Development of Harvard Catalyst Imaging Consultation Service

Simon K. Warfield, Ph.D.

Valerie Humblet, Ph.D.

on behalf of the CTSC Imaging Committee

http://catalyst.harvard.edu

Outline

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• Harvard Catalyst

• Imaging Consortium

• Technology effort: Inter-site data exchange

• Why be a consultant ?

• Contact

Harvard Catalyst: The Basics

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• We are a cross-Harvard enterprise dedicated to improving human health by:– Creating Connections– Enabling research At the Cutting Edge of discovery– Nurturing clinical and translational researchers

National Effort in C/T Research

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• Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium

Source: http://www.ctsaweb.org/

Institutions participating in Harvard

CTSC

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Hospitals and Institutes• Beth Israel-Deaconess Medical Center• Brigham and Women’s Hospital• Massachusetts General Hospital• Children’s Hospital Boston• Dana-Farber Cancer Institute• Forsyth Dental Institute• Joslin Diabetes Center• Massachusetts Eye and Ear Infirmary• McLean Hospital• Schepens Eye Research Institute

Massachusetts Institute of Technology

Harvard University• Faculty of Arts and Sciences• Harvard Business School• Harvard School of Dental Medicine• Harvard Divinity School• Graduate School of Design• Graduate School of Education• Kennedy School of Government• Harvard Law School• Harvard Medical School• Harvard School of Public Health• Harvard School of Engineering

Community Healthcare Institutions• Cambridge Health Alliance• HMS Department of Ambulatory

Care and Prevention at Harvard Pilgrim Healthcare

Mission of the Imaging Consortium

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• Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research

• Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging and image processing capabilities in the Harvard environment.

Bruce Rosen, DirectorRandy Gollub, Co-DirectorGordon J. Harris, Site Co-Director

Robert Lenkinski, Site Co-DirectorNeil Rofsky, Site Co-Director

Clare Tempany, Site Co-DirectorRon Kikinis, Site Co-DirectorGordon Williams, PI for CTSC Translational Technologies

Stephan Voss, Site Co-DirectorSimon Warfield, Site Co-Director

Annick D. Van den Abbeele, Site Co-DirectorJeff Yap, Site Co-Director

Gordon J. Harris, Site Co-DirectorAnnick D. Van den Abbeele, Site Co-DirectorWilliam Hanlon, Core Manager

Valerie Humblet, Imaging Liaison

Imaging Consortium Team

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XNATEnterprise

DataRepository

(CRC)

FileRepository

IdentityManagement

OntologyManagement

CorrelationAnalysis

De -Identification

Of dataNatural

LanguageProcessing

AnnotatingGenomicData #1

ProjectManagement

WorkflowFramework

AnnotatingGenomicData #2PACS PACS

i2b2 HIVE

Dr X Desktop Pediatric

rare disease

Dr YDesktop

Alzheimer

Dr ZDesktop

Chronic pain management Dr W

Desktop Quantitative

cancer biomarkers

Inter-site data exchange

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Becoming an Imaging Consultant

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• Potential benefits of volunteering to be a consultant:– Networking leading to collaborations and

funding (eg: pilot grants)– Increase user base of service– Mentoring new investigators

Radiology at Children’s Hospital

• Expertise in Pediatric Imaging

• Image analysis algorithms especially suited to pediatrics

• Software implementation supported by NIH to create a platform for scientific discovery:– Computational Radiology Kit (CRKit)– Open source software

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Radiology at Children’s Hospital

• Computational Radiology Kit (CRKit)– Pediatric MRI image segmentation– Intra-subject multi-modality image fusion– Inter-subject alignment

• Neuroimage atlasing• Diffusion tensor image group analysis for RCT

– Tractography– Visualization– Validation for quantitative image analysis

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http://catalyst.harvard.eduImage_Consult@catalyst.harvard.edu