SPECIAL FEATURES

Highlights of This Issue 725

CCR Translations

727 Novel In Vitro Cancer Models for OptimizingAnti-EGFR TherapiesStefania Napolitano and Fortunato CiardielloSee related article, p. 807

Statistics in CCR

730 Sequential, Multiple Assignment, RandomizedTrial Designs in Immuno-oncology ResearchKelley M. Kidwell, Michael A. Postow, andKatherine S. Panageas

Review

737 Adaptive Global Innovative LearningEnvironment for Glioblastoma: GBM AGILEBrian M. Alexander, Sujuan Ba, Mitchel S. Berger,Donald A. Berry, Webster K. Cavenee, Susan M. Chang,Timothy F. Cloughesy, Tao Jiang, Mustafa Khasraw,Wenbin Li, Robert Mittman, George H. Poste,Patrick Y. Wen, W.K. Alfred Yung, and Anna D. Barker, onbehalf of the GBM AGILE Network

CANCER THERAPY: CLINICAL

744 A Phase I Clinical Trial of the Poly(ADP-ribose)Polymerase Inhibitor Veliparib and WeeklyTopotecan in Patients with Solid TumorsAndrea E. Wahner Hendrickson, Michael E. Menefee,Lynn C. Hartmann, Harry J. Long, Donald W. Northfelt,Joel M. Reid, Felix Boakye-Agyeman, Olumide Kayode,Karen S. Flatten, Maria I. Harrell, Elizabeth M. Swisher,Guy G. Poirer, Daniel Satele, Jake Allred, Janet L. Lensing,Alice Chen, Jiuping Ji, Yiping Zang, Charles Erlichman,Paul Haluska, and Scott H. Kaufmann

753 Outcomes of Children and Adolescents withAdvanced Hereditary Medullary ThyroidCarcinoma Treated with VandetanibIra L. Kraft, Srivandana Akshintala, Yuelin Zhu, Haiyan Lei,Claudia Derse-Anthony, Eva Dombi, Seth M. Steinberg,Maya Lodish, Steven G. Waguespack, Oxana Kapustina,Elizabeth Fox, Frank M. Balis, Maria J. Merino,Paul S. Meltzer, John W. Glod, Jack F. Shern, andBrigitte C. Widemann

766 Autologous Dendritic Cells Pulsed withAllogeneic Tumor Cell Lysate in Mesothelioma:From Mouse to HumanJoachim G.J.V. Aerts, Pauline L. de Goeje,Robin Cornelissen, Margaretha E.H. Kaijen-Lambers,Koen Bezemer, Cor H. van der Leest, Niken M. Mahaweni,Andr�e Kunert, Ferry A.L.M. Eskens, Cynthia Waasdorp,Eric Braakman, Bronno van der Holt, Arnold G. Vulto,Rudi W. Hendriks, Joost P.J.J. Hegmans, andHenk C. Hoogsteden

PERSONALIZED MEDICINE AND IMAGING

777 Mutations in Homologous Recombination Genesand Outcomes in Ovarian Carcinoma Patients inGOG 218: An NRG Oncology/GynecologicOncology Group StudyBarbara M. Norquist, Mark F. Brady, Maria I. Harrell,Tom Walsh, Ming K. Lee, Suleyman Gulsuner,Sarah S. Bernards, Silvia Casadei, Robert A. Burger,Krishnansu S. Tewari, Floor Backes, Robert S. Mannel,Gretchen Glaser, Cheryl Bailey, Stephen Rubin, John Soper,Heather A. Lankes, Nilsa C. Ramirez, Mary Claire King,Michael J. Birrer, and Elizabeth M. Swisher

784 A Polymorphism within the Vitamin DTransporter Gene Predicts Outcome in MetastaticColorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/CetuximabMartin D. Berger, Sebastian Stintzing, Volker Heinemann,Shu Cao, Dongyun Yang, Yu Sunakawa,Satoshi Matsusaka, Yan Ning, Satoshi Okazaki,Yuji Miyamoto, Mitsukuni Suenaga, Marta Schirripa,Diana L. Hanna, Shivani Soni, Alberto Puccini, Wu Zhang,Chiara Cremolini, Alfredo Falcone, Fotios Loupakis, andHeinz-Josef Lenz

794 Colorectal Cancer Consensus Molecular SubtypesTranslated to Preclinical Models UncoverPotentially Targetable Cancer Cell DependenciesAnita Sveen, Jarle Bruun, Peter W. Eide, Ina A. Eilertsen,Lorena Ramirez, Astrid Murum€agi, Mariliina Arjama,Stine A. Danielsen, Kushtrim Kryeziu, Elena Elez,Josep Tabernero, Justin Guinney, Hector G. Palmer,Arild Nesbakken, Olli Kallioniemi, Rodrigo Dienstmann,and Ragnhild A. Lothe

February 15, 2018 � Volume 24 � Number 4

Clinical Cancer Research

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CANCER THERAPY: PRECLINICAL

807 A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem–Like Cells to AssessGenetic and Nongenetic Mechanisms ofResistance to Anti-EGFR TherapyPaolo Luraghi, Viola Bigatto, Elia Cipriano,Gigliola Reato, Francesca Orzan, Francesco Sassi,Francesca De Bacco, Claudio Isella, Sara E. Bellomo,Enzo Medico, Paolo M. Comoglio, Andrea Bertotti,Livio Trusolino, and Carla BoccaccioSee related commentary, p. 727

821 Development of a Function-Blocking AntibodyAgainst Fibulin-3 as a Targeted Reagent forGlioblastomaMohan S. Nandhu, Prajna Behera, Vivek Bhaskaran,Sharon L. Longo, Lina M. Barrera-Arenas,Sadhak Sengupta, Diego J. Rodriguez-Gil,E. Antonio Chiocca, and Mariano S. Viapiano

834 PTEN Loss Promotes Intratumoral AndrogenSynthesis and Tumor MicroenvironmentRemodeling via Aberrant Activation of RUNX2in Castration-Resistant Prostate CancerYinhui Yang, Yang Bai, Yundong He, Yu Zhao,Jiaxiang Chen, Linlin Ma, Yunqian Pan, Michael Hinten,Jun Zhang, R. Jeffrey Karnes, Manish Kohli,Jennifer J. Westendorf, Benyi Li, Runzhi Zhu,Haojie Huang, and Wanhai Xu

847 Olaratumab Exerts Antitumor Activity inPreclinical Models of Pediatric Bone and SoftTissue Tumors through Inhibition of Platelet-Derived Growth Factor Receptor aCaitlin D. Lowery, Wayne Blosser, Michele Dowless,Shelby Knoche, Jennifer Stephens, Huiling Li,David Surguladze, Nick Loizos, Debra Luffer-Atlas,Gerard J. Oakley III, Qianxu Guo, Seema Iyer,Brian P. Rubin, and Louis Stancato

858 Honokiol Radiosensitizes Squamous CellCarcinoma of the Head and Neck byDownregulation of SurvivinXu Wang, Jonathan J. Beitler, Wen Huang, Guo Chen,Guoqing Qian, Kelly Magliocca, Mihir R. Patel,Amy Y. Chen, Jun Zhang, Sreenivas Nannapaneni,Sungjin Kim, Zhengjia Chen, Xingming Deng,Nabil F. Saba, Zhuo Georgia Chen, Jack L. Arbiser, andDong M. Shin

BIOLOGY OF HUMAN TUMORS

870 T Cells Expressing Checkpoint Receptor TIGITAre Enriched in Follicular Lymphoma Tumorsand Characterized by Reversible Suppression ofT-cell Receptor SignalingSarah E. Josefsson, Kanutte Huse, Arne Kolstad,Klaus Beiske, Daniela Pende, Chlo�e B. Steen,Else Marit Inderberg, Ole Christian Lingjærde,Bjørn Østenstad, Erlend B. Smeland, Ronald Levy,Jonathan M. Irish, and June H. Myklebust

882 NKG2D-Dependent Antitumor Effects ofChemotherapy and Radiotherapy againstGlioblastomaTobias Weiss, Hannah Schneider, Manuela Silginer,Alexander Steinle, Martin Pruschy, Bojan Poli�c,Michael Weller, and Patrick Roth

896 Clinical Significance of PD-L1þ Exosomes inPlasma of Head and Neck Cancer PatientsMarie-Nicole Theodoraki, Saigopalakrishna S. Yerneni,Thomas K. Hoffmann, William E. Gooding, andTheresa L. Whiteside

906 Genome-Wide Association Study Identifies aNew Locus at 7q21.13 Associated with HepatitisB Virus–Related Hepatocellular CarcinomaYuanfeng Li, Yun Zhai, Qingfeng Song, Haitao Zhang,Pengbo Cao, Jie Ping, Xinyi Liu, Bingqian Guo,Guanjun Liu, Jin Song, Ying Zhang, Aiqing Yang,Hongbo Yan, Liang Yang, Ying Cui, Yilong Ma,Jinliang Xing, Xizhong Shen, Taotao Liu, Hongxin Zhang,Jiaze An, Jin-Xin Bei, Weihua Jia, Longli Kang, Lijun Liu,Dongya Yuan, Zhibin Hu, Hongbing Shen, Lei Lu,Xuan Wang, Hua Li, Fuchu He, Hongxing Zhang, andGangqiao Zhou

916 FAM198B Is Associated with Prolonged Survivaland Inhibits Metastasis in Lung Adenocarcinomavia Blockage of ERK-Mediated MMP-1 ExpressionChia-Ying Hsu, Gee-Chen Chang, Yi-Ju Chen,Yi-Chiung Hsu, Yi-Jing Hsiao, Kang-Yi Su,Hsuan-Yu Chen, Chien-Yu Lin, Jin-Shing Chen,Yu-Ju Chen, Qi-ShengHong,Wen-Hui Ku, Chih-YingWu,Bing-Ching Ho, Ching-Cheng Chiang, Pan-Chyr Yang,and Sung-Liang Yu

927 The Glucocorticoid Receptor Is a Key Player forProstate Cancer Cell Survival and a Target forImproved Antiandrogen TherapyMartin Puhr, Julia Hoefer, Andrea Eigentler,Christian Ploner, Florian Handle, Georg Schaefer,Jan Kroon, Angela Leo, Isabel Heidegger, Iris Eder,Zoran Culig, Gabri Van der Pluijm, and Helmut Klocker

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939 Whole-Exome Sequencing of Cell-Free DNAReveals Temporo-spatial Heterogeneity andIdentifies Treatment-Resistant Clones inNeuroblastomaMathieu Chicard, Leo Colmet-Daage, Nathalie Clement,Adrien Danzon, Myl�ene Bohec, Virginie Bernard,Sylvain Baulande, Angela Bellini, Paul Deveau,Ga€elle Pierron, Eve Lapouble, Isabelle Janoueix-Lerosey,Michel Peuchmaur, Nad�ege Corradini,Anne Sophie Defachelles, Dominique Valteau-Couanet,Jean Michon, Val�erie Combaret, Olivier Delattre, andGudrun Schleiermacher

950 Etk Interaction with PFKFB4 ModulatesChemoresistance of Small-cell Lung Cancer byRegulating AutophagyQiongyao Wang, Fanrui Zeng, Yanqin Sun,Qianqian Qiu, Jian Zhang, Weimei Huang, Jie Huang,Xiaomin Huang, and Linlang Guo

963 Merkel Cell Carcinoma Patients PresentingWithout a Primary Lesion Have Elevated Markersof Immunity, Higher Tumor Mutation Burden,and Improved SurvivalNatalie Vandeven, Christopher W. Lewis,Vladimir Makarov, Nadeem Riaz, Kelly G. Paulson,Daniel Hippe, Amy Bestick, Ryan Doumani, Tessa Marx,Seesha Takagishi, Timothy A. Chan, Jaehyuk Choi, andPaul Nghiem

972 Mitochondrial Inhibition Augments the Efficacyof Imatinib by Resetting the MetabolicPhenotype of Gastrointestinal Stromal TumorGerardo A. Vitiello, Benjamin D. Medina, Shan Zeng,Timothy G. Bowler, Jennifer Q. Zhang, Jennifer K. Loo,Nesteene J. Param, Mengyuan Liu, Alec J. Moral,Julia N. Zhao, Ferdinand Rossi, Cristina R. Antonescu,Vinod P. Balachandran, Justin R. Cross, andRonald P. DeMatteo

CORRECTION

985 Correction: Differential Toxicity in Patients withand without DNA Repair Mutations: Phase IStudy of Carboplatin and Talazoparib inAdvanced Solid Tumors

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ABOUT THE COVER

The cover shows a branched blood vessel in a tissue section from a patient withglioblastoma. Immunohistochemical staining reveals accumulation of the matrix proteinfibulin-3, forming long perivascular fibers. For details, see the article by Nandhu andcolleagues on page 821 of this issue.

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2018;24:725-985. Clin Cancer Res     24 (4)

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