The California Institute for Telecommunications and Information Technology

Dynamics of Your Gut Microbiome in Health and DiseasePresentationExponential MedicineSan Diego, CAOctober 9, 2016Dr. Larry SmarrDirector, California Institute for Telecommunications and Information TechnologyHarry E. Gruber Professor, Dept. of Computer Science and EngineeringJacobs School of Engineering, UCSDhttp://lsmarr.calit2.net1

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There are 100 billion stars in the Andromeda galaxyand 100 billion galaxies in theknown universe.

Its a microbial world

there are 100 million times as many bacteria on Earth as stars in the universe. Microbiology is the ultimate Big Data science!

Most of Lifes Evolutionary Time Was in the Microbial World

You Are Here

Source: Carl Woese, et al

Tree of Life Derived from 16S rRNA Sequences

President Obama Announces National Microbiome InitiativeMay 13, 2016

Your Microbiome is YourNear-Body EnvironmentThe MicrobiomeContains 300x as Many DNA GenesAs Your Human DNAInclusion of the Dark Matter of the BodyWill Radically Alter Medicine

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Your Gut Microbiome Contains Hundreds of Microbial Species

Average Over 250 Healthy PeopleFrom NIH Human Microbiome Project

Note Log ScaleClostridium difficileSource: Weizhong Li, Andrew Prudomme, Larry Smarr, UCSD

Exploring the Gut Microbiome Time Series byCollaborating with the UCSD Knight Lab

My Welcome Present to Rob

MouthStoolVaginaSkinSource: Knight Lab, UCSD

Source: Knight Lab, UCSD

But Microbiome Time SeriesAre Very Different in Disease States

Fecal TransplantsFrom Healthy DonorTo C. Diff PatientsSource: Knight Lab, UCSD

As a Model for the Precision Medicine Initiative, I Have Tracked My Internal Biomarkers To Understand My Bodys Dynamics

My Quarterly Blood DrawCalit2 64 Megapixel VROOM

By Creating a Time Series of an Immune System BiomarkerI Discovered I Had an Autoimmune DiseaseNormal Range