dove medical press web viewsupplementary materials: figure s2. the distribution of her2 s310f...

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Supplementary materials: Figure S2. The distribution of HER2 S310F mutation across cancers. (A) The distribution of S310F mutation occurred in top 10 cancer types. (B) The landscape of mutations occurring more than three times in STAD. (C) The landscape of mutations occurring more than twice in BLCA. (D) The landscape of mutations occurring more than twice in BRCA.

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Page 1: Dove Medical Press Web viewSupplementary materials: Figure S2. The distribution of HER2 S310F mutation across cancers. (A) The distribution of S310F mutation occurred in top 10 cancer

Supplementary materials:Figure S2. The distribution of HER2 S310F mutation across cancers. (A) The distribution of S310F mutation occurred in top 10 cancer types. (B) The

landscape of mutations occurring more than three times in STAD. (C) The landscape of mutations occurring more than twice in BLCA. (D) The landscape of

mutations occurring more than twice in BRCA.

Page 2: Dove Medical Press Web viewSupplementary materials: Figure S2. The distribution of HER2 S310F mutation across cancers. (A) The distribution of S310F mutation occurred in top 10 cancer

Figure S3. The distribution of HER2 mutations in (A) BLCA, (B) STAD and (C) BRCA.

Page 3: Dove Medical Press Web viewSupplementary materials: Figure S2. The distribution of HER2 S310F mutation across cancers. (A) The distribution of S310F mutation occurred in top 10 cancer

Figure S4. SDS-PAGE analysis of HER2 ECD Fc-tagged proteins under reductive condition.

Lane 1, molecular weight protein markers; lane 2, HER2-ECD-WT Fc-tagged protein; lane 3,

HER2-ECD-S310F Fc-tagged protein.

Figure S5. SPR analysis of the trastuzumab/pertuzumab-WT/S310F-mutant HER2 interaction

by a Biacore 3000 instrument. Representative sensorgrams (coloured lines) obtained from

injection of different concentrations (ranging from 0.96 to 600 nM) of trastuzumab/pertuzumab

over coupled WT/S310F-mutant HER2 antigen. Curves were fitted using a bivalent analyte

model (black lines).

Page 4: Dove Medical Press Web viewSupplementary materials: Figure S2. The distribution of HER2 S310F mutation across cancers. (A) The distribution of S310F mutation occurred in top 10 cancer

Table S1. PCR primers used for plasmids construction

Primers Primer sequence (5’- 3’)

Primer 1 CGGACGTGGGATTCTGCACCCTCGT

Primer 2 ACGAGGGTGCAGAATCCCACGTCCG

Primer 3 CGGAATTCGCCACCATGAGGGCGAACGA

Primer 4 ATTCTTATGCGGCCGCTTACGTTCTCTGG

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