Examples of Epigenetic Phenomena

Monozygotic

Genomes are identical

Epigenetic phenomena

heritable alternative states

of gene activity that do not result

from altered nucleotide sequence

lrsquoepigenoma e lrsquoepigenetica

Epigenoma trasformazioni del genoma a livello

cellulare

Epigenetica la trasmissibilitagrave di queste

trasformazioni nelle generazioni successive

Ambiente

ambiente

citoplasma

genomalrsquoambiente cellulare dellrsquoorganismo

lrsquoambiente esterno

Nutrizione ed epigenetica - Profssa Franca Saccucci

AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved

Epigenetic phenomena

heritable alternative states

of gene activity that do not result

from altered nucleotide sequence

lrsquoepigenoma e lrsquoepigenetica

Epigenoma trasformazioni del genoma a livello

cellulare

Epigenetica la trasmissibilitagrave di queste

trasformazioni nelle generazioni successive

Ambiente

ambiente

citoplasma

genomalrsquoambiente cellulare dellrsquoorganismo

lrsquoambiente esterno

Nutrizione ed epigenetica - Profssa Franca Saccucci

AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved

lrsquoepigenoma e lrsquoepigenetica

Epigenoma trasformazioni del genoma a livello

cellulare

Epigenetica la trasmissibilitagrave di queste

trasformazioni nelle generazioni successive

Ambiente

ambiente

citoplasma

genomalrsquoambiente cellulare dellrsquoorganismo

lrsquoambiente esterno

Nutrizione ed epigenetica - Profssa Franca Saccucci

AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved

Ambiente

ambiente

citoplasma

genomalrsquoambiente cellulare dellrsquoorganismo

lrsquoambiente esterno

Nutrizione ed epigenetica - Profssa Franca Saccucci

AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved

Nutrizione ed epigenetica - Profssa Franca Saccucci

AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved

AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved