"overview of the harvard catalyst imaging program"
DESCRIPTION
TRANSCRIPT
Overview of the Harvard Catalyst Imaging program
Ron Kikinis, MD;Clare Tempany, MD;
Valerie Humblet, PhD
http://catalyst.harvard.edu July 20, 2009
Harvard Catalyst: The History and the Basics
2
• GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued– BWH/MGH imaging cores
• CTSA 2007(Roadmap initiative)• HU- Response-Harvard Catalyst
– (PI Lee Nadler/Co-Director: Steve Freedman)– GCRC at BWH incorporated in Center for Clinical Investigation
• We are a pan-Harvard enterprise dedicated to improving human health by:– Creating Connections– Enabling research At the Cutting Edge of discovery– Nurturing clinical and translational researchers
National Effort in C/T Research
39 AHC/23 states
3
• Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium
Source: http://www.ctsaweb.org/
Duke
Mayo Clinic
Cornell
J.Hopkins
UC Davis
Wash. U.
Northwestern
Emory U.
• 30 Imaging programs-(Dan Sullivan/RSNA)
Institutions participating in Harvard CTSC
4
Academic Healthcare Centers• Beth Israel-Deaconess Medical
Center• Brigham and Women’s Hospital• Massachusetts General Hospital• Children’s Hospital Boston
Specialty Hospitals and Institutes• Dana-Farber Cancer Institute• Forsyth Dental Institute• Joslin Diabetes Center• Massachusetts Eye and Ear
Infirmary• McLean Hospital• Schepens Eye Research Institute
Massachusetts Institutes of Technology
Harvard University• Faculty of Arts and Sciences• Harvard Business School• Harvard School of Dental Medicine• Harvard Divinity School• Graduate School of Design• Graduate School of Education• Kennedy School of Government• Harvard Law School• Harvard Medical School• Harvard School of Public Health• Harvard School of Engineering
Community Healthcare Institutions• Cambridge Health Alliance• HMS Department of Ambulatory
Care and Prevention at Harvard Pilgrim Healthcare
Red –Imaging Consortium
Yearly budget: $38 million (23 NIH + 15 matching)
Harvard Catalyst
• Programs (Selected list)
– Development of Novel C/T Methodologies– Biomedical Informatics– Research Education, Career Development– Pilot studies– Community Engagement– Design and Biostatistics– Diversity and Health Disparities Research– Ethics– Linkages across the institutions– Regulatory Knowledge and Support
5
Harvard Catalyst
• Programs– Translational Technologies and Resources
• Imaging and Genetics– increases investigator awareness and
utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies.
6
Bruce Rosen, DirectorRandy Gollub, Co-DirectorGordon J. Harris, ConsultantWilliam Hanlon, Consultant
Robert Lenkinski, ConsultantNeil Rofsky, Consultant
Clare Tempany, ConsultantRon Kikinis, ConsultantCharles Guttmann, ConsultantTodd Perlstein, ConsultantGordon Williams, PI for CTSC Translational Technologies
Stephan Voss, ConsultantSimon Warfield, Consultant
Annick D. Van den Abbeele, ConsultantJeff Yap, Consultant, Director of Education
Valerie Humblet, Imaging LiaisonYong Gao, Imaging Informatics Architect
Imaging Consortium Team
7
Mission of the Imaging Consortium
8
• Expand imaging in clinical research– Build & deploy infrastructure (expertise in single and
cross site image acquisition, image analysis, visualization & data management software tools)
– Provide expert consultation in the use of imaging as part of clinical translational research
– Educate and advise about available imaging and image processing capabilities in the Harvard environment.
– Provide leadership & education at the local and national level
Harvard Catalyst website
9
http://catalyst.harvard.edu/home.html
Image Consortium Consultation Service
10
Image Consortium Consultation Service
11
Technologies and Expertise
12
• Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging.
• Focused on assisting with planning and design of research proposals and/or methods for image analysis.
• Consultation is available for the preparation of a grant or IRB submission.
• We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies.
Examples of Imaging Consultation
13
• Standardization of physiologic monitoring system for MRI.
– Deployed at 6 institutions (MGH, BWH, BIDMC, CHB, MIT, Harvard)
– Creation of a biomedical engineer working group
Examples of Imaging Consultation
14
• Development of lingual nerve imaging (MGH-BIDMC)
– MGH maxillofacial surgeon contacted us regarding pre-op imaging of lingual nerve
– Bob Lenkinski (BIDMC) had expertise in MRI nerve imaging
– Healthy volunteer was scanned at BIDMC
– Head and neck radiologist (BIDMC) will help with reading of images
Examples of Imaging Consultation
15
• Study of brain-development in premature infants (CHB-BWH-MGH)
Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR)
Optical Imaging of Cerebral Oxygenation in Infants (MGH)
CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center
CTSC Imaging Informatics Mission
16
• Provide imaging informatics services and support to Harvard Catalyst affiliated – Individual investigators
– Organizations (departments, centers, hospitals)
• Enable medical imaging data sharing across individual investigators and organizations with dedicated hardware and software
• Integrate Imaging Data Management capabilities into i2b2
CTSC Imaging Informatics
17
• IT Catalyst infrastructure:– i2b2: scalable computational framework to help
translation of genomic findings. – BIRN: XNAT imaging informatics platform: large
collections of images and study-specific metadata to be managed by image-driven clinical translational research groups.
– NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer.
XNATEnterprise
DataRepository
(CRC)
FileRepository
IdentityManagement
OntologyManagement
CorrelationAnalysis
De -Identification
Of dataNatural
LanguageProcessing
AnnotatingGenomicData #1
ProjectManagement
WorkflowFramework
AnnotatingGenomicData #2PACS PACS
i2b2 HIVE
Dr X Desktop Pediatric
rare disease
Dr YDesktop
Alzheimer
Dr ZDesktop
Chronic pain management Dr W
Desktop Quantitative
cancer biomarkers
CTSC Imaging Informatics
18
CTSC Imaging Informatics
19
Secondary Use of Clinical Imaging Data (Integration with i2b2)Automated MRI measures identify individuals with mild cognitive impairments and Alzheimer’s disease
QuickTime™ and aTIFF (LZW) decompressor
are needed to see this picture.
Desikan et al, Brain (published online on May 21, 2009)
Standard T1 MRI scan
AUC 0.95 (specificity 91%, sensitivity 90% to discriminate) MCI from age matched controls
Catalyst Educational Program
20
• Creation of a new Harvard post-graduate education program in C/T science (Elliott Antman, BWH)– Introduction to Clinical Investigator Training
First course: Nov 2-6, 2009
– Advanced Clinical Research Training To prepare investigators for writing and conducting a clinical trial
– Masters K12 ProgramsPreparation for career in clinical research
Imaging Consortium Educational Program
21
• Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff
• Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc)
• Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms
• Dissemination: through national networks (CTSA, RSNA, IRAT, SNM)
Pilot grants
• To foster cross-institutional and cross-disciplinary collaboration, Harvard Catalyst offers seed funds in the form of Pilot Grants.– All Harvard faculty are eligible to apply, regardless of
degree or institutional affiliation.
– First round: 62 projects funded (out of 602)
– This year (application closed): Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected)
– Contact:Harvard Catalyst Research Navigators617 432-7800
22