excellence in phenotyping: assessment of oxidative stress and microinflammation jan menne/hermann...
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Excellence in phenotyping: Excellence in phenotyping: Assessment of oxidative stress and Assessment of oxidative stress and
microinflammationmicroinflammation
Jan Menne/Hermann Haller Department of NephrologyMedical School Hannover [email protected]
The problem: The problem: how translate risk factors into vascular disase ?how translate risk factors into vascular disase ?
Risk factors Vascular damage Vascular damage „subclinical“„subclinical“
Clinical diseaseClinical disease
years and decadesyears and decades
glucoseglucoselipidslipids
smokingsmokinghypertensionhypertension
The problem: The problem: how to recognize these „patients“ ?how to recognize these „patients“ ?
Risk factors Vascular damage Vascular damage „subclinical“„subclinical“
Clinical diseaseClinical disease
years and decadesyears and decades
glucoseglucoselipidslipids
smokingsmokinghypertensionhypertension
phenotyping - what are we looking for ?phenotyping - what are we looking for ?
hypertensionhypertension
OxidativeOxidativestressstress
Micro-Micro-inflammationinflammation
EM Gefäß
PermeabilityPermeabilityNONO
NOS NOS
NONO
Non-adhesiveNon-adhesive
Healthy endotheliumHealthy endothelium
NONO
NOS NOS
NONO
Non-adhesiveNon-adhesive
Healthy endotheliumHealthy endothelium Hypertension Glucose Cholesterol riskHypertension Glucose Cholesterol risk
factorsfactors
ROSROS
Oxidases Oxidases
NOSNOS
inhibitorsinhibitors
ChemokinesChemokines
PermeabilityPermeabilityPermeabilityPermeability
PermeabilityPermeabilityNONO
NOS NOS
NONO
Non-adhesiveNon-adhesive
Healthy endotheliumHealthy endothelium
PermeabilityPermeability
Oxidases Oxidases
ROSROS
NOSNOS
inhibitorsinhibitors
ChemokinesChemokines
Hypertension Glucose Cholesterol riskHypertension Glucose Cholesterol risk
factorsfactors
EM Leukozytenadhäsion
PermeabilityPermeabilityNONO
NOS NOS
NONO
Non-adhesiveNon-adhesive
Healthy endotheliumHealthy endothelium
PermeabilityPermeability
Oxidases Oxidases
ROSROS
NOSNOS
inhibitorsinhibitors
ChemokinesChemokines
MCP-1, CCR-7 etcMCP-1, CCR-7 etc
selectinsselectins
Hypertension Glucose Cholesterol riskHypertension Glucose Cholesterol risk
factorsfactors