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This is a live program offered by the Department of Pathology at BIDMC and the HMS Department of Continuing Education to provide pathologists with a comprehensive review and update of the pathologic diagnosis and clinical significance of benign, in situ and malignant lesions of the breast. Material is presented in lecture format by leading experts in the field of breast pathology and related clinical disciplines. The course additionally includes interactive sessions consisting of case-based presentations, Q&A and an audience response system.

LEARNING OBJECTIVESUpon completion of this course, participants will be ableto:

• Evaluate the diagnostic criteria and clinical significance of various benign, in situ and malignant breast lesions and determine appropriate diagnostic testing

• Summarize the uses and limitations of techniques such as core needle biopsy and immunohistochemistry

• Review the role and the limitations of prognostic marker studies in patients with breast cancer

• Analyze the emerging role of molecular biology in the study of breast diseases

• Describe differential diagnostic problems commonly encountered in breast pathology and develop strategies to resolve them in your practice environment

• Determine the importance of pathologic-radiologic correlation in the assessment of non-palpable breast lesions

• Utilize the latest information on evaluation and reporting of breast lumpectomy margins

• Recognize the existence of borderline lesions that are better classified as such on initial core needle biopsy samples

COURSE DESCRIPTION

https://cmeregistration.hms.harvard.edu/732432-1702

HARVARDMEDICAL SCHOOL

BETH ISRAEL DEACONESS

MEDICAL CENTER

DEPARTMENT OF PATHOLOGY

BREAST PATHOLOGYCURRENT CONCEPTS

AND CONTROVERSIES

June 5–6, 2017

Course Directors:Stuart J. Schnitt, MDLaura C. Collins, MD

The Fairmont Copley Plaza HotelBoston, Massachusetts

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HARVARD MEDICAL SCHOOLGabrielle M. Baker, MDStaff Pathologist, Beth Israel Deaconess Medical Center, Instructor in Pathology, Harvard Medical School, Boston, MA

Jane E. Brock, MD, PhDAssociate Pathologist and Medical Director of Surgical Grossing Room, Brigham and Women's Hospital,Assistant Professor, Harvard Medical School, Boston, MA

Laura C. Collins, MDDirector of Anatomic Pathology, Beth Israel Deaconess Medical Center, Associate Professor of Pathology, Harvard Medical School, Boston, MA

James L. Connolly, MDSenior Pathologist, Beth Israel Deaconess Medical Center, Professor of Pathology Harvard Medical School, Boston, MA

Deborah A. Dillon, MDStaff Pathologist, Brigham and Women's Hospital, Assistant Professor of Pathology, Harvard Medical School, Boston, MA

Ted A. James, MD, MS, FACSChief, Breast Surgical Oncology and Co-Director of the Linsey BreastCare Center at Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

Susan C. Lester, MD, PhDStaff Pathologist, Brigham and Women's Hospital, Assistant Professor of Pathology, Harvard Medical School, Boston, MA

Tejas S. Mehta, MD, MPHChief of Breast Imaging and Co-Director of Linsey BreastCare Center, Beth Israel Deaconess Medical Center, Assistant Professor of Radiology, Harvard Medical School, Boston, MA

Stuart J. Schnitt, MDVice Chair for Anatomic Pathology, Beth Israel Deaconess Medical Center, Professor of Pathology, Harvard Medical School, Boston, MA

GUEST FACULTYEdi Brogi, MD, PhDDirector of Breast Pathology, Attending PathologistMemorial Sloan Kettering Cancer CenterProfessor of Pathology and Laboratory MedicineWeill Cornell Medical College, New York, NY

7:30–8:00 Registration and Continental Breakfast

8:00–8:10 Welcome and Introduction Laura C. Collins, MD

8:10–8:55 1) Lesions of the low grade breast neoplasia pathway Laura C. Collins, MD8:55–9:35 2) Lesions of the high grade breast neoplasia pathway Stuart J. Schnitt, MD9:35–10:00 3) Panel Discussion/ Questions & Answers Session I Speakers10:00–10:30 BREAK

Program changes/substitutions may be made without notice.

MONDAY, JUNE 5, 2017

SESSION I: LOW GRADE AND HIGH GRADEBREAST NEOPLASIA

MODERATOR: LAURA C. COLLINS, MD

10:30–11:00 1) Molecular Classification of Breast Cancer Laura C. Collins, MD11:00–11:30 2) Pathologic Features of Local Recurrence Susan C. Lester, MD, PhD11:30–12:00 3) Pathology Evaluation of Breast Specimens After Neoadjuvant Systemic Therapy Gabrielle Baker, MD12:00–1:15 LUNCH (on your own)

SESSION II: CONTEMPORARY ASPECTS OFINVASIVE BREAST CANCER

MODERATOR: STUART J. SCHNITT, MD

1:15–1:45 1) Fibroepithelial Lesions Edi Brogi, MD, PhD1:45–2:15 2) Spindle Cell Lesions Stuart J. Schnitt, MD2:15–2:30 3) Panel Discussion/ Questions & Answers Session III Speakers2:30–2:45 BREAK

SESSION III: DIAGNOSTIC CHALLENGES IMODERATOR: LAURA C. COLLINS, MD

2:45–3:45 1) Breast Radiology-Pathology Correlation Tejas Mehta, MD and James L. Connolly, MD3:45–4:00 2) Panel Discussion/ Questions & Answers Session IV Speakers

SESSION IV: CLINICAL AND RADIOLOGIC ISSUESMODERATOR: STUART J. SCHNITT, MD

4:00–5:00 Case-Based Presentations with Audience Response

SESSION V: CASE-BASED PRESENTATIONS WITHAUDIENCE RESPONSE

MODERATOR: LAURA C. COLLINS, MD ANDSTUART J. SCHNITT, MD

7:30–8:00 Continental Breakfast

8:00–8:30 1) Core Needle Biopsy: Striving for Fewer Excisions Laura C. Collins, MD8:30–9:00 2) Combined Epithelial Myoepithelial Lesions Deborah A. Dillon, MD9:00–9:30 3) Lobular Cardinoma in Situ and Problematic in Situ Lesions Edi Brogi, MD, PhD9:30–10:00 4) Inflammatory and Reactive Breast Lesions Stuart J. Schnitt, MD10:00–10:15 5) Panel Discussion/ Questions & Answers Session VI Speakers10:15–10:45 BREAK

TUESDAY, JUNE 6, 2017

SESSION VI: DIAGNOSTIC CHALLENGES INBREAST PATHOLOGY II

MODERATOR: STUART J. SCHNITT, MD

10:45–11:15 1) Update on Biomarker Immunohistochemistry (ER, PR, HER2) Deborah A. Dillon, MD11:15–11:45 2) Newer Prognostic and Predictive Assays in Breast Cancer Jane E. Brock, MD, PhD11:45–12:00 3) Panel Discussion/ Questions & Answers Session VII Speakers12:00–1:15 LUNCH (on your own)

SESSION VII: ANCILLARY TESTING INBREAST PATHOLOGY

MODERATOR: LAURA C. COLLINS, MD

1:15–1:45 1) Nipple Lesions Susan C. Lester, MD, PhD1:45–2:15 2) Papillary Lesions Laura C. Collins, MD2:15–2:30 3) Panel Discussion/ Questions & Answers Session VIII Speakers2:30–2:45 BREAK

SESSION VIII: DIAGNOSTIC CHALLENGES INBREAST PATHOLOGY III

MODERATOR: STUART J. SCHNITT, MD

2:45–3:15 1) Pathology and Decision Making in Breast Cancer: The Surgeon's Perspective Ted James, MD, MS, FACS3:15–3:45 2) A Contemporary View of Lumpectomy Margin Evaluation Stuart J. Schnitt, MD3:45–4:00 3) Panel Discussion/ Questions & Answers Session IX Speakers

SESSION IX: SPECIMEN EVALUATION INBREAST PATHOLOGY

MODERATOR: LAURA C. COLLINS, MD

4:00–5:00 Case-Based Presentations with Audience Response

SESSION X: CASE-BASED PRESENTATIONS WITHAUDIENCE RESPONSE

MODERATOR: LAURA C. COLLINS, MD ANDSTUART J. SCHNITT, MD

TARGET AUDIENCEThe target audience for this course is pathologists whopractice general surgical pathology as well as those witha particular interest in breast pathology. Pathologytrainees and breast care providers in related specialtieswill also benefit from this course.

ACCREDITATIONThe Harvard Medical School is accredited by theAccreditation Council for Continuing Medical Educationto provide continuing medical education for physicians.The Harvard Medical School designates this live activityfor a maximum of 13.75 AMA PRA Cateory 1 CreditsTM.Physicians should claim only the credit commensuratewith the extent of their participation in the activity.This activity also provides 13.75 SAM eligible CME for the American Board of Pathology MOC Program

ABMS/ACGME COMPETENCIESThis course is designed to meet one or more of the follow-ing American Board of Medical Specialties and Accredita-tion Council of Graduate Medical Education competencies:• Patient Care and Procedural Skills• Medical Knowledge• Practice-based Learning and Improvement

IOM COMPETENCIESThis course is designed to meet one or more of the follow-ing Institute of Medicine competencies:• Work in Interdisciplinary Teams• Employ Evidence Based Practice• Apply Quality Improvement

REGISTRATION INFORMATIONFULL FEE• Registrations Postmarked On or Before April 1, 2017 . . $575• Registrations Postmarked After April 1, 2017. . . . . . . . . $625• Reduced Fee for Past Participants Physicians . . . . . . . . $575REDUCED FEE• Residents, Fellows in Training, and• Allied Health Professionals . . . . . . . . . . . . . . . . . . . . . . . . $395• Past Participants Residents or Fellows in Training . . . . . $375*Processing (non-refundable service fee) $5. All fees shown in USD.

Registration by credit card or check (VISA, MasterCardor American Express) can be made through HarvardMedical School’s secure online registration system at:https://cmeregistration.hms.harvard.edu/732432-1702.Registration by check (draft on a US bank), please makepayable to Harvard Medical School. Learners whochoose to pay by check will be prompted to download anonline form to send in with a payment. Telephone or faxregistration is not accepted. Registration with cash pay-ment is not permitted. Upon receipt of your payment,you will receive an email confirmation. Be sure toinclude an email address that you check frequently.

INQUIRIESBy phone 617-384-8600, Monday-Friday, 9 AM to 5 PM

(EST) or by email at: ceprograms@hms.harvard.edu.

ONLINE INFORMATIONTo register or view activity information online, visit:https://cmeregistration.hms.harvard.edu/732432-1702.

DISCLOSURE POLICYHarvard Medical School (HMS) adheres to all ACCME Accreditation Criteria and Policies. It is HMS’s policy that those who have influenced the content of a CME activity (eg., planners, faculty, authors, reviewers, and others) disclo-sure all relevent financial relationships with commercial entities so that HMS may identify and resolve any conflicts on interest prior to the activity. These disclosures will be provided in the activity materials along with disclosure of any commercial support received for the activity. Addition-ally, faculty members have been instructed to disclose any limitations of data and unlabeled or investigational uses of products during their presentations.

REFUND POLICYRefunds, less an administrative fee of $75, will be issued for all cancellations received two weeks prior to the start of the course. No refund will be issued should cancellation occur less than two weeks prior. “No shows” are subject to the full course fee.

COURSE LOCATIONAll sessions for this course will beheld at The Fairmont CopleyPlaza Hotel, 138 St. JamesAvenue, Boston, MA (Telephone:617-267-5300 or 1-800-441-1414).www.fairmont.com/CopleyPlaza

ACCOMMODATIONS/TRAVELA limited number of rooms have been reserved at TheFairmont Copley Plaza Hotel (Telephone: 617-267-5300 or 1-800-441-1414) until May 8, 2017. Please specify that you are enrolled in this course to receive a reduced room rate of $345 per night Fairmont Rooms/$375 per night Deluxe Rooms. Hotel arrangements can also be made online at: https://resweb.passkey.com/go/breastpathology2017.Please do not purchase non-refundable airline ticket(s)until you have received an email from our office confirm-ing your paid registration.