressed as a proenzyme of 45kDa in many tissues and is activated by proteolytic cleavage. Active caspase-1 is a tetramer of two subunits p10 and p20. Caspase-1 (cystein aspartic-specific protease 1) cleaves interleukin beta into its active form which further exerts its proinflammatory effects. Overexpression of caspase-1 can induce apoptosis in fibroblasts.






Clone: N/A

Immunogen: Synthetic peptide corresponding to N-terminus of human caspase-8 protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Stomach stained with anti-Caspase-8 antibody E228

Product Description: Caspase-8 binds to the death effector domain (DED) through an analogous DED domain. Recruitment of caspase-8 to the Fas receptor results in oligomerization of the caspase-8 protein, which in turn drives its autoactivation through self-cleavage. Activated caspase-8 then activates other downstream caspases including caspase-9, thereby commiting the cell to undergo apoptosis. This antibody also detects the processed forms (42/44kDa, 25kDA, and 14kDa) of caspase-8.






Clone: N/A

Immunogen: Synthetic peptide from C-terminus of human caspase-10.

Application: IHC-P


Isotype: Rabbit IgG

Control Tissue: Liver Carcinoma


Human Liver Carcinoma stained with anti-Caspase-10 antibody E1085

Product Description: Caspase-10 is a member of the Ced-3 cystein protease family and it has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli. Caspase-1 to-10 function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity.

Catenin-beta Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide from C-terminus of the catenin-beta protein.



Isotype: Rabbit IgG



Control Lysate: A431


Human Breast Carcinoma stained with anti-Catenin-beta antibody E226

Product Description: The catenins (, and ) are ubiquitously expressed, cytoplasmic proteins associated with E-cadherin at cellular junctions. -catenin also binds to N-cadherin and co-immunoprecipitates with APC. Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between -actin and -catenin. Increased tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing cellular adhesion.

Catenin-gamma Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Synthetic peptide derived from C-terminus of human catenin-gamma protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Breast Carcinoma stained with anti-Catenin-gamma antibody E368

Product Description: The catenins (, and ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin. -catenin can also bind P-cadherin and N-cadherin. -catenin, also known as plakoglobin, is an 82kDa protein that binds with -catenin and N-cadherin.


Cathepsin d Rabbit Polyclonal Catalog No. Size Format





Clone: N/A

Immunogen: Recombinant human cathepsin D protein.

Application: IHC-P


Isotype: Rabbit IgG



Human Breast Carcinoma stained with anti-Cathepsin d antibody E282

Product Description: Cathepsin D is synthesized as a 54kDa precursor and is proteolytically processed to an intermediate 48kDa single chain. The 48KDa form is further processed into the more stable 34kDa and 14kDa mature forms. Cathepsin D is an estrogen-regulated lysosomal protease that facilitates cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and connective tissue. Cathepsin D is expressed in epithelial cells as well as in macrophages.

Caveolin-1 Rabbit Monoclonal Catalog No. Size Format





Clone: SP43

Immunogen: Synthetic peptide corresponding to C-terminus of human caveolin-1 protein.

Application: IHC-P

Species Reactivity: Human*, Mouse*

Isotype: Rabbit IgG

Control Tissue: Lung, Lung Carcinoma


Human Lung Carcinoma stained with anti-Caveolin-1 antibody M343

Product Description: Caveolae are 50-100 nm flask-shaped subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules across capillary endothelial cells, uptake of small molecules via

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